ENSMUSG00000031688


Mus musculus

Features
Gene ID: ENSMUSG00000031688
  
Biological name :Pou4f2
  
Synonyms : Pou4f2 / POU domain, class 4, transcription factor 2 / Q63934
  
Possible biological names infered from orthology : POU class 4 homeobox 2 / Q12837
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: C1
Gene start: 78433010
Gene end: 78436645
  
Corresponding Affymetrix probe sets: 10579825 (MoGene1.0st)   1437588_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034115
NCBI entrez gene - 18997     See in Manteia.
MGI - MGI:102524
RefSeq - NM_138944
RefSeq Peptide - NP_620394
swissprot - Q63934
Ensembl - ENSMUSG00000031688
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pou4f2ENSDARG00000069737Danio rerio
 POU4F2ENSGALG00000037094Gallus gallus
 POU4F2ENSG00000151615Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P17208 / Pou4f1 / POU domain, class 4, transcription factor 1 / Q01851* / POU class 4 homeobox 1*ENSMUSG0000004834963
Pou4f3 / Q63955 / POU domain, class 4, transcription factor 3 / Q15319* / POU class 4 homeobox 3*ENSMUSG0000002449760
P31361 / Pou3f3 / POU domain, class 3, transcription factor 3 / P20264* / POU class 3 homeobox 3*ENSMUSG0000004551528
P62515 / Pou3f4 / POU domain, class 3, transcription factor 4 / P49335* / POU class 3 homeobox 4*ENSMUSG0000005685425
Pou2f2 / Q00196 / POU domain, class 2, transcription factor 2 / P09086* / POU class 2 homeobox 2*ENSMUSG0000000849625
P20263 / Pou5f1 / POU domain, class 5, transcription factor 1 / Q06416* / Q01860* / POU5F1B* / POU class 5 homeobox 1* / POU class 5 homeobox 1B*ENSMUSG0000002440624
P25425 / Pou2f1 / POU domain, class 2, transcription factor 1 / P14859* / POU class 2 homeobox 1*ENSMUSG0000002656523
P31360 / Pou3f2 / POU domain, class 3, transcription factor 2 / P20265* / POU class 3 homeobox 2*ENSMUSG0000009513923
Pou2f3 / POU domain, class 2, transcription factor 3 / Q9UKI9* / POU class 2 homeobox 3*ENSMUSG0000003201523
P21952 / Pou3f1 / POU domain, class 3, transcription factor 1 / Q03052* / POU class 3 homeobox 1*ENSMUSG0000009012523
Pou1f1 / Q00286 / POU domain, class 1, transcription factor 1 / P28069* / POU class 1 homeobox 1*ENSMUSG0000000484222
Pou5f2 / POU domain class 5, transcription factor 2 / Q8N7G0*ENSMUSG0000009366817


Protein motifs (from Interpro)
Interpro ID Name
 IPR000327  POU-specific domain
 IPR001356  Homeobox domain
 IPR001387  Cro/C1-type helix-turn-helix domain
 IPR009057  Homeobox-like domain superfamily
 IPR010982  Lambda repressor-like, DNA-binding domain superfamily
 IPR013847  POU domain
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007409 axonogenesis IMP
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0007605 sensory perception of sound IGI
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030182 neuron differentiation IMP
 biological_processGO:0030520 intracellular estrogen receptor signaling pathway IEA
 biological_processGO:0031290 retinal ganglion cell axon guidance IMP
 biological_processGO:0045596 negative regulation of cell differentiation IMP
 biological_processGO:0045597 positive regulation of cell differentiation IMP
 biological_processGO:0045672 positive regulation of osteoclast differentiation IMP
 biological_processGO:0045773 positive regulation of axon extension IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048675 axon extension IGI
 biological_processGO:0050885 neuromuscular process controlling balance IGI
 biological_processGO:0060041 retina development in camera-type eye IMP
 biological_processGO:0071345 cellular response to cytokine stimulus IDA
 biological_processGO:0090259 regulation of retinal ganglion cell axon guidance IMP
 biological_processGO:1902870 negative regulation of amacrine cell differentiation IMP
 biological_processGO:1990791 dorsal root ganglion development IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016607 nuclear speck ISO
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0003714 transcription corepressor activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:1990841 promoter-specific chromatin binding IDA


Pathways (from Reactome)
Pathway description
Regulation of TP53 Activity through Association with Co-factors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000904 abnormal superior colliculus "dysmorphology or disorganization of the paired superior eminence of the mesencephalic tectum that is involved in auditory processing" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Abl2tm1Ajk/Abl2tm1Ajk
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Pou4f2tm1Nat/Pou4f2tm2.1Nat,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
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Allelic Composition: Pou4f2tm3Whk/Pou4f2tm3Whk
Genetic Background: Not Specified

