ENSMUSG00000026565


Mus musculus

Features
Gene ID: ENSMUSG00000026565
  
Biological name :Pou2f1
  
Synonyms : P25425 / Pou2f1 / POU domain, class 2, transcription factor 1
  
Possible biological names infered from orthology : P14859 / POU class 2 homeobox 1
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H2.3
Gene start: 165865154
Gene end: 166002678
  
Corresponding Affymetrix probe sets: 10359770 (MoGene1.0st)   1419716_a_at (Mouse Genome 430 2.0 Array)   1427695_a_at (Mouse Genome 430 2.0 Array)   1427835_at (Mouse Genome 430 2.0 Array)   1435555_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000125371
Ensembl peptide - ENSMUSP00000141618
Ensembl peptide - ENSMUSP00000139271
Ensembl peptide - ENSMUSP00000138962
Ensembl peptide - ENSMUSP00000135565
Ensembl peptide - ENSMUSP00000135329
Ensembl peptide - ENSMUSP00000125444
Ensembl peptide - ENSMUSP00000027850
Ensembl peptide - ENSMUSP00000064000
Ensembl peptide - ENSMUSP00000107055
Ensembl peptide - ENSMUSP00000107056
Ensembl peptide - ENSMUSP00000107057
Ensembl peptide - ENSMUSP00000124738
NCBI entrez gene - 18986     See in Manteia.
MGI - MGI:101898
RefSeq - XM_017319360
RefSeq - NM_011137
RefSeq - NM_198932
RefSeq - NM_198933
RefSeq - NM_198934
RefSeq - XM_006496704
RefSeq - XM_011238767
RefSeq - XM_011238769
RefSeq Peptide - NP_945151
RefSeq Peptide - NP_945152
RefSeq Peptide - NP_035267
RefSeq Peptide - NP_945150
swissprot - A0A0R4J1Z4
swissprot - A0A0A6YWN1
swissprot - A0A0A0MQM6
swissprot - A0A0A0MQE0
swissprot - F8VQL7
swissprot - H3BKX3
swissprot - A0A1Y7VFH6
swissprot - I1E4X2
swissprot - P25425
swissprot - V9GXQ7
swissprot - E9Q6Z8
Ensembl - ENSMUSG00000026565
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pou2f1bENSDARG00000007996Danio rerio
 POU2F1ENSGALG00000015446Gallus gallus
 P14859ENSG00000143190Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pou2f2 / Q00196 / POU domain, class 2, transcription factor 2 / P09086* / POU class 2 homeobox 2*ENSMUSG0000000849639
Pou2f3 / POU domain, class 2, transcription factor 3 / Q9UKI9* / POU class 2 homeobox 3*ENSMUSG0000003201526
P31361 / Pou3f3 / POU domain, class 3, transcription factor 3 / P20264* / POU class 3 homeobox 3*ENSMUSG0000004551519
P31360 / Pou3f2 / POU domain, class 3, transcription factor 2 / P20265* / POU class 3 homeobox 2*ENSMUSG0000009513917
P62515 / Pou3f4 / POU domain, class 3, transcription factor 4 / P49335* / POU class 3 homeobox 4*ENSMUSG0000005685417
P21952 / Pou3f1 / POU domain, class 3, transcription factor 1 / Q03052* / POU class 3 homeobox 1*ENSMUSG0000009012516
P20263 / Pou5f1 / POU domain, class 5, transcription factor 1 / Q06416* / Q01860* / POU5F1B* / POU class 5 homeobox 1* / POU class 5 homeobox 1B*ENSMUSG0000002440616
Pou4f2 / Q63934 / POU domain, class 4, transcription factor 2 / Q12837* / POU class 4 homeobox 2*ENSMUSG0000003168812
P17208 / Pou4f1 / POU domain, class 4, transcription factor 1 / Q01851* / POU class 4 homeobox 1*ENSMUSG0000004834912
Pou4f3 / Q63955 / POU domain, class 4, transcription factor 3 / Q15319* / POU class 4 homeobox 3*ENSMUSG0000002449712
Pou1f1 / Q00286 / POU domain, class 1, transcription factor 1 / P28069* / POU class 1 homeobox 1*ENSMUSG0000000484212
Pou5f2 / POU domain class 5, transcription factor 2 / Q8N7G0*ENSMUSG0000009366811


Protein motifs (from Interpro)
Interpro ID Name
 IPR000327  POU-specific domain
 IPR000972  Octamer-binding transcription factor
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR010982  Lambda repressor-like, DNA-binding domain superfamily
 IPR013847  POU domain
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0030910 olfactory placode formation IGI
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0060235 lens induction in camera-type eye IGI
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex ISO
 molecular_functionGO:0000979 RNA polymerase II core promoter sequence-specific DNA binding ISO
 molecular_functionGO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
RNA polymerase II transcribes snRNA genes
RNA Polymerase III Transcription Initiation From Type 3 Promoter
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pnpla6tm1Mos/Pnpla6tm1Mos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000601 small liver "reduced size of the liver" [J:23170]
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Allelic Composition: Pnpla6tm1Mos/Pnpla6tm1Mos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Btktm1Wk/Btktm1Wk,Tectm1Welm/Tectm1Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
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Allelic Composition: Pou2f1tm1Shrp/Pou2f1tm1Shrp,Sox2tm1.1Vep/Sox2+
Genetic Background: involves: 129S4/SvJae * C3H/HeN * C57BL/6

