| MP:0000005 | increased brown fat amount | "increased amount of thermogenic tissue in the body that is composed of cells containing multiple small fat droplets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:14208] |
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Allelic Composition: Slc8a1tm1Yin/Slc8a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0000029 | abnormal malleus morphology | "structural anomaly in the largest of the three auditory ossicles, which resembles a club or hammer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu,Pax1tm2Neu/Pax1tm2Neu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
Allelic Composition: Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0000078 | abnormal supraoccipital bone morphology | "malformed upper part of the occipital bone" [J:61509] |
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0000104 | abnormal sphenoid bone morphology | "malformed irregularly shaped bone of the base of the skull" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840] |
Show
Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0000106 | abnormal basisphenoid bone morphology | "malformed base of the sphenoid bone" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583] |
Show
Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0000111 | cleft palate | "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840] |
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Allelic Composition: Pitx2tm2Sac/Pitx2tm2Sac
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
| MP:0000141 | abnormal vertebral body morphology | "malformed main portion of the vertebra anterior to the vertebral canal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583] |
Show
Allelic Composition: Wnt3atm1Amc/Wnt3atm1Amc
Genetic Background: involves: 129S1/Sv
Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0000154 | rib fusion | "appearance of one or more ribs as a single structure" [J:62022, J:62023] |
Show
Allelic Composition: Wnt3atm1Amc/Wnt3atm1Amc
Genetic Background: involves: 129S1/Sv
Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0000163 | abnormal cartilage morphology | "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Pitx2tm2Sac/Pitx2tm2Sac
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
| MP:0000259 | abnormal vascular development | "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509] |
Show
Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0000291 | enlarged pericardium | "extended fibroserous membrane covering the heart and beginning of the great vessels" [J:29971] |
Show
Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0000295 | poorly developed ventricular trabeculae | "retarded differentation of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:29971] |
Show
Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0000431 | absent palatine shelf | "missing outgrowth of the palatine bone; normally fuses with maxillary shelf to form secondary palate " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489] |
Show
Allelic Composition: Pitx2tm2Sac/Pitx2tm2Sac
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
| MP:0000519 | hydronephrosis | "dilation of the pelvis and calices of one or both kidneys" [J:56641] |
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Allelic Composition: Hoxa1tm2Mrc/Hoxa1tm2Mrc,Hoxa2tm1Mrc/Hoxa2tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0000520 | absent kidney | "missing paired organs that excrete urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471] |
Show
Allelic Composition: Hoxa1tm2Mrc/Hoxa1tm2Mrc,Hoxa2tm1Mrc/Hoxa2tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0000536 | hydroureter | "distention of the ureter with urine, due to blockage from any cause" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:Cml, J:13044] |
Show
Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0000599 | enlarged liver | "larger than average size of the liver" [J:65146] |
Show
Allelic Composition: Hoxa1tm2Mrc/Hoxa1tm2Mrc,Hoxa2tm1Mrc/Hoxa2tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0000702 | enlarged lymph nodes | "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Slc8a1tm1Yin/Slc8a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0000733 | abnormal muscle development | "anomalous differentiation of muscle tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Wnt3atm1Amc/Wnt3atm1Amc
Genetic Background: involves: 129S1/Sv
|
| MP:0000928 | incomplete cephalic closure | "arrest of the fusion of the cephalic neural folds" [J:12622] |
Show
Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0000961 | abnormal dorsal root ganglia morphology | "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159] |
Show
Allelic Composition: Wnt3atm1Amc/Wnt3atm1Amc
Genetic Background: involves: 129S1/Sv
|
| MP:0001177 | atelectasis | "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu,Pax1tm2Neu/Pax1tm2Neu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
|
| MP:0001258 | decreased body length | "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Wnt3atm1Amc/Wnt3atm1Amc
Genetic Background: involves: 129S1/Sv
|
| MP:0001302 | eyelids open at birth | "widely open eyes instead of closed at perinatal stage" [J:51966] |
Show
Allelic Composition: Hoxa1tm2Mrc/Hoxa1tm2Mrc,Hoxa2tm1Mrc/Hoxa2tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0001304 | cataracts | "complete or partial opacity of the lens" [J:65031] |
Show
Allelic Composition: Slc8a1tm1Yin/Slc8a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0001312 | abnormal cornea morphology | "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Hoxa1tm2Mrc/Hoxa1tm2Mrc,Hoxa2tm1Mrc/Hoxa2tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0001322 | abnormal iris morphology | "structural anomaly of the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Hoxa1tm2Mrc/Hoxa1tm2Mrc,Hoxa2tm1Mrc/Hoxa2tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Foxc2tm1Blh/Foxc2+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0001344 | blepharoptosis | "ptosis, drooping eyelids " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:24414] |
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Allelic Composition: Slc8a1tm1Yin/Slc8a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0001614 | abnormal vasculature | "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Pitx2tm2Sac/Pitx2tm2Sac
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
