ENSG00000168283


Homo sapiens

Features
Gene ID: ENSG00000168283
  
Biological name :BMI1
  
Synonyms : BMI1 / BMI1 proto-oncogene, polycomb ring finger / P35226
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: p12.2
Gene start: 22321211
Gene end: 22331484
  
Corresponding Affymetrix probe sets: 202265_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000365851
Ensembl peptide - ENSP00000390768
Ensembl peptide - ENSP00000397912
Ensembl peptide - ENSP00000399220
NCBI entrez gene - 648     See in Manteia.
OMIM - 164831
RefSeq - NM_005180
RefSeq Peptide - NP_005171
swissprot - P35226
swissprot - Q5T8Z2
swissprot - Q5T8Z4
swissprot - Q5T8Z6
Ensembl - ENSG00000168283
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bmi1aENSDARG00000006010Danio rerio
 bmi1bENSDARG00000013076Danio rerio
 BMI1ENSGALG00000041267Gallus gallus
 Bmi1ENSMUSG00000026739Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
COMMD3-BMI1 / COMMD3-BMI1 readthroughENSG00000269897100
PCGF2 / P35227 / polycomb group ring finger 2ENSG0000027725865
PCGF1 / Q9BSM1 / polycomb group ring finger 1ENSG0000011528926
PCGF3 / Q3KNV8 / polycomb group ring finger 3ENSG0000018561925
PCGF6 / Q9BYE7 / polycomb group ring finger 6ENSG0000015637424
PCGF5 / Q86SE9 / polycomb group ring finger 5ENSG0000018062822


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR032443  RAWUL domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007379 segment specification TAS
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0030097 hemopoiesis IEP
 biological_processGO:0036353 histone H2A-K119 monoubiquitination IMP
 biological_processGO:0045814 negative regulation of gene expression, epigenetic IMP
 biological_processGO:0048146 positive regulation of fibroblast proliferation IMP
 biological_processGO:0051443 positive regulation of ubiquitin-protein transferase activity IDA
 biological_processGO:0070317 negative regulation of G0 to G1 transition TAS
 cellular_componentGO:0000151 ubiquitin ligase complex IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0031519 PcG protein complex IDA
 cellular_componentGO:0035102 PRC1 complex IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0071535 RING-like zinc finger domain binding IPI
 molecular_functionGO:1990841 promoter-specific chromatin binding IDA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription cofactors
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA methylation proteins
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of PTEN gene transcription
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000173889 PHC3 / Q8NDX5 / polyhomeotic homolog 3  / complex
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / complex
 ENSG00000111752 PHC1 / P78364 / polyhomeotic homolog 1  / complex
 ENSG00000204227 RING1 / Q06587 / ring finger protein 1  / complex
 ENSG00000163602 RYBP / Q8N488 / RING1 and YY1 binding protein  / complex






 

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