Manteia - Molecule gene

ENSMUSG00000026739

Mus musculus

Features

Gene ID:	ENSMUSG00000026739

Biological name :	Bmi1

Synonyms :	Bmi1 / P25916 / Polycomb complex protein BMI-1

Possible biological names infered from orthology :	BMI1 proto-oncogene, polycomb ring finger / COMMD3-BMI1 / COMMD3-BMI1 readthrough / P35226

Species:	Mus musculus

Chr. number:	2
Strand:	1
Band:	A3
Gene start:	18677018
Gene end:	18686629

Corresponding Affymetrix probe sets:	10469514 (MoGene1.0st) 1417493_at (Mouse Genome 430 2.0 Array) 1448733_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000110300 Ensembl peptide - ENSMUSP00000121876 Ensembl peptide - ENSMUSP00000119331 Ensembl peptide - ENSMUSP00000118730 Ensembl peptide - ENSMUSP00000118273 Ensembl peptide - ENSMUSP00000028071 NCBI entrez gene - 12151 See in Manteia. MGI - MGI:88174 RefSeq - XM_006497312 RefSeq - NM_007552 RefSeq - XM_006497311 RefSeq Peptide - NP_031578 swissprot - A2ASR8 swissprot - A2ASR7 swissprot - Q2LC58 swissprot - A2ASR6 swissprot - A2ASR5 swissprot - P25916 Ensembl - ENSMUSG00000026739

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
bmi1a	ENSDARG00000006010	Danio rerio
bmi1b	ENSDARG00000013076	Danio rerio
BMI1	ENSGALG00000041267	Gallus gallus
BMI1	ENSG00000168283	Homo sapiens
COMMD3-BMI1	ENSG00000269897	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Pcgf2 / P23798 / Polycomb group RING finger protein 2 / P35227* / polycomb group ring finger 2*	ENSMUSG00000018537	65
Pcgf1 / Q8R023 / Polycomb group RING finger protein 1 / Q9BSM1* / polycomb group ring finger 1*	ENSMUSG00000069678	26
Pcgf3 / Q8BTQ0 / Polycomb group RING finger protein 3 / Q3KNV8* / polycomb group ring finger 3*	ENSMUSG00000033623	25
Pcgf6 / Q99NA9 / Polycomb group RING finger protein 6 / Q9BYE7* / polycomb group ring finger 6*	ENSMUSG00000025050	24
Pcgf5 / Q3UK78 / Polycomb group RING finger protein 5 / Q86SE9* / polycomb group ring finger 5*	ENSMUSG00000024805	21

Protein motifs (from Interpro)

Interpro ID	Name
IPR001841	Zinc finger, RING-type
IPR013083	Zinc finger, RING/FYVE/PHD-type
IPR017907	Zinc finger, RING-type, conserved site
IPR032443	RAWUL domain

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP
biological_process	GO:0001501	skeletal system development	IMP
biological_process	GO:0001701	in utero embryonic development	IGI
biological_process	GO:0006306	DNA methylation	IMP
biological_process	GO:0006325	chromatin organization	IEA
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006959	humoral immune response	IMP
biological_process	GO:0007420	brain development	IMP
biological_process	GO:0009987	cellular process	TAS
biological_process	GO:0016573	histone acetylation	IGI
biological_process	GO:0016574	histone ubiquitination	IDA
biological_process	GO:0021903	rostrocaudal neural tube patterning	IMP
biological_process	GO:0030890	positive regulation of B cell proliferation	IMP
biological_process	GO:0033092	positive regulation of immature T cell proliferation in thymus	IMP
biological_process	GO:0036353	histone H2A-K119 monoubiquitination	ISS
biological_process	GO:0045814	negative regulation of gene expression, epigenetic	ISS
biological_process	GO:0048103	somatic stem cell division	IMP
biological_process	GO:0048704	embryonic skeletal system morphogenesis	IGI
biological_process	GO:0048706	embryonic skeletal system development	IGI
biological_process	GO:0050790	regulation of catalytic activity	IEA
biological_process	GO:0051443	positive regulation of ubiquitin-protein transferase activity	ISS
biological_process	GO:0061484	hematopoietic stem cell homeostasis	ISO
biological_process	GO:0071347	cellular response to interleukin-1	IEA
biological_process	GO:0071549	cellular response to dexamethasone stimulus	IEA
biological_process	GO:2000011	regulation of adaxial/abaxial pattern formation	IGI
biological_process	GO:2001234	negative regulation of apoptotic signaling pathway	IGI
cellular_component	GO:0000151	ubiquitin ligase complex	ISS
cellular_component	GO:0000792	heterochromatin	IDA
cellular_component	GO:0005634	nucleus	ISO
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0016604	nuclear body	IDA
cellular_component	GO:0031519	PcG protein complex	IDA
molecular_function	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	IDA
molecular_function	GO:0003682	chromatin binding	IDA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0008270	zinc ion binding	ISS
molecular_function	GO:0043565	sequence-specific DNA binding	IDA
molecular_function	GO:0046872	metal ion binding	IEA
molecular_function	GO:0097027	ubiquitin-protein transferase activator activity	IDA
molecular_function	GO:1990841	promoter-specific chromatin binding	ISS

