ENSMUSG00000050397


Mus musculus

Features
Gene ID: ENSMUSG00000050397
  
Biological name :Foxl2
  
Synonyms : Forkhead box protein L2 / Foxl2 / O88470
  
Possible biological names infered from orthology : forkhead box L2 / P58012
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: E3.3
Gene start: 98955288
Gene end: 98958543
  
Corresponding Affymetrix probe sets: 10588081 (MoGene1.0st)   1444002_at (Mouse Genome 430 2.0 Array)   1456410_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000053297
NCBI entrez gene - 26927     See in Manteia.
MGI - MGI:1349428
RefSeq - NM_012020
RefSeq Peptide - NP_036150
swissprot - O88470
swissprot - Q2TVT7
Ensembl - ENSMUSG00000050397
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 foxl2aENSDARG00000042180Danio rerio
 foxl2bENSDARG00000068417Danio rerio
 FOXL2ENSGALG00000029282Gallus gallus
 FOXL2ENSG00000183770Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Foxc1 / Q61572 / Forkhead box protein C1 / Q12948* / forkhead box C1*ENSMUSG0000005029529
Foxc2 / Q61850 / Forkhead box protein C2 / Q99958* / forkhead box C2*ENSMUSG0000004671428
Foxs1 / Q61574 / Forkhead box protein S1 / O43638* / forkhead box S1*ENSMUSG0000007467625
Foxl1 / Q64731 / Forkhead box protein L1 / Q12952* / forkhead box L1*ENSMUSG0000009708425
Foxi1 / Q922I5 / Forkhead box protein I1 / Q12951* / forkhead box I1*ENSMUSG0000004786123
Foxi3 / forkhead box I3 / A8MTJ6*ENSMUSG0000005587422
Foxa2 / P35583 / Mus musculus forkhead box A2 (Foxa2), transcript variant 3, mRNA. / Q9Y261* / forkhead box A2*ENSMUSG0000003702522
Foxb1 / Q64732 / Forkhead box protein B1 / Q99853* / forkhead box B1*ENSMUSG0000005924622
Foxb2 / Q64733 / Forkhead box protein B2 / Q5VYV0* / forkhead box B2*ENSMUSG0000005682921
Foxa1 / P35582 / Hepatocyte nuclear factor 3-alpha / P55317* / forkhead box A1*ENSMUSG0000003545121
Foxi2 / forkhead box I2 / Q6ZQN5*ENSMUSG0000004837721
Foxa3 / P35584 / Hepatocyte nuclear factor 3-gamma / P55318* / forkhead box A3*ENSMUSG0000004089119


Protein motifs (from Interpro)
Interpro ID Name
 IPR001766  Fork head domain
 IPR018122  Fork head domain conserved site1
 IPR030456  Fork head domain conserved site 2
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0001541 ovarian follicle development IEA
 biological_processGO:0001555 oocyte growth IMP
 biological_processGO:0002074 extraocular skeletal muscle development IEA
 biological_processGO:0006309 apoptotic DNA fragmentation IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007338 single fertilization IGI
 biological_processGO:0008585 female gonad development IGI
 biological_processGO:0019101 female somatic sex determination IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0033686 positive regulation of luteinizing hormone secretion IGI
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0046881 positive regulation of follicle-stimulating hormone secretion IGI
 biological_processGO:0048048 embryonic eye morphogenesis IMP
 biological_processGO:0060014 granulosa cell differentiation IMP
 biological_processGO:0060065 uterus development IGI
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0045171 intercellular bridge IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030331 estrogen receptor binding IPI
 molecular_functionGO:0031624 ubiquitin conjugating enzyme binding IEA
 molecular_functionGO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
SUMOylation of transcription factors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001126 abnormal ovary morphology "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Foxl2tm2.1Tre/Foxl2tm2.1Tre,Gt(ROSA)26Sortm9(cre/ESR1)Arte/?
Genetic Background: involves: 129S/Sv * C57BL/6

Allelic Composition: Foxl2tm2.1Tre/Foxl2tm2.1Tre,Tg(Cga-cre)3Sac/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Badtm1Meg/Badtm1Meg
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Foxl2tm4(cre)Tre/Foxl2tm4(cre)Tre
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001129 impaired ovarian folliculogenesis "a block in the formation of the spherical ovum in the ovary" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Badtm1Meg/Badtm1Meg
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Foxl2tm1Gpil/Foxl2tm1Gpil
Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * C57BL/6J) or (involves: 129S6/SvEvTac * NIHS-BC)

Allelic Composition: Foxl2tm4(cre)Tre/Foxl2tm4(cre)Tre
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001131 abnormal ovarian follicles "malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
Show

Allelic Composition: Badtm1Meg/Badtm1Meg
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Foxl2tm4(cre)Tre/Foxl2tm4(cre)Tre
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Foxl2tm2.1Tre/Foxl2tm2.1Tre,Gt(ROSA)26Sortm9(cre/ESR1)Arte/?
Genetic Background: involves: 129S/Sv * C57BL/6

Allelic Composition: Foxl2tm2.1Tre/Foxl2tm2.1Tre,Tg(Cga-cre)3Sac/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001132 absent mature ovarian follicles "failure of ovarian follicle differentiation" [J:35782]
Show

Allelic Composition: Badtm1Meg/Badtm1Meg
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Foxl2tm4(cre)Tre/Foxl2tm4(cre)Tre
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
Show

Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Badtm1Meg/Badtm1Meg
Genetic Background: involves: 129S4/SvJae

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Badtm1Meg/Badtm1Meg
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Foxl2tm1Gpil/Foxl2tm1Gpil
Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * C57BL/6J) or (involves: 129S6/SvEvTac * NIHS-BC)

Allelic Composition: Foxl2tm4(cre)Tre/Foxl2tm4(cre)Tre
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Scn11atm1Lex/Scn11atm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox9tm1(cre/ERT2)Haak/Sox9+
Genetic Background: B6.129S7-Sox9tm1(cre/ERT2)Haak

 MP:0002995 primary sex reversal "gonad type is not consistent with chromosomal sex" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxl2tm2.1Tre/Foxl2tm2.1Tre,Gt(ROSA)26Sortm9(cre/ESR1)Arte/?
Genetic Background: involves: 129S/Sv * C57BL/6

Allelic Composition: Foxl2tm2.1Tre/Foxl2tm2.1Tre,Tg(Cga-cre)3Sac/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0004701 decreased circulating insulin-like growth factor I level "reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxl2tm1Gpil/Foxl2tm1Gpil
Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * C57BL/6J) or (involves: 129S6/SvEvTac * NIHS-BC)

 MP:0004853 abnormal ovary size "anomaly in the average size of the female reproductive gland containing the germ cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxl2tm2.1Tre/Foxl2tm2.1Tre,Tg(Cga-cre)3Sac/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Badtm1Meg/Badtm1Meg
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Foxl2tm1Gpil/Foxl2tm1Gpil
Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * C57BL/6J) or (involves: 129S6/SvEvTac * NIHS-BC)

 MP:0013395 eyelid hypoplasia "underdevelopment or reduced size of the skin folds covering the front of the eyeball, usually due to a decreased cell number" [MGI:Anna]
Show

Allelic Composition: Foxl2tm1Gpil/Foxl2tm1Gpil
Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * C57BL/6J) or (involves: 129S6/SvEvTac * NIHS-BC)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / reaction / complex
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction






 

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