ENSMUSG00000035451


Mus musculus

Features
Gene ID: ENSMUSG00000035451
  
Biological name :Foxa1
  
Synonyms : Foxa1 / Hepatocyte nuclear factor 3-alpha / P35582
  
Possible biological names infered from orthology : forkhead box A1 / P55317
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: C1
Gene start: 57540628
Gene end: 57546916
  
Corresponding Affymetrix probe sets: 10400504 (MoGene1.0st)   1418496_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000041118
NCBI entrez gene - 15375     See in Manteia.
MGI - MGI:1347472
RefSeq - XM_017314962
RefSeq - NM_008259
RefSeq - XM_006515481
RefSeq - XM_006515483
RefSeq - XM_006515479
RefSeq Peptide - NP_032285
swissprot - P35582
Ensembl - ENSMUSG00000035451
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FOXA1ENSGALG00000032713Gallus gallus
 FOXA1ENSG00000129514Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Foxa2 / P35583 / Mus musculus forkhead box A2 (Foxa2), transcript variant 3, mRNA. / Q9Y261* / forkhead box A2*ENSMUSG0000003702556
Foxa3 / P35584 / Hepatocyte nuclear factor 3-gamma / P55318* / forkhead box A3*ENSMUSG0000004089140
Foxc2 / Q61850 / Forkhead box protein C2 / Q99958* / forkhead box C2*ENSMUSG0000004671425
Foxc1 / Q61572 / Forkhead box protein C1 / Q12948* / forkhead box C1*ENSMUSG0000005029525
Foxb1 / Q64732 / Forkhead box protein B1 / Q99853* / forkhead box B1*ENSMUSG0000005924624
Foxb2 / Q64733 / Forkhead box protein B2 / Q5VYV0* / forkhead box B2*ENSMUSG0000005682924
Foxs1 / Q61574 / Forkhead box protein S1 / O43638* / forkhead box S1*ENSMUSG0000007467619
Foxi1 / Q922I5 / Forkhead box protein I1 / Q12951* / forkhead box I1*ENSMUSG0000004786119
Foxi3 / forkhead box I3 / A8MTJ6*ENSMUSG0000005587419
Foxl1 / Q64731 / Forkhead box protein L1 / Q12952* / forkhead box L1*ENSMUSG0000009708418
Foxi2 / forkhead box I2 / Q6ZQN5*ENSMUSG0000004837717
Foxl2 / O88470 / Forkhead box protein L2 / P58012* / forkhead box L2*ENSMUSG0000005039717


Protein motifs (from Interpro)
Interpro ID Name
 IPR001766  Fork head domain
 IPR013638  Fork-head N-terminal
 IPR018122  Fork head domain conserved site1
 IPR018533  Forkhead box protein, C-terminal
 IPR030456  Fork head domain conserved site 2
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006338 chromatin remodeling IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007219 Notch signaling pathway IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0010468 regulation of gene expression IGI
 biological_processGO:0010719 negative regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0021904 dorsal/ventral neural tube patterning IGI
 biological_processGO:0030324 lung development IGI
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0033148 positive regulation of intracellular estrogen receptor signaling pathway IEA
 biological_processGO:0035239 tube morphogenesis IMP
 biological_processGO:0042445 hormone metabolic process IMP
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0045666 positive regulation of neuron differentiation IMP
 biological_processGO:0045880 positive regulation of smoothened signaling pathway IGI
 biological_processGO:0045931 positive regulation of mitotic cell cycle IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048646 anatomical structure formation involved in morphogenesis IGI
 biological_processGO:0048665 neuron fate specification IGI
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051726 regulation of cell cycle IMP
 biological_processGO:0060425 lung morphogenesis IMP
 biological_processGO:0060441 epithelial tube branching involved in lung morphogenesis IGI
 biological_processGO:0060487 lung epithelial cell differentiation IGI
 biological_processGO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development IMP
 biological_processGO:0060738 epithelial-mesenchymal signaling involved in prostate gland development IGI
 biological_processGO:0060740 prostate gland epithelium morphogenesis IMP
 biological_processGO:0060741 prostate gland stromal morphogenesis IMP
 biological_processGO:0060743 epithelial cell maturation involved in prostate gland development IMP
 biological_processGO:0061144 alveolar secondary septum development IMP
 biological_processGO:0061448 connective tissue development IGI
 biological_processGO:1902691 respiratory basal cell differentiation IMP
 cellular_componentGO:0001650 fibrillar center IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005902 microvillus IDA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISO
 molecular_functionGO:0008134 transcription factor binding ISO
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA


