ENSMUSG00000090125


Mus musculus

Features
Gene ID: ENSMUSG00000090125
  
Biological name :Pou3f1
  
Synonyms : P21952 / Pou3f1 / POU domain, class 3, transcription factor 1
  
Possible biological names infered from orthology : POU class 3 homeobox 1 / Q03052
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D2.2
Gene start: 124656807
Gene end: 124660655
  
Corresponding Affymetrix probe sets: 10507905 (MoGene1.0st)   1422068_at (Mouse Genome 430 2.0 Array)   1460038_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000137374
NCBI entrez gene - 18991     See in Manteia.
MGI - MGI:101896
RefSeq - NM_011141
RefSeq Peptide - NP_035271
swissprot - P21952
Ensembl - ENSMUSG00000090125
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pou3f1ENSDARG00000009823Danio rerio
 POU3F1ENSG00000185668Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P31361 / Pou3f3 / POU domain, class 3, transcription factor 3 / P20264* / POU class 3 homeobox 3*ENSMUSG0000004551555
P31360 / Pou3f2 / POU domain, class 3, transcription factor 2 / P20265* / POU class 3 homeobox 2*ENSMUSG0000009513951
P62515 / Pou3f4 / POU domain, class 3, transcription factor 4 / P49335* / POU class 3 homeobox 4*ENSMUSG0000005685442
Pou2f2 / Q00196 / POU domain, class 2, transcription factor 2 / P09086* / POU class 2 homeobox 2*ENSMUSG0000000849629
Pou2f3 / POU domain, class 2, transcription factor 3 / Q9UKI9* / POU class 2 homeobox 3*ENSMUSG0000003201528
P25425 / Pou2f1 / POU domain, class 2, transcription factor 1 / P14859* / POU class 2 homeobox 1*ENSMUSG0000002656528
P20263 / Pou5f1 / POU domain, class 5, transcription factor 1 / Q06416* / Q01860* / POU5F1B* / POU class 5 homeobox 1* / POU class 5 homeobox 1B*ENSMUSG0000002440626
Pou1f1 / Q00286 / POU domain, class 1, transcription factor 1 / P28069* / POU class 1 homeobox 1*ENSMUSG0000000484223
Pou4f3 / Q63955 / POU domain, class 4, transcription factor 3 / Q15319* / POU class 4 homeobox 3*ENSMUSG0000002449722
P17208 / Pou4f1 / POU domain, class 4, transcription factor 1 / Q01851* / POU class 4 homeobox 1*ENSMUSG0000004834922
Pou4f2 / Q63934 / POU domain, class 4, transcription factor 2 / Q12837* / POU class 4 homeobox 2*ENSMUSG0000003168821
Pou5f2 / POU domain class 5, transcription factor 2 / Q8N7G0*ENSMUSG0000009366818


Protein motifs (from Interpro)
Interpro ID Name
 IPR000327  POU-specific domain
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR010982  Lambda repressor-like, DNA-binding domain superfamily
 IPR013847  POU domain
 IPR016362  POU-domain transcription factor, class 3
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0008544 epidermis development IGI
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0014044 Schwann cell development IMP
 biological_processGO:0022011 myelination in peripheral nervous system IGI
 biological_processGO:0030216 keratinocyte differentiation IGI
 biological_processGO:0030900 forebrain development IMP
 biological_processGO:0042552 myelination IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IDA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding ISO
 molecular_functionGO:0043565 sequence-specific DNA binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gli3add/Gli3Xt
Genetic Background: involves: 101/H * C3H/HeH * C57BL/6 * CBA/H * SJL

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pou3f1tm1Mejr/Pou3f1tm1Mejr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pou3f1tm2.1Mejr/Pou3f1tm2.1Mejr
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Pou3f1tm1Mejr/Pou3f1tm2.1Mejr,Pou3f2tm1Mejr/Pou3f2tm1Mejr,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Pou3f1tm1Mejr/Pou3f1tm2.1Mejr
Genetic Background: involves: 129P2/OlaHsd

 MP:0001078 abnormal phrenic nerve "malformed or misprojection of motor and sensory neuron axons to the diaphragm and other tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001106 abnormal Schwann cell "malformed or absent cells which form the insulating myelin sheaths of peripheral axons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pou3f1tm1Mejr/Pou3f1tm2.1Mejr
Genetic Background: involves: 129P2/OlaHsd

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Gli3add/Gli3Xt
Genetic Background: involves: 101/H * C3H/HeH * C57BL/6 * CBA/H * SJL

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atrnmg/Atrnmg
Genetic Background: LDJ/Le

 MP:0002651 abnormal sciatic nerve "malformation, absence or misprojection of the nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pou3f1tm1Mejr/Pou3f1tm1Mejr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005237 abnormal olfactory tract morphology "structural anomaly of the nervelike, white band composed primarily of nerve fibers originating from the mitral cells and tufted cells of the olfactory bulb, but also containing the scattered cells of the anterior olfactory nucleus " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34460]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pou3f1tm1Mejr/Pou3f1tm2.1Mejr,Pou3f2tm1Mejr/Pou3f2tm1Mejr,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pou3f1tm1Rsd/Pou3f1tm1Rsd
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6J

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pou2f3tm1Rsd/Pou2f3tm1Rsd,Pou3f1tm1Rsd/Pou3f1tm1Rsd
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6J

Allelic Composition: Pou3f1tm1Mejr/Pou3f1tm1Mejr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr