Manteia

ENSMUSG00000037025

Mus musculus

Features

Gene ID:	ENSMUSG00000037025

Biological name :	Foxa2

Synonyms :	Foxa2 / Mus musculus forkhead box A2 (Foxa2), transcript variant 3, mRNA. / P35583

Possible biological names infered from orthology :	forkhead box A2 / Q9Y261

Species:	Mus musculus

Chr. number:	2
Strand:	-1
Band:	G3
Gene start:	148042877
Gene end:	148046969

Corresponding Affymetrix probe sets:	10488374 (MoGene1.0st) 1422833_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000045918 Ensembl peptide - ENSMUSP00000105590 Ensembl peptide - ENSMUSP00000134081 NCBI entrez gene - 15376 See in Manteia. MGI - MGI:1347476 RefSeq - NM_001291065 RefSeq - NM_001291067 RefSeq - NM_010446 RefSeq Peptide - NP_034576 RefSeq Peptide - NP_001277994 RefSeq Peptide - NP_001277996 swissprot - P35583 swissprot - G5E8P5 swissprot - G3UYH0 Ensembl - ENSMUSG00000037025

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
foxa2	ENSDARG00000003411	Danio rerio
FOXA2	ENSGALG00000030889	Gallus gallus
FOXA2	ENSG00000125798	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Foxa1 / P35582 / Hepatocyte nuclear factor 3-alpha / P55317* / forkhead box A1*	ENSMUSG00000035451	57
Foxa3 / P35584 / Hepatocyte nuclear factor 3-gamma / P55318* / forkhead box A3*	ENSMUSG00000040891	37
Foxb1 / Q64732 / Forkhead box protein B1 / Q99853* / forkhead box B1*	ENSMUSG00000059246	24
Foxc2 / Q61850 / Forkhead box protein C2 / Q99958* / forkhead box C2*	ENSMUSG00000046714	24
Foxc1 / Q61572 / Forkhead box protein C1 / Q12948* / forkhead box C1*	ENSMUSG00000050295	23
Foxb2 / Q64733 / Forkhead box protein B2 / Q5VYV0* / forkhead box B2*	ENSMUSG00000056829	22
Foxi1 / Q922I5 / Forkhead box protein I1 / Q12951* / forkhead box I1*	ENSMUSG00000047861	21
Foxi3 / forkhead box I3 / A8MTJ6*	ENSMUSG00000055874	20
Foxl1 / Q64731 / Forkhead box protein L1 / Q12952* / forkhead box L1*	ENSMUSG00000097084	18
Foxl2 / O88470 / Forkhead box protein L2 / P58012* / forkhead box L2*	ENSMUSG00000050397	18
Foxi2 / forkhead box I2 / Q6ZQN5*	ENSMUSG00000048377	18
Foxs1 / Q61574 / Forkhead box protein S1 / O43638* / forkhead box S1*	ENSMUSG00000074676	18

Protein motifs (from Interpro)

Interpro ID	Name
IPR001766	Fork head domain
IPR013638	Fork-head N-terminal
IPR018122	Fork head domain conserved site1
IPR018533	Forkhead box protein, C-terminal
IPR030456	Fork head domain conserved site 2
IPR036388	Winged helix-like DNA-binding domain superfamily
IPR036390	Winged helix DNA-binding domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000432	positive regulation of transcription from RNA polymerase II promoter by glucose	IDA
biological_process	GO:0001701	in utero embryonic development	IMP
biological_process	GO:0001705	ectoderm formation	IGI
biological_process	GO:0001708	cell fate specification	IDA
biological_process	GO:0006325	chromatin organization	IEA
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006357	regulation of transcription by RNA polymerase II	ISO
biological_process	GO:0006366	transcription by RNA polymerase II	IEA
biological_process	GO:0007219	Notch signaling pathway	IDA
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0007389	pattern specification process	IGI
biological_process	GO:0008344	adult locomotory behavior	IMP
biological_process	GO:0009653	anatomical structure morphogenesis	IGI
biological_process	GO:0009952	anterior/posterior pattern specification	IGI
biological_process	GO:0009953	dorsal/ventral pattern formation	IGI
biological_process	GO:0010468	regulation of gene expression	IGI
biological_process	GO:0010719	negative regulation of epithelial to mesenchymal transition	ISO
biological_process	GO:0019216	regulation of lipid metabolic process	IMP
biological_process	GO:0019218	regulation of steroid metabolic process	IMP
biological_process	GO:0021533	cell differentiation in hindbrain	IMP
biological_process	GO:0021904	dorsal/ventral neural tube patterning	IGI
biological_process	GO:0023019	signal transduction involved in regulation of gene expression	IDA
biological_process	GO:0030193	regulation of blood coagulation	ISO
biological_process	GO:0030324	lung development	IGI
biological_process	GO:0031018	endocrine pancreas development	ISO
biological_process	GO:0032525	somite rostral/caudal axis specification	IMP
biological_process	GO:0033132	negative regulation of glucokinase activity	IDA
biological_process	GO:0040019	positive regulation of embryonic development	IMP
biological_process	GO:0043433	negative regulation of DNA-binding transcription factor activity	ISO
biological_process	GO:0045665	negative regulation of neuron differentiation	IGI
biological_process	GO:0045666	positive regulation of neuron differentiation	IMP
biological_process	GO:0045880	positive regulation of smoothened signaling pathway	IGI
biological_process	GO:0045893	positive regulation of transcription, DNA-templated	IMP
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO
biological_process	GO:0045945	positive regulation of transcription by RNA polymerase III	IMP
biological_process	GO:0048468	cell development	IMP
biological_process	GO:0048646	anatomical structure formation involved in morphogenesis	IGI
biological_process	GO:0048665	neuron fate specification	IMP
biological_process	GO:0060441	epithelial tube branching involved in lung morphogenesis	IGI
biological_process	GO:0060487	lung epithelial cell differentiation	IGI
biological_process	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus	IDA
biological_process	GO:0061448	connective tissue development	IGI
biological_process	GO:0061987	negative regulation of transcription from RNA polymerase II promoter by glucose	IDA
biological_process	GO:0070741	response to interleukin-6	TAS
biological_process	GO:0071542	dopaminergic neuron differentiation	ISO
biological_process	GO:0090009	primitive streak formation	IMP
biological_process	GO:2000543	positive regulation of gastrulation	IMP
biological_process	GO:2000971	negative regulation of detection of glucose	IDA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005654	nucleoplasm	ISO
