ENSG00000125798


Homo sapiens

Features
Gene ID: ENSG00000125798
  
Biological name :FOXA2
  
Synonyms : forkhead box A2 / FOXA2 / Q9Y261
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: -1
Band: p11.21
Gene start: 22581005
Gene end: 22585455
  
Corresponding Affymetrix probe sets: 210103_s_at (Human Genome U133 Plus 2.0 Array)   214312_at (Human Genome U133 Plus 2.0 Array)   40284_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000400341
Ensembl peptide - ENSP00000366319
NCBI entrez gene - 3170     See in Manteia.
OMIM - 600288
RefSeq - NM_021784
RefSeq - NM_153675
RefSeq Peptide - NP_068556
RefSeq Peptide - NP_710141
swissprot - Q9Y261
swissprot - B0ZTD4
Ensembl - ENSG00000125798
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 foxa2ENSDARG00000003411Danio rerio
 FOXA2ENSGALG00000030889Gallus gallus
 Foxa2ENSMUSG00000037025Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FOXA1 / P55317 / forkhead box A1ENSG0000012951457
FOXA3 / P55318 / forkhead box A3ENSG0000017060837
FOXC2 / Q99958 / forkhead box C2ENSG0000017669225
FOXC1 / Q12948 / forkhead box C1ENSG0000005459824
FOXB1 / Q99853 / forkhead box B1ENSG0000017195624
FOXB2 / Q5VYV0 / forkhead box B2ENSG0000020461222
FOXI1 / Q12951 / forkhead box I1ENSG0000016826921
FOXS1 / O43638 / forkhead box S1ENSG0000017977219
FOXL1 / Q12952 / forkhead box L1ENSG0000017667819
FOXI3 / A8MTJ6 / forkhead box I3ENSG0000021433619
FOXI2 / Q6ZQN5 / forkhead box I2ENSG0000018676618
FOXL2 / P58012 / forkhead box L2ENSG0000018377017


Protein motifs (from Interpro)
Interpro ID Name
 IPR001766  Fork head domain
 IPR013638  Fork-head N-terminal
 IPR018122  Fork head domain conserved site1
 IPR018533  Forkhead box protein, C-terminal
 IPR030456  Fork head domain conserved site 2
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000432 positive regulation of transcription from RNA polymerase II promoter by glucose ISS
 biological_processGO:0001708 cell fate specification ISS
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008344 adult locomotory behavior ISS
 biological_processGO:0009653 anatomical structure morphogenesis IBA
 biological_processGO:0010719 negative regulation of epithelial to mesenchymal transition IMP
 biological_processGO:0030193 regulation of blood coagulation IDA
 biological_processGO:0031018 endocrine pancreas development IDA
 biological_processGO:0033132 negative regulation of glucokinase activity ISS
 biological_processGO:0040019 positive regulation of embryonic development ISS
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II TAS
 biological_processGO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus ISS
 biological_processGO:0061987 negative regulation of transcription from RNA polymerase II promoter by glucose ISS
 biological_processGO:0070741 response to interleukin-6 TAS
 biological_processGO:0071542 dopaminergic neuron differentiation TAS
 biological_processGO:0090009 primitive streak formation ISS
 biological_processGO:2000049 positive regulation of cell-cell adhesion mediated by cadherin IC
 biological_processGO:2000543 positive regulation of gastrulation ISS
 biological_processGO:2000971 negative regulation of detection of glucose ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0030054 cell junction IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IMP


Pathways (from Reactome)
Pathway description
Regulation of gene expression in beta cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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