ENSG00000121481


Homo sapiens

Features
Gene ID: ENSG00000121481
  
Biological name :RNF2
  
Synonyms : Q99496 / ring finger protein 2 / RNF2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q25.3
Gene start: 185045364
Gene end: 185102608
  
Corresponding Affymetrix probe sets: 205215_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000356479
Ensembl peptide - ENSP00000356480
Ensembl peptide - ENSP00000400722
NCBI entrez gene - 6045     See in Manteia.
OMIM - 608985
RefSeq - XM_011509852
RefSeq - NM_007212
RefSeq - XM_005245413
RefSeq - XM_011509851
RefSeq Peptide - NP_009143
swissprot - Q99496
swissprot - X6RFN3
Ensembl - ENSG00000121481
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rnf2ENSDARG00000010381Danio rerio
 RNF2ENSGALG00000037219Gallus gallus
 Rnf2ENSMUSG00000026484Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RING1 / Q06587 / ring finger protein 1ENSG0000020422765


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR032443  RAWUL domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISS
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0001702 gastrulation with mouth forming second IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007281 germ cell development IEA
 biological_processGO:0009948 anterior/posterior axis specification IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0016574 histone ubiquitination IEA
 biological_processGO:0035518 histone H2A monoubiquitination IDA
 biological_processGO:0036353 histone H2A-K119 monoubiquitination ISS
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IMP
 biological_processGO:0070317 negative regulation of G0 to G1 transition TAS
 cellular_componentGO:0000151 ubiquitin ligase complex IDA
 cellular_componentGO:0000791 euchromatin IEA
 cellular_componentGO:0000792 heterochromatin IEA
 cellular_componentGO:0001739 sex chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0031519 PcG protein complex IDA
 cellular_componentGO:0035102 PRC1 complex IDA
 cellular_componentGO:0071339 MLL1 complex IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA
 molecular_functionGO:0071535 RING-like zinc finger domain binding IPI


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription cofactors
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA methylation proteins
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of PTEN gene transcription
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100395 Q969R5 / L3MBTL2 / L3MBTL2, polycomb repressive complex 1 subunit  / complex
 ENSG00000015153 YAF2 / Q8IY57 / YY1 associated factor 2  / complex
 ENSG00000174197 MGA / Q8IWI9 / MGA, MAX dimerization protein  / complex / reaction
 ENSG00000156374 PCGF6 / Q9BYE7 / polycomb group ring finger 6  / complex
 ENSG00000125952 MAX / P61244 / MYC associated factor X  / reaction / complex
 ENSG00000122565 CBX3 / Q13185 / chromobox 3  / reaction / complex
 ENSG00000181090 EHMT1 / Q9H9B1 / euchromatic histone lysine methyltransferase 1  / complex / reaction
 ENSG00000204371 EHMT2 / Q96KQ7 / euchromatic histone lysine methyltransferase 2  / reaction / complex
 ENSG00000169016 E2F6 / O75461 / E2F transcription factor 6  / complex / reaction
 ENSG00000198176 TFDP1 / Q14186 / transcription factor Dp-1  / complex / reaction






 

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