Pathways (from Reactome)

Pathway description

Oxidative Stress Induced Senescence

SUMOylation of DNA damage response and repair proteins

SUMOylation of transcription cofactors

SUMOylation of chromatin organization proteins

RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

Regulation of PTEN gene transcription

Transcriptional Regulation by E2F6

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000137	abnormal vertebrae morphology	"malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn,E2f6^tm1Lees/E2f6^tm1Lees Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn,E2f6^tm1Lees/E2f6⁺ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0000149	abnormal scapula morphology	"malformation of either or both of the large, flat bones of the back part of the shoulder" [J:13049]	Show Allelic Composition: Pcgf2^tm1Hko/Pcgf2^tm1Hko,Bmi1^tm1Brn/Bmi1⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Pcgf2^tm1Hko/Pcgf2⁺,Bmi1^tm1Brn/Bmi1^tm1Brn Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0000245	abnormal erythropoiesis	"atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon,Commd10^{Tg(Vav1-icre)A2Kio}/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca
MP:0000333	decreased bone marrow cell number	"decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn,E2f6^tm1Lees/E2f6^tm1Lees Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon,Commd10^{Tg(Vav1-icre)A2Kio}/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca
MP:0000352	decreased cell proliferation	"less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn,E2f6^tm1Lees/E2f6^tm1Lees Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0000490	abnormal crypts of Lieberkuhn morphology	"malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Bmi1^{tm1(cre/ERT)Mrc}/Bmi1⁺,Gt(ROSA)26Sor^tm1(DTA)Mrc/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0000689	abnormal spleen morphology	"atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]	Show Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon,Commd10^{Tg(Vav1-icre)A2Kio}/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca
MP:0000692	small spleen	"decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon,Commd10^{Tg(Vav1-icre)A2Kio}/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca
MP:0000703	abnormal thymus morphology	"anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]	Show Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon,Commd10^{Tg(Vav1-icre)A2Kio}/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca
MP:0000706	small thymus	"reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]	Show Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon,Commd10^{Tg(Vav1-icre)A2Kio}/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca
MP:0000711	thymic cortex hypoplasia	"reduced cell number in the outer portion of the thymus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ
MP:0000715	decreased thymocyte number	"fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ
MP:0000716	abnormal immune system cell morphology	"anomalous structure, development, or number of immune cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon,Commd10^{Tg(Vav1-icre)A2Kio}/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca
MP:0000745	tremors	"repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ
MP:0000780	abnormal corpus callosum morphology	"malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ
MP:0000811	hippocampal neuron degeneration	"a retrogressive impairment of function or destruction of the neuronal cells in the hippocampus" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:72427]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ
MP:0000851	cerebellum hypoplasia	"reduced cell number in the cerebellum" [MGI:CLS, J:45302]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn,E2f6^tm1Lees/E2f6^tm1Lees Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0000852	small cerebellum	"reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn,Rnf2^tm1Mvl/Rnf2⁺ Genetic Background: involves: 129/Ola * FVB
MP:0000877	abnormal Purkinje cell	"any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ
MP:0000880	decreased Purkinje cell number	"fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ
MP:0000886	abnormal cerebellar granule layer	"any malformation or absence of the innermost cortical layer of the cerebellum; contains densly packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn,Rnf2^tm1Mvl/Rnf2⁺ Genetic Background: involves: 129/Ola * FVB
MP:0000889	abnormal cerebellar molecular layer	"any malformation or absence of the outermost layer of the cerebral cortex that contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn,Rnf2^tm1Mvl/Rnf2⁺ Genetic Background: involves: 129/Ola * FVB
