ENSG00000129514


Homo sapiens

Features
Gene ID: ENSG00000129514
  
Biological name :FOXA1
  
Synonyms : forkhead box A1 / FOXA1 / P55317
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q21.1
Gene start: 37589984
Gene end: 37596059
  
Corresponding Affymetrix probe sets: 204667_at (Human Genome U133 Plus 2.0 Array)   237086_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000250448
Ensembl peptide - ENSP00000451704
NCBI entrez gene - 3169     See in Manteia.
OMIM - 602294
RefSeq - NM_004496
RefSeq Peptide - NP_004487
swissprot - P55317
swissprot - G3V4B9
Ensembl - ENSG00000129514
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FOXA1ENSGALG00000032713Gallus gallus
 Foxa1ENSMUSG00000035451Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FOXA2 / Q9Y261 / forkhead box A2ENSG0000012579856
FOXA3 / P55318 / forkhead box A3ENSG0000017060839
FOXC1 / Q12948 / forkhead box C1ENSG0000005459825
FOXC2 / Q99958 / forkhead box C2ENSG0000017669225
FOXB2 / Q5VYV0 / forkhead box B2ENSG0000020461224
FOXB1 / Q99853 / forkhead box B1ENSG0000017195624
FOXI1 / Q12951 / forkhead box I1ENSG0000016826920
FOXL1 / Q12952 / forkhead box L1ENSG0000017667819
FOXI3 / A8MTJ6 / forkhead box I3ENSG0000021433619
FOXI2 / Q6ZQN5 / forkhead box I2ENSG0000018676618
FOXS1 / O43638 / forkhead box S1ENSG0000017977217
FOXL2 / P58012 / forkhead box L2ENSG0000018377017


Protein motifs (from Interpro)
Interpro ID Name
 IPR001766  Fork head domain
 IPR013638  Fork-head N-terminal
 IPR018122  Fork head domain conserved site1
 IPR018533  Forkhead box protein, C-terminal
 IPR030456  Fork head domain conserved site 2
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006338 chromatin remodeling IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009653 anatomical structure morphogenesis IBA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010719 negative regulation of epithelial to mesenchymal transition IMP
 biological_processGO:0021904 dorsal/ventral neural tube patterning IEA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0032355 response to estradiol IDA
 biological_processGO:0033148 positive regulation of intracellular estrogen receptor signaling pathway IMP
 biological_processGO:0035239 tube morphogenesis IEA
 biological_processGO:0042445 hormone metabolic process IEA
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0045880 positive regulation of smoothened signaling pathway IEA
 biological_processGO:0045931 positive regulation of mitotic cell cycle IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048646 anatomical structure formation involved in morphogenesis IEA
 biological_processGO:0048665 neuron fate specification IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IMP
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0060425 lung morphogenesis IEA
 biological_processGO:0060441 epithelial tube branching involved in lung morphogenesis IEA
 biological_processGO:0060487 lung epithelial cell differentiation IEA
 biological_processGO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development IEA
 biological_processGO:0060738 epithelial-mesenchymal signaling involved in prostate gland development IEA
 biological_processGO:0060740 prostate gland epithelium morphogenesis IEA
 biological_processGO:0060741 prostate gland stromal morphogenesis IEA
 biological_processGO:0060743 epithelial cell maturation involved in prostate gland development IEA
 biological_processGO:0061144 alveolar secondary septum development IEA
 biological_processGO:0061448 connective tissue development IEA
 biological_processGO:0071542 dopaminergic neuron differentiation TAS
 biological_processGO:1902691 respiratory basal cell differentiation IEA
 biological_processGO:2000049 positive regulation of cell-cell adhesion mediated by cadherin IC
 cellular_componentGO:0001650 fibrillar center IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005902 microvillus IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISS
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA


Pathways (from Reactome)
Pathway description
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000108654 DDX5 / P17844 / DEAD-box helicase 5  / complex / reaction
 ENSG00000275714 P68431 / HIST1H3A / histone cluster 1 H3 family member a  / reaction / complex
 ENSG00000183598 Q71DI3 / HIST2H3D / histone cluster 2 H3 family member d  / complex / reaction
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / reaction / complex
 ENSG00000126457 PRMT1 / Q99873 / protein arginine methyltransferase 1  / complex / reaction
 ENSG00000165417 GTF2A1 / P52655 / general transcription factor IIA subunit 1  / complex / reaction
 ENSG00000116478 HDAC1 / Q13547 / histone deacetylase 1  / reaction
 ENSG00000132475 H3F3B / P84243 / H3 histone family member 3B  / reaction / complex
 ENSG00000107485 GATA3 / P23771 / GATA binding protein 3  / complex / reaction
 ENSG00000091831 ESR1 / P03372 / estrogen receptor 1  / reaction / complex
 ENSG00000100393 EP300 / Q09472 / E1A binding protein p300  / reaction / complex
 ENSG00000142453 CARM1 / Q86X55 / coactivator associated arginine methyltransferase 1  / reaction / complex
 ENSG00000100811 YY1 / P25490 / YY1 transcription factor  / reaction
 ENSG00000140307 GTF2A2 / P52657 / general transcription factor IIA subunit 2  / reaction / complex
 ENSG00000112592 TBP / P20226 / TATA-box binding protein  / complex / reaction






 

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