ENSGALG00000032713


Gallus gallus

Features
Gene ID: ENSGALG00000032713
  
Biological name :FOXA1
  
Synonyms : forkhead box A1 / FOXA1
  
Possible biological names infered from orthology : Hepatocyte nuclear factor 3-alpha / P35582 / P55317
  
Species: Gallus gallus
  
Chr. number: 5
Strand: -1
Band:
Gene start: 37211187
Gene end: 37215720
  
Corresponding Affymetrix probe sets: Gga.11137.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000050398
NCBI entrez gene - 101752179     See in Manteia.
RefSeq - XM_004941922
swissprot - A0A1D5PCB1
Ensembl - ENSGALG00000032713
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FOXA1ENSG00000129514Homo sapiens
 Foxa1ENSMUSG00000035451Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FOXA2 / hepatocyte nuclear factor 3-beta / P35583* / Q9Y261* / forkhead box A2* / Mus musculus forkhead box A2 (Foxa2), transcript variant 3, mRNA.*ENSGALG0000003088958
FOXB1 / forkhead box B1 / Q64732* / Q99853* / Forkhead box protein B1 *ENSGALG0000002749824
FOXB2 / forkhead box B2 / Q5VYV0* / Q64733* / Forkhead box protein B2 *ENSGALG0000002881922
FOXI1 / forkhead box I1 / Q12951* / Q922I5* / Forkhead box protein I1 *ENSGALG0000000210520
FOXI3 / forkhead box I3 / A8MTJ6*ENSGALG0000003745718
FOXL1 / forkhead box L1 / Q12952* / Q64731* / Forkhead box protein L1 *ENSGALG0000002927817
FOXL2 / forkhead box L2 / O88470* / P58012* / Forkhead box protein L2 *ENSGALG0000002928217
FOXS1 / forkhead box S1 / O43638* / Q61574* / Forkhead box protein S1 *ENSGALG0000004301516


Protein motifs (from Interpro)
Interpro ID Name
 IPR001766  Fork head domain
 IPR011991  ArsR-like helix-turn-helix domain
 IPR013638  Fork-head N-terminal
 IPR018122  Fork head domain conserved site1
 IPR018533  Forkhead box protein, C-terminal
 IPR030456  Fork head domain conserved site 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006338 chromatin remodeling IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010719 negative regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0021904 dorsal/ventral neural tube patterning IEA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0033148 positive regulation of intracellular estrogen receptor signaling pathway IEA
 biological_processGO:0035239 tube morphogenesis IEA
 biological_processGO:0042445 hormone metabolic process IEA
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0045880 positive regulation of smoothened signaling pathway IEA
 biological_processGO:0045931 positive regulation of mitotic cell cycle IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048646 anatomical structure formation involved in morphogenesis IEA
 biological_processGO:0048665 neuron fate specification IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0060425 lung morphogenesis IEA
 biological_processGO:0060441 epithelial tube branching involved in lung morphogenesis IEA
 biological_processGO:0060487 lung epithelial cell differentiation IEA
 biological_processGO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development IEA
 biological_processGO:0060738 epithelial-mesenchymal signaling involved in prostate gland development IEA
 biological_processGO:0060740 prostate gland epithelium morphogenesis IEA
 biological_processGO:0060741 prostate gland stromal morphogenesis IEA
 biological_processGO:0060743 epithelial cell maturation involved in prostate gland development IEA
 biological_processGO:0061144 alveolar secondary septum development IEA
 biological_processGO:0061448 connective tissue development IEA
 biological_processGO:1902691 respiratory basal cell differentiation IEA
 cellular_componentGO:0001650 fibrillar center IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005902 microvillus IEA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA


Pathways (from Reactome)
Pathway description
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000004570 NCOA3 / nuclear receptor coactivator 3 / Q9Y6Q9*  / reaction / complex
 ENSGALG00000016617 NCOA1 / nuclear receptor coactivator 1 / P70365* / Q15788*  / reaction / complex
 ENSGALG00000011992 EP300 / E1A binding protein p300 / B2RWS6* / Q09472* / Histone acetyltransferase p300 *  / reaction / complex
 ENSGALG00000003793 GTF2A2 / general transcription factor IIA subunit 2 / P52657* / Q80ZM7* / Transcription initiation factor IIA subunit 2 *  / complex / reaction
 ENSGALG00000043062 P84229 / HIST2H3D / Histone H3.2 / Q71DI3* / histone cluster 2 H3 family member d*  / complex / reaction
 ENSGALG00000042491 P62801 / Histone H4   / complex / reaction
 ENSGALG00000011171 TBP / TATA-box-binding protein / P20226* / P29037*  / complex / reaction
 ENSGALG00000020078 H3F3C / histone H3.2 / H3.Y* / H3F3B* / H3F3A* / Q6NXT2* / P84243* / P84244* / Histone H3.3 * / H3 histone family member 3B* / H3 histone family member 3A* / H3 histone family member 3C* /...  / reaction / complex
 ENSGALG00000003297 HDAC1 / P56517 / Histone deacetylase 1 / O09106* / Q13547* / Gm10093*  / reaction
 ENSGALG00000010576 GTF2A1 / general transcription factor IIA subunit 1 / P52655* / Q99PM3* / Transcription initiation factor IIA subunit 1 Transcription initiation factor IIA alpha chain Transcription initiat...  / reaction / complex
 ENSGALG00000029270 GATA3 / P23825 / GATA-binding factor 3 / P23771* / P23772* / GATA binding protein 3* / Mus musculus GATA binding protein 3 (Gata3), transcript variant 3, mRNA.*  / reaction / complex






 

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