ENSMUSG00000074676


Mus musculus

Features
Gene ID: ENSMUSG00000074676
  
Biological name :Foxs1
  
Synonyms : Forkhead box protein S1 / Foxs1 / Q61574
  
Possible biological names infered from orthology : forkhead box S1 / O43638
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: H1
Gene start: 152931898
Gene end: 152933208
  
Corresponding Affymetrix probe sets: 10488673 (MoGene1.0st)   1437820_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000096806
NCBI entrez gene - 14239     See in Manteia.
MGI - MGI:95546
RefSeq - NM_010226
RefSeq Peptide - NP_034356
swissprot - Q4VA05
swissprot - Q61574
Ensembl - ENSMUSG00000074676
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FOXS1ENSGALG00000043015Gallus gallus
 FOXS1ENSG00000179772Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Foxc2 / Q61850 / Forkhead box protein C2 / Q99958* / forkhead box C2*ENSMUSG0000004671437
Foxc1 / Q61572 / Forkhead box protein C1 / Q12948* / forkhead box C1*ENSMUSG0000005029536
Foxl1 / Q64731 / Forkhead box protein L1 / Q12952* / forkhead box L1*ENSMUSG0000009708429
Foxl2 / O88470 / Forkhead box protein L2 / P58012* / forkhead box L2*ENSMUSG0000005039729
Foxb2 / Q64733 / Forkhead box protein B2 / Q5VYV0* / forkhead box B2*ENSMUSG0000005682926
Foxa1 / P35582 / Hepatocyte nuclear factor 3-alpha / P55317* / forkhead box A1*ENSMUSG0000003545126
Foxb1 / Q64732 / Forkhead box protein B1 / Q99853* / forkhead box B1*ENSMUSG0000005924625
Foxi3 / forkhead box I3 / A8MTJ6*ENSMUSG0000005587425
Foxa2 / P35583 / Mus musculus forkhead box A2 (Foxa2), transcript variant 3, mRNA. / Q9Y261* / forkhead box A2*ENSMUSG0000003702525
Foxi1 / Q922I5 / Forkhead box protein I1 / Q12951* / forkhead box I1*ENSMUSG0000004786124
Foxi2 / forkhead box I2 / Q6ZQN5*ENSMUSG0000004837724
Foxa3 / P35584 / Hepatocyte nuclear factor 3-gamma / P55318* / forkhead box A3*ENSMUSG0000004089122


Protein motifs (from Interpro)
Interpro ID Name
 IPR001766  Fork head domain
 IPR018122  Fork head domain conserved site1
 IPR030456  Fork head domain conserved site 2
 IPR033067  Forkhead box protein S1
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0009653 anatomical structure morphogenesis IBA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0040018 positive regulation of multicellular organism growth IMP
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0050885 neuromuscular process controlling balance IMP
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdx4tm1.1Gqda/Cdx4tm1.1Gqda
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003858 enhanced coordination "improved ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Npm1Gt(VICTR37)704Lex/Npm1Gt(VICTR37)704Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0004245 genital hemorrhage "bleeding into the genitals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdx4tm1.1Gqda/Cdx4tm1.1Gqda
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Foxs1tm1Kmor/Foxs1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6JJcl

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Npm1Gt(VICTR37)704Lex/Npm1Gt(VICTR37)704Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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