ENSMUSG00000014767


Mus musculus

Features
Gene ID: ENSMUSG00000014767
  
Biological name :Tbp
  
Synonyms : P29037 / TATA box binding protein / Tbp
  
Possible biological names infered from orthology : P20226
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: A2
Gene start: 15499888
Gene end: 15528379
  
Corresponding Affymetrix probe sets: 10441973 (MoGene1.0st)   1426469_a_at (Mouse Genome 430 2.0 Array)   1426470_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117551
Ensembl peptide - ENSMUSP00000125691
Ensembl peptide - ENSMUSP00000124317
Ensembl peptide - ENSMUSP00000122696
Ensembl peptide - ENSMUSP00000120484
Ensembl peptide - ENSMUSP00000014911
Ensembl peptide - ENSMUSP00000112794
Ensembl peptide - ENSMUSP00000113999
Ensembl peptide - ENSMUSP00000114007
Ensembl peptide - ENSMUSP00000114471
NCBI entrez gene - 21374     See in Manteia.
MGI - MGI:101838
RefSeq - NM_013684
RefSeq Peptide - NP_038712
swissprot - D3Z453
swissprot - F6XYI9
swissprot - F8WJ67
swissprot - P29037
swissprot - Q6RI65
swissprot - E9Q9Z7
swissprot - Q91YM5
swissprot - E9Q6D9
swissprot - E9Q084
Ensembl - ENSMUSG00000014767
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tbpENSDARG00000014994Danio rerio
 TBPENSGALG00000011171Gallus gallus
 TBPENSG00000112592Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tbpl2 / Q6SJ95 / TATA box-binding protein-like protein 2 / Q6SJ96* / TATA-box binding protein like 2*ENSMUSG0000006180954
Tbpl1 / P62340 / TATA box-binding protein-like protein 1 / P62380* / TATA-box binding protein like 1*ENSMUSG0000007135923


Protein motifs (from Interpro)
Interpro ID Name
 IPR000814  TATA-box binding protein
 IPR011989  Armadillo-like helical
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR030491  TATA-box binding protein, conserved site
 IPR033710  TATA-box binding protein, eukaryotic


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006352 DNA-templated transcription, initiation IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006359 regulation of transcription by RNA polymerase III IEA
 biological_processGO:0006366 transcription by RNA polymerase II ISS
 biological_processGO:0006383 transcription by RNA polymerase III ISO
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0051123 RNA polymerase II transcriptional preinitiation complex assembly ISO
 cellular_componentGO:0000120 RNA polymerase I transcription factor complex TAS
 cellular_componentGO:0000790 nuclear chromatin ISO
 cellular_componentGO:0001939 female pronucleus IDA
 cellular_componentGO:0001940 male pronucleus IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005669 transcription factor TFIID complex ISO
 cellular_componentGO:0005672 transcription factor TFIIA complex ISO
 cellular_componentGO:0005719 nuclear euchromatin ISO
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0045120 pronucleus IDA
 cellular_componentGO:0097550 transcriptional preinitiation complex ISO
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000987 proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001047 core promoter binding ISO
 molecular_functionGO:0001093 TFIIB-class transcription factor binding ISO
 molecular_functionGO:0001103 RNA polymerase II repressing transcription factor binding IPI
 molecular_functionGO:0001129 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008134 transcription factor binding ISO
 molecular_functionGO:0017162 aryl hydrocarbon receptor binding ISO
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0044212 transcription regulatory region DNA binding ISO
 molecular_functionGO:0070491 repressing transcription factor binding ISO


Pathways (from Reactome)
Pathway description
B-WICH complex positively regulates rRNA expression
RNA Polymerase II Pre-transcription Events
Regulation of TP53 Activity through Phosphorylation
RNA polymerase II transcribes snRNA genes
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase II Promoter Escape
RNA Polymerase I Chain Elongation
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase I Transcription Termination
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Polymerase III Transcription Initiation From Type 1 Promoter
RNA Polymerase III Transcription Initiation From Type 2 Promoter
RNA Polymerase III Transcription Initiation From Type 3 Promoter
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbptm1Xjl/Tbp+,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0000851 cerebellum hypoplasia "reduced cell number in the cerebellum" [MGI:CLS, J:45302]
Show

Allelic Composition: Hmgcrtm2Ishi/Hmgcrtm2Ishi
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0000876 Purkinje cell degeneration "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]
Show

Allelic Composition: Tbptm1Xjl/Tbp+,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0000890 thin cerebellar molecular layer "reduced width of the outer of the three cortical layers of the cerebellum" [J:46854]
Show