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0030054	cell junction	ISO
molecular_function	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	ISO
molecular_function	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding	IDA
molecular_function	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003700	DNA-binding transcription factor activity	IEA
molecular_function	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	IDA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0008134	transcription factor binding	IEA
molecular_function	GO:0019904	protein domain specific binding	IEA
molecular_function	GO:0043565	sequence-specific DNA binding	IEA
molecular_function	GO:0044212	transcription regulatory region DNA binding	ISO

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000120	malocclusion	"perturbations in the normal patterned arrangement of the teeth or alignment of the jaw, resulting in the incorrect position of biting or chewing surfaces of the upper and lower teeth" [J:61509]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Msr1^tm1Csk/Msr1^tm1Csk Genetic Background: either: (involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J * ICR) or (involves: 129P2/OlaHsd * 129X1/SvJ * 129/Sv * ICR) Allelic Composition: Foxa2^tm1Jrt/Foxa2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 Allelic Composition: Foxa2^tm1Dnl/Foxa2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0000189	hypoglycemia	"low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Foxa2^tm1Khk/Foxa2^tm1Khk,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA Allelic Composition: Foxa2^tm1Khk/Foxa2^tm1Khk,Tg(Foxa3-cre)1Khk/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA
MP:0000219	increased neutrophil count	"greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pkia^tm1Idz/Pkia^tm1Idz,Pkib^tm1Idz/Pkib^tm1Idz Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
MP:0000259	abnormal vascular development	"malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]	Show Allelic Composition: Mesp1^tm2(cre)Ysa/Mesp1⁺,Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt/0 Genetic Background: Not Specified
MP:0000267	abnormal cardiac development	"aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]	Show Allelic Composition: Wnt3a^tm1Amc/Wnt3a^tm1Amc Genetic Background: involves: 129S1/Sv
MP:0000269	abnormal looping morphogenesis	"atypical bending of the primitive heart tube during early development" [J:27443]	Show Allelic Composition: Wnt3a^tm1Amc/Wnt3a^tm1Amc Genetic Background: involves: 129S1/Sv
MP:0000313	abnormal cell death	"anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Tnfrsf21^tm1Ddy/Tnfrsf21^tm1Ddy Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0000474	abnormal foregut morphology	"malformed cephalic portion of the primitive digestive tube of the embryo" [J:35802]	Show Allelic Composition: Foxa2^tm1Jrt/Foxa2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0000783	abnormal forebrain morphology	"malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]	Show Allelic Composition: Bad^tm1Meg/Bad^tm1Meg Genetic Background: involves: 129S4/SvJae
MP:0000926	absent floor plate	"missing ventral midline thinning of the developing neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35802]	Show Allelic Composition: Foxa2^tm1Jrt/Foxa2^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 Allelic Composition: Foxa2^tm1Dnl/Foxa2^tm1Dnl Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0000932	absent notochord	"missing axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]	Show Allelic Composition: Foxa2^tm1Jrt/Foxa2^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 Allelic Composition: Foxa2^tm1Dnl/Foxa2^tm1Dnl Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0000956	reduced spinal cord size	"smaller appearance of the spinal cord" [J:35802]	Show Allelic Composition: Wnt3a^tm1Amc/Wnt3a^tm1Amc Genetic Background: involves: 129S1/Sv
MP:0001177	atelectasis	"collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pkia^tm1Idz/Pkia^tm1Idz,Pkib^tm1Idz/Pkib^tm1Idz Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Msr1^tm1Csk/Msr1^tm1Csk Genetic Background: either: (involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J * ICR) or (involves: 129P2/OlaHsd * 129X1/SvJ * 129/Sv * ICR) Allelic Composition: Foxa2^tm1Jrt/Foxa2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 Allelic Composition: Foxa2^tm1Khk/Foxa2^tm1Khk,Tg(Foxa3-cre)1Khk/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA
MP:0001286	abnormal eye development	"malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]	Show Allelic Composition: Foxa2^tm1Dnl/Foxa2^tm1Dnl Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0001385	pup cannibalization	"the killing and eating of newborn mice by the mother; can be a normal response if the mother does not recognize the pups as her own" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pkia^tm1Idz/Pkia^tm1Idz,Pkib^tm1Idz/Pkib^tm1Idz Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
MP:0001394	circling	"repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Msr1^tm1Csk/Msr1^tm1Csk Genetic Background: either: (involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J * ICR) or (involves: 129P2/OlaHsd * 129X1/SvJ * 129/Sv * ICR) Allelic Composition: Foxa2^tm1Jrt/Foxa2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0001399	hyperactivity	"general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]	Show Allelic Composition: Rif1^{Gt(A045A01)Wrst}/Rif1^{Gt(A045A01)Wrst} Genetic Background: involves: 129S2/SvPas * C57BL/6J Allelic Composition: Foxa2^tm1.1Stf/Foxa2^tm1.1Stf Genetic Background: B6.129-Foxa2^tm1.1Stf
