ENSG00000204531


Homo sapiens

Features
Gene ID: ENSG00000204531
  
Biological name :POU5F1
  
Synonyms : POU5F1 / POU class 5 homeobox 1 / Q01860
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: p21.33
Gene start: 31164337
Gene end: 31180731
  
Corresponding Affymetrix probe sets: 208286_x_at (Human Genome U133 Plus 2.0 Array)   210265_x_at (Human Genome U133 Plus 2.0 Array)   210905_x_at (Human Genome U133 Plus 2.0 Array)   214532_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000484778
Ensembl peptide - ENSP00000491205
Ensembl peptide - ENSP00000475512
Ensembl peptide - ENSP00000475880
Ensembl peptide - ENSP00000259915
Ensembl peptide - ENSP00000389359
Ensembl peptide - ENSP00000425083
Ensembl peptide - ENSP00000425479
NCBI entrez gene - 5460     See in Manteia.
OMIM - 164177
RefSeq - NM_001173531
RefSeq - NM_001285987
RefSeq - NM_002701
RefSeq - NM_203289
RefSeq - NM_001285986
RefSeq Peptide - NP_001167002
RefSeq Peptide - NP_001272916
RefSeq Peptide - NP_002692
RefSeq Peptide - NP_976034
RefSeq Peptide - NP_001272915
swissprot - U3KQH6
swissprot - A0A1W2PP83
swissprot - D2IYK3
swissprot - F2Z381
swissprot - M1S623
swissprot - Q01860
Ensembl - ENSG00000204531
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pou5f3ENSDARG00000044774Danio rerio
 Pou5f3ENSGALG00000031482Gallus gallus
 P20263ENSMUSG00000024406Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q06416 / POU5F1B / POU class 5 homeobox 1BENSG0000021299396
POU5F2 / Q8N7G0 / POU domain class 5, transcription factor 2ENSG0000024848347
P20264 / POU3F3 / POU class 3 homeobox 3ENSG0000019891436
P14859 / POU2F1 / POU class 2 homeobox 1ENSG0000014319035
P49335 / POU3F4 / POU class 3 homeobox 4ENSG0000019676735
POU2F3 / Q9UKI9 / POU class 2 homeobox 3ENSG0000013770935
P09086 / POU2F2 / POU class 2 homeobox 2ENSG0000002827734
POU3F1 / Q03052 / POU class 3 homeobox 1ENSG0000018566833
P20265 / POU3F2 / POU class 3 homeobox 2ENSG0000018448632
P28069 / POU1F1 / POU class 1 homeobox 1ENSG0000006483529
POU4F2 / Q12837 / POU class 4 homeobox 2ENSG0000015161528
POU4F3 / Q15319 / POU class 4 homeobox 3ENSG0000009101027
POU4F1 / Q01851 / POU class 4 homeobox 1ENSG0000015219226


Protein motifs (from Interpro)
Interpro ID Name
 IPR000327  POU-specific domain
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR010982  Lambda repressor-like, DNA-binding domain superfamily
 IPR013847  POU domain
 IPR015585  POU domain-containing protein, class 5
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001714 endodermal cell fate specification IDA
 biological_processGO:0001824 blastocyst development ISS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II ISS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009611 response to wounding IEP
 biological_processGO:0009653 anatomical structure morphogenesis TAS
 biological_processGO:0009786 regulation of asymmetric cell division ISS
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0010628 positive regulation of gene expression ISS
 biological_processGO:0010629 negative regulation of gene expression ISS
 biological_processGO:0035019 somatic stem cell population maintenance IMP
 biological_processGO:0042789 mRNA transcription by RNA polymerase II ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0060965 negative regulation of gene silencing by miRNA IMP
 cellular_componentGO:0000790 nuclear chromatin ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISS
 molecular_functionGO:0001158 enhancer sequence-specific DNA binding ISS
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019955 cytokine binding ISS
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0035198 miRNA binding IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Transcriptional regulation of pluripotent stem cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000111704 NANOG / Q9H9S0 / Nanog homeobox  / reaction / complex
 ENSG00000168610 STAT3 / P40763 / signal transducer and activator of transcription 3  / reaction / complex
 ENSG00000181449 SOX2 / P48431 / SRY-box 2  / reaction / complex






 

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