ENSG00000198176


Homo sapiens

Features
Gene ID: ENSG00000198176
  
Biological name :TFDP1
  
Synonyms : Q14186 / TFDP1 / transcription factor Dp-1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: 1
Band: q34
Gene start: 113584721
Gene end: 113641470
  
Corresponding Affymetrix probe sets: 204147_s_at (Human Genome U133 Plus 2.0 Array)   212330_at (Human Genome U133 Plus 2.0 Array)   242939_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000438450
Ensembl peptide - ENSP00000364519
Ensembl peptide - ENSP00000386145
Ensembl peptide - ENSP00000401389
NCBI entrez gene - 7027     See in Manteia.
OMIM - 189902
RefSeq - XM_017020722
RefSeq - XM_011537520
RefSeq - XM_017020717
RefSeq - XM_017020718
RefSeq - XM_017020719
RefSeq - XM_017020720
RefSeq - XM_017020721
RefSeq - NM_007111
RefSeq - XM_005268327
RefSeq - XM_005268328
RefSeq - XM_005268331
RefSeq - XM_011537518
RefSeq - XM_011537519
RefSeq Peptide - NP_009042
swissprot - F5H452
swissprot - A0A024RDY4
swissprot - Q14186
swissprot - Q5JSB5
swissprot - Q5JSB6
Ensembl - ENSG00000198176
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tfdp1aENSDARG00000019293Danio rerio
 ENSGALG00000016823Gallus gallus
 Tfdp1ENSMUSG00000038482Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TFDP3 / Q5H9I0 / transcription factor Dp family member 3ENSG0000018343474
TFDP2 / Q14188 / transcription factor Dp-2ENSG0000011412663


Protein motifs (from Interpro)
Interpro ID Name
 IPR003316  E2F/DP family, winged-helix DNA-binding domain
 IPR014889  Transcription factor DP, C-terminal
 IPR015648  Transcription factor DP
 IPR028313  Transcription factor DP1
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily
 IPR037241  E2F-DP heterodimerization region


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II TAS
 biological_processGO:0070317 negative regulation of G0 to G1 transition TAS
 biological_processGO:0070345 negative regulation of fat cell proliferation ISS
 biological_processGO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003713 transcription coactivator activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0019904 protein domain specific binding IPI


Pathways (from Reactome)
Pathway description
Activation of NOXA and translocation to mitochondria
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
Activation of PUMA and translocation to mitochondria
G0 and Early G1
Pre-NOTCH Transcription and Translation
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Oxidative Stress Induced Senescence
Oncogene Induced Senescence
Activation of E2F1 target genes at G1/S
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
Cyclin A:Cdk2-associated events at S phase entry
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100395 Q969R5 / L3MBTL2 / L3MBTL2, polycomb repressive complex 1 subunit  / complex / reaction
 ENSG00000110092 CCND1 / P24385 / cyclin D1  / reaction
 ENSG00000111276 CDKN1B / P46527 / cyclin dependent kinase inhibitor 1B  / reaction
 ENSG00000174197 MGA / Q8IWI9 / MGA, MAX dimerization protein  / reaction / complex
 ENSG00000125952 MAX / P61244 / MYC associated factor X  / complex / reaction
 ENSG00000124762 CDKN1A / P38936 / cyclin dependent kinase inhibitor 1A  / reaction
 ENSG00000175387 SMAD2 / Q15796 / SMAD family member 2  / reaction / complex
 ENSG00000123374 CDK2 / P24941 / cyclin dependent kinase 2  / reaction / complex
 ENSG00000103479 RBL2 / Q08999 / RB transcriptional corepressor like 2  / complex
 ENSG00000135446 CDK4 / P11802 / cyclin dependent kinase 4  / reaction
 ENSG00000139687 RB1 / P06400 / RB transcriptional corepressor 1  / complex / reaction
 ENSG00000141510 TP53 / P04637 / tumor protein p53  / reaction / complex
 ENSG00000101412 E2F1 / Q01094 / E2F transcription factor 1  / complex
 ENSG00000166949 SMAD3 / P84022 / SMAD family member 3  / complex / reaction
 ENSG00000156374 PCGF6 / Q9BYE7 / polycomb group ring finger 6  / complex / reaction
 ENSG00000141646 SMAD4 / Q13485 / SMAD family member 4  / complex / reaction
 ENSG00000015153 YAF2 / Q8IY57 / YY1 associated factor 2  / reaction / complex
 ENSG00000181090 EHMT1 / Q9H9B1 / euchromatic histone lysine methyltransferase 1  / complex / reaction
 ENSG00000121481 RNF2 / Q99496 / ring finger protein 2  / complex / reaction
 ENSG00000204227 RING1 / Q06587 / ring finger protein 1  / reaction / complex
 ENSG00000116478 HDAC1 / Q13547 / histone deacetylase 1  / complex / reaction
 ENSG00000204371 EHMT2 / Q96KQ7 / euchromatic histone lysine methyltransferase 2  / complex / reaction
 ENSG00000112242 E2F3 / O00716 / E2F transcription factor 3  / complex
 ENSG00000162521 RBBP4 / Q09028 / RB binding protein 4, chromatin remodeling factor  / reaction / complex
 ENSG00000133740 E2F5 / Q15329 / E2F transcription factor 5  / complex
 ENSG00000102054 RBBP7 / Q16576 / RB binding protein 7, chromatin remodeling factor  / complex / reaction
 ENSG00000178691 SUZ12 / Q15022 / SUZ12 polycomb repressive complex 2 subunit  / reaction / complex
 ENSG00000106462 EZH2 / Q15910 / enhancer of zeste 2 polycomb repressive complex 2 subunit  / complex / reaction
 ENSG00000205250 E2F4 / Q16254 / E2F transcription factor 4  / complex
 ENSG00000120616 EPC1 / Q9H2F5 / enhancer of polycomb homolog 1  / reaction / complex
 ENSG00000074266 EED / O75530 / embryonic ectoderm development  / complex / reaction
 ENSG00000122565 CBX3 / Q13185 / chromobox 3  / reaction / complex
 ENSG00000185591 SP1 / P08047 / Sp1 transcription factor  / reaction / complex
 ENSG00000080839 RBL1 / P28749 / RB transcriptional corepressor like 1  / complex
 ENSG00000169016 E2F6 / O75461 / E2F transcription factor 6  / complex / reaction
 ENSG00000007968 E2F2 / Q14209 / E2F transcription factor 2  / complex






 

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