ENSG00000028277


Homo sapiens

Features
Gene ID: ENSG00000028277
  
Biological name :POU2F2
  
Synonyms : P09086 / POU2F2 / POU class 2 homeobox 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: q13.2
Gene start: 42086110
Gene end: 42196585
  
Corresponding Affymetrix probe sets: 211660_at (Human Genome U133 Plus 2.0 Array)   211771_s_at (Human Genome U133 Plus 2.0 Array)   227749_at (Human Genome U133 Plus 2.0 Array)   228343_at (Human Genome U133 Plus 2.0 Array)   229750_at (Human Genome U133 Plus 2.0 Array)   235661_at (Human Genome U133 Plus 2.0 Array)   242866_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000471890
Ensembl peptide - ENSP00000454179
Ensembl peptide - ENSP00000475664
Ensembl peptide - ENSP00000490838
Ensembl peptide - ENSP00000490407
Ensembl peptide - ENSP00000490243
Ensembl peptide - ENSP00000486228
Ensembl peptide - ENSP00000476062
Ensembl peptide - ENSP00000339369
Ensembl peptide - ENSP00000373992
Ensembl peptide - ENSP00000431603
Ensembl peptide - ENSP00000436100
Ensembl peptide - ENSP00000436988
Ensembl peptide - ENSP00000437224
Ensembl peptide - ENSP00000452930
Ensembl peptide - ENSP00000453255
Ensembl peptide - ENSP00000453995
NCBI entrez gene - 5452     See in Manteia.
OMIM - 164176
RefSeq - XM_017026896
RefSeq - NM_002698
RefSeq - XM_005259010
RefSeq - XM_011527040
RefSeq - XM_011527041
RefSeq - XM_011527042
RefSeq - XM_011527043
RefSeq - XM_017026884
RefSeq - XM_017026885
RefSeq - XM_017026886
RefSeq - XM_017026887
RefSeq - XM_017026888
RefSeq - XM_017026889
RefSeq - XM_017026890
RefSeq - XM_017026891
RefSeq - XM_017026892
RefSeq - XM_017026893
RefSeq - XM_017026894
RefSeq - XM_017026895
RefSeq - NM_001207025
RefSeq - NM_001207026
RefSeq - NM_001247994
RefSeq Peptide - NP_001193954
RefSeq Peptide - NP_001193955
RefSeq Peptide - NP_001234923
RefSeq Peptide - NP_002689
swissprot - A0A1B0GUT9
swissprot - H0YKT2
swissprot - H0YLL6
swissprot - H0YNG1
swissprot - H0YNW1
swissprot - E9PR37
swissprot - P09086
swissprot - U3KQ96
swissprot - U3KQN1
swissprot - A0A0D9SF23
swissprot - M0R1I6
swissprot - B5ME60
swissprot - A0A1B0GW97
swissprot - A0A1B0GV81
Ensembl - ENSG00000028277
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pou2f2aENSDARG00000036816Danio rerio
 pou2f2aENSDARG00000019658Danio rerio
 Pou2f2ENSMUSG00000008496Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P14859 / POU2F1 / POU class 2 homeobox 1ENSG0000014319053
POU2F3 / Q9UKI9 / POU class 2 homeobox 3ENSG0000013770944
P20264 / POU3F3 / POU class 3 homeobox 3ENSG0000019891430
P20265 / POU3F2 / POU class 3 homeobox 2ENSG0000018448629
P49335 / POU3F4 / POU class 3 homeobox 4ENSG0000019676728
POU3F1 / Q03052 / POU class 3 homeobox 1ENSG0000018566828
POU5F1 / Q01860 / POU class 5 homeobox 1ENSG0000020453126
Q06416 / POU5F1B / POU class 5 homeobox 1BENSG0000021299325
P28069 / POU1F1 / POU class 1 homeobox 1ENSG0000006483522
POU4F1 / Q01851 / POU class 4 homeobox 1ENSG0000015219222
POU4F3 / Q15319 / POU class 4 homeobox 3ENSG0000009101021
POU4F2 / Q12837 / POU class 4 homeobox 2ENSG0000015161521
POU5F2 / Q8N7G0 / POU domain class 5, transcription factor 2ENSG0000024848318


Protein motifs (from Interpro)
Interpro ID Name
 IPR000327  POU-specific domain
 IPR000972  Octamer-binding transcription factor
 IPR001356  Homeobox domain
 IPR001387  Cro/C1-type helix-turn-helix domain
 IPR009057  Homeobox-like domain superfamily
 IPR010982  Lambda repressor-like, DNA-binding domain superfamily
 IPR013847  POU domain
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002335 mature B cell differentiation IEA
 biological_processGO:0002380 immunoglobulin secretion involved in immune response IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0006959 humoral immune response TAS
 biological_processGO:0042795 snRNA transcription by RNA polymerase II TAS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048305 immunoglobulin secretion IEA
 biological_processGO:0048469 cell maturation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
RNA polymerase II transcribes snRNA genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000166478 P52747 / ZNF143 / zinc finger protein 143  / reaction / complex
 ENSG00000185591 SP1 / P08047 / Sp1 transcription factor  / reaction / complex






 

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