Allelic Composition: Tbptm1Xjl/Tbp+,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: ApcMin/Apc+,Ccdc80tm1.1Ftk/Ccdc80tm1.1Ftk
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Hmgcrtm2Ishi/Hmgcrtm2Ishi
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Tbptm1Xjl/Tbp+,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Hmgcrtm2Ishi/Hmgcrtm2Ishi
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hmgcrtm2Ishi/Hmgcrtm2Ishi
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Tbptm1Xjl/Tbp+,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Tbptm1Xjl/Tbp+,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0001407 short stride length "reduced average distance between steps" [J:34193]
Show

Allelic Composition: Tbptm1Xjl/Tbp+,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0001447 abnormal nest building behavior "deviation from the usual behavior of mice to build sleeping nests out of any available materials; also of female mice to bulid nests to protect offspring" [J:42758, What s wrong with my mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: Hmgcrtm2Ishi/Hmgcrtm2Ishi
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
Show

Allelic Composition: Hmgcrtm2Ishi/Hmgcrtm2Ishi
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbptm1Xjl/Tbp+,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
Show

Allelic Composition: Tbptm1Xjl/Tbp+,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0001711 abnormal placenta 
Show

Allelic Composition: T6Or/T6Or
Genetic Background: involves: 101 * C3H

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Tbptm1.1Ees/Tbptm1.1Ees
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: T6Or/T6Or
Genetic Background: involves: 101 * C3H

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: ApcMin/Apc+,Ccdc80tm1.1Ftk/Ccdc80tm1.1Ftk
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: T6Or/T6Or
Genetic Background: involves: 101 * C3H

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: T6Or/T6Or
Genetic Background: involves: 101 * C3H

Allelic Composition: Tbptm1.1Ees/Tbp+
Genetic Background: B6.129X1(Cg)-Tbptm1.1Ees

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hmgcrtm2Ishi/Hmgcrtm2Ishi
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0008572 abnormal Purkinje cell dendrite morphology "any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbptm1Xjl/Tbp+,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: T6Or/T6Or
Genetic Background: involves: 101 * C3H

 MP:0011093 complete embryonic lethality at implantation "death of all organisms of a given genotype in a population at the point of implantation (Mus: E4.5)" [MGI:csmith]
Show

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Tbptm1.1Ees/Tbptm1.1Ees
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: T6Or/T6Or
Genetic Background: involves: 101 * C3H

Allelic Composition: Tbptm1.1Ees/Tbp+
Genetic Background: B6.129X1(Cg)-Tbptm1.1Ees

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Tbptm1.1Ees/Tbptm1.1Ees
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032185 Carm1 / Q9WVG6 / Histone-arginine methyltransferase CARM1 / Q86X55* / coactivator associated arginine methyltransferase 1*  / complex / reaction
 ENSMUSG00000061079 O70230 / Zfp143 / zinc finger protein 143 / P52747* / ZNF143*  / reaction / complex
 ENSMUSG00000020962 Gtf2a1 / Q99PM3 / Transcription initiation factor IIA subunit 1 Transcription initiation factor IIA alpha chain Transcription initiation factor IIA beta chain / P52655* / general transcript...  / reaction / complex
 ENSMUSG00000033543 Gtf2a2 / Q80ZM7 / Transcription initiation factor IIA subunit 2 / P52657* / general transcription factor IIA subunit 2*  / complex / reaction
 ENSMUSG00000026565 P25425 / Pou2f1 / POU domain, class 2, transcription factor 1 / P14859* / POU class 2 homeobox 1*  / complex / reaction
 ENSMUSG00000031487 Brf2 / BRF2, RNA polymerase III transcription initiation factor subunit / Q9HAW0*  / complex
 ENSMUSG00000011158 Brf1 / BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit / Q92994* / BRF1, RNA polymerase III transcription initiation factor subunit*  / complex
 ENSMUSG00000049658 Bdp1 / Q571C7 / Transcription factor TFIIIB component B homolog / A6H8Y1* / B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB*  / complex
 ENSMUSG00000109324 Prmt1 / Q9JIF0 / protein arginine N-methyltransferase 1 / Q99873* / protein arginine methyltransferase 1*  / reaction / complex
 ENSMUSG00000035451 Foxa1 / P35582 / Hepatocyte nuclear factor 3-alpha / P55317* / forkhead box A1*  / complex / reaction
 ENSMUSG00000019768 Esr1 / P19785 / Estrogen receptor / P03372* / estrogen receptor 1*  / complex / reaction
 ENSMUSG00000015619 Gata3 / P23772 / Mus musculus GATA binding protein 3 (Gata3), transcript variant 3, mRNA. / P23771* / GATA binding protein 3*  / complex / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr