ENSG00000173889


Homo sapiens

Features
Gene ID: ENSG00000173889
  
Biological name :PHC3
  
Synonyms : PHC3 / polyhomeotic homolog 3 / Q8NDX5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: q26.2
Gene start: 170086732
Gene end: 170181749
  
Corresponding Affymetrix probe sets: 1552644_a_at (Human Genome U133 Plus 2.0 Array)   215521_at (Human Genome U133 Plus 2.0 Array)   220328_at (Human Genome U133 Plus 2.0 Array)   226508_at (Human Genome U133 Plus 2.0 Array)   238693_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000419089
Ensembl peptide - ENSP00000419899
Ensembl peptide - ENSP00000420713
Ensembl peptide - ENSP00000420454
Ensembl peptide - ENSP00000420294
Ensembl peptide - ENSP00000420271
Ensembl peptide - ENSP00000417360
Ensembl peptide - ENSP00000417540
Ensembl peptide - ENSP00000417633
Ensembl peptide - ENSP00000417860
Ensembl peptide - ENSP00000418039
Ensembl peptide - ENSP00000418835
NCBI entrez gene - 80012     See in Manteia.
RefSeq - XM_017007239
RefSeq - XM_006713753
RefSeq - XM_006713754
RefSeq - XM_006713756
RefSeq - XM_006713757
RefSeq - XM_011513186
RefSeq - XM_011513187
RefSeq - XM_011513188
RefSeq - XM_011513189
RefSeq - XM_017007235
RefSeq - XM_017007236
RefSeq - XM_017007237
RefSeq - XM_017007238
RefSeq - NM_001308116
RefSeq - NM_024947
RefSeq - XM_005247789
RefSeq - XM_005247791
RefSeq - XM_005247793
RefSeq Peptide - NP_001295045
RefSeq Peptide - NP_079223
swissprot - C9JAU4
swissprot - C9J6H0
swissprot - F8WDA4
swissprot - G5E9U7
swissprot - E7EX82
swissprot - H7C528
swissprot - Q8NDX5
swissprot - B4DTC4
swissprot - H7C4H9
swissprot - C9JYH7
Ensembl - ENSG00000173889
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000009372Gallus gallus
 Phc3ENSMUSG00000037652Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PHC2 / Q8IXK0 / polyhomeotic homolog 2ENSG0000013468637
PHC1 / P78364 / polyhomeotic homolog 1ENSG0000011175232
Q96NU1 / SAMD11 / sterile alpha motif domain containing 11ENSG0000018763411
SAMD7 / Q7Z3H4 / sterile alpha motif domain containing 7ENSG000001870338


Protein motifs (from Interpro)
Interpro ID Name
 IPR001660  Sterile alpha motif domain
 IPR012313  Zinc finger, FCS-type
 IPR013761  Sterile alpha motif/pointed domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0070317 negative regulation of G0 to G1 transition TAS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0031519 PcG protein complex IDA
 cellular_componentGO:0035102 PRC1 complex IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription cofactors
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA methylation proteins
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of PTEN gene transcription
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000204227 RING1 / Q06587 / ring finger protein 1  / complex
 ENSG00000168283 BMI1 / P35226 / BMI1 proto-oncogene, polycomb ring finger  / complex
 ENSG00000163602 RYBP / Q8N488 / RING1 and YY1 binding protein  / complex
 ENSG00000277258 PCGF2 / P35227 / polycomb group ring finger 2  / complex






 

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