 MP:0001288 abnormal lens induction "malformation of or failure to form the transparent, biconvex structure of the eye which is situated behind the iris and in front of the vitreous humor" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pou2f1tm1Shrp/Pou2f1tm1Shrp,Sox2tm1.1Vep/Sox2+
Genetic Background: involves: 129S4/SvJae * C3H/HeN * C57BL/6

 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
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Allelic Composition: Pou2f1tm1Shrp/Pou2f1tm1Shrp,Sox2tm1.1Vep/Sox2+
Genetic Background: involves: 129S4/SvJae * C3H/HeN * C57BL/6

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Pou2f1tm1Shrp/Pou2f1tm1Shrp,Sox2tm1.1Vep/Sox2+
Genetic Background: involves: 129S4/SvJae * C3H/HeN * C57BL/6

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Hspb7tm1.2Chen/Hspb7tm1.2Chen,Tg(Myh6-Tmod1)65Msus/Tg(Myh6-Tmod1)65Msus
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * FVB/N

Allelic Composition: Pou2f1tm1Shrp/Pou2f1+,Sox2tm1.1Vep/Sox2+
Genetic Background: involves: 129S4/SvJae * C3H/HeN * C57BL/6

 MP:0001306 small lens "reduced size of the transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Pnpla6tm1Mos/Pnpla6tm1Mos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Pnpla6tm1Mos/Pnpla6tm1Mos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Pnpla6tm1Mos/Pnpla6tm1Mos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pou2f1tm1Cav/Pou2f1tm1Cav
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001717 absent ectoplacental cone 
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pnpla6tm1Mos/Pnpla6tm1Mos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003817 abnormal Rathke s pouch "malformation or incomplete differentiation of a pouch of ectoderm that grows out from the upper surface of the embryonic stomodeum and gives rise to the anterior and intermediate lobes of the pituitary gland" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:51160]
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Allelic Composition: Pou2f1tm1Shrp/Pou2f1tm1Shrp,Sox2tm1.1Vep/Sox2+
Genetic Background: involves: 129S4/SvJae * C3H/HeN * C57BL/6

 MP:0003890 abnormal embryonic-extraembryonic boundary morphology "anomaly in the normal development /maintenance of the connection between the embryo proper and extraembryonic tissues" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Pou2f1tm1Cav/Pou2f1tm1Cav
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004163 abnormal adenophysis morphology "any malformation or absence of the anterior part of the pituitary that secretes a variety of hormones; its function is regulated by the hypothalamus" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pou2f1tm1Shrp/Pou2f1tm1Shrp,Sox2tm1.1Vep/Sox2+
Genetic Background: involves: 129S4/SvJae * C3H/HeN * C57BL/6

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Btktm1Wk/Btktm1Wk,Tectm1Welm/Tectm1Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006293 absent olfactory placodes "absence of the paired ectodermal placodes that come to lie in the bottom of the olfactory pits as the pits are deepened by the growth of the surrounding medial and lateral nasal processes " [J:71787, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pou2f1tm1Shrp/Pou2f1tm1Shrp,Sox2tm1.1Vep/Sox2+
Genetic Background: involves: 129S4/SvJae * C3H/HeN * C57BL/6

 MP:0008533 abnormal anterior visceral endoderm "any structural anomaly of the extraembryonic tissue that is responsible for the proper orientation of the anterior-posterior axis of the embryo and for appropriate patterning of adjacent embryonic tissue" [PMID:17078044]
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Allelic Composition: Pou2f1tm1Cav/Pou2f1tm1Cav
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010736 abnormal extraembryonic ectoderm morphology "any structural anomaly of the layer of the ectoderm of the extraembryonic tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pou2f1tm1Cav/Pou2f1tm1Cav
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Btktm1Wk/Btktm1Wk,Tectm1Welm/Tectm1Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Btktm1Wk/Btktm1Wk,Tectm1Welm/Tectm1Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011095 complete embryonic lethality between implantation and placentation "death of all organisms of a given genotype in a population between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9)" [MGI:csmith]
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Allelic Composition: Pou2f1tm1Cav/Pou2f1tm1Cav
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Pnpla6tm1Mos/Pnpla6tm1Mos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Pnpla6tm1Mos/Pnpla6tm1Mos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000014767 Tbp / P29037 / TATA box binding protein / P20226*  / complex / reaction
 ENSMUSG00000001280 Sp1 / O89090 / Transcription factor Sp1 / P08047* / Sp1 transcription factor*  / complex
 ENSMUSG00000049658 Bdp1 / Q571C7 / Transcription factor TFIIIB component B homolog / A6H8Y1* / B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB*  / reaction / complex
 ENSMUSG00000031487 Brf2 / BRF2, RNA polymerase III transcription initiation factor subunit / Q9HAW0*  / reaction / complex
 ENSMUSG00000061079 O70230 / Zfp143 / zinc finger protein 143 / P52747* / ZNF143*  / complex / reaction






 

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