ENSMUSG00000059246


Mus musculus

Features
Gene ID: ENSMUSG00000059246
  
Biological name :Foxb1
  
Synonyms : Forkhead box protein B1 / Foxb1 / Q64732
  
Possible biological names infered from orthology : forkhead box B1 / Q99853
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: D
Gene start: 69757710
Gene end: 69760940
  
Corresponding Affymetrix probe sets: 10594754 (MoGene1.0st)   1420705_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000096197
NCBI entrez gene - 64290     See in Manteia.
MGI - MGI:1927549
RefSeq - NM_022378
RefSeq Peptide - NP_071773
swissprot - Q64732
Ensembl - ENSMUSG00000059246
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 foxb1aENSDARG00000089042Danio rerio
 foxb1bENSDARG00000053650Danio rerio
 FOXB1ENSGALG00000027498Gallus gallus
 FOXB1ENSG00000171956Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Foxb2 / Q64733 / Forkhead box protein B2 / Q5VYV0* / forkhead box B2*ENSMUSG0000005682957
Foxa1 / P35582 / Hepatocyte nuclear factor 3-alpha / P55317* / forkhead box A1*ENSMUSG0000003545134
Foxa2 / P35583 / Mus musculus forkhead box A2 (Foxa2), transcript variant 3, mRNA. / Q9Y261* / forkhead box A2*ENSMUSG0000003702534
Foxa3 / P35584 / Hepatocyte nuclear factor 3-gamma / P55318* / forkhead box A3*ENSMUSG0000004089132
Foxc2 / Q61850 / Forkhead box protein C2 / Q99958* / forkhead box C2*ENSMUSG0000004671429
Foxc1 / Q61572 / Forkhead box protein C1 / Q12948* / forkhead box C1*ENSMUSG0000005029529
Foxs1 / Q61574 / Forkhead box protein S1 / O43638* / forkhead box S1*ENSMUSG0000007467626
Foxl2 / O88470 / Forkhead box protein L2 / P58012* / forkhead box L2*ENSMUSG0000005039725
Foxl1 / Q64731 / Forkhead box protein L1 / Q12952* / forkhead box L1*ENSMUSG0000009708424
Foxi1 / Q922I5 / Forkhead box protein I1 / Q12951* / forkhead box I1*ENSMUSG0000004786121
Foxi3 / forkhead box I3 / A8MTJ6*ENSMUSG0000005587421
Foxi2 / forkhead box I2 / Q6ZQN5*ENSMUSG0000004837721


Protein motifs (from Interpro)
Interpro ID Name
 IPR001766  Fork head domain
 IPR018122  Fork head domain conserved site1
 IPR030456  Fork head domain conserved site 2
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001655 urogenital system development IEP
 biological_processGO:0001756 somitogenesis IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007412 axon target recognition IMP
 biological_processGO:0007595 lactation IMP
 biological_processGO:0008542 visual learning IMP
 biological_processGO:0021510 spinal cord development IEP
 biological_processGO:0021767 mammillary body development IMP
 biological_processGO:0021794 thalamus development IEP
 biological_processGO:0021855 hypothalamus cell migration IMP
 biological_processGO:0022029 telencephalon cell migration IMP
 biological_processGO:0030901 midbrain development IMP
 biological_processGO:0033504 floor plate development IMP
 biological_processGO:0043524 negative regulation of neuron apoptotic process IMP
 biological_processGO:0061030 epithelial cell differentiation involved in mammary gland alveolus development IMP
 biological_processGO:0061374 mammillothalamic axonal tract development IMP
 biological_processGO:0061377 mammary gland lobule development IMP
 biological_processGO:0061379 inferior colliculus development IMP
 biological_processGO:0061381 cell migration in diencephalon IMP
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000627 abnormal mammary gland morphology "malformation of the milk-secreting gland that lies within the breast; usually rudimentary in males" [J:70183]
Show

Allelic Composition: Tgm3we/Tgm3we
Genetic Background: Not Specified

Allelic Composition: Foxb1tm1Lby/Foxb1tm1Lby
Genetic Background: B6.129S6-Foxb1tm1Lby

 MP:0000837 abnormal hypothalamus morphology "any malformation or absence of the ventral part of the diencephalon extending from the region of the optic chiasm to the caudal border of the mammillary bodies and forming the inferior and lateral walls of the third ventricle; this region regulates the autonomic nervous system via hormone production and release" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Foxb1tm1Pgr/Foxb1tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Foxb1tm1Pgr/Foxb1tm1Pgr
Genetic Background: B6.129-Foxb1tm1Pgr

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Foxb1tm1Pgr/Foxb1tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000867 abnormal anterior vermis "malformation in the anterior portion of the narrow middle zone between the two hemispheres of the cerebellum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61509]
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Allelic Composition: Foxb1tm1Pgr/Foxb1tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000897 abnormal midbrain "malformation or malfunction associated with the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions, including eye movement and coordination of auditory and visual reflexes" [J:23882, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Foxb1tm1Pgr/Foxb1tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Foxb1tm1Pgr/Foxb1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Agtpbp1pcd-4J/Agtpbp1pcd-4J
Genetic Background: involves: C3H * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Foxb1tm1Pgr/Foxb1tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Foxb1tm1Pgr/Foxb1tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Agtpbp1pcd-4J/Agtpbp1pcd-4J
Genetic Background: involves: C3H * C57BL/6J

Allelic Composition: Foxb1tm1Pgr/Foxb1tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Foxb1tm1Sli/Foxb1tm1Sli
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001382 abnormal nursing "females do not nurse pups or nurse pups infrequently" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxb1tm1Pgr/Foxb1tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
Show

Allelic Composition: Foxb1tm1Pgr/Foxb1tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxb1tm1Sli/Foxb1tm1Sli
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Foxb1tm1Sli/Foxb1tm1Sli
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Foxb1tm1Sli/Foxb1tm1Sli
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Foxb1tm1Pgr/Foxb1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Agtpbp1pcd-4J/Agtpbp1pcd-4J
Genetic Background: involves: C3H * C57BL/6J

Allelic Composition: Foxb1tm1Sli/Foxb1tm1Sli
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Agtpbp1pcd-4J/Agtpbp1pcd-4J
Genetic Background: involves: C3H * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Foxb1tm1Pgr/Foxb1tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Foxb1tm1Pgr/Foxb1tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Foxb1tm1Sli/Foxb1tm1Sli
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Foxb1tm1Pgr/Foxb1tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002566 abnormal sexual interaction "altered initiation, failure of initiation or incomplete mating behavior" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Agtpbp1pcd-4J/Agtpbp1pcd-4J
Genetic Background: involves: C3H * C57BL/6J

 MP:0003718 maternal effect "expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxb1tm1Pgr/Foxb1tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004073 caudal body truncation "caudal part of body truncated with anterior portion relatively normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Agtpbp1pcd-4J/Agtpbp1pcd-4J
Genetic Background: involves: C3H * C57BL/6J

 MP:0004162 abnormal mammilary body morphology "any malformation or absence of the protrusion at the posterior end of the hypothalamus that contains hypothalamic nuclei" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxb1tm1Pgr/Foxb1tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Foxb1tm1Pgr/Foxb1tm1Pgr
Genetic Background: B6.129-Foxb1tm1Pgr

Allelic Composition: Foxb1tm1Lby/Foxb1tm1Lby
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Foxb1tm1Lby/Foxb1tm1Lby
Genetic Background: B6.129S6-Foxb1tm1Lby

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxb1tm1Pgr/Foxb1tm1Pgr
Genetic Background: B6.129-Foxb1tm1Pgr

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agtpbp1pcd-4J/Agtpbp1pcd-4J
Genetic Background: involves: C3H * C57BL/6J

 MP:0009038 decreased inferior colliculus size "decreased size of the paired inferior eminence of the mesencephalic tectum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxb1tm1Pgr/Foxb1tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Foxb1tm1Pgr/Foxb1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Foxb1tm1Lby/Foxb1tm1Lby
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Foxb1tm1Lby/Foxb1tm1Lby
Genetic Background: B6.129S6-Foxb1tm1Lby

 MP:0009504 abnormal mammary gland epithelium morphology "any structural anomaly of the epithelial layer of the luminal surfaces of the mammary gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxb1tm1Lby/Foxb1tm1Lby
Genetic Background: B6.129S6-Foxb1tm1Lby

 MP:0009505 abnormal mammary gland lobule morphology "any structural anomaly of a group of alveoli and the intralobular portion of the terminal duct of the mammary gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxb1tm1Lby/Foxb1tm1Lby
Genetic Background: B6.129S6-Foxb1tm1Lby

 MP:0009506 abnormal mammary gland alveolus morphology "any structural anomaly of the sac-like structure of the mammary gland that secretes milk after pregnancy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxb1tm1Lby/Foxb1tm1Lby
Genetic Background: B6.129S6-Foxb1tm1Lby

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Foxb1tm1Sli/Foxb1tm1Sli
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Agtpbp1pcd-4J/Agtpbp1pcd-4J
Genetic Background: involves: C3H * C57BL/6J

Allelic Composition: Foxb1tm1Pgr/Foxb1tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Foxb1tm1Sli/Foxb1tm1Sli
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Foxb1tm1Pgr/Foxb1tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Agtpbp1pcd-4J/Agtpbp1pcd-4J
Genetic Background: involves: C3H * C57BL/6J

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Foxb1tm1Pgr/Foxb1tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0013718 galactostasis "abnormal accumulation of milk within the mammary gland alveoli and ducts due to failure of ejection (letdown) from the gland; may be associated with nipple anatomic abnormalities" [MGI:Anna]
Show

Allelic Composition: Agtpbp1pcd-4J/Agtpbp1pcd-4J
Genetic Background: involves: C3H * C57BL/6J

Allelic Composition: Foxb1tm1Lby/Foxb1tm1Lby
Genetic Background: B6.129S6-Foxb1tm1Lby

Allelic Composition: Foxb1tm1Lby/Foxb1tm1Lby
Genetic Background: 129S6/SvEvTac-Foxb1tm1Lby

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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