ENSMUSG00000024406


Mus musculus

Features
Gene ID: ENSMUSG00000024406
  
Biological name :Pou5f1
  
Synonyms : P20263 / Pou5f1 / POU domain, class 5, transcription factor 1
  
Possible biological names infered from orthology : POU5F1B / POU class 5 homeobox 1 / POU class 5 homeobox 1B / Q01860 / Q06416
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: B1
Gene start: 35506018
Gene end: 35510772
  
Corresponding Affymetrix probe sets: 10444853 (MoGene1.0st)   1417945_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134654
Ensembl peptide - ENSMUSP00000134729
Ensembl peptide - ENSMUSP00000025271
Ensembl peptide - ENSMUSP00000133633
Ensembl peptide - ENSMUSP00000134060
Ensembl peptide - ENSMUSP00000134493
NCBI entrez gene - 18999     See in Manteia.
MGI - MGI:101893
RefSeq - NM_001252452
RefSeq - NM_013633
RefSeq Peptide - NP_001239381
RefSeq Peptide - NP_038661
swissprot - P20263
swissprot - G3UZG9
swissprot - E2JL30
Ensembl - ENSMUSG00000024406
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pou5f3ENSDARG00000044774Danio rerio
 Pou5f3ENSGALG00000031482Gallus gallus
 POU5F1ENSG00000204531Homo sapiens
 Q06416ENSG00000212993Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pou5f2 / POU domain class 5, transcription factor 2 / Q8N7G0*ENSMUSG0000009366846
P25425 / Pou2f1 / POU domain, class 2, transcription factor 1 / P14859* / POU class 2 homeobox 1*ENSMUSG0000002656536
Pou2f3 / POU domain, class 2, transcription factor 3 / Q9UKI9* / POU class 2 homeobox 3*ENSMUSG0000003201535
Pou2f2 / Q00196 / POU domain, class 2, transcription factor 2 / P09086* / POU class 2 homeobox 2*ENSMUSG0000000849635
P31361 / Pou3f3 / POU domain, class 3, transcription factor 3 / P20264* / POU class 3 homeobox 3*ENSMUSG0000004551535
P62515 / Pou3f4 / POU domain, class 3, transcription factor 4 / P49335* / POU class 3 homeobox 4*ENSMUSG0000005685435
P21952 / Pou3f1 / POU domain, class 3, transcription factor 1 / Q03052* / POU class 3 homeobox 1*ENSMUSG0000009012533
P31360 / Pou3f2 / POU domain, class 3, transcription factor 2 / P20265* / POU class 3 homeobox 2*ENSMUSG0000009513932
Pou4f2 / Q63934 / POU domain, class 4, transcription factor 2 / Q12837* / POU class 4 homeobox 2*ENSMUSG0000003168828
Pou1f1 / Q00286 / POU domain, class 1, transcription factor 1 / P28069* / POU class 1 homeobox 1*ENSMUSG0000000484227
Pou4f3 / Q63955 / POU domain, class 4, transcription factor 3 / Q15319* / POU class 4 homeobox 3*ENSMUSG0000002449727
P17208 / Pou4f1 / POU domain, class 4, transcription factor 1 / Q01851* / POU class 4 homeobox 1*ENSMUSG0000004834926


Protein motifs (from Interpro)
Interpro ID Name
 IPR000327  POU-specific domain
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR010982  Lambda repressor-like, DNA-binding domain superfamily
 IPR013847  POU domain
 IPR015585  POU domain-containing protein, class 5
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0001710 mesodermal cell fate commitment IDA
 biological_processGO:0001711 endodermal cell fate commitment IDA
 biological_processGO:0001712 ectodermal cell fate commitment IDA
 biological_processGO:0001714 endodermal cell fate specification ISO
 biological_processGO:0001824 blastocyst development IEP
 biological_processGO:0001829 trophectodermal cell differentiation IGI
 biological_processGO:0001832 blastocyst growth IGI
 biological_processGO:0003130 BMP signaling pathway involved in heart induction ISO
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009786 regulation of asymmetric cell division IEP
 biological_processGO:0010033 response to organic substance IDA
 biological_processGO:0010468 regulation of gene expression ISO
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0010629 negative regulation of gene expression IDA
 biological_processGO:0019827 stem cell population maintenance IMP
 biological_processGO:0030718 germ-line stem cell population maintenance IMP
 biological_processGO:0032526 response to retinoic acid IDA
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0035019 somatic stem cell population maintenance ISO
 biological_processGO:0042789 mRNA transcription by RNA polymerase II IDA
 biological_processGO:0045165 cell fate commitment IMP
 biological_processGO:0045596 negative regulation of cell differentiation IGI
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0045955 negative regulation of calcium ion-dependent exocytosis IDA
 biological_processGO:0048863 stem cell differentiation IDA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IMP
 biological_processGO:0051898 negative regulation of protein kinase B signaling IMP
 biological_processGO:0060391 positive regulation of SMAD protein signal transduction ISO
 biological_processGO:0060795 cell fate commitment involved in formation of primary germ layer ISO
 biological_processGO:0060913 cardiac cell fate determination ISO
 biological_processGO:0060965 negative regulation of gene silencing by miRNA ISO
 biological_processGO:0090081 regulation of heart induction by regulation of canonical Wnt signaling pathway ISO
 biological_processGO:0090308 regulation of methylation-dependent chromatin silencing ISO
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005667 transcription factor complex ISO
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0017053 transcriptional repressor complex IDA
 cellular_componentGO:0044798 nuclear transcription factor complex IDA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001158 enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003714 transcription corepressor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0019955 cytokine binding IDA
 molecular_functionGO:0031490 chromatin DNA binding IDA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0035198 miRNA binding ISO
 molecular_functionGO:0043565 sequence-specific DNA binding ISO
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0046982 protein heterodimerization activity IDA
 molecular_functionGO:0070974 POU domain binding IEA
 molecular_functionGO:0071837 HMG box domain binding IEA