MP:0000890	thin cerebellar molecular layer	"reduced width of the outer of the three cortical layers of the cerebellum" [J:46854]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ
MP:0000951	sporadic seizures	"occasional seizures occuring at irregular intervals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn,Rnf2^tm1Mvl/Rnf2⁺ Genetic Background: involves: 129/Ola * FVB
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn,Rnf2^tm1Mvl/Rnf2⁺ Genetic Background: involves: 129/Ola * FVB
MP:0001393	ataxia	"inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn,E2f6^tm1Lees/E2f6^tm1Lees Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0001405	impaired coordination	"reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn,Rnf2^tm1Mvl/Rnf2⁺ Genetic Background: involves: 129/Ola * FVB
MP:0001406	abnormal gait	"unusual or distinctive way of walking" [J:65038]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn,Rnf2^tm1Mvl/Rnf2⁺ Genetic Background: involves: 129/Ola * FVB
MP:0001505	hunched posture	"stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn,Apc^tm2Cip/Apc⁺,Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2
MP:0001577	anemia	"less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn,E2f6^tm1Lees/E2f6^tm1Lees Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0001688	abnormal somite development	"anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Pcgf2^tm1Hko/Pcgf2⁺,Bmi1^tm1Brn/Bmi1^tm1Brn Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001730	embryonic growth arrest	"the cessation of development beyond a particular stage" [J:17509]	Show Allelic Composition: Pcgf2^tm1Hko/Pcgf2⁺,Bmi1^tm1Brn/Bmi1^tm1Brn Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn,E2f6^tm1Lees/E2f6^tm1Lees Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn,Rnf2^tm1Mvl/Rnf2⁺ Genetic Background: involves: 129/Ola * FVB
MP:0001806	decreased IgM	"less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ
MP:0001824	abnormal thymic involution	"premature or late decline in thymic function normally associated with advancing age" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ
MP:0001861	lung inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ
MP:0002020	increased tumor incidence	"greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]	Show Allelic Composition: Gt(ROSA)26Sor^{tm4(EWSR1/ATF1)Mrc}/Gt(ROSA)26Sor⁺,Tg(Prrx1-cre/ERT2)1Mlgn/? Genetic Background: involves: C57BL/6
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn,E2f6^tm1Lees/E2f6^tm1Lees Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 Allelic Composition: Bmi1^{tm1(cre/ERT)Mrc}/Bmi1⁺,Gt(ROSA)26Sor^tm1(DTA)Mrc/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Bmi1^{tm1(cre/ERT)Mrc}/Bmi1⁺,Ctnnb1^tm1Mmt/Ctnnb1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn,Rnf2^tm1Mvl/Rnf2⁺ Genetic Background: involves: 129/Ola * FVB Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon,Commd10^{Tg(Vav1-icre)A2Kio}/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon,Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/? Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
MP:0002114	abnormal axial skeleton morphology	"abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Vegfd^tm1Mach/Y Genetic Background: involves: 129S1/Sv Allelic Composition: Pcgf2^tm1Hko/Pcgf2⁺,Bmi1^tm1Brn/Bmi1^tm1Brn Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn,Rnf2^tm1Mvl/Rnf2⁺ Genetic Background: involves: 129/Ola * FVB
MP:0002116	abnormal craniofacial bone morphology	"abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pcgf2^tm1Hko/Pcgf2^tm1Hko,Bmi1^tm1Brn/Bmi1⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Pcgf2^tm1Hko/Pcgf2⁺,Bmi1^tm1Brn/Bmi1^tm1Brn Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002123	abnormal hematopoiesis	"abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ
MP:0002151	abnormal neural tube morphology/development	"anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pcgf2^tm1Hko/Pcgf2⁺,Bmi1^tm1Brn/Bmi1^tm1Brn Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002152	abnormal brain morphology	"anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]	Show Allelic Composition: Pcgf2^tm1Hko/Pcgf2⁺,Bmi1^tm1Brn/Bmi1^tm1Brn Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Phex^Pug/Y Genetic Background: involves: C57BL/6J Allelic Composition: Bmi1^tm2Ilw/Bmi1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Bmi1^tm1.1Lees/Bmi1^tm1.1Lees Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0002183	gliosis	"increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn,Rnf2^tm1Mvl/Rnf2⁺ Genetic Background: involves: 129/Ola * FVB