MP:0001406	abnormal gait	"unusual or distinctive way of walking" [J:65038]	Show Allelic Composition: Foxa2^tm1Dnl/Foxa2^tm1Dnl Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0001505	hunched posture	"stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Msr1^tm1Csk/Msr1^tm1Csk Genetic Background: either: (involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J * ICR) or (involves: 129P2/OlaHsd * 129X1/SvJ * 129/Sv * ICR) Allelic Composition: Foxa2^tm1Jrt/Foxa2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0001523	impaired righting response	"reduced ability or greater amount of time needed to recover from supine position" [J:25565]	Show Allelic Composition: Foxa2^tm1Dnl/Foxa2^tm1Dnl Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0001552	increased circulating triglyceride level	"higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]	Show Allelic Composition: Foxa2^tm1Dnl/Foxa2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0001554	increased circulating free fatty acid level	"higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]	Show Allelic Composition: Foxa2^tm1Dnl/Foxa2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0001559	hyperglycemia	"abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Foxa1^tm1Khk/Foxa1⁺,Foxa2^tm1Khk/Foxa2^tm1Khk,Tg(Pdx1-cre)6Cvw/0 Genetic Background: involves: 129 * C57BL/6 * CBA * SJL
MP:0001575	cyanosis	"a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]	Show Allelic Composition: Pkia^tm1Idz/Pkia^tm1Idz,Pkib^tm1Idz/Pkib^tm1Idz Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
MP:0001672	abnormal embryogenesis/ development	"anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Wnt3a^tm1Amc/Wnt3a^tm1Amc Genetic Background: involves: 129S1/Sv Allelic Composition: Foxa2^tm1Jrt/Foxa2^tm1Jrt,Gsc^tm1Bhr/Gsc^tm1Bhr Genetic Background: involves: 129/Sv * C57BL/6 * CD-1 Allelic Composition: Foxa2^tm1Jrt/Foxa2^tm1Jrt,Gsc^tm1Bhr/Gsc⁺ Genetic Background: involves: 129/Sv * C57BL/6 * CD-1
MP:0001683	absent mesoderm	"missing or failure to differentiate the middle primary germ layer " [J:40594]	Show Allelic Composition: Foxa2^tm1Jrt/Foxa2^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 Allelic Composition: Foxa2^tm1Jrt/Foxa2^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001685	abnormal endoderm development	"failure or abnormality in the formation of the endoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxa2^tm1Dnl/Foxa2^tm1Dnl Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0001688	abnormal somite development	"anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Foxa2^tm1Dnl/Foxa2^tm1Dnl Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0001691	abnormal somite shape	"atypical characteristic surface configuration of a segmental mass along the notochord of the developing embryo" [J:37888]	Show Allelic Composition: Foxa2^tm1Jrt/Foxa2^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0001698	reduced embryo size	"smaller proportions of embryo compared to littermates" [J:61790]	Show Allelic Composition: Foxa2^tm1Jrt/Foxa2^tm1Jrt,Gsc^tm1Bhr/Gsc^tm1Bhr Genetic Background: involves: 129/Sv * C57BL/6 * CD-1 Allelic Composition: Foxa2^tm1Jrt/Foxa2^tm1Jrt,Gsc^tm1Bhr/Gsc⁺ Genetic Background: involves: 129/Sv * C57BL/6 * CD-1 Allelic Composition: Foxa2^tm1Dnl/Foxa2^tm1Dnl Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0001704	abnormal dorsal-ventral axis patterning	"anomaly in the development or formation of the axis that runs from the front to the back surface of the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Wnt3a^tm1Amc/Wnt3a^tm1Amc Genetic Background: involves: 129S1/Sv
MP:0001730	embryonic growth arrest	"the cessation of development beyond a particular stage" [J:17509]	Show Allelic Composition: Wnt3a^tm1Amc/Wnt3a^tm1Amc Genetic Background: involves: 129S1/Sv
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Foxa2^tm1Khk/Foxa2^tm1Khk,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA
MP:0001923	reduced female fertility	"reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Foxa2^tm1Dnl/Foxa2^tm1Dnl Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0001944	abnormal pancreas morphology	"malformation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [il:Ira Lu , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxa1^tm1Khk/Foxa1⁺,Foxa2^tm1Khk/Foxa2^tm1Khk,Tg(Pdx1-cre)6Cvw/0 Genetic Background: involves: 129 * C57BL/6 * CBA * SJL
MP:0001954	respiratory distress	"physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]	Show Allelic Composition: Pkia^tm1Idz/Pkia^tm1Idz,Pkib^tm1Idz/Pkib^tm1Idz Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
MP:0002064	seizures	"sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxa2^tm1Khk/Foxa2^tm1Khk,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA
MP:0002078	abnormal glucose homeostasis	"anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxa2^tm1Dnl/Foxa2^tm1Dnl Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0002079	increased circulating insulin level	"greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Foxa2^tm1Khk/Foxa2^tm1Khk,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA
MP:0002082	postnatal lethality	"premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Msr1^tm1Csk/Msr1^tm1Csk Genetic Background: either: (involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J * ICR) or (involves: 129P2/OlaHsd * 129X1/SvJ * 129/Sv * ICR) Allelic Composition: Foxa2^tm1Jrt/Foxa2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Msr1^tm1Csk/Msr1^tm1Csk Genetic Background: either: (involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J * ICR) or (involves: 129P2/OlaHsd * 129X1/SvJ * 129/Sv * ICR) Allelic Composition: Foxa2^tm1Jrt/Foxa2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0002084	abnormal developmental patterning	"abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxa2^tm1Jrt/Foxa2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0002085	abnormal embryonic tissue morphology	"structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxa2^tm1Jrt/Foxa2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 Allelic Composition: Foxa2^tm1Dnl/Foxa2^tm1Dnl Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0002151	abnormal neural tube morphology/development	"anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Wnt3a^tm1Amc/Wnt3a^tm1Amc Genetic Background: involves: 129S1/Sv Allelic Composition: Foxa2^tm1Jrt/Foxa2^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 Allelic Composition: Foxa2^tm1Dnl/Foxa2^tm1Dnl Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0002152	abnormal brain morphology	"anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]	Show Allelic Composition: Wnt3a^tm1Amc/Wnt3a^tm1Amc Genetic Background: involves: 129S1/Sv
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tmc1^Mhdabth/Tmc1⁺ Genetic Background: C3HeB/FeJ-Tmc1^Mhdabth/Ieg Allelic Composition: Foxa2^tm1Khk/Foxa2^tm1Khk,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA Allelic Composition: Foxa2^{tm1.1(rtTa)Moon}/Foxa2^{tm1.1(rtTa)Moon},Gt(ROSA)26Sor^tm1Sor/?,Tg(tetO-cre)1Jaw/? Genetic Background: involves: C57BL/6 * SJL Allelic Composition: Foxa2^{tm2.1(cre/Esr1)Moon}/Foxa2^{tm2.1(cre/Esr1)Moon},Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Foxa2^{tm1(cre/ERT2)Hssk}/Foxa2^{tm1(cre/ERT2)Hssk} Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj * ICR Allelic Composition: Foxa2^tm2.1Heli/Foxa2^tm2.1Heli Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL
MP:0002230	abnormal primitive streak formation	"anomaly in the establishment of the midline ridge of embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxa2^tm1Jrt/Foxa2^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0002234	abnormal pharynx morphology	"structural anomaly in the passage between the mouth and the posterior nares and the larynx and esophagus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Wnt3a^tm1Amc/Wnt3a^tm1Amc Genetic Background: involves: 129S1/Sv
MP:0002273	abnormal alveolar epithelial cell morphology	"any structural anomaly of the cells lining the alveoli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pkia^tm1Idz/Pkia^tm1Idz,Pkib^tm1Idz/Pkib^tm1Idz Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
MP:0002275	abnormal type II pneumocyte morphology	"any structural anomaly of the epithelial cells lining the alveoli that produce surfactant " [Pathology , 2nd edition:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pkia^tm1Idz/Pkia^tm1Idz,Pkib^tm1Idz/Pkib^tm1Idz Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
MP:0002314	abnormal respiratory mechanics	"anomaly in the action of the lungs, diaphragm, ribs and chest wall during respiration" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pkia^tm1Idz/Pkia^tm1Idz,Pkib^tm1Idz/Pkib^tm1Idz Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
MP:0002696	decreased circulating glucagon level	"lower than normal blood concentration of this peptide hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxa2^tm1Khk/Foxa2^tm1Khk,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA Allelic Composition: Foxa2^tm1Khk/Foxa2^tm1Khk,Tg(Foxa3-cre)1Khk/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA
MP:0002702	decreased circulating free fatty acid level	"lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Rif1^{Gt(A045A01)Wrst}/Rif1^{Gt(A045A01)Wrst} Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0002727	decreased circulating insulin level	"less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]	Show Allelic Composition: Rif1^{Gt(A045A01)Wrst}/Rif1^{Gt(A045A01)Wrst} Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0002767	situs ambiguus	"abnormal organ position" [J:62608]	Show Allelic Composition: Nodal^tm1Rob/Nodal⁺ Genetic Background: involves: 129S/SvEv
MP:0002825	abnormal notochord	"malformation or absence of the axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Wnt3a^tm1Amc/Wnt3a^tm1Amc Genetic Background: involves: 129S1/Sv
MP:0002884	abnormal branchial arches	"malformation or anomaly in the transient structures of the embryo that develop into regions of the head, neck and ears" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Wnt3a^tm1Amc/Wnt3a^tm1Amc Genetic Background: involves: 129S1/Sv
MP:0002891	increased insulin sensitivity	"greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]	Show Allelic Composition: Rif1^{Gt(A045A01)Wrst}/Rif1^{Gt(A045A01)Wrst} Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0003232	abnormal forebrain development	"anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Wnt3a^tm1Amc/Wnt3a^tm1Amc Genetic Background: involves: 129S1/Sv
MP:0003331	hepatocellular carcinoma	"malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Syk^tm1Tyb/Syk^tm1Tyb Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0003339	decreased number of pancreatic beta cells	"fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Pparg^tm1.1Auw/Pparg^tm1.1Auw Genetic Background: B6.Cg-Pparg^tm1.1Auw Allelic Composition: Foxa1^tm1Khk/Foxa1^tm1Khk,Foxa2^tm1Khk/Foxa2^tm1Khk,Tg(Pdx1-cre)6Cvw/0 Genetic Background: involves: 129 * C57BL/6 * CBA * SJL
MP:0003400	kinked neural tube	"twists or kinks in the embryonic neural tube" [J:66514, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Foxa2^tm1Jrt/Foxa2^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0003425	abnormal optic vesicle formation	"anomalous formation of the hollow outgrowth from the lateral aspects of the embryonic forebrain from which the retina and optic nerve develop" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94391]	Show Allelic Composition: Wnt3a^tm1Amc/Wnt3a^tm1Amc Genetic Background: involves: 129S1/Sv
MP:0003564	abnormal insulin secretion	"aberrant release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Foxa2^tm1Khk/Foxa2^tm1Khk,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA
MP:0003653	decreased skin turgor	"reduced ability of the skin to resist deformation; influential factors include dehydration and age" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxa2^tm1Khk/Foxa2^tm1Khk,Tg(Foxa3-cre)1Khk/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA
