ENSDARG00000044774


Danio rerio

Features
Gene ID: ENSDARG00000044774
  
Biological name :pou5f3
  
Synonyms : pou5f3 / POU domain, class 5, transcription factor 3
  
Possible biological names infered from orthology : P20263 / POU5F1 / POU5F1B / POU5F2 / POU class 5 homeobox 1 / POU class 5 homeobox 1B / POU domain, class 5, transcription factor 1 / POU domain class 5, transcription factor 2 / Q01860 / Q06416 / Q8N7G0
  
Species: Danio rerio
  
Chr. number: 21
Strand: -1
Band:
Gene start: 13685853
Gene end: 13690712
  
Corresponding Affymetrix probe sets: Dr.258.1.S1_at (Zebrafish Array)   NM_131112_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000065816
NCBI entrez gene - 30333     See in Manteia.
RefSeq - NM_131112
RefSeq Peptide - NP_571187
swissprot - A0A0R4I9C7
ZFIN ID - ZDB-GENE-980526-485
Ensembl - ENSDARG00000044774
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Pou5f3ENSGALG00000031482Gallus gallus
 POU5F1ENSG00000204531Homo sapiens
 POU5F2ENSG00000248483Homo sapiens
 Q06416ENSG00000212993Homo sapiens
 P20263ENSMUSG00000024406Mus musculus
 Pou5f2ENSMUSG00000093668Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P56224 / pou3f3a / POU class 3 homeobox 3aENSDARG0000004203229
P79745 / pou3f3b / POU class 3 homeobox 3bENSDARG0000009589629
P79746 / pou3f2b / POU class 3 homeobox 2b / POU3F2* / P20265* / P31360* / POU class 3 homeobox 2* / POU domain, class 3, transcription factor 2*ENSDARG0000007626227
pou3f2a / POU class 3 homeobox 2aENSDARG0000007022026
pou2f2a / POU class 2 homeobox 2a / Q00196* / P09086* / POU2F2* / POU class 2 homeobox 2* / POU domain, class 2, transcription factor 2 *ENSDARG0000001965826
Q90482 / pou3f1 / POU class 3 homeobox 1 / Q03052* / P21952* / POU domain, class 3, transcription factor 1 *ENSDARG0000000982325
pou2f1b / POU class 2 homeobox 1b / P25425* / POU2F1* / P14859* / POU class 2 homeobox 1* / POU domain, class 2, transcription factor 1 *ENSDARG0000000799624
pou2f2a / POU class 2 homeobox 2a / Q00196* / P09086* / POU2F2* / POU class 2 homeobox 2* / POU domain, class 2, transcription factor 2 *ENSDARG0000003681624
pou2f3 / POU class 2 homeobox 3 / Q9UKI9*ENSDARG0000005238723
pou1f1 / POU class 1 homeobox 1 / P28069* / Q00286* / POU domain, class 1, transcription factor 1*ENSDARG0000005892419
zgc:158291ENSDARG0000004437518
pou4f2 / POU class 4 homeobox 2 / Q12837* / Q63934* / POU domain, class 4, transcription factor 2 *ENSDARG0000006973718
pou4f1 / POU class 4 homeobox 1 / Q01851*ENSDARG0000000555918
pou4f3 / Q90435 / POU class 4 homeobox 3 / Q15319*ENSDARG0000000620617


Protein motifs (from Interpro)
Interpro ID Name
 IPR000327  POU-specific domain
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR010982  Lambda repressor-like, DNA-binding domain superfamily
 IPR013847  POU domain
 IPR015585  POU domain-containing protein, class 5
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
Transcriptional regulation of pluripotent stem cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain quality , abnormal
Show

 ZFA:0000016 ectoderm ectoderm ventral region physical object quality , abnormal
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 ZFA:0000029 hindbrain hindbrain axon morphology , abnormal
hindbrain axon mislocalised , abnormal
hindbrain quality , abnormal
hindbrain morphology , abnormal
hindbrain disorganized , abnormal
hindbrain radial glial cell disorganized , abnormal
Show