MP:0002356	abnormal spleen red pulp morphology	"anomalous structure of the area of the spleen that screens and eliminates defective or foreign cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ
MP:0002357	abnormal spleen white pulp morphology	"anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon,Commd10^{Tg(Vav1-icre)A2Kio}/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca
MP:0002358	abnormal spleen periarteriolar lymphoid sheath morphology	"anomalous structure of the area of the spleen in which T cells surround the central arteriole " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon,Commd10^{Tg(Vav1-icre)A2Kio}/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca
MP:0002398	abnormal bone marrow cell morphology/development	"anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn,E2f6^tm1Lees/E2f6^tm1Lees Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0002404	intestinal adenoma	"benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Bmi1^{tm1(cre/ERT)Mrc}/Bmi1⁺,Ctnnb1^tm1Mmt/Ctnnb1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn,Apc^tm2Cip/Apc⁺,Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2
MP:0002407	abnormal double-negative T cell	"anomalous structure, development, or number of the subset of T cells found in the thymus that express neither CD4 nor CD8" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ
MP:0002722	abnormal immune system organ morphology	"anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon,Commd10^{Tg(Vav1-icre)A2Kio}/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca
MP:0002825	abnormal notochord	"malformation or absence of the axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Pcgf2^tm1Hko/Pcgf2⁺,Bmi1^tm1Brn/Bmi1^tm1Brn Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002861	abnormal tail bud morphology	"anomalous formation of the primordial region of the embryo that arises to form the tail of the adult; appears approximately ten days following conception as a short stump, and then initiates elongation and thinning in normal development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pcgf2^tm1Hko/Pcgf2⁺,Bmi1^tm1Brn/Bmi1^tm1Brn Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0003036	vertebral transformation	"homeotic transformation of a specific vertebrae to adopt the fate of another" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ
MP:0003077	abnormal cell cycle	"failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn,E2f6^tm1Lees/E2f6^tm1Lees Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0003644	thymus atrophy	"wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon,Commd10^{Tg(Vav1-icre)A2Kio}/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca
MP:0004342	scapular bone foramen	"presence of a hole in either or both of the large, flat bones of the back part of the shoulder" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pcgf2^tm1Hko/Pcgf2^tm1Hko,Bmi1^tm1Brn/Bmi1⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Pcgf2^tm1Hko/Pcgf2⁺,Bmi1^tm1Brn/Bmi1^tm1Brn Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0004345	abnormal acromion morphology	"any structural anomaly of the lateral end of the spine of the scapula which projects as a broad flattened process and articulates with the clavicle, and forms the point of the shoulder" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Pcgf2^tm1Hko/Pcgf2^tm1Hko,Bmi1^tm1Brn/Bmi1⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Pcgf2^tm1Hko/Pcgf2⁺,Bmi1^tm1Brn/Bmi1^tm1Brn Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0004446	split exoccipital bone	"the appearance of an abnormal division in the bone or region on the lateral sides of the great foremen of the skull, which often forms a part of the occipital in the adult, but is usually distinct in the young" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Pcgf2^tm1Hko/Pcgf2^tm1Hko,Bmi1^tm1Brn/Bmi1⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Pcgf2^tm1Hko/Pcgf2⁺,Bmi1^tm1Brn/Bmi1^tm1Brn Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0004599	abnormal vertebral arch morphology	"any structural anomaly of the dorsal part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ
MP:0004607	abnormal cervical atlas morphology	"any structural anomaly of the first (topmost, C1) cervical vertebra which supports the globe of the head" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pcgf2^tm1Hko/Pcgf2^tm1Hko,Bmi1^tm1Brn/Bmi1⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Pcgf2^tm1Hko/Pcgf2⁺,Bmi1^tm1Brn/Bmi1^tm1Brn Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Pcgf2^tm1Hko/Pcgf2^tm1Hko,Bmi1^tm1Brn/Bmi1^tm1Brn Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0004615	cervical vertebral transformation	"homeotic transformation of any cervical vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Bmi1^tm1Brn/Bmi1⁺ Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Pcgf2^tm1Hko/Pcgf2^tm1Hko,Bmi1^tm1Brn/Bmi1⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Pcgf2^tm1Hko/Pcgf2⁺,Bmi1^tm1Brn/Bmi1^tm1Brn Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Pcgf2^tm1Hko/Pcgf2^tm1Hko,Bmi1^tm1Brn/Bmi1^tm1Brn Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn,E2f6^tm1Lees/E2f6^tm1Lees Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 Allelic Composition: Bmi1^tm1Brn/Bmi1⁺,E2f6^tm1Lees/E2f6^tm1Lees Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 Allelic Composition: Bmi1^tm1Brn/Bmi1⁺,E2f6^tm1Lees/E2f6⁺ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn,E2f6^tm1Lees/E2f6⁺ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0004616	lumbar vertebral transformation	"homeotic transformation of any lumbar vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Bmi1^tm1Brn/Bmi1⁺ Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn,E2f6^tm1Lees/E2f6^tm1Lees Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 Allelic Composition: Bmi1^tm1Brn/Bmi1⁺,E2f6^tm1Lees/E2f6^tm1Lees Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 Allelic Composition: Bmi1^tm1Brn/Bmi1⁺,E2f6^tm1Lees/E2f6⁺ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn,E2f6^tm1Lees/E2f6⁺ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0004618	thoracic vertebral transformation	"homeotic transformation of any thoracic vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Bmi1^tm1Brn/Bmi1⁺ Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn,E2f6^tm1Lees/E2f6^tm1Lees Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 Allelic Composition: Bmi1^tm1Brn/Bmi1⁺,E2f6^tm1Lees/E2f6^tm1Lees Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 Allelic Composition: Bmi1^tm1Brn/Bmi1⁺,E2f6^tm1Lees/E2f6⁺ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn,E2f6^tm1Lees/E2f6⁺ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0004625	abnormal rib attachment	"any anomaly in the in the normal joining of the ribs to the vertebral column or to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pcgf2^tm1Hko/Pcgf2^tm1Hko,Bmi1^tm1Brn/Bmi1⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Pcgf2^tm1Hko/Pcgf2⁺,Bmi1^tm1Brn/Bmi1^tm1Brn Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0004710	small notochord	"reduced size of the axial fibrocellular cord in embryos around which develops the vertebral primordia" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Pcgf2^tm1Hko/Pcgf2^tm1Hko,Bmi1^tm1Brn/Bmi1^tm1Brn Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0004713	split notochord	"the appearance of an abnormal division in the axial fibrocellular cord in embryos around which develops the vertebral primordia" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Pcgf2^tm1Hko/Pcgf2^tm1Hko,Bmi1^tm1Brn/Bmi1^tm1Brn Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0004787	abnormal dorsal aorta morphology	"any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]	Show Allelic Composition: Pcgf2^tm1Hko/Pcgf2^tm1Hko,Bmi1^tm1Brn/Bmi1^tm1Brn Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0004810	decreased hematopoietic stem cell number	"reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon,Commd10^{Tg(Vav1-icre)A2Kio}/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon,Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/? Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
MP:0004953	decreased spleen weight	"reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon,Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/? Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
MP:0005016	decreased lymphocyte number	"fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon,Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/? Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
MP:0005017	decreased B cell number	"fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon,Commd10^{Tg(Vav1-icre)A2Kio}/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca
MP:0005018	decreased T cell number	"fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon,Commd10^{Tg(Vav1-icre)A2Kio}/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca
MP:0005092	decreased double-positive T cell count	"less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn,E2f6^tm1Lees/E2f6^tm1Lees Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0005150	cachexia	"general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn,Apc^tm2Cip/Apc⁺,Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2
MP:0006042	increased apoptosis	"greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Hprt^{tm352a(Hspa1a-icre/ERT2)Ems}/Y Genetic Background: B6.Cg-Hprt^{tm352a(Hspa1a-icre/ERT2)Ems}
