ENSG00000015153


Homo sapiens

Features
Gene ID: ENSG00000015153
  
Biological name :YAF2
  
Synonyms : Q8IY57 / YAF2 / YY1 associated factor 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q12
Gene start: 42157104
Gene end: 42238349
  
Corresponding Affymetrix probe sets: 206238_s_at (Human Genome U133 Plus 2.0 Array)   244783_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000450394
Ensembl peptide - ENSP00000450097
Ensembl peptide - ENSP00000451626
Ensembl peptide - ENSP00000328004
Ensembl peptide - ENSP00000370167
Ensembl peptide - ENSP00000439256
Ensembl peptide - ENSP00000447217
Ensembl peptide - ENSP00000447686
Ensembl peptide - ENSP00000447863
Ensembl peptide - ENSP00000448291
Ensembl peptide - ENSP00000448312
Ensembl peptide - ENSP00000448533
NCBI entrez gene - 10138     See in Manteia.
OMIM - 607534
RefSeq - XM_017018670
RefSeq - NM_001190977
RefSeq - NM_001190979
RefSeq - NM_001190980
RefSeq - NM_001320080
RefSeq - NM_005748
RefSeq - XM_006719184
RefSeq - XM_011537728
RefSeq Peptide - NP_001307009
RefSeq Peptide - NP_005739
RefSeq Peptide - NP_001177906
RefSeq Peptide - NP_001177908
RefSeq Peptide - NP_001177909
swissprot - G3V219
swissprot - F8VRE5
swissprot - F8VZR2
swissprot - F8W0B9
swissprot - G3V1X5
swissprot - Q8IY57
swissprot - A0A0B4J255
swissprot - G3V212
Ensembl - ENSG00000015153
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 yaf2ENSDARG00000015966Danio rerio
 YAF2ENSGALG00000009540Gallus gallus
 Yaf2ENSMUSG00000022634Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RYBP / Q8N488 / RING1 and YY1 binding proteinENSG0000016360253


Protein motifs (from Interpro)
Interpro ID Name
 IPR001876  Zinc finger, RanBP2-type
 IPR033774  Yaf2/RYBP C-terminal binding motif
 IPR036443  Zinc finger, RanBP2-type superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0070317 negative regulation of G0 to G1 transition TAS
 biological_processGO:1903506 regulation of nucleic acid-templated transcription IEA
 biological_processGO:1903507 negative regulation of nucleic acid-templated transcription IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0003713 transcription coactivator activity IDA
 molecular_functionGO:0003714 transcription corepressor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000204227 RING1 / Q06587 / ring finger protein 1  / complex
 ENSG00000204371 EHMT2 / Q96KQ7 / euchromatic histone lysine methyltransferase 2  / reaction / complex
 ENSG00000122565 CBX3 / Q13185 / chromobox 3  / complex / reaction
 ENSG00000125952 MAX / P61244 / MYC associated factor X  / complex / reaction
 ENSG00000174197 MGA / Q8IWI9 / MGA, MAX dimerization protein  / reaction / complex
 ENSG00000181090 EHMT1 / Q9H9B1 / euchromatic histone lysine methyltransferase 1  / reaction / complex
 ENSG00000100395 Q969R5 / L3MBTL2 / L3MBTL2, polycomb repressive complex 1 subunit  / complex
 ENSG00000156374 PCGF6 / Q9BYE7 / polycomb group ring finger 6  / complex
 ENSG00000198176 TFDP1 / Q14186 / transcription factor Dp-1  / reaction / complex
 ENSG00000169016 E2F6 / O75461 / E2F transcription factor 6  / reaction / complex
 ENSG00000121481 RNF2 / Q99496 / ring finger protein 2  / complex






 

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