Allelic Composition: Pou4f2tm3Whk/Pou4f2tm3Whk,Pou4f3tm1Whk/Pou4f3tm1Whk
Genetic Background: Not Specified

 MP:0001059 optic nerve atrophy "wasting of the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pou4f2tm4Whk/Pou4f2+,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pou4f2tm3Whk/Pou4f2tm3Whk
Genetic Background: Not Specified

Allelic Composition: Pou4f2tm3Whk/Pou4f2tm3Whk,Pou4f3tm1Whk/Pou4f3tm1Whk
Genetic Background: Not Specified

Allelic Composition: Pou4f2tm4Whk/Pou4f2tm4Whk,Tg(Six3-cre)69Frty/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan,Pou4f2tm1Nat/Pou4f2tm1Nat
Genetic Background: B6.Cg-Pou4f2tm1Nat Atoh7tm1Gan

 MP:0001330 abnormal optic nerve morphology "malformation, misprojection or atrophy in the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxp3tm2Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pou4f2tm3Whk/Pou4f2tm3Whk
Genetic Background: Not Specified

Allelic Composition: Pou4f2tm4Whk/Pou4f2tm4Whk,Tg(Six3-cre)69Frty/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

Allelic Composition: Pou4f2tm4Whk/Pou4f2+,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0001332 abnormal optic nerve innervation "misprojection or aberrant target finding of the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxp3tm2Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001967 deafness "inability to hear" [J:57651]
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Allelic Composition: Pou4f2tm3Whk/Pou4f2tm3Whk,Pou4f3tm1Whk/Pou4f3tm1Whk
Genetic Background: Not Specified

 MP:0002003 meiotic pupils "charcterized by contraction of the pupils " [J:17194]
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Allelic Composition: Pou4f2tm1Nat/Pou4f2tm2.1Nat,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002090 abnormal vision "inability or decreased ability to see " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pou4f2tm4Whk/Pou4f2tm4Whk,Tg(Six3-cre)69Frty/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm2(SNCA*119)Djmo/Gt(ROSA)26Sor+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Pou4f2tm1.1(cre)Tcba/Pou4f2tm1.1(cre)Tcba
Genetic Background: involves: 129 * C57BL/6

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pou4f2tm4Whk/Pou4f2+,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: B6NCrl.Cg-Cplx2tm1Rmnd

Allelic Composition: Opn4tm2.1(cre/ERT2)Saha/Opn4+,Pou4f2tm2.1Nat/Pou4f2+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Opn4tm1.1(cre)Saha/Opn4+,Pou4f2tm4Whk/Pou4f2+,Tg(CAG-Bgeo/ALPP)1Lbe/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Opn4tm1.1(cre)Saha/Opn4tm1Yau,Pou4f2tm4Whk/Pou4f2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002984 retina hypoplasia "less than normal number of cells in the thin layer of neural tissue lining the back of the eyeball which contains visual receptors" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80994]
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Allelic Composition: Pou4f2tm1Nat/Pou4f2tm2.1Nat,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan,Pou4f2tm1Nat/Pou4f2tm1Nat
Genetic Background: B6.Cg-Pou4f2tm1Nat Atoh7tm1Gan

 MP:0004165 abnormal lateral geniculate nucleus morphology "any malformation or absence of the group of neurons that serve as the primary processor of visual information received from the retina via the optic tract and send processed information to the visual cortex of the occipital lobe" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pou4f2tm1Nat/Pou4f2tm2.1Nat,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004267 abnormal optic tract morphology "any structural anomaly of the band of optic nerve fibers running from the optic chiasma to the lateral geniculate body and midbrain" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Pou4f2tm1Nat/Pou4f2tm2.1Nat,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004742 abnormal vestibular system physiology "any functional anomaly of the sensory system responsible for the sense of head position and movement of the body through space; such anomalies may include impaired balance, dizziness, poor regulation of postural muscle tone and inability to detect quick movements of the head " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pou4f2tm3Whk/Pou4f2tm3Whk,Pou4f3tm1Whk/Pou4f3tm1Whk
Genetic Background: Not Specified

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Pou4f2tm1Nat/Pou4f2tm1Nat
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005253 abnormal eye physiology "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Srftm1.1Wtp/Srftm1.1Wtp
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL * Swiss Webster

 MP:0005547 abnormal Muller cell morphology "anomalous structure of the elongated neuroglial cells that traverse all the layers of the retina and that act as supporting elements" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan,Pou4f2tm1Nat/Pou4f2tm1Nat
Genetic Background: B6.Cg-Pou4f2tm1Nat Atoh7tm1Gan

