ENSG00000111704


Homo sapiens

Features
Gene ID: ENSG00000111704
  
Biological name :NANOG
  
Synonyms : NANOG / Nanog homeobox / Q9H9S0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: p13.31
Gene start: 7787794
Gene end: 7799141
  
Corresponding Affymetrix probe sets: 220184_at (Human Genome U133 Plus 2.0 Array)   231079_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000229307
Ensembl peptide - ENSP00000435288
Ensembl peptide - ENSP00000444434
NCBI entrez gene - 79923     See in Manteia.
OMIM - 607937
RefSeq - XM_011520852
RefSeq - NM_001297698
RefSeq - NM_024865
RefSeq - XM_011520850
RefSeq Peptide - NP_079141
RefSeq Peptide - NP_001284627
swissprot - Q9H9S0
swissprot - F5GZI2
Ensembl - ENSG00000111704
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NANOGENSGALG00000027772Gallus gallus
 NanogENSMUSG00000012396Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NANOGP8 / Nanog homeobox retrogene P8ENSG0000025519299


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001714 endodermal cell fate specification IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0019827 stem cell population maintenance IEP
 biological_processGO:0030154 cell differentiation IEP
 biological_processGO:0035019 somatic stem cell population maintenance IMP
 biological_processGO:0045595 regulation of cell differentiation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:1903507 negative regulation of nucleic acid-templated transcription IEA
 cellular_componentGO:0005634 nucleus IC
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IC
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0003714 transcription corepressor activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA


Pathways (from Reactome)
Pathway description
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Transcriptional regulation of pluripotent stem cells
Interleukin-4 and Interleukin-13 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000204531 POU5F1 / Q01860 / POU class 5 homeobox 1  / reaction / complex
 ENSG00000181449 SOX2 / P48431 / SRY-box 2  / complex / reaction






 

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