ENSG00000176678


Homo sapiens

Features
Gene ID: ENSG00000176678
  
Biological name :FOXL1
  
Synonyms : forkhead box L1 / FOXL1 / Q12952
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: q24.1
Gene start: 86576368
Gene end: 86582160
  
Corresponding Affymetrix probe sets: 216572_at (Human Genome U133 Plus 2.0 Array)   243409_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000326272
Ensembl peptide - ENSP00000472376
NCBI entrez gene - 2300     See in Manteia.
OMIM - 603252
RefSeq - NM_005250
RefSeq Peptide - NP_005241
swissprot - Q12952
swissprot - M0R279
Ensembl - ENSG00000176678
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 foxl1ENSDARG00000008133Danio rerio
 FOXL1ENSGALG00000029278Gallus gallus
 Foxl1ENSMUSG00000097084Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FOXC1 / Q12948 / forkhead box C1ENSG0000005459837
FOXC2 / Q99958 / forkhead box C2ENSG0000017669235
FOXS1 / O43638 / forkhead box S1ENSG0000017977229
FOXL2 / P58012 / forkhead box L2ENSG0000018377027
FOXI3 / A8MTJ6 / forkhead box I3ENSG0000021433626
FOXA1 / P55317 / forkhead box A1ENSG0000012951426
FOXA3 / P55318 / forkhead box A3ENSG0000017060826
FOXA2 / Q9Y261 / forkhead box A2ENSG0000012579825
FOXI1 / Q12951 / forkhead box I1ENSG0000016826925
FOXI2 / Q6ZQN5 / forkhead box I2ENSG0000018676624
FOXB1 / Q99853 / forkhead box B1ENSG0000017195623
FOXB2 / Q5VYV0 / forkhead box B2ENSG0000020461222


Protein motifs (from Interpro)
Interpro ID Name
 IPR001766  Fork head domain
 IPR018122  Fork head domain conserved site1
 IPR030456  Fork head domain conserved site 2
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development NAS
 biological_processGO:0007495 visceral mesoderm-endoderm interaction involved in midgut development IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0009653 anatomical structure morphogenesis IBA
 biological_processGO:0030111 regulation of Wnt signaling pathway IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0030166 proteoglycan biosynthetic process IEA
 biological_processGO:0061146 Peyer"s patch morphogenesis IEA
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISS
 molecular_functionGO:0008301 DNA binding, bending NAS
 molecular_functionGO:0043565 sequence-specific DNA binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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