Pathways (from Reactome)
Pathway description
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ighmtm4Bgmn/Ighmtm4Bgmn
Genetic Background: involves: 129/Sv

 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Runx1tm2(Runx1)Toku/Runx1tm2(Runx1)Toku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Foxa1tm1Stf/Foxa1tm1Stf
Genetic Background: Not Specified

 MP:0000662 abnormal branching of the mammary ductal tree "anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Plaurtm1Mlg/Plaurtm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Foxa1tm1Gsc/Foxa1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Ighmtm4Bgmn/Ighmtm4Bgmn
Genetic Background: involves: 129/Sv

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Foxa1tm1Khk/Foxa1+,Foxa2tm1Khk/Foxa2tm1Khk,Tg(Pdx1-cre)6Cvw/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

 MP:0001560 abnormal circulating insulin level "anomalous blood concentration of this polypeptide hormone, secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Runx1tm2(Runx1)Toku/Runx1tm2(Runx1)Toku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Runx1tm2(Runx1)Toku/Runx1tm2(Runx1)Toku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Foxa1tm1Stf/Foxa1tm1Stf
Genetic Background: Not Specified

 MP:0001739 abnormal adrenal secretion "altered ability of the surparenal gland to secrete hormones " [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Runx1tm2(Runx1)Toku/Runx1tm2(Runx1)Toku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001944 abnormal pancreas morphology "malformation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxa1tm1Khk/Foxa1+,Foxa2tm1Khk/Foxa2tm1Khk,Tg(Pdx1-cre)6Cvw/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ighmtm4Bgmn/Ighmtm4Bgmn
Genetic Background: involves: 129/Sv

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Arxtm1Gldn/Y,Tg(Pou3f4-cre)32Cren/0
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxa1tm1Stf/Foxa1tm1Stf
Genetic Background: Not Specified

 MP:0002696 decreased circulating glucagon level "lower than normal blood concentration of this peptide hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Runx1tm2(Runx1)Toku/Runx1tm2(Runx1)Toku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Foxa1tm1Stf/Foxa1tm1Stf
Genetic Background: Not Specified

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxa1tm1Stf/Foxa1tm1Stf
Genetic Background: Not Specified

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Foxa1tm1Stf/Foxa1tm1Stf
Genetic Background: Not Specified

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Syktm1Tyb/Syktm1Tyb
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0003339 decreased number of pancreatic beta cells "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw
Genetic Background: B6.Cg-Ppargtm1.1Auw

Allelic Composition: Foxa1tm1Khk/Foxa1tm1Khk,Foxa2tm1Khk/Foxa2tm1Khk,Tg(Pdx1-cre)6Cvw/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

 MP:0003934 abnormal pancreas development "anomaly in the formation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxa1tm1Khk/Foxa1tm1Khk,Foxa2tm1Khk/Foxa2tm1Khk,Tg(Pdx1-cre)6Cvw/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Syktm1Tyb/Syktm1Tyb
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Syktm1Tyb/Syktm1Tyb
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0005123 increased circulating growth hormone level "greater than the expected blood concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Foxa1tm1Stf/Foxa1tm1Stf
Genetic Background: Not Specified

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Foxa1tm1Stf/Foxa1tm1Stf
Genetic Background: Not Specified

 MP:0005492 acinar hypoplasia "decreased numbers of cells in the portion of the pancreas that secretes digestive enzymes " [J:48446, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw
Genetic Background: B6.Cg-Ppargtm1.1Auw

Allelic Composition: Foxa1tm1Khk/Foxa1tm1Khk,Foxa2tm1Khk/Foxa2tm1Khk,Tg(Pdx1-cre)6Cvw/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

