ENSG00000185591


Homo sapiens

Features
Gene ID: ENSG00000185591
  
Biological name :SP1
  
Synonyms : P08047 / SP1 / Sp1 transcription factor
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q13.13
Gene start: 53380176
Gene end: 53416446
  
Corresponding Affymetrix probe sets: 1553685_s_at (Human Genome U133 Plus 2.0 Array)   214732_at (Human Genome U133 Plus 2.0 Array)   224754_at (Human Genome U133 Plus 2.0 Array)   224760_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000329357
Ensembl peptide - ENSP00000404263
Ensembl peptide - ENSP00000457804
Ensembl peptide - ENSP00000458133
NCBI entrez gene - 6667     See in Manteia.
OMIM - 189906
RefSeq - XM_011538696
RefSeq - NM_001251825
RefSeq - NM_003109
RefSeq - NM_138473
RefSeq Peptide - NP_001238754
RefSeq Peptide - NP_003100
RefSeq Peptide - NP_612482
swissprot - H3BUU5
swissprot - H3BVI2
swissprot - P08047
Ensembl - ENSG00000185591
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sp1ENSDARG00000088347Danio rerio
 SP1ENSGALG00000035487Gallus gallus
 Sp1ENSMUSG00000001280Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SP4 / Q02446 / Sp4 transcription factorENSG0000010586638
SP3 / Q02447 / Sp3 transcription factorENSG0000017284536
SP2 / Q02086 / Sp2 transcription factorENSG0000016718225
SP8 / Q8IXZ3 / Sp8 transcription factorENSG0000016465120
SP9 / P0CG40 / Sp9 transcription factorENSG0000021723619
SP5 / Q6BEB4 / Sp5 transcription factorENSG0000020433517
SP7 / Q8TDD2 / Sp7 transcription factorENSG0000017037416
SP6 / Q3SY56 / Sp6 transcription factorENSG0000018912015
KLF11 / O14901 / Kruppel like factor 11ENSG0000017205914
KLF10 / Q13118 / Kruppel like factor 10ENSG0000015509013
KLF9 / Q13886 / Kruppel like factor 9ENSG0000011913810
KLF16 / Q9BXK1 / Kruppel like factor 16ENSG0000012991110
KLF13 / Q9Y2Y9 / Kruppel like factor 13ENSG0000016992610
KLF14 / Kruppel like factor 14ENSG0000026626510


Protein motifs (from Interpro)
Interpro ID Name
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR030449  Transcription factor Sp1
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0016032 viral process IEA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0042795 snRNA transcription by RNA polymerase II TAS
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IMP
 biological_processGO:0043923 positive regulation by host of viral transcription IDA
 biological_processGO:0045540 regulation of cholesterol biosynthetic process TAS
 biological_processGO:0045766 positive regulation of angiogenesis IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II TAS
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0100057 regulation of phenotypic switching by transcription from RNA polymerase II promoter IC
 biological_processGO:1904828 positive regulation of hydrogen sulfide biosynthetic process IDA
 biological_processGO:1905564 positive regulation of vascular endothelial cell proliferation IMP
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0017053 transcriptional repressor complex IDA
 cellular_componentGO:0032993 protein-DNA complex ISS
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISS
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000987 proximal promoter sequence-specific DNA binding ISS
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding ISS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001103 RNA polymerase II repressing transcription factor binding ISS
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0035035 histone acetyltransferase binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0042826 histone deacetylase binding IPI
 molecular_functionGO:0043425 bHLH transcription factor binding ISS
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070491 repressing transcription factor binding IPI
 molecular_functionGO:0071837 HMG box domain binding IPI


Pathways (from Reactome)
Pathway description
PPARA activates gene expression
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Activation of gene expression by SREBF (SREBP)
Oncogene Induced Senescence
RNA polymerase II transcribes snRNA genes
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000120837 NFYB / P25208 / nuclear transcription factor Y subunit beta  / reaction / complex
 ENSG00000175387 SMAD2 / Q15796 / SMAD family member 2  / reaction / complex
 ENSG00000072310 P36956 / SREBF1 / sterol regulatory element binding transcription factor 1  / reaction / complex
 ENSG00000066136 NFYC / Q13952 / nuclear transcription factor Y subunit gamma  / complex / reaction
 ENSG00000143190 P14859 / POU2F1 / POU class 2 homeobox 1  / complex / reaction
 ENSG00000101412 E2F1 / Q01094 / E2F transcription factor 1  / reaction / complex
 ENSG00000166949 SMAD3 / P84022 / SMAD family member 3  / reaction / complex
 ENSG00000141646 SMAD4 / Q13485 / SMAD family member 4  / reaction / complex
 ENSG00000001167 NFYA / P23511 / nuclear transcription factor Y subunit alpha  / complex / reaction
 ENSG00000166478 P52747 / ZNF143 / zinc finger protein 143  / reaction / complex
 ENSG00000028277 P09086 / POU2F2 / POU class 2 homeobox 2  / reaction / complex
 ENSG00000007968 E2F2 / Q14209 / E2F transcription factor 2  / reaction / complex
 ENSG00000112242 E2F3 / O00716 / E2F transcription factor 3  / complex / reaction
 ENSG00000198911 Q12772 / SREBF2 / sterol regulatory element binding transcription factor 2  / reaction / complex
 ENSG00000198176 TFDP1 / Q14186 / transcription factor Dp-1  / complex / reaction
 ENSG00000114126 TFDP2 / Q14188 / transcription factor Dp-2  / complex / reaction






 

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