 ZFA:0000037 anatomical structure anatomical structure decreased amount , abnormal
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 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary quality , abnormal
midbrain hindbrain boundary aplastic , abnormal
midbrain hindbrain boundary hypoplastic , abnormal
midbrain hindbrain boundary absent , abnormal
midbrain hindbrain boundary morphology , abnormal
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 ZFA:0000051 otic vesicle otic vesicle morphology , abnormal
otic vesicle decreased size , abnormal
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 ZFA:0000059 postoptic commissure postoptic commissure morphology , abnormal
postoptic commissure defasciculated , abnormal
postoptic commissure astrocyte mislocalised , abnormal
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 ZFA:0000071 shield shield decreased size , abnormal
shield malformed , abnormal
shield increased thickness , abnormal
Show

 ZFA:0000075 spinal cord spinal cord has fewer parts of type ventricular zone radial glial cell, abnormal
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 ZFA:0000084 yolk yolk morphology , abnormal
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 ZFA:0000086 EVL EVL physical object quality , abnormal
EVL epiboly delayed , abnormal
EVL lamellipodium increased amount , abnormal
EVL blastoderm cell morphology , abnormal
EVL blastoderm cell circular , abnormal
EVL poorly differentiated , abnormal
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 ZFA:0000088 YSL YSL morphology , abnormal
YSL actin filament spatial pattern , abnormal
YSL cortical cytoskeleton morphology , abnormal
YSL microtubule spatial pattern , abnormal
YSL microtubule disorganized , abnormal
YSL vesicle present , abnormal
YSL increased size , abnormal
Show

 ZFA:0000100 cerebellum cerebellum aplastic , abnormal
Show

 ZFA:0000109 forebrain forebrain commissural neuron axon guidance disrupted , abnormal
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 ZFA:0000111 germ ring germ ring morphology , abnormal
germ ring increased thickness , abnormal
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 ZFA:0000128 midbrain midbrain quality , abnormal
midbrain morphology , abnormal
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 ZFA:0000135 notochord notochord malformed , abnormal
notochord decreased length , abnormal
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 ZFA:0000150 pronephric duct pronephric duct morphology , abnormal
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 ZFA:0000155 somite somite fused with somite , abnormal
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 ZFA:0000217 inner ear inner ear quality , abnormal
inner ear decreased size , abnormal
inner ear lacks all parts of type otolith , abnormal
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 ZFA:0000282 sensory system sensory system quality , abnormal
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 ZFA:0000435 cranial nerve II cranial nerve II absent , abnormal
cranial nerve II decreased thickness , abnormal
cranial nerve II defasciculated , abnormal
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 ZFA:0000445 optic tectum optic tectum increased size , abnormal
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 ZFA:0000541 marginal blastomere marginal blastomere constricted , abnormal
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 ZFA:0000559 otolith organ otolith organ has fewer parts of type otolith , abnormal
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 ZFA:0000711 DEL DEL epiboly delayed , abnormal
DEL increased thickness , abnormal
DEL translucent , abnormal
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 ZFA:0001064 rhombomere rhombomere primary neuron crowded , abnormal
rhombomere primary neuron disorganized , abnormal
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 ZFA:0001094 whole organism whole organism decreased length , abnormal
whole organism wholly dorsalized , abnormal
whole organism embryo development arrested , abnormal
whole organism decreased amount , abnormal
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 ZFA:0001108 anterior commissure anterior commissure morphology , abnormal
anterior commissure defasciculated , abnormal
anterior commissure astrocyte mislocalised , abnormal
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 ZFA:0001114 head head decreased size , abnormal
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 ZFA:0001115 trunk trunk decreased length , abnormal
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 ZFA:0001117 post-vent region post-vent region curved ventral , abnormal
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 ZFA:0001120 neuroectoderm neuroectoderm increased size , abnormal
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 ZFA:0001176 blastoderm blastoderm decreased size , abnormal
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 ZFA:0001178 non neural ectoderm non neural ectoderm decreased size , abnormal
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 ZFA:0001376 presumptive ectoderm presumptive ectoderm ventral region physical object quality , abnormal
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 ZFA:0001617 otolith otolith quality , abnormal
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 ZFA:0001692 hindbrain commissure hindbrain commissure neuron decreased amount , abnormal
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 ZFA:0009242 primary neuron primary neuron axon fasciculation , abnormal
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 ZFA:0009292 radial glial cell radial glial cell cell projection disorganized , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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