 MP:0009111 pancreas hypoplasia "underdevelopment or reduced size of the pancreas, usually due to a reduced number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw
Genetic Background: B6.Cg-Ppargtm1.1Auw

Allelic Composition: Foxa1tm1Khk/Foxa1tm1Khk,Foxa2tm1Khk/Foxa2tm1Khk,Tg(Pdx1-cre)6Cvw/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

 MP:0009169 pancreatic islet hypoplasia "underdevelopment or decreased size of the clusters of hormone-producing cells that are scattered throughout the pancreas, usually due an decreased number of cells" [MA:0000127, MESH:A03.734.414]
Show

Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw
Genetic Background: B6.Cg-Ppargtm1.1Auw

Allelic Composition: Foxa1tm1Khk/Foxa1tm1Khk,Foxa2tm1Khk/Foxa2tm1Khk,Tg(Pdx1-cre)6Cvw/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Runx1tm2(Runx1)Toku/Runx1tm2(Runx1)Toku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Foxa1tm1Stf/Foxa1tm1Stf
Genetic Background: Not Specified

Allelic Composition: Foxa1tm1Khk/Foxa1+,Foxa2tm1Khk/Foxa2tm1Khk,Tg(Pdx1-cre)6Cvw/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

Allelic Composition: Foxa1tm1Khk/Foxa1tm1Khk,Foxa2tm1Khk/Foxa2tm1Khk,Tg(Pdx1-cre)6Cvw/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

 MP:0014126 increased mammary gland apoptosis "increase in the number of any cells of a mammary gland undergoing programmed cell death" [MGI:Anna]
Show

Allelic Composition: Foxa1tm1Gsc/Foxa1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0014161 increased circulating cortisol level "greater than the normal blood concentration of the principal glucocorticoid produced by the zona fasciculata of the adrenal cortex within the adrenal gland and released in response to stress and a low level of blood glucose" [https://en.wikipedia.org/wiki/Cortisol]
Show

Allelic Composition: Foxa1tm1Stf/Foxa1tm1Stf
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000109324 Prmt1 / Q9JIF0 / protein arginine N-methyltransferase 1 / Q99873* / protein arginine methyltransferase 1*  / complex / reaction
 ENSMUSG00000055024 Ep300 / B2RWS6 / Histone acetyltransferase p300 / Q09472* / E1A binding protein p300*  / reaction / complex
 ENSMUSG00000028800 Hdac1 / O09106 / Histone deacetylase 1 / Q13547*  / reaction
 ENSMUSG00000021264 Yy1 / Q00899 / YY1 transcription factor / P25490*  / reaction
 ENSMUSG00000061062 Gm10093 / HDAC1* / Q13547* / histone deacetylase 1*  / reaction
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / complex / reaction
 ENSMUSG00000019768 Esr1 / P19785 / Estrogen receptor / P03372* / estrogen receptor 1*  / complex / reaction
 ENSMUSG00000099517 P68433 / Hist1h3g / Histone H3.1   / complex / reaction
 ENSMUSG00000060743 H3f3a / P84244 / Histone H3.3 / P84243* / H3 histone family member 3A*  / reaction / complex
 ENSMUSG00000033543 Gtf2a2 / Q80ZM7 / Transcription initiation factor IIA subunit 2 / P52657* / general transcription factor IIA subunit 2*  / reaction / complex
 ENSMUSG00000020962 Gtf2a1 / Q99PM3 / Transcription initiation factor IIA subunit 1 Transcription initiation factor IIA alpha chain Transcription initiation factor IIA beta chain / P52655* / general transcript...  / reaction / complex
 ENSMUSG00000015619 Gata3 / P23772 / Mus musculus GATA binding protein 3 (Gata3), transcript variant 3, mRNA. / P23771* / GATA binding protein 3*  / reaction / complex
 ENSMUSG00000014767 Tbp / P29037 / TATA box binding protein / P20226*  / reaction / complex
 ENSMUSG00000032185 Carm1 / Q9WVG6 / Histone-arginine methyltransferase CARM1 / Q86X55* / coactivator associated arginine methyltransferase 1*  / complex / reaction
 ENSMUSG00000100210 P84228 / Hist1h3f / Histone H3.2   / reaction / complex






 

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