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Pou4f2tm4Whk/Pou4f2tm4Whk,Tg(Six3-cre)69Frty/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

Allelic Composition: Pou4f2tm1Nat/Pou4f2tm1Nat
Genetic Background: B6.129S7-Pou4f2tm1Nat

Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan,Pou4f2tm1Nat/Pou4f2tm1Nat
Genetic Background: B6.Cg-Pou4f2tm1Nat Atoh7tm1Gan

 MP:0006074 abnormal retinal rod bipolar cell morphology "anomalous structure of the bipolar cells that function in low light and transmit signals only through amacrine cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92623]
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Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan,Pou4f2tm1Nat/Pou4f2tm1Nat
Genetic Background: B6.Cg-Pou4f2tm1Nat Atoh7tm1Gan

 MP:0006156 abnormal visual pursuit "anomaly in the ability to selectively track a moving object" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pou4f2tm1Nat/Pou4f2tm2.1Nat,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129S7/SvEvBrd

 MP:0006219 optic nerve degeneration "retrogressive pathologic change of the optic nerve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pou4f2tm4Whk/Pou4f2+,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0006221 optic nerve hypoplasia "less than the normal number of fibers in the optic nerve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Isl1tm2Gan/Isl1tm2Gan,Pou4f2tm1(ALPP)Whk/Pou4f2tm2Whk,Tg(Six3-cre)69Frty/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Isl1tm1Gan/Isl1tm2Gan,Pou4f2tm1(ALPP)Whk/Pou4f2tm2Whk,Tg(Six3-cre)69Frty/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Pou4f2tm1Nat/Pou4f2tm1Nat
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0006243 abnormal pupil dilation reaction to light "the pupil fails to constrict fully when exposed to bright light" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Opn4tm1.1(cre)Saha/Opn4+,Pou4f2tm4Whk/Pou4f2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0006303 abnormal retinal nerve fiber layer morphology "malformation of the layer of the retina formed by expansion of the fibers of the optic nerve" [ISBN:0-914294-08-3 "Gray s Anatomy", J:67382, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pou4f2tm3Whk/Pou4f2tm3Whk
Genetic Background: Not Specified

Allelic Composition: Pou4f2tm3Whk/Pou4f2tm3Whk,Pou4f3tm1Whk/Pou4f3tm1Whk
Genetic Background: Not Specified

 MP:0006309 decreased retinal ganglion cell number "reduced number of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pou4f2tm3Whk/Pou4f2tm3Whk
Genetic Background: Not Specified

Allelic Composition: Pou4f2tm3Whk/Pou4f2tm3Whk,Pou4f3tm1Whk/Pou4f3tm1Whk
Genetic Background: Not Specified

Allelic Composition: Pou4f2tm1Nat/Pou4f2tm2.1Nat,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Pou4f2tm1Nat/Pou4f2tm1Nat
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Pou4f2tm1Nat/Pou4f2tm1Nat
Genetic Background: B6.129S7-Pou4f2tm1Nat

Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan,Pou4f2tm1Nat/Pou4f2tm1Nat
Genetic Background: B6.Cg-Pou4f2tm1Nat Atoh7tm1Gan

Allelic Composition: Opn4tm1.1(cre)Saha/Opn4+,Pou4f2tm4Whk/Pou4f2+,Tg(CAG-Bgeo/ALPP)1Lbe/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Opn4tm1.1(cre)Saha/Opn4+,Pou4f2tm4Whk/Pou4f2+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Opn4tm1.1(cre)Saha/Opn4tm1Yau,Pou4f2tm4Whk/Pou4f2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008056 abnormal retinal ganglion cell morphology "any structural anomaly of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pou4f2tm3Whk/Pou4f2tm3Whk
Genetic Background: Not Specified

Allelic Composition: Pou4f2tm3Whk/Pou4f2tm3Whk,Pou4f3tm1Whk/Pou4f3tm1Whk
Genetic Background: Not Specified

Allelic Composition: Pou4f2tm1Nat/Pou4f2tm2.1Nat,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan,Pou4f2tm1Nat/Pou4f2tm1Nat
Genetic Background: B6.Cg-Pou4f2tm1Nat Atoh7tm1Gan

 MP:0008067 retinal ganglion cell degeneration "degeneration or loss of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxp3tm2Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pou4f2tm1Rsd/Pou4f2tm1Rsd
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Isl1tm2Gan/Isl1tm2Gan,Pou4f2tm1(ALPP)Whk/Pou4f2tm2Whk,Tg(Six3-cre)69Frty/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Isl1tm1Gan/Isl1tm2Gan,Pou4f2tm1(ALPP)Whk/Pou4f2tm2Whk,Tg(Six3-cre)69Frty/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0008105 increased amacrine cell number "increase in the number of one of the three types of interneurons found in the inner nuclear layer of the mature retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pou4f2tm3Whk/Pou4f2tm3Whk
Genetic Background: Not Specified

