ENSG00000204227


Homo sapiens

Features
Gene ID: ENSG00000204227
  
Biological name :RING1
  
Synonyms : Q06587 / RING1 / ring finger protein 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p21.32
Gene start: 33208495
Gene end: 33212722
  
Corresponding Affymetrix probe sets: 208371_s_at (Human Genome U133 Plus 2.0 Array)   35685_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000363787
NCBI entrez gene - 6015     See in Manteia.
OMIM - 602045
RefSeq - NM_002931
RefSeq Peptide - NP_002922
swissprot - A0A1U9X8F2
swissprot - Q06587
Ensembl - ENSG00000204227
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Ring1ENSMUSG00000024325Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RNF2 / Q99496 / ring finger protein 2ENSG0000012148153


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR032443  RAWUL domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0009952 anterior/posterior pattern specification IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0016574 histone ubiquitination IEA
 biological_processGO:0035518 histone H2A monoubiquitination IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0048593 camera-type eye morphogenesis IEA
 biological_processGO:0050790 regulation of catalytic activity IEA
 biological_processGO:0070317 negative regulation of G0 to G1 transition TAS
 cellular_componentGO:0000151 ubiquitin ligase complex IEA
 cellular_componentGO:0001739 sex chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0031519 PcG protein complex IDA
 cellular_componentGO:0035102 PRC1 complex IDA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0097027 ubiquitin-protein transferase activator activity IEA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription cofactors
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA methylation proteins
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of PTEN gene transcription
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100395 Q969R5 / L3MBTL2 / L3MBTL2, polycomb repressive complex 1 subunit  / complex
 ENSG00000015153 YAF2 / Q8IY57 / YY1 associated factor 2  / complex
 ENSG00000198176 TFDP1 / Q14186 / transcription factor Dp-1  / complex / reaction
 ENSG00000169016 E2F6 / O75461 / E2F transcription factor 6  / reaction / complex
 ENSG00000204371 EHMT2 / Q96KQ7 / euchromatic histone lysine methyltransferase 2  / reaction / complex
 ENSG00000173889 PHC3 / Q8NDX5 / polyhomeotic homolog 3  / complex
 ENSG00000122565 CBX3 / Q13185 / chromobox 3  / complex / reaction
 ENSG00000125952 MAX / P61244 / MYC associated factor X  / complex / reaction
 ENSG00000174197 MGA / Q8IWI9 / MGA, MAX dimerization protein  / reaction / complex
 ENSG00000181090 EHMT1 / Q9H9B1 / euchromatic histone lysine methyltransferase 1  / reaction / complex
 ENSG00000156374 PCGF6 / Q9BYE7 / polycomb group ring finger 6  / complex
 ENSG00000111752 PHC1 / P78364 / polyhomeotic homolog 1  / complex
 ENSG00000168283 BMI1 / P35226 / BMI1 proto-oncogene, polycomb ring finger  / complex
 ENSG00000163602 RYBP / Q8N488 / RING1 and YY1 binding protein  / complex
 ENSG00000277258 PCGF2 / P35227 / polycomb group ring finger 2  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr