ENSG00000134686


Homo sapiens

Features
Gene ID: ENSG00000134686
  
Biological name :PHC2
  
Synonyms : PHC2 / polyhomeotic homolog 2 / Q8IXK0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p35.1
Gene start: 33323623
Gene end: 33431052
  
Corresponding Affymetrix probe sets: 200919_at (Human Genome U133 Plus 2.0 Array)   238131_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000362521
Ensembl peptide - ENSP00000389436
Ensembl peptide - ENSP00000257118
Ensembl peptide - ENSP00000362517
NCBI entrez gene - 1912     See in Manteia.
OMIM - 602979
RefSeq - XM_017000522
RefSeq - XM_017000516
RefSeq - XM_017000517
RefSeq - XM_017000518
RefSeq - XM_017000519
RefSeq - XM_017000520
RefSeq - XM_017000521
RefSeq - NM_001330488
RefSeq - NM_004427
RefSeq - NM_198040
RefSeq - XM_005270570
RefSeq - XM_017000513
RefSeq - XM_017000514
RefSeq - XM_017000515
RefSeq Peptide - NP_932157
RefSeq Peptide - NP_001317417
RefSeq Peptide - NP_004418
swissprot - B3KPJ4
swissprot - Q8IXK0
swissprot - A0A0A0MSI2
Ensembl - ENSG00000134686
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 phc2aENSDARG00000056695Danio rerio
 phc2bENSDARG00000013224Danio rerio
 ENSGALG00000039532Gallus gallus
 Phc2ENSMUSG00000028796Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PHC3 / Q8NDX5 / polyhomeotic homolog 3ENSG0000017388943
PHC1 / P78364 / polyhomeotic homolog 1ENSG0000011175238
Q96NU1 / SAMD11 / sterile alpha motif domain containing 11ENSG0000018763413
SAMD7 / Q7Z3H4 / sterile alpha motif domain containing 7ENSG0000018703310


Protein motifs (from Interpro)
Interpro ID Name
 IPR001660  Sterile alpha motif domain
 IPR012313  Zinc finger, FCS-type
 IPR013761  Sterile alpha motif/pointed domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEA
 cellular_componentGO:0000792 heterochromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0031519 PcG protein complex IEA
 cellular_componentGO:0035102 PRC1 complex IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription cofactors
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA methylation proteins
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of PTEN gene transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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