MP:0003861	abnormal nervous system development	"impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxa2^tm1Dnl/Foxa2^tm1Dnl Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0003934	abnormal pancreas development	"anomaly in the formation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Foxa1^tm1Khk/Foxa1^tm1Khk,Foxa2^tm1Khk/Foxa2^tm1Khk,Tg(Pdx1-cre)6Cvw/0 Genetic Background: involves: 129 * C57BL/6 * CBA * SJL Allelic Composition: Mib1^tm2Kong/Mib1^tm2Kong,Foxa2^{tm3.1(icre)Heli}/Foxa2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL Allelic Composition: Hes1^tm1Kag/Hes1^tm1Kag,Foxa2^{tm3.1(icre)Heli}/Foxa2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Gt(ROSA)26Sor^{tm1.1(Maml1/EGFP)Hri}/?,Foxa2^{tm3.1(icre)Heli}/Foxa2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL Allelic Composition: Dll1^tm1.1Hri/Dll1^tm1.1Hri,Foxa2^{tm3.1(icre)Heli}/Foxa2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
MP:0003935	abnormal craniofacial development	"anomaly in the process of forming the face and/or cranium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Drd1^tm1Stl/Drd1^tm1Stl Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0003960	increased lean body mass	"more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]	Show Allelic Composition: Rif1^{Gt(A045A01)Wrst}/Rif1^{Gt(A045A01)Wrst} Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0003984	embryonic growth retardation	"slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Wnt3a^tm1Amc/Wnt3a^tm1Amc Genetic Background: involves: 129S1/Sv
MP:0004188	delayed embryo turning	"completion of axial rotation occurs later than in controls but is eventually completed" [smb:Susan M Bello, Mouse Genome Informatics Curator ""]	Show Allelic Composition: Nodal^tm1Rob/Nodal⁺ Genetic Background: involves: 129S/SvEv
MP:0004190	abnormal direction of embryo turning	"axial rotation of the embryo in a direction other than the normal anticlockwise direction when viewed towards the caudal pole during the late primitive streak/early somite stage (Mus E8.5-E9.5); clockwise rotation is frequently associated with heart and visceral defects" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development"]	Show Allelic Composition: Nodal^tm1Rob/Nodal⁺ Genetic Background: involves: 129S/SvEv
MP:0004244	abnormal spontaneous abortion rate	"change in frequency of a natural or accidental termination of a pregnancy at a stage where the embryo or the fetus is incapable of surviving independently of the mother" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxa2^tm1Dnl/Foxa2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0004499	increased incidence of chemically-induced tumors	"higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Syk^tm1Tyb/Syk^tm1Tyb Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0004502	decreased incidence of chemically-induced tumors	"lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Syk^tm1Tyb/Syk^tm1Tyb Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0004554	small pharynx	"reduced size/diameter of the passage between the mouth and the posterior nares and the larynx and esophagus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Wnt3a^tm1Amc/Wnt3a^tm1Amc Genetic Background: involves: 129S1/Sv
MP:0004780	abnormal surfactant secretion	"anomaly in the production or release from pneumocytes of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pkia^tm1Idz/Pkia^tm1Idz,Pkib^tm1Idz/Pkib^tm1Idz Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
MP:0004781	abnormal surfactant composition	"anomaly in the chemical consituents of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pkia^tm1Idz/Pkia^tm1Idz,Pkib^tm1Idz/Pkib^tm1Idz Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
MP:0004784	abnormal anterior cardinal vein morphology	"any structural anomaly of the two paired veins draining the cephalic part of the body" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Wnt3a^tm1Amc/Wnt3a^tm1Amc Genetic Background: involves: 129S1/Sv
MP:0004787	abnormal dorsal aorta morphology	"any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]	Show Allelic Composition: Wnt3a^tm1Amc/Wnt3a^tm1Amc Genetic Background: involves: 129S1/Sv
MP:0004831	long incisors	"increased length of the long pointed teeth; most anterior and prominent in the jaw" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Msr1^tm1Csk/Msr1^tm1Csk Genetic Background: either: (involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J * ICR) or (involves: 129P2/OlaHsd * 129X1/SvJ * 129/Sv * ICR) Allelic Composition: Foxa2^tm1Jrt/Foxa2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0005217	abnormal pancreatic beta cell morphology	"malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Foxa2^tm1Khk/Foxa2^tm1Khk,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA
MP:0005221	abnormal rostral-caudal axis patterning	"anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxa2^tm1Jrt/Foxa2^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0005266	abnormal metabolism	"anomalous chemical and physical changes occurring in tissue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Foxa2^tm1Dnl/Foxa2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0005289	increased oxygen consumption	"greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Rif1^{Gt(A045A01)Wrst}/Rif1^{Gt(A045A01)Wrst} Genetic Background: involves: 129S2/SvPas * C57BL/6J Allelic Composition: Foxa2^tm1.1Stf/Foxa2^tm1.1Stf Genetic Background: B6.129-Foxa2^tm1.1Stf
MP:0005292	improved glucose tolerance	"better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Rif1^{Gt(A045A01)Wrst}/Rif1^{Gt(A045A01)Wrst} Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0005425	increased macrophage count	"greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]	Show Allelic Composition: Pkia^tm1Idz/Pkia^tm1Idz,Pkib^tm1Idz/Pkib^tm1Idz Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
MP:0005440	increased glycogen level	"greater than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Foxa2^tm1Khk/Foxa2^tm1Khk,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA
MP:0005492	acinar hypoplasia	"decreased numbers of cells in the portion of the pancreas that secretes digestive enzymes " [J:48446, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Pparg^tm1.1Auw/Pparg^tm1.1Auw Genetic Background: B6.Cg-Pparg^tm1.1Auw Allelic Composition: Foxa1^tm1Khk/Foxa1^tm1Khk,Foxa2^tm1Khk/Foxa2^tm1Khk,Tg(Pdx1-cre)6Cvw/0 Genetic Background: involves: 129 * C57BL/6 * CBA * SJL
MP:0005560	decreased circulating glucose level	"less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rif1^{Gt(A045A01)Wrst}/Rif1^{Gt(A045A01)Wrst} Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0006027	impaired alveologenesis	"a block or reduction in the generation of alveoli" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:85546]	Show Allelic Composition: Pkia^tm1Idz/Pkia^tm1Idz,Pkib^tm1Idz/Pkib^tm1Idz Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
MP:0006294	absent optic vesicle	"absence of the hollow outgrowth from the lateral aspects of the embryonic forebrain from which the retina and optic nerve develop" [J:94391, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Wnt3a^tm1Amc/Wnt3a^tm1Amc Genetic Background: involves: 129S1/Sv
MP:0006337	abnormal first branchial arch morphology	"anomaly in the structure of the first arch which contributes to development of mastication muscles, maxilla, mandible, incus, malleus, Meckel s cartilage, trigeminal nerve, and maxillary artery" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Wnt3a^tm1Amc/Wnt3a^tm1Amc Genetic Background: involves: 129S1/Sv
MP:0006338	abnormal second branchial arch morphology	"anomaly in the structure of the second arch which contributes to the development of the stapes, styloid process, hyoid bone, stylohyoid ligament, muscles of facial expression, stapedius muscle, stylohyoid muscle, and lining of the palatine tonsils" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Wnt3a^tm1Amc/Wnt3a^tm1Amc Genetic Background: involves: 129S1/Sv
MP:0006341	small first branchial arch	"reduced size of the first branchial arch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Wnt3a^tm1Amc/Wnt3a^tm1Amc Genetic Background: involves: 129S1/Sv
MP:0006344	small second branchial arch	"reduced size of the second branchial arch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Wnt3a^tm1Amc/Wnt3a^tm1Amc Genetic Background: involves: 129S1/Sv
MP:0008029	abnormal paraxial mesoderm	"failure or abnormality in the formation of the mesoderm lying at either side of the midline embryonic notochord; on segmentation, paraxial mesoderm forms the paired somites" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxa2^tm1Dnl/Foxa2^tm1Dnl Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0008963	increased carbon dioxide production	"increase in the rate at which carbon dioxide leaves the blood and enters the alveolar gas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rif1^{Gt(A045A01)Wrst}/Rif1^{Gt(A045A01)Wrst} Genetic Background: involves: 129S2/SvPas * C57BL/6J Allelic Composition: Foxa2^tm1.1Stf/Foxa2^tm1.1Stf Genetic Background: B6.129-Foxa2^tm1.1Stf
MP:0008965	increased basal metabolism	"increase in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state" [MESH:E01.370.374.750.100]	Show Allelic Composition: Rif1^{Gt(A045A01)Wrst}/Rif1^{Gt(A045A01)Wrst} Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0009009	absent estrous cycle	"failure of female animals to enter or progress through their sexual cycle" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxa2^tm1Dnl/Foxa2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0009021	absent estrus	"absence or failure of the estrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxa2^tm1Dnl/Foxa2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0009111	pancreas hypoplasia	"underdevelopment or reduced size of the pancreas, usually due to a reduced number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pparg^tm1.1Auw/Pparg^tm1.1Auw Genetic Background: B6.Cg-Pparg^tm1.1Auw Allelic Composition: Foxa1^tm1Khk/Foxa1^tm1Khk,Foxa2^tm1Khk/Foxa2^tm1Khk,Tg(Pdx1-cre)6Cvw/0 Genetic Background: involves: 129 * C57BL/6 * CBA * SJL
MP:0009163	absent pancreatic duct	"absence of the excretory duct of the exocrine pancreas that collects fluid containing digestive enzymes and transports it to the duodenum" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A03.734.667]	Show Allelic Composition: Mib1^tm2Kong/Mib1^tm2Kong,Foxa2^{tm3.1(icre)Heli}/Foxa2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
MP:0009169	pancreatic islet hypoplasia	"underdevelopment or decreased size of the clusters of hormone-producing cells that are scattered throughout the pancreas, usually due an decreased number of cells" [MA:0000127, MESH:A03.734.414]	Show Allelic Composition: Pparg^tm1.1Auw/Pparg^tm1.1Auw Genetic Background: B6.Cg-Pparg^tm1.1Auw Allelic Composition: Foxa1^tm1Khk/Foxa1^tm1Khk,Foxa2^tm1Khk/Foxa2^tm1Khk,Tg(Pdx1-cre)6Cvw/0 Genetic Background: involves: 129 * C57BL/6 * CBA * SJL
MP:0009175	abnormal pancreatic beta cell differentiation	"atypical production of or inability to produce the cells of the pancreas that secrete insulin, and/or accumulation of pancreatic beta cell precursors" [MESH:A03.734.414.131]	Show Allelic Composition: Mib1^tm2Kong/Mib1^tm2Kong,Foxa2^{tm3.1(icre)Heli}/Foxa2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL Allelic Composition: Hes1^tm1Kag/Hes1^tm1Kag,Foxa2^{tm3.1(icre)Heli}/Foxa2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Gt(ROSA)26Sor^{tm1.1(Maml1/EGFP)Hri}/?,Foxa2^{tm3.1(icre)Heli}/Foxa2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
MP:0009177	decreased pancreatic alpha cell number	"reduction in the number of the cells of the pancreas that secrete glucagon" [MESH:A03.734.414.065]	Show Allelic Composition: Foxa2^tm1Khk/Foxa2^tm1Khk,Tg(Foxa3-cre)1Khk/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA
MP:0009254	disorganized pancreatic islets	"derangement of the normal pattern of the hormone-producing cells within an islet; normally, the beta cells occupy the central portion of the islet and are surrounded by a corona of alpha and delta cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxa2^tm1Khk/Foxa2^tm1Khk,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA Allelic Composition: Foxa2^tm1Khk/Foxa2^tm1Khk,Tg(Foxa3-cre)1Khk/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA
MP:0009266	abnormal mesendoderm development	"failure or abnormality in the formation of the embryonic cell layer that gives rise to both the endoderm and mesoderm" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bad^tm1Meg/Bad^tm1Meg Genetic Background: involves: 129S4/SvJae
MP:0009331	absent primitive node	"absence of the regional thickening of cells at the rostral tip of the vertebrate primitive streak through which gastrulating cells migrate anteriorally to form tissues in the future head and neck; this region organizes the formation of the three embryonic layers and establishes the longitudinal axis and the polarity of the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxa2^tm1Jrt/Foxa2^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 Allelic Composition: Foxa2^tm1Dnl/Foxa2^tm1Dnl Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0009355	increased liver triglyceride level	"higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxa2^tm1Dnl/Foxa2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0009937	abnormal neuron differentiation	"abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxa2^tm1Dnl/Foxa2^tm1Dnl Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0010018	lung vascular congestion	"obstruction of the normal flux of blood within the blood vessel network of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pkia^tm1Idz/Pkia^tm1Idz,Pkib^tm1Idz/Pkib^tm1Idz Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
MP:0010025	decreased total body fat amount	"less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rif1^{Gt(A045A01)Wrst}/Rif1^{Gt(A045A01)Wrst} Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0010355	abnormal first branchial arch artery morphology	"any structural anomaly of the vessels formed within the first pair of branchial arches in embryogenesis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Wnt3a^tm1Amc/Wnt3a^tm1Amc Genetic Background: involves: 129S1/Sv
MP:0010549	absent dorsal mesocardium	"absence of the part of the mesocardium that lies dorsal to the embryonic heart; the dorsal mesocardium gives rise to the transverse sinus of the pericardium in the adult" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Wnt3a^tm1Amc/Wnt3a^tm1Amc Genetic Background: involves: 129S1/Sv
MP:0010814	absent alveolar lamellar bodies	"absence of the specialized secretory organelles found in the cytoplasm of type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pkia^tm1Idz/Pkia^tm1Idz,Pkib^tm1Idz/Pkib^tm1Idz Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
MP:0010817	absent type I pneumocytes	"absence of the flattened, branched squamous cells that covers more than 98 percent of the alveolar surface, and have thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange" [PMID:20054144]	Show Allelic Composition: Pkia^tm1Idz/Pkia^tm1Idz,Pkib^tm1Idz/Pkib^tm1Idz Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
MP:0010825	abnormal lung saccule morphology	"any structural anomaly of the transient dilations of the developing alveolar (or transient) ducts, which transform into a transitory alveolar duct as soon as it develops further branches; the last transitory saccule formed on each pathway is a terminal saccule that develops into an alveolar sac after birth" [GO:0060430, ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pkia^tm1Idz/Pkia^tm1Idz,Pkib^tm1Idz/Pkib^tm1Idz Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
MP:0010856	dilated respiratory conducting tubes	"expansion or widening of the lumens of the tubes of the respiratory system that allow passage of air from the trachea to the alveoli of the lungs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pkia^tm1Idz/Pkia^tm1Idz,Pkib^tm1Idz/Pkib^tm1Idz Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
MP:0010861	increased respiratory mucosa goblet cell number	"greater number of the cells of the respiratory epithelial lining that produce and secrete mucins" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pkia^tm1Idz/Pkia^tm1Idz,Pkib^tm1Idz/Pkib^tm1Idz Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 Allelic Composition: Foxa2^tm1Khk/Foxa2^tm1Khk,Tg(Scgb1a1-rtTA)1Jaw/0,Tg(tetO-cre)1Jaw/0 Genetic Background: Not Specified
MP:0010896	decreased lung compliance	"reduced ability of the lung to distend in response to pressure without disruption, usually expressed as the unit volume of change in the lung per unit of pressure" [ISBN:070202788 "Saunders Comprehensive Veterinary Dictionary, 3rd edition"]	Show Allelic Composition: Foxa2^tm1Khk/Foxa2^tm1Khk,Tg(Scgb1a1-rtTA)1Jaw/0,Tg(tetO-cre)1Jaw/0 Genetic Background: Not Specified
MP:0010903	abnormal pulmonary alveolus wall morphology		Show Allelic Composition: Pkia^tm1Idz/Pkia^tm1Idz,Pkib^tm1Idz/Pkib^tm1Idz Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
MP:0010935	increased airway resistance	"greater opposition to flow of air caused by the forces of friction, measured as the ratio of driving pressure to the rate of air flow" [MGI:csmith]	Show Allelic Composition: Foxa2^tm1Khk/Foxa2^tm1Khk,Tg(Scgb1a1-rtTA)1Jaw/0,Tg(tetO-cre)1Jaw/0 Genetic Background: Not Specified
MP:0010993	decreased surfactant secretion	"decreased production or release from pneumocytes of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pkia^tm1Idz/Pkia^tm1Idz,Pkib^tm1Idz/Pkib^tm1Idz Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
MP:0011018	pulmonary hyaline membrane formation	"abnormal presence of an eosinophilic hyaline (glass-like) material composed of fibrin, proteinaceous exudate and cellular debris, and lining or filling the alveoli, alveolar ducts and bronchioles; hyaline membranes block gas exchange and are usually found at autopsy in individuals that have died of respiratory distress syndrome in the neonatal stages" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pkia^tm1Idz/Pkia^tm1Idz,Pkib^tm1Idz/Pkib^tm1Idz Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
