ENSG00000007968


Homo sapiens

Features
Gene ID: ENSG00000007968
  
Biological name :E2F2
  
Synonyms : E2F2 / E2F transcription factor 2 / Q14209
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p36.12
Gene start: 23506430
Gene end: 23531220
  
Corresponding Affymetrix probe sets: 207042_at (Human Genome U133 Plus 2.0 Array)   228361_at (Human Genome U133 Plus 2.0 Array)   235582_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000355249
NCBI entrez gene - 1870     See in Manteia.
OMIM - 600426
RefSeq - XM_011540871
RefSeq - NM_004091
RefSeq - XM_011540868
RefSeq - XM_011540870
RefSeq Peptide - NP_004082
swissprot - Q14209
Ensembl - ENSG00000007968
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 E2F2ENSDARG00000079233Danio rerio
 E2f2ENSMUSG00000018983Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
E2F3 / O00716 / E2F transcription factor 3ENSG0000011224249
E2F1 / Q01094 / E2F transcription factor 1ENSG0000010141240
E2F4 / Q16254 / E2F transcription factor 4ENSG0000020525030
E2F5 / Q15329 / E2F transcription factor 5ENSG0000013374028
E2F6 / O75461 / E2F transcription factor 6ENSG0000016901627


Protein motifs (from Interpro)
Interpro ID Name
 IPR003316  E2F/DP family, winged-helix DNA-binding domain
 IPR015633  E2F Family
 IPR032198  E2F transcription factor, CC-MB domain
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily
 IPR037241  E2F-DP heterodimerization region


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator IEA
 biological_processGO:1903671 negative regulation of sprouting angiogenesis IGI
 biological_processGO:1990086 lens fiber cell apoptotic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001047 core promoter binding IDA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding TAS
 molecular_functionGO:0003700 DNA-binding transcription factor activity NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
Oncogene Induced Senescence
CDC6 association with the ORC:origin complex
Cyclin D associated events in G1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000139687 RB1 / P06400 / RB transcriptional corepressor 1  / complex / reaction
 ENSG00000185591 SP1 / P08047 / Sp1 transcription factor  / complex / reaction
 ENSG00000198176 TFDP1 / Q14186 / transcription factor Dp-1  / complex
 ENSG00000114126 TFDP2 / Q14188 / transcription factor Dp-2  / complex






 

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