ENSMUSG00000055874


Mus musculus

Features
Gene ID: ENSMUSG00000055874
  
Biological name :Foxi3
  
Synonyms : forkhead box I3 / Foxi3
  
Possible biological names infered from orthology : A8MTJ6
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: C1
Gene start: 70956531
Gene end: 70961066
  
Corresponding Affymetrix probe sets: 10538959 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000065664
Ensembl peptide - ENSMUSP00000125380
NCBI entrez gene - 232077     See in Manteia.
MGI - MGI:3511278
RefSeq - NM_001101464
RefSeq Peptide - NP_001094934
swissprot - E0CZH3
swissprot - D3Z120
Ensembl - ENSMUSG00000055874
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 foxi2ENSDARG00000069715Danio rerio
 FOXI3ENSGALG00000037457Gallus gallus
 FOXI3ENSG00000214336Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Foxi1 / Q922I5 / Forkhead box protein I1 / Q12951* / forkhead box I1*ENSMUSG0000004786141
Foxi2 / forkhead box I2 / Q6ZQN5*ENSMUSG0000004837734
Foxc1 / Q61572 / Forkhead box protein C1 / Q12948* / forkhead box C1*ENSMUSG0000005029525
Foxc2 / Q61850 / Forkhead box protein C2 / Q99958* / forkhead box C2*ENSMUSG0000004671424
Foxa2 / P35583 / Mus musculus forkhead box A2 (Foxa2), transcript variant 3, mRNA. / Q9Y261* / forkhead box A2*ENSMUSG0000003702524
Foxa1 / P35582 / Hepatocyte nuclear factor 3-alpha / P55317* / forkhead box A1*ENSMUSG0000003545123
Foxa3 / P35584 / Hepatocyte nuclear factor 3-gamma / P55318* / forkhead box A3*ENSMUSG0000004089122
Foxs1 / Q61574 / Forkhead box protein S1 / O43638* / forkhead box S1*ENSMUSG0000007467621
Foxl1 / Q64731 / Forkhead box protein L1 / Q12952* / forkhead box L1*ENSMUSG0000009708421
Foxl2 / O88470 / Forkhead box protein L2 / P58012* / forkhead box L2*ENSMUSG0000005039721
Foxb1 / Q64732 / Forkhead box protein B1 / Q99853* / forkhead box B1*ENSMUSG0000005924617
Foxb2 / Q64733 / Forkhead box protein B2 / Q5VYV0* / forkhead box B2*ENSMUSG0000005682916


Protein motifs (from Interpro)
Interpro ID Name
 IPR001766  Fork head domain
 IPR018122  Fork head domain conserved site1
 IPR030456  Fork head domain conserved site 2
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0009653 anatomical structure morphogenesis IBA
 biological_processGO:0030154 cell differentiation IBA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000049 abnormal middle ear morphology "malformation or malfunction of any components of the tympanic cavity or its ossicles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ap3d1mh-4J/Ap3d1mh-4J
Genetic Background: involves: 129P2/OlaHsd * BALB/cByJ * C57BL/6J

 MP:0000453 absent mouth "missing oral cavity" [J:35802]
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Allelic Composition: Ap3d1mh-4J/Ap3d1mh-4J
Genetic Background: involves: 129P2/OlaHsd * BALB/cByJ * C57BL/6J

 MP:0000455 abnormal maxilla morphology "malformation of the upper bony framework of the mouth where the superior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ap3d1mh-4J/Ap3d1mh-4J
Genetic Background: involves: 129P2/OlaHsd * BALB/cByJ * C57BL/6J

 MP:0000458 abnormal mandible morphology "malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ap3d1mh-4J/Ap3d1mh-4J
Genetic Background: involves: 129P2/OlaHsd * BALB/cByJ * C57BL/6J

 MP:0000919 cranioschisis "incomplete closure of the skull, usually congenital " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Ap3d1mh-4J/Ap3d1mh-4J
Genetic Background: involves: 129P2/OlaHsd * BALB/cByJ * C57BL/6J

 MP:0001082 abnormal geniculate ganglion morphology "malformed group of sensory neuron cell bodies associated with the facial nerve (seventh cranial nerve)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
Show

Allelic Composition: Oca2p-7Btlr/Oca2p-7Btlr
Genetic Background: C57BL/6J-Oca2p-7Btlr

Allelic Composition: Foxi3tm1.2Akg/Foxi3tm1.2Akg
Genetic Background: involves: 129X1/SvJ

 MP:0001092 abnormal trigeminal ganglion morphology "malformed group of sensory neuron cell bodies associated with the trigeminal nerve (fifth cranial nerve)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33038]
Show

Allelic Composition: Oca2p-7Btlr/Oca2p-7Btlr
Genetic Background: C57BL/6J-Oca2p-7Btlr

Allelic Composition: Foxi3tm1.2Akg/Foxi3tm1.2Akg
Genetic Background: involves: 129X1/SvJ

 MP:0001284 absent vibrissae "missing whiskers" [J:18378]
Show

Allelic Composition: Ap3d1mh-4J/Ap3d1mh-4J
Genetic Background: involves: 129P2/OlaHsd * BALB/cByJ * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Krastm4Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003138 absent tympanic ring "missing the bony ring at the ear canal to which the tympanic membrane is attached" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:46972]
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Allelic Composition: Ap3d1mh-4J/Ap3d1mh-4J
Genetic Background: involves: 129P2/OlaHsd * BALB/cByJ * C57BL/6J

 MP:0003703 abnormal vestibulocochlear ganglion morphology "malformed group of neuron cell bodies associated with the eighth cranial nerve during embryogenesis; splits in later development to form the cochlear and vestibular ganglia" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Oca2p-7Btlr/Oca2p-7Btlr
Genetic Background: C57BL/6J-Oca2p-7Btlr