MP:0011085	complete postnatal lethality	"premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Foxa2^tm1Khk/Foxa2^tm1Khk,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA Allelic Composition: Foxa2^tm1Khk/Foxa2^tm1Khk,Tg(Foxa3-cre)1Khk/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA Allelic Composition: Foxa1^tm1Khk/Foxa1⁺,Foxa2^tm1Khk/Foxa2^tm1Khk,Tg(Pdx1-cre)6Cvw/0 Genetic Background: involves: 129 * C57BL/6 * CBA * SJL Allelic Composition: Foxa1^tm1Khk/Foxa1^tm1Khk,Foxa2^tm1Khk/Foxa2^tm1Khk,Tg(Pdx1-cre)6Cvw/0 Genetic Background: involves: 129 * C57BL/6 * CBA * SJL
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Pkia^tm1Idz/Pkia^tm1Idz,Pkib^tm1Idz/Pkib^tm1Idz Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
MP:0011088	partial neonatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Pkia^tm1Idz/Pkia^tm1Idz,Pkib^tm1Idz/Pkib^tm1Idz Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 Allelic Composition: Foxa2^tm1Dnl/Foxa2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0011092	complete embryonic lethality	"death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]	Show Allelic Composition: Drd1^tm1Stl/Drd1^tm1Stl Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0011098	complete embryonic lethality during organogenesis	"death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Wnt3a^tm1Amc/Wnt3a^tm1Amc Genetic Background: involves: 129S1/Sv Allelic Composition: Foxa2^tm1Jrt/Foxa2^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 Allelic Composition: Foxa2^tm1Jrt/Foxa2^tm1Khk,Tg(Nes-cre)1Wme/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Foxa2^tm1Dnl/Foxa2^tm1Dnl Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0011183	abnormal primitive endoderm morphology	"any structural anomaly of the monolayer of cells derived from and located on the surface of inner cell mass, directly facing the blastocoele, and is separated from the more centrally located epiblast by basal lamina; the primitive endoderm give rises to the visceral endoderm and the parietal endoderm" [PMID:21123814]	Show Allelic Composition: Foxa2^tm1Jrt/Foxa2^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0011732	decreased somite size	"reduced size of any of the segmental masses along the notochord of the developing embryo" [MGI:smb]	Show Allelic Composition: Wnt3a^tm1Amc/Wnt3a^tm1Amc Genetic Background: involves: 129S1/Sv Allelic Composition: Foxa2^tm1Jrt/Foxa2^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0011733	fused somites	"a defect in which there is an appearance of a single enlarged somite resulting from partial or complete fusion of the two somitic anlage" [MGI:smb]	Show Allelic Composition: Foxa2^tm1Jrt/Foxa2^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0011939	increased food intake	"increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]	Show Allelic Composition: Rif1^{Gt(A045A01)Wrst}/Rif1^{Gt(A045A01)Wrst} Genetic Background: involves: 129S2/SvPas * C57BL/6J Allelic Composition: Foxa2^tm1.1Stf/Foxa2^tm1.1Stf Genetic Background: B6.129-Foxa2^tm1.1Stf
MP:0011941	increased fluid intake	"increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]	Show Allelic Composition: Rif1^{Gt(A045A01)Wrst}/Rif1^{Gt(A045A01)Wrst} Genetic Background: involves: 129S2/SvPas * C57BL/6J Allelic Composition: Foxa2^tm1.1Stf/Foxa2^tm1.1Stf Genetic Background: B6.129-Foxa2^tm1.1Stf
MP:0012082	delayed heart development	"late onset of the induction and/or differentiation of the heart" [MGI:anna]	Show Allelic Composition: Drd1^tm1Stl/Drd1^tm1Stl Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0012135	embryonic-extraembryonic boundary constriction	"an invagination or pinching in the visceral endoderm that is centered at the boundary between embryonic and extra-embryonic regions of the developing embryo, often resulting in physical separation of embryonic and extraembryonic ectoderm" [MGI:csmith]	Show Allelic Composition: Foxa2^tm1Jrt/Foxa2^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0012138	decreased forebrain size	"size reduction or truncation of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]	Show Allelic Composition: Wnt3a^tm1Amc/Wnt3a^tm1Amc Genetic Background: involves: 129S1/Sv
MP:0012157	rostral body truncation	"rostral part of body truncated; typically with the caudal portion of the body relatively normal" [MGI:csmith]	Show Allelic Composition: Foxa2^tm1Jrt/Foxa2^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0012263	decreased hindbrain size	"size reduction or truncation of the part of the brain developed from the posterior of the three primary brain vesicles of the embryonic neural tube from which the metencephalon and myelencephalon are derived" [MGI:anna]	Show Allelic Composition: Wnt3a^tm1Amc/Wnt3a^tm1Amc Genetic Background: involves: 129S1/Sv
MP:0012271	abnormal chordamesoderm morphology	"any structural anomaly of the area of axial mesoderm that develops into the notochord" [MGI:anna]	Show Allelic Composition: Foxa2^tm1Dnl/Foxa2^tm1Dnl Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0012685	abnormal primitive streak elongation	"any anomaly in the process by which the primitive streak extends anteriorly and elongates towards the distal (cranial) end of the embryo to reach its full length" [MGI:anna]	Show Allelic Composition: Foxa2^tm1Jrt/Foxa2^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0012703	decreased embryonic neuroepithelium thickness	"reduced width of the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [MGI:anna]	Show Allelic Composition: Wnt3a^tm1Amc/Wnt3a^tm1Amc Genetic Background: involves: 129S1/Sv
MP:0013504	increased embryonic tissue cell apoptosis	"increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]	Show Allelic Composition: Foxa2^tm1Jrt/Foxa2^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 Allelic Composition: Foxa2^tm1Jrt/Foxa2^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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