| MP:0001688 | abnormal somite development | "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Tlr7rsq2/Y
Genetic Background: C57BL/6J-Tlr7rsq2
|
| MP:0001691 | abnormal somite shape | "atypical characteristic surface configuration of a segmental mass along the notochord of the developing embryo" [J:37888] |
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Allelic Composition: Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0001698 | reduced embryo size | "smaller proportions of embryo compared to littermates" [J:61790] |
Show
Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0001787 | pericardial edema | "accumulation of watery fluid in the pericardial sac of the heart" [J:52597] |
Show
Allelic Composition: Hhextm1Ngu/Hhextm1Ngu
Genetic Background: involves: 129/Sv * C57BL/6
|
| MP:0001788 | periorbital edema | "accumulation of an excessive amount of fluid in the area around the orbit " [MGI:tc, J:60896] |
Show
Allelic Composition: Slc8a1tm1Yin/Slc8a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0001915 | intracranial hemorrhage | "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0002092 | abnormal eye morphology | "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Slc8a1tm1Yin/Slc8a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0002116 | abnormal craniofacial bone morphology | "abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu,Pax1tm2Neu/Pax1tm2Neu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
|
| MP:0002151 | abnormal neural tube morphology/development | "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Wnt3atm1Amc/Wnt3atm1Amc
Genetic Background: involves: 129S1/Sv
|
| MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Foxc1tm1.1Tsku/Foxc1tm1.1Tsku
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL * Tac:NIHBS
|
| MP:0002188 | small heart | "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044] |
Show
Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0002190 | disorganized myocardium | "malformed or poorly developed cardiac muscle layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67044] |
Show
Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0002192 | hydrops fetalis | "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Hoxa1tm2Mrc/Hoxa1tm2Mrc,Hoxa2tm1Mrc/Hoxa2tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0002218 | increased lymph node number | "greater than the normal number of lymph nodes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Slc8a1tm1Yin/Slc8a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0002400 | multipotent stem cell abnormalities | "anomalies of the specialized cells that are committed to giving rise to cells with particular functions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0002633 | persistent truncus arteriosis | "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Hhextm1Ngu/Hhextm1Ngu
Genetic Background: involves: 129/Sv * C57BL/6
|
| MP:0002652 | thin myocardial wall | "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Foxc1tm1.1Tsku/Foxc1tm1.1Tsku
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL * Tac:NIHBS
|
| MP:0002672 | abnormal branchial arch artery morphology | "malformation of the vessels formed within the five pairs of branchial arches in embryogenesis; in the adult, some of these vessels give rise to the great vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0002747 | abnormal aortic valve morphology | "malformation of the valve between the left ventricle and the ascending aorta" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0002748 | abnormal pulmonary valve morphology | "malformation of the valve between the right ventricle and the pulmonary trunk" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0002898 | absent cartilage | "absence of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the thorax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0002989 | small kidney | "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * ICR
|
| MP:0003054 | spina bifida | "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003] |
Show
Allelic Composition: Wnt3atm1Amc/Wnt3atm1Amc
Genetic Background: involves: 129S1/Sv
|
| MP:0003140 | dilated atria | "an expansion in the volume of one or both of the upper chambers of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Ednratm1Ywa/Ednratm1Ywa,Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
|
| MP:0003201 | extremity edema | "an accumulation of serous fluid in the limbs, paws and tail" [RGD:Rat Genome Database submission] |
Show
Allelic Composition: Slc8a1tm1Yin/Slc8a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0003235 | abnormal alisphenoid bone morphology | "malformation in either of the broad curved winglike expanses on each side of the sphenoid bone" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93183, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0003345 | decreased number of ribs | "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0003390 | lymphedema | "abnormal swelling in the soft tissues of the limbs, or less often the trunk, caused by the buildup of lymph fluid" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Slc8a1tm1Yin/Slc8a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0003400 | kinked neural tube | "twists or kinks in the embryonic neural tube" [J:66514, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0003446 | renal hypoplasia | "decreased cell number in the kidney leading to reduced size" [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0003659 | abnormal lymph circulation | "abnormalities in the flow of the lymph from the tissues into the veins of the circulatory system" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:95885] |
Show
Allelic Composition: Slc8a1tm1Yin/Slc8a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0004017 | duplex kidney | "a kidney that is split into two separate collecting systems; there may be a duplex ureter or a single ureter; may present unilaterally or bilaterally" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0004038 | lymphangiectasis | "dilation of the lymphatic vessels, the basic process that may result in the formation of a lymphangioma" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:71816] |