Allelic Composition: Pou4f2tm3Whk/Pou4f2tm3Whk,Pou4f3tm1Whk/Pou4f3tm1Whk
Genetic Background: Not Specified

 MP:0008106 decreased amacrine cell number "reduction in the number of one of the three types of interneurons found in the inner nuclear layer of the mature retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan,Pou4f2tm1Nat/Pou4f2tm1Nat
Genetic Background: B6.Cg-Pou4f2tm1Nat Atoh7tm1Gan

 MP:0008259 abnormal optic disc morphology "any structural anomaly of the area in the retina where all of the axons of the ganglion cells exit the retina to form the optic nerve" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pou4f2tm4Whk/Pou4f2tm4Whk,Tg(Six3-cre)69Frty/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0008507 thin retinal ganglion layer "reduced thickness of the innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pou4f2tm3Whk/Pou4f2tm3Whk
Genetic Background: Not Specified

Allelic Composition: Pou4f2tm3Whk/Pou4f2tm3Whk,Pou4f3tm1Whk/Pou4f3tm1Whk
Genetic Background: Not Specified

Allelic Composition: Pou4f2tm4Whk/Pou4f2tm4Whk,Tg(Six3-cre)69Frty/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

Allelic Composition: Pou4f2tm4Whk/Pou4f2+,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

Allelic Composition: Pou4f2tm1Nat/Pou4f2tm1Nat
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan,Pou4f2tm1Nat/Pou4f2tm1Nat
Genetic Background: B6.Cg-Pou4f2tm1Nat Atoh7tm1Gan

 MP:0008511 thin retinal inner nuclear layer "reduced thickness of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Pou4f2tm1Nat/Pou4f2tm1Nat
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan,Pou4f2tm1Nat/Pou4f2tm1Nat
Genetic Background: B6.Cg-Pou4f2tm1Nat Atoh7tm1Gan

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Pou4f2tm1Nat/Pou4f2tm1Nat
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan,Pou4f2tm1Nat/Pou4f2tm1Nat
Genetic Background: B6.Cg-Pou4f2tm1Nat Atoh7tm1Gan

 MP:0008847 abnormal suprachiasmatic nucleus morphology "any structural anomaly of an ovoid densely packed collection of small cells of the anterior hypothalamus lying close to the midline in a shallow impression of the optic chiasm; it receives input from the retina and influences neuroendocrine function" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.730.317.357.342.625]
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Allelic Composition: Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: B6NCrl.Cg-Cplx2tm1Rmnd

Allelic Composition: Opn4tm2.1(cre/ERT2)Saha/Opn4+,Pou4f2tm2.1Nat/Pou4f2+
Genetic Background: involves: 129 * C57BL/6

 MP:0009639 abnormal olivary pretectal nucleus morphology "any strucural anomaly of one of several pretectal nuclei with direct input from the eye and the only one containing neurons whose rate of firing is linearly related to the intensity of light falling on the retina" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Opn4tm1.1(cre)Saha/Opn4+,Pou4f2tm4Whk/Pou4f2+,Tg(CAG-Bgeo/ALPP)1Lbe/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Opn4tm1.1(cre)Saha/Opn4tm1Yau,Pou4f2tm4Whk/Pou4f2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0011965 decreased total retina thickness "decreased width of the retina through the center plane" [MGI:csmith]
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Allelic Composition: Pou4f2tm4Whk/Pou4f2tm4Whk,Tg(Six3-cre)69Frty/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0020468 abnormal circadian behavior period "any change in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [MGI:smb]
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Allelic Composition: Opn4tm1.1(cre)Saha/Opn4+,Pou4f2tm4Whk/Pou4f2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0020470 shortened circadian behavior period "decrease in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [MGI:smb]
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Allelic Composition: Pou4f2tm1Nat/Pou4f2tm1Nat
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0020476 abnormal circardian behavior entrainment "anomaly in the synchronization of a circadian behavior to environmental time cues such as light" [GO:0009649]
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Allelic Composition: Pou4f2tm1Nat/Pou4f2tm1Nat
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0030005 increased retinal apoptosis "increase in the number of cells in the retina undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Foxp3tm2Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan,Pou4f2tm1Nat/Pou4f2tm1Nat
Genetic Background: B6.Cg-Pou4f2tm1Nat Atoh7tm1Gan

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000059552 Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*  / reaction / complex






 

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