Pathways (from Reactome)
Pathway description
Transcriptional regulation of pluripotent stem cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001152 Leydig cell hyperplasia "increased number of interstitial cells of the seminiferous tubules that secrete testosterone" [J:45065]
Show

Allelic Composition: Cd2aptm1Shaw/Cd2ap+
Genetic Background: Not Specified

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Alpltm1(cre)Nagy/Alpl+,Pou5f1tm1Scho/Pou5f1tm1.1Scho
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Alpltm1(cre)Nagy/Alpl+,Pou5f1tm1Scho/Pou5f1tm1.1Scho
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Alpltm1(cre)Nagy/Alpl+,Pou5f1tm1Scho/Pou5f1tm1.1Scho
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pax4tm1Pgr/Pax4tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pou5f1tm1Jae/Pou5f1tm1Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Pou5f1tm1.1(cre/Esr1*)Yseg/Pou5f1+
Genetic Background: C57BL/6-Pou5f1tm1.1(cre/Esr1*)Yseg

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Alpltm1(cre)Nagy/Alpl+,Pou5f1tm1Scho/Pou5f1tm1.1Scho
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002718 abnormal inner cell mass "malformed or absent cells of the blastocyst that develop into the body of the embryo" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tulp1tvrm124/Tulp1tvrm124
Genetic Background: involves: C57BL/6J

 MP:0002777 absent ovarian follicles "lack of the sac-like structures in the ovaries that surround the ova" [J:42612, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Alpltm1(cre)Nagy/Alpl+,Pou5f1tm1Scho/Pou5f1tm1.1Scho
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004964 absent inner cell mass "absence of the cells of the blastocyst that develop into the body of the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Mxi1tm1Rdp/Mxi1tm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dazap1tm1.2Pyen/Dazap1tm1.2Pyen
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Mir34atm1.1Lhe/Mir34atm1.1Lhe,Pou5f1tm2Jae/Pou5f1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J

 MP:0008392 decreased primordial germ cell number "reduced number of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Alpltm1(cre)Nagy/Alpl+,Pou5f1tm1Scho/Pou5f1tm1.1Scho
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009361 abnormal primordial ovarian follicle morphology "any structural abnormality in the ovarian follicle in which the primary oocyte is surrounded by a single layer of flattened follicular cells; primordial follicles are indiscernible to the naked eye and develop to primary, secondary, and finally mature vesicular follicles" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Alpltm1(cre)Nagy/Alpl+,Pou5f1tm1Scho/Pou5f1tm1.1Scho
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Tg(CMV-GFP,-Smarcc2,-lacZ)#Stoy/0
Genetic Background: involves: 129S2/SvPas

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Mxi1tm1Rdp/Mxi1tm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0011183 abnormal primitive endoderm morphology "any structural anomaly of the monolayer of cells derived from and located on the surface of inner cell mass, directly facing the blastocoele, and is separated from the more centrally located epiblast by basal lamina; the primitive endoderm give rises to the visceral endoderm and the parietal endoderm" [PMID:21123814]
Show

Allelic Composition: Tulp1tvrm124/Tulp1tvrm124
Genetic Background: involves: C57BL/6J

 MP:0011411 abnormal gonadal ridge morphology "any structural anomaly of the elevation of thickened mesothelium and underlying mesenchyme found on the ventromedial border of the embryonic mesonephros in which the primordial germ cells become embedded, establishing it as the primordium of the testis or ovary" [MGI:anna]
Show

Allelic Composition: Alpltm1(cre)Nagy/Alpl+,Pou5f1tm1Scho/Pou5f1tm1.1Scho
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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