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Allelic Composition: Slc8a1tm1Yin/Slc8a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0004068 | dilated dorsal aorta | "an expansion in the volume of the dorsal region of the main trunk of the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0004076 | abnormal vitelline vascular remodelling | "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0004085 | abnormal heartbeat | "anomaly in the appearance of regularly spaced contractions of the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0004095 | ocular distichiasis | "presence of a double row of eyelashes on an eyelid, one or both of which are turned in against the eyeball" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:83436] |
Show
Allelic Composition: Slc8a1tm1Yin/Slc8a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0004105 | corneal abrasion | "scraping away or denuding of the corneal surface" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Slc8a1tm1Yin/Slc8a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0004106 | lymphatic vessel hyperplasia | "increased cell number in lymphatic vessels" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Slc8a1tm1Yin/Slc8a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0004107 | abnormal thoracic duct morphology | "any structural abnormality in the largest lymph vessel in the body, beginning at the cisterna chyli at about the level of the second lumbar vertebra" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Slc8a1tm1Yin/Slc8a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0004113 | abnormal aortic arch morphology | "structural anomoly of the portion of the descending aorta proceeding from the arch of the aorta and extending to the diaphragm " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0004157 | interrupted aortic arch | "complete discontinuation/blockage between the ascending and descending aorta; includes Type A, interruption distal to the subclavian artery that is ipsilateral to the second carotid artery, and Type B, interruption between second carotid artery and ipsilateral subclavian artery" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0004204 | absent stapes | "absence of the smallest and innermost of the three auditory ossicles" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0004206 | abnormal dermomyotome development | "any structural anomaly of the portion of the embryonic somite that remains after migration of the sclerotomic tissue" [J:50279, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Wnt3atm1Amc/Wnt3atm1Amc
Genetic Background: involves: 129S1/Sv
|
| MP:0004221 | abnormal iridocorneal angle | "any structural abnormality of the acute angle occurring between the iris and the cornea at the periphery of the anterior chamber of the eye" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
Allelic Composition: Foxc2tm1Blh/Foxc2+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0004318 | absent incus | "absence of the middle of the three auditory ossicles" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0004384 | small interparietal bone | "reduced size of the bone of the cranium that lies above and anterior to the occipital bone in some mammals" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0004443 | absent supraoccipital bone | "absence of the bone on the dorsal side of the great foramen of the skull, usually forming a part of the occipital in the adult, but distinct in the young" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0004445 | small exoccipital bone | "reduced size of the bone or region on the lateral sides of the great foremen of the skull, which often forms a part of the occipital in the adult, but is usually distinct in the young" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0004447 | small basioccipital bone | "reduced size of the bone in the base of the cranium, frequently forming a part of the occipital in the adult, but usually distinct in the young" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0004448 | abnormal presphenoid bone morphology | "any structural anomaly of the anterior part of the body of the sphenoid bone in front of the basisphenoid; it is usually a separate bone in the young or fetus, but becomes a part of the sphenoid in the adult" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0004449 | absent presphenoid bone | "absence of the anterior part of the body of the sphenoid bone in front of the basisphenoid; it is usually a separate bone in the young or fetus, but becomes a part of the sphenoid in the adult" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0004452 | abnormal pterygoid process morphology | "any structural anomaly of the process projecting downward from either side of the sphenoid bone, in vertebrates divided into two plates, an inner and an outer (sometimes called the lateral and medial); the posterior nares pass through the space, called the pterygoid fossa, between the processes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0004456 | small pterygoid bone | "reduced size of the bone region which corresponds to the inner plate of the pterygoid process of the mammalian skull" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0004476 | absent palatine bone | "absence of either of two irregularly shaped bones that form the back of the hard palate and helps to form the nasal cavity and the floor of the orbits" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0004505 | decreased renal glomerulus number | "reduced number of the capillary loops of the kidney that normally function as a filtration unit" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * ICR
|
| MP:0004537 | abnormal palatine shelf | "any structural anomaly of the palatine bone; normally fuses with maxillary shelf to form secondary (hard) palate" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0004592 | small mandible | "reduced size of the lower bony framework of the mouth where the inferior teeth are held" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0004599 | abnormal vertebral arch morphology | "any structural anomaly of the dorsal part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0004604 | abnormal vertebral pedicle morphology | "any structural anomaly of the two short, thick processes, which project backward, one on either side, from the upper part of the body to the laminae" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Wnt3atm1Amc/Wnt3atm1Amc
Genetic Background: involves: 129S1/Sv
|
| MP:0004605 | abnormal vertebral lamina morphology | "any structural anomaly of two broad plates directed dorsomedially from the pedicles; these fuse at the dorsal midline, and complete the dorsal wall of the vertebral foramen
" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Wnt3atm1Amc/Wnt3atm1Amc
Genetic Background: involves: 129S1/Sv
|
| MP:0004609 | vertebral fusion | "the union of one or more vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Wnt3atm1Amc/Wnt3atm1Amc
Genetic Background: involves: 129S1/Sv
|
| MP:0004670 | small vertebral body | "decreased size of the main cylindrical portion of the vertebra ventral to the vertebral canal" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0004683 | absent intervertebral disk | "absence of the cartilaginous and gelatinous structure found between vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Wnt3atm1Amc/Wnt3atm1Amc
Genetic Background: involves: 129S1/Sv
|
| MP:0004704 | short vertebral column | "decreased rostral-caudal length of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu,Pax1tm2Neu/Pax1tm2Neu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
|
| MP:0004706 | short vertebral body | "reduced length of the main cylindrical portion of the vertebra ventral to the vertebral canal" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0004787 | abnormal dorsal aorta morphology | "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"] |
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu,Pax1tm2Neu/Pax1tm2Neu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
Allelic Composition: Ednratm1Ywa/Ednratm1Ywa,Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
|
| MP:0005099 | abnormal ciliary body morphology | "structural anomaly of the thickened portion of the vascular tunic, which lies between the choroid and the iris" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0005105 | abnormal middle ear ossicle morphology | "anomalous structure or development of the three small bones of the middle ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0005199 | abnormal iris pigment epithelium | "anomaly in the epithelial layer of the iris composed of cells containing pigment granules " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Foxc2tm1Blh/Foxc2+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0005203 | abnormal trabecular meshwork morphology | "structural anomaly in the porelike structure surrounding the entire circumference of the anterior chamber through which aqueous humor circulates" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
Allelic Composition: Foxc2tm1Blh/Foxc2+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0005204 | abnormal canal of Schlemm morphology | "structural anomaly in the vascular structure encircling the anterior chamber of the eye, through which the aqueous humor is returned to the blood circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
Allelic Composition: Foxc2tm1Blh/Foxc2+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0005223 | abnormal anterior-posterior polarity of the somites | "anomalous development or formation of the somites along the axis that runs from the front to the back surface of the body
" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:72325] |
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Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0005225 | abnormal vertebrae development | "anomalous formation of the vertebrae from the sclerotome" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Wnt3atm1Amc/Wnt3atm1Amc
Genetic Background: involves: 129S1/Sv
|
| MP:0005297 | spina bifida occulta | "common congenital midline defect of fusion of the vertebral arch without protrusion of the spinal cord or meninges" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0005325 | abnormal glomerulus | "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd
|
| MP:0005326 | abnormal podocytes | "anomalous structure of the foot processes of the epithelial cells of the glomerulus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57971] |
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Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd
|
| MP:0005327 | abnormal mesangial cell | "anomalous structure of the phagocytic cell in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57971] |
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Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd
|
| MP:0005542 | corneal vascularization | "formation of blood vessels in the cornea, which normally lacks vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0005587 | abnormal Meckel s cartilage morphology | "structural anomaly of this cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible; gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17694] |
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Allelic Composition: Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0005602 | decreased angiogenesis | "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission] |
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Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0006020 | reduced size of tympanic ring | "smaller than average tympanic ring" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0006029 | abnormal sclerotome | "malformation of the one or more of the masses of mesodermal tissue that is derived from the somites and is adjacent to the notochord that give rise to the ribs and vertebrae" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99] |
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Allelic Composition: Wnt3atm1Amc/Wnt3atm1Amc
Genetic Background: involves: 129S1/Sv
|
| MP:0006030 | abnormal otic vesicle formation | "anomalous formation of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:57313:] |
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0006031 | abnormal branchial pouch morphology | "malfomation or anomaly in the series of grooves that form between the branchial arches; these endodermal evaginations develop into epithelial tissues and organs" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3] |
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Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0006054 | spinal hemorrhage | "bleeding into the spine" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0006064 | abnormal superior vena cava morphology | "structural malformation in the principal vein draining blood from the upper portion of the body" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99] |
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Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0006230 | iris stroma hypoplasia | "less than the normal number of cells in the iris stroma" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
Allelic Composition: Foxc2tm1Blh/Foxc2+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0006341 | small first branchial arch | "reduced size of the first branchial arch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0006345 | absent second branchial arch | "missing the second branchial arch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0006354 | abnormal fourth branchial arch artery morphology | "any structural anomaly of the vessels formed within the fourth pair of branchial arches in embryogenesis" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0006356 | abnormal third branchial arch artery morphology | "any structural anomaly of the vessels formed within the third pair of branchial arches in embryogenesis" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0006386 | absent somites | "missing all somites" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0008061 | absent podocyte slit diaphragm | "absence of the thin membrane that covers the podocyte filtration slit which allows small molecules such as water, glucose, and ionic salts to pass through while retaining larger macromolecules in the bloodstream" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * ICR
|
| MP:0008138 | absent podocyte foot process | "absence of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * ICR
|
| MP:0008149 | abnormal rib-vertebral column attachment | "any anomaly in the in the normal joining of the ribs to the vertebral column" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu,Pax1tm2Neu/Pax1tm2Neu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
|
| MP:0008271 | abnormal bone ossification | "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503] |
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0008380 | abnormal gonial bone morphology | "any structural abnormality of the investing bone that lies on the surface of the malleus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0008382 | gonial bone hypoplasia | "underdevelopment or reduced size of the investing bone that lies on the surface of the malleus, usually due to reduced cell number" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0008487 | abnormal mesonephros morphology | "any structural anomaly of the excretory organ of the embryo, collective Wolffian tubules, which forms the urogenital fold from which the reproductive organs develop" [MESH:A16.254.500] |
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Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac
|
| MP:0009037 | abnormal subarachnoid space development | "anomaly in the formation of the space between the arachnoid and dura mater that is traversed by fibrous trabeculae and contains cerebrospinal fluid" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu,Pax1tm2Neu/Pax1tm2Neu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
|
| MP:0009825 | cornea ulcer | "an area of tissue erosion in the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0009859 | eye opacity | "changes in the eye grossly observed as a milky or cloudy appearance that may be progressive and persistent throughout life" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Slc8a1tm1Yin/Slc8a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0009890 | cleft secondary palate | "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722] |
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0009929 | meningomyelocele | "hernial protrusion of the spinal cord and its meninges through an opening or defect in the vertebral column" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu,Pax1tm2Neu/Pax1tm2Neu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
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| MP:0010030 | abnormal orbit morphology | "any structural anomaly of the bony ring that supports the eyeball and supporting tissues and is formed by parts of several cranial bones" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Slc8a1tm1Yin/Slc8a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0010326 | malleus hypoplasia | "underdevelopment or reduced size, usually due to a reduced number of cells, of the largest of the three auditory ossicles, which resembles a club or hammer" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0010402 | ventricular septal defect | "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540] |
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Foxc2tm1.2Tsku/Foxc2tm1.2Tsku
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL * Tac:NIHBS
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| MP:0010418 | perimembraneous ventricular septal defect | "abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com] |
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Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
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| MP:0010502 | ventricle myocardium hypoplasia | "underdevelopment or reduced size, usually due to a reduced number of cells, of the ventricular part of the heart myocardium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
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| MP:0010526 | aortic arch coarctation | "a congenital focal constriction of the aortic arch" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
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| MP:0010593 | thick aortic valve cusps | "an increase in the ratio of the aortic valve cusp thickness to the aortic wall thickness" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
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| MP:0010605 | thick pulmonary valve cusps | "an increase in the ratio of the pulmonary valve cusp thickness to the pulmonary artery wall thickness" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
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| MP:0010701 | fusion of atlas and odontoid process | "the large protuberance that projects upward from the cervical axis (C2), around which the cervical atlas normally rotates, is instead fused to elements of the atlas; the odontoid process may or may not remain attached to the axis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu,Pax1tm2Neu/Pax1tm2Neu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
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| MP:0010980 | ectopic ureteric bud | "ureteric bud(s) are not located in the normal or expected position" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
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| MP:0010981 | abnormal branching involved in ureteric bud morphogenesis | "anomaly in the process in which the branching structure of the ureteric bud is generated and organized" [GO:0001658] |
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Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
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| MP:0011089 | complete perinatal lethality | "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith] |
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0011090 | partial perinatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith] |
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu,Pax1tm2Neu/Pax1tm2Neu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
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| MP:0011098 | complete embryonic lethality during organogenesis | "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
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| MP:0011108 | partial embryonic lethality during organogenesis | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
Allelic Composition: Ednratm1Ywa/Ednratm1Ywa,Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
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| MP:0011109 | partial lethality throughout fetal growth and development | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
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| MP:0011339 | abnormal glomerular mesangium morphology | "any structural anomaly of the inner layer of the glomerulus within the basement membrane surrounding the glomerular capillaries that contain the intraglomerular mesangial cells" [MGI:csmith] |
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * ICR
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| MP:0011348 | abnormal renal glomerulus basement membrane morphology | "any structural anomaly of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule; it is a fusion of the endothelial cell and podocyte basal laminas and acts as a physical barrier and an ion-selective filter" [MGI:anna] |
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * ICR
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| MP:0011359 | decreased glomerular capillary number | "reduced number of the small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles" [MGI:csmith] |
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * ICR
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| MP:0011437 | glomerulus hemorrhage | "bleeding in the renal glomerulus" [MGI:anna] |
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * ICR
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| MP:0011455 | absent glomerular endothelium fenestra | "absence of the large plasma membrane-lined circular pores that normally perforate the flattened glomerular endothelium; loss of fenestrae may lead to a reduction in the glomerular filtration rate or proteinuria" [MGI:anna] |
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * ICR
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| MP:0011493 | double ureter | "two ureters open separately into the renal pelvis superiorly and drain separately into the urinary bladder or genital tract; if two ureteral buds arise from the Wolffian duct, a duplex kidney with complete ureteral duplication ensues" [http://emedicine.medscape.com/article/378075-overview, MGI:anna] |
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Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
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| MP:0011509 | dilated glomerular capillary | "stretched or widened aperture of the luminal space of the small branching blood vessel in the kidney glomerulus that receives blood from the kidney afferent arteriole" [MGI:anna] |
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * ICR
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| MP:0011732 | decreased somite size | "reduced size of any of the segmental masses along the notochord of the developing embryo" [MGI:smb] |
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Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
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| MP:0012176 | abnormal head development | "anomaly in the process in which the anatomical structures of the head are generated and organized" [GO:0060323] |
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
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| MP:0012184 | absent paraxial mesoderm | "absence or loss of the mesoderm normally found at either side of the midline embryonic notochord that, on segmentation, forms the paired somites." [MGI:anna] |
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
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| MP:0013200 | head mesenchyme hypoplasia | "underdevelopment or reduced size of the head mesenchyme, usually due to a reduced cell number" [MGI:anna] |
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
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| MP:0030026 | small Meckel s cartilage | "reduced size of the cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible and gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments" [MGI:anna] |
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Allelic Composition: Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
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| MP:0030121 | small temporal bone squamous part | "reduced size of the anterosuperior portion of the temporal bone that is thin, scale-like, and translucent and forms part of the lateral wall of the cranial vault" [MGI:anna] |
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Allelic Composition: Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
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| MP:0030290 | absent soft palate | "absence of the musculomembranous fold that partly separates the mouth and pharynx, located behind the hard palate in the adult" [MGI:anna] |
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0030337 | enlarged third pharyngeal arch artery | "increased size of the third pharyngeal arch artery" [MGI:anna] |
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Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
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