ENSGALG00000031960


Gallus gallus

Features
Gene ID: ENSGALG00000031960
  
Biological name :LEF1
  
Synonyms : LEF1 / lymphoid enhancer binding factor 1
  
Possible biological names infered from orthology : P27782 / Q9UJU2
  
Species: Gallus gallus
  
Chr. number: 4
Strand: 1
Band:
Gene start: 38153406
Gene end: 38207540
  
Corresponding Affymetrix probe sets: Gga.17240.1.A1_at (Chicken Array)   Gga.2694.1.S1_at (Chicken Array)   Gga.2694.1.S2_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000050823
NCBI entrez gene - 395865     See in Manteia.
RefSeq - XM_015276137
RefSeq - NM_205013
RefSeq - XM_015276135
RefSeq - XM_015276136
RefSeq Peptide - NP_990344
swissprot - O93345
Ensembl - ENSGALG00000031960
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lef1ENSDARG00000031894Danio rerio
 LEF1ENSG00000138795Homo sapiens
 Lef1ENSMUSG00000027985Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TCF7L2 / transcription factor 7 like 2 / Q924A0* / Q9NQB0* / transcription factor 7 like 2, T cell specific, HMG box*ENSGALG0000000888364
TCF7 / transcription factor 7 / P36402* / Q00417* / transcription factor 7, T cell specific*ENSGALG0000000648060


Protein motifs (from Interpro)
Interpro ID Name
 IPR009071  High mobility group box domain
 IPR013558  CTNNB1 binding, N-teminal
 IPR024940  Transcription factor TCF/LEF
 IPR027397  Catenin binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001569 branching involved in blood vessel morphogenesis ISS
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0001755 neural crest cell migration IBA
 biological_processGO:0001756 somitogenesis IEA
 biological_processGO:0001837 epithelial to mesenchymal transition IEA
 biological_processGO:0001944 vasculature development ISS
 biological_processGO:0002040 sprouting angiogenesis ISS
 biological_processGO:0006357 regulation of transcription by RNA polymerase II ISS
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0009953 dorsal/ventral pattern formation IMP
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0016055 Wnt signaling pathway ISS
 biological_processGO:0016202 regulation of striated muscle tissue development IBA
 biological_processGO:0021542 dentate gyrus development ISS
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0021854 hypothalamus development IBA
 biological_processGO:0021861 forebrain radial glial cell differentiation ISS
 biological_processGO:0021873 forebrain neuroblast division ISS
 biological_processGO:0021879 forebrain neuron differentiation IBA
 biological_processGO:0021943 formation of radial glial scaffolds ISS
 biological_processGO:0022407 regulation of cell-cell adhesion ISS
 biological_processGO:0030111 regulation of Wnt signaling pathway ISS
 biological_processGO:0030223 neutrophil differentiation IEA
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0030326 embryonic limb morphogenesis IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030509 BMP signaling pathway ISS
 biological_processGO:0030854 positive regulation of granulocyte differentiation IEA
 biological_processGO:0032696 negative regulation of interleukin-13 production IEA
 biological_processGO:0032713 negative regulation of interleukin-4 production IEA
 biological_processGO:0032714 negative regulation of interleukin-5 production IEA
 biological_processGO:0033153 T cell receptor V(D)J recombination ISS
 biological_processGO:0035108 limb morphogenesis NAS
 biological_processGO:0042100 B cell proliferation ISS
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0043392 negative regulation of DNA binding IEA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0043586 tongue development ISS
 biological_processGO:0043923 positive regulation by host of viral transcription IEA
 biological_processGO:0043966 histone H3 acetylation IEA
 biological_processGO:0043967 histone H4 acetylation IEA
 biological_processGO:0045063 T-helper 1 cell differentiation ISS
 biological_processGO:0045665 negative regulation of neuron differentiation IMP
 biological_processGO:0045843 negative regulation of striated muscle tissue development IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046632 alpha-beta T cell differentiation ISS
 biological_processGO:0048069 eye pigmentation IMP
 biological_processGO:0048341 paraxial mesoderm formation IEA
 biological_processGO:0048468 cell development IEA
 biological_processGO:0048747 muscle fiber development IBA
 biological_processGO:0050909 sensory perception of taste ISS
 biological_processGO:0060021 roof of mouth development IEA
 biological_processGO:0060033 anatomical structure regression ISS
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0060325 face morphogenesis IEA
 biological_processGO:0060326 cell chemotaxis IEA
 biological_processGO:0060561 apoptotic process involved in morphogenesis IEA
 biological_processGO:0061072 iris morphogenesis IMP
 biological_processGO:0061073 ciliary body morphogenesis IMP
 biological_processGO:0061153 trachea gland development ISS
 biological_processGO:0071345 cellular response to cytokine stimulus IEA
 biological_processGO:0071353 cellular response to interleukin-4 IEA
 biological_processGO:0071864 positive regulation of cell proliferation in bone marrow IEA
 biological_processGO:0071866 negative regulation of apoptotic process in bone marrow IEA
 biological_processGO:0071895 odontoblast differentiation IBA
 biological_processGO:0071899 negative regulation of estrogen receptor binding IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:1902262 apoptotic process involved in blood vessel morphogenesis ISS
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0032993 protein-DNA complex IEA
 cellular_componentGO:1990907 beta-catenin-TCF complex IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISS
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding ISS
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IEA
 molecular_functionGO:0008013 beta-catenin binding IBA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008301 DNA binding, bending IEA
 molecular_functionGO:0030284 estrogen receptor activity IEA
 molecular_functionGO:0030331 estrogen receptor binding IEA
 molecular_functionGO:0035326 enhancer binding IEA
 molecular_functionGO:0042393 histone binding IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0045295 gamma-catenin binding IEA
 molecular_functionGO:0070016 armadillo repeat domain binding IEA
 molecular_functionGO:0070742 C2H2 zinc finger domain binding IEA


Pathways (from Reactome)
Pathway description
Formation of the beta-catenin:TCF transactivating complex
Deactivation of the beta-catenin transactivating complex
Ca2+ pathway
Repression of WNT target genes
RUNX3 regulates WNT signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000005699 NLK / nemo like kinase / O54949* / Q9UBE8* / Serine/threonine-protein kinase NLK *  / reaction
 ENSGALG00000011992 EP300 / E1A binding protein p300 / B2RWS6* / Q09472* / Histone acetyltransferase p300 *  / reaction / complex
 ENSGALG00000003297 HDAC1 / P56517 / Histone deacetylase 1 / O09106* / Q13547* / Gm10093*  / complex
 ENSGALG00000003596 TRRAP / transformation/transcription domain associated protein / Q9Y4A5*  / reaction / complex
 ENSGALG00000037655 BCL9 / B cell CLL/lymphoma 9 / O00512* / Q9D219* / B-cell CLL/lymphoma 9 protein *  / complex / reaction
 ENSGALG00000032994 SOX17* / Q61473* / Q9H6I2* / SRY-box 17* / Transcription factor SOX-17 *  / reaction / complex
 ENSGALG00000012575 TLE1 / transducin like enhancer of split 1 / Q04724* / Q62440* / Transducin-like enhancer protein 1 *  / complex / reaction
 ENSGALG00000002469 CDC73 / Q5ZLM0 / Parafibromin / Q6P1J9* / Q8JZM7* / cell division cycle 73*  / reaction / complex
 ENSGALG00000004369 PYGO1 / pygopus family PHD finger 1 / Q9D0P5* / Q9Y3Y4* / pygopus 1*  / complex / reaction
 ENSGALG00000005931 RUVBL1 / ruvB-like 1 / Q9Y265* / P60122* / RuvB-like protein 1* / RuvB like AAA ATPase 1*  / reaction / complex
 ENSGALG00000015184 TLE4Z1 / transducin like enhancer of split 4-Z 1 / TLE4* / Q62441* / Q04727* / transducin like enhancer of split 4* / Transducin-like enhancer protein 4 *  / reaction / complex






 

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