Allelic Composition: Foxi3tm1.2Akg/Foxi3tm1.2Akg
Genetic Background: involves: 129X1/SvJ

 MP:0003743 abnormal facial morphology "anomalous structure or development of the face" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Ap3d1mh-4J/Ap3d1mh-4J
Genetic Background: involves: 129P2/OlaHsd * BALB/cByJ * C57BL/6J

 MP:0003861 abnormal nervous system development "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Oca2p-7Btlr/Oca2p-7Btlr
Genetic Background: C57BL/6J-Oca2p-7Btlr

Allelic Composition: Foxi3tm1.2Akg/Foxi3tm1.2Akg
Genetic Background: involves: 129X1/SvJ

 MP:0003874 absent branchial arches "missing the transient structures of the embryo that develop into regions of the head, neck and ears" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ap3d1mh-4J/Ap3d1mh-4J
Genetic Background: involves: 129P2/OlaHsd * BALB/cByJ * C57BL/6J

 MP:0004204 absent stapes "absence of the smallest and innermost of the three auditory ossicles" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ap3d1mh-4J/Ap3d1mh-4J
Genetic Background: involves: 129P2/OlaHsd * BALB/cByJ * C57BL/6J

 MP:0004318 absent incus "absence of the middle of the three auditory ossicles" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ap3d1mh-4J/Ap3d1mh-4J
Genetic Background: involves: 129P2/OlaHsd * BALB/cByJ * C57BL/6J

 MP:0004319 absent malleus "absence of the largest of the three auditory ossicles, which resembles a club or hammer" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ap3d1mh-4J/Ap3d1mh-4J
Genetic Background: involves: 129P2/OlaHsd * BALB/cByJ * C57BL/6J

 MP:0004423 abnormal squamosal bone morphology "any structural anomaly of the thin, platelike part of the temporal bone" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ap3d1mh-4J/Ap3d1mh-4J
Genetic Background: involves: 129P2/OlaHsd * BALB/cByJ * C57BL/6J

 MP:0004467 absent zygomatic bone "absence of the quadrilateral bone that forms the prominence of the cheek" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ap3d1mh-4J/Ap3d1mh-4J
Genetic Background: involves: 129P2/OlaHsd * BALB/cByJ * C57BL/6J

 MP:0005249 abnormal palatine bone morphology "structural anomaly of the anteriorly located rigid section of the palate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ap3d1mh-4J/Ap3d1mh-4J
Genetic Background: involves: 129P2/OlaHsd * BALB/cByJ * C57BL/6J

 MP:0005579 absent outer ear "missing auricles or external acoustic meatus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:17694]
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Allelic Composition: Ap3d1mh-4J/Ap3d1mh-4J
Genetic Background: involves: 129P2/OlaHsd * BALB/cByJ * C57BL/6J

 MP:0005587 abnormal Meckel s cartilage morphology "structural anomaly of this cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible; gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17694]
Show

Allelic Composition: Ap3d1mh-4J/Ap3d1mh-4J
Genetic Background: involves: 129P2/OlaHsd * BALB/cByJ * C57BL/6J

 MP:0006031 abnormal branchial pouch morphology "malfomation or anomaly in the series of grooves that form between the branchial arches; these endodermal evaginations develop into epithelial tissues and organs" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]
Show

Allelic Composition: Ap3d1mh-4J/Ap3d1mh-4J
Genetic Background: involves: 129P2/OlaHsd * BALB/cByJ * C57BL/6J

 MP:0006285 absent inner ear "absence of all components of the labyrinth, including the semicircular canals, vestibule and cochlea" [J:86619, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ap3d1mh-4J/Ap3d1mh-4J
Genetic Background: involves: 129P2/OlaHsd * BALB/cByJ * C57BL/6J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Ap3d1mh-4J/Ap3d1mh-4J
Genetic Background: involves: 129P2/OlaHsd * BALB/cByJ * C57BL/6J

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Ap3d1mh-4J/Ap3d1mh-4J
Genetic Background: involves: 129P2/OlaHsd * BALB/cByJ * C57BL/6J

 MP:0011173 abnormal otic placode morphology "any structural anomaly of two paired thickened areas of ectoderm close to the hindbrain from which the vestibular system and the auditory system develops; the otic placode invaginates into the mesenchyme adjacent to the rhombencephalon to form the otic pit" [PMID:9507049]
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Allelic Composition: Foxi3tm1.2Akg/Foxi3tm1.2Akg
Genetic Background: involves: 129X1/SvJ

 MP:0012761 increased cranial neural crest cell apoptosis "increased number of cranial neural crest cells (NCCs) undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Ap3d1mh-4J/Ap3d1mh-4J
Genetic Background: involves: 129P2/OlaHsd * BALB/cByJ * C57BL/6J

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Foxi3tm1.2Akg/Foxi3tm1.2Akg
Genetic Background: involves: 129X1/SvJ

 MP:0030064 small face "presence of an abnormally small face" [MGI:anna]
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Allelic Composition: Ap3d1mh-4J/Ap3d1mh-4J
Genetic Background: involves: 129P2/OlaHsd * BALB/cByJ * C57BL/6J

 MP:0030085 syngnathia "fusion of the upper and lower jaw; fusion can range from simple mucosal bands (synechiae) to complete bony fusion (synostosis); syngnathia can occur in the midline, or laterally, and it can be uni- or bilateral" [https://doi.org/10.1016/j.pedneo.2013.04.009, PMID:24385915]
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Allelic Composition: Ap3d1mh-4J/Ap3d1mh-4J
Genetic Background: involves: 129P2/OlaHsd * BALB/cByJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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