ENSGALG00000003297


Gallus gallus

Features
Gene ID: ENSGALG00000003297
  
Biological name :HDAC1
  
Synonyms : HDAC1 / Histone deacetylase 1 / P56517
  
Possible biological names infered from orthology : Gm10093 / O09106 / Q13547
  
Species: Gallus gallus
  
Chr. number: 23
Strand: -1
Band:
Gene start: 5137852
Gene end: 5152251
  
Corresponding Affymetrix probe sets: Gga.10603.1.A1_at (Chicken Array)   Gga.10603.1.S1_at (Chicken Array)   Gga.4985.1.S1_a_at (Chicken Array)   Gga.4985.1.S2_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000005212
Ensembl peptide - ENSGALP00000059784
Ensembl peptide - ENSGALP00000056012
NCBI entrez gene - 373961     See in Manteia.
RefSeq - NM_204156
RefSeq Peptide - NP_989487
swissprot - A0A1N8W591
swissprot - A0A1D5PSX2
swissprot - P56517
Ensembl - ENSGALG00000003297
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hdac1ENSDARG00000015427Danio rerio
 HDAC1ENSG00000116478Homo sapiens
 Gm10093ENSMUSG00000061062Mus musculus
 Hdac1ENSMUSG00000028800Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HDAC2 / histone deacetylase 2 / Q92769*ENSGALG0000001499178
HDAC3 / histone deacetylase 3 / O15379*ENSGALG0000000263448
HDAC8 / histone deacetylase 8 / Q8VH37* / Q9BY41*ENSGALG0000000482531
HDAC11 / histone deacetylase 11 / Q91WA3* / Q96DB2*ENSGALG0000000509215


Protein motifs (from Interpro)
Interpro ID Name
 IPR000286  Histone deacetylase family
 IPR003084  Histone deacetylase
 IPR023801  Histone deacetylase domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006346 methylation-dependent chromatin silencing IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006476 protein deacetylation IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010870 positive regulation of receptor biosynthetic process IEA
 biological_processGO:0016575 histone deacetylation IEA
 biological_processGO:0043922 negative regulation by host of viral transcription IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0060766 negative regulation of androgen receptor signaling pathway IEA
 biological_processGO:0070932 histone H3 deacetylation IEA
 biological_processGO:0070933 histone H4 deacetylation IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 cellular_componentGO:0000118 histone deacetylase complex TAS
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016580 Sin3 complex IEA
 cellular_componentGO:0016581 NuRD complex IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001047 core promoter binding IEA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0001103 RNA polymerase II repressing transcription factor binding IEA
 molecular_functionGO:0002039 p53 binding IEA
 molecular_functionGO:0004407 histone deacetylase activity IEA
 molecular_functionGO:0008134 transcription factor binding TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) IEA
 molecular_functionGO:0033558 protein deacetylase activity IEA
 molecular_functionGO:0033613 activating transcription factor binding IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047485 protein N-terminus binding IEA
 molecular_functionGO:0051059 NF-kappaB binding IEA
 molecular_functionGO:0070491 repressing transcription factor binding IEA


Pathways (from Reactome)
Pathway description
G0 and Early G1
Formation of the beta-catenin:TCF transactivating complex
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Deactivation of the beta-catenin transactivating complex
SUMOylation of chromatin organization proteins
Regulation of TP53 Activity through Acetylation
RNA Polymerase I Transcription Initiation
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Regulation of PTEN gene transcription
Estrogen-dependent gene expression
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000015184 TLE4Z1 / transducin like enhancer of split 4-Z 1 / TLE4* / Q62441* / Q04727* / transducin like enhancer of split 4* / Transducin-like enhancer protein 4 *  / complex
 ENSGALG00000016823 TFDP1* / TFDP3* / Q5H9I0* / Q08639* / Q14186* / transcription factor Dp-1* / transcription factor Dp family member 3*  / reaction / complex
 ENSGALG00000025759 TFDP2 / transcription factor Dp-2 / Q14188*  / complex / reaction
 ENSGALG00000038915 E2F5 / transcription factor E2F5 / Q15329* / Q61502* / E2F transcription factor 5*  / complex / reaction
 ENSGALG00000014184 SMAD2* / Q15796* / Q62432* / SMAD family member 2* / Mothers against decapentaplegic homolog 2 *  / complex / reaction
 ENSGALG00000001722 E2F4 / E2F transcription factor 4 / Q16254* / Q8R0K9* / Transcription factor E2F4 *  / reaction / complex
 ENSGALG00000016022 RUNX1 / runt related transcription factor 1 / Q01196*  / complex
 ENSGALG00000001644 SIN3A / SIN3 transcription regulator family member A / Q60520* / Q96ST3* / Mus musculus transcriptional regulator, SIN3A (yeast) (Sin3a), transcript variant 4, mRNA.*  / complex
 ENSGALG00000043062 P84229 / HIST2H3D / Histone H3.2 / Q71DI3* / histone cluster 2 H3 family member d*  / complex
 ENSGALG00000042491 P62801 / Histone H4   / complex
 ENSGALG00000008435 SUMO1 / Q8QGH2 / Small ubiquitin-related modifier 1 / P63166* / P63165* / small ubiquitin-like modifier 1*  / reaction / complex
 ENSGALG00000006428 UBE2I / P63283 / SUMO-conjugating enzyme UBC9 / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSGALG00000024081 TGIF2 / TGFB induced factor homeobox 2 / Q8C0Y1* / Q9GZN2*  / reaction / complex
 ENSGALG00000014795 TGIF1 / Q90655 / Homeobox protein AKR / Q15583* / P70284* / TGFB induced factor homeobox 1*  / reaction / complex
 ENSGALG00000012575 TLE1 / transducin like enhancer of split 1 / Q04724* / Q62440* / Transducin-like enhancer protein 1 *  / complex
 ENSGALG00000036001 SMAD2Z / SMAD2* / Q62432* / Q15796* / SMAD family member 2* / Mothers against decapentaplegic homolog 2 *  / complex / reaction
 ENSGALG00000020078 H3F3C / histone H3.2 / H3.Y* / H3F3B* / H3F3A* / Q6NXT2* / P84243* / P84244* / Histone H3.3 * / H3 histone family member 3B* / H3 histone family member 3A* / H3 histone family member 3C* /...  / complex
 ENSGALG00000008883 TCF7L2 / transcription factor 7 like 2 / Q924A0* / Q9NQB0* / transcription factor 7 like 2, T cell specific, HMG box*  / complex
 ENSGALG00000029270 GATA3 / P23825 / GATA-binding factor 3 / P23771* / P23772* / GATA binding protein 3* / Mus musculus GATA binding protein 3 (Gata3), transcript variant 3, mRNA.*  / reaction
 ENSGALG00000031960 LEF1 / lymphoid enhancer binding factor 1 / P27782* / Q9UJU2*  / complex
 ENSGALG00000032713 FOXA1 / forkhead box A1 / P35582* / P55317* / Hepatocyte nuclear factor 3-alpha *  / reaction






 

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