MP:0006305	abnormal optic eminence morphology	"malformation of the embryonic structure that gives rise to the corneal ectoderm" [J:119812, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator", UNSW_embryology site:http://embryology.med.unsw.edu.au/Notes/eye.htm#stage13]	Show Allelic Composition: Pcgf2^tm1Hko/Pcgf2^tm1Hko,Bmi1^tm1Brn/Bmi1^tm1Brn Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0006337	abnormal first branchial arch morphology	"anomaly in the structure of the first arch which contributes to development of mastication muscles, maxilla, mandible, incus, malleus, Meckel s cartilage, trigeminal nerve, and maxillary artery" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pcgf2^tm1Hko/Pcgf2^tm1Hko,Bmi1^tm1Brn/Bmi1^tm1Brn Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0006338	abnormal second branchial arch morphology	"anomaly in the structure of the second arch which contributes to the development of the stapes, styloid process, hyoid bone, stylohyoid ligament, muscles of facial expression, stapedius muscle, stylohyoid muscle, and lining of the palatine tonsils" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pcgf2^tm1Hko/Pcgf2^tm1Hko,Bmi1^tm1Brn/Bmi1^tm1Brn Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0008008	early cellular replicative senescence	"increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn,E2f6^tm1Lees/E2f6^tm1Lees Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0008211	decreased mature B cell number	"reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ
MP:0008215	decreased immature B cell number	"reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ
MP:0008277	abnormal sternum ossification	"anomaly in the process of the formation of the sternum bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958, MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pcgf2^tm1Hko/Pcgf2^tm1Hko,Bmi1^tm1Brn/Bmi1⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Pcgf2^tm1Hko/Pcgf2⁺,Bmi1^tm1Brn/Bmi1^tm1Brn Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0008474	absent spleen germinal center	"absence of the area of the spleen secondary B follicle where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]	Show Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon,Commd10^{Tg(Vav1-icre)A2Kio}/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca
MP:0008477	decreased spleen red pulp amount	"reduction in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon,Commd10^{Tg(Vav1-icre)A2Kio}/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca
MP:0008479	decreased spleen white pulp amount	"reduction in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon,Commd10^{Tg(Vav1-icre)A2Kio}/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca
MP:0008489	postnatal slow weight gain	"the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bmi1^{tm1(cre/ERT)Mrc}/Bmi1⁺,Gt(ROSA)26Sor^tm1(DTA)Mrc/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0008572	abnormal Purkinje cell dendrite morphology	"any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn,Rnf2^tm1Mvl/Rnf2⁺ Genetic Background: involves: 129/Ola * FVB
MP:0008813	decreased common myeloid progenitor cell number	"reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon,Commd10^{Tg(Vav1-icre)A2Kio}/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca
MP:0009335	decreased splenocyte proliferation	"reduction in the expansion rate of a splenocyte cell population by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ
MP:0009890	cleft secondary palate	"congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]	Show Allelic Composition: Pcgf2^tm1Hko/Pcgf2^tm1Hko,Bmi1^tm1Brn/Bmi1⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Pcgf2^tm1Hko/Pcgf2⁺,Bmi1^tm1Brn/Bmi1^tm1Brn Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0009956	abnormal cerebellar layer morphology	"any structural anomaly of the laminar structure of the cerebellar cortex comprising the gray matter of the cerebellum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn,E2f6^tm1Lees/E2f6^tm1Lees Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0011098	complete embryonic lethality during organogenesis	"death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Pcgf2^tm1Hko/Pcgf2^tm1Hko,Bmi1^tm1Brn/Bmi1^tm1Brn Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0011101	partial prenatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn,E2f6^tm1Lees/E2f6^tm1Lees Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0011110	partial preweaning lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Arf4^{tm1b(KOMP)Wtsi}/Arf4^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Arf4^{tm1b(KOMP)Wtsi}/Ucd
MP:0011182	decreased hematopoietic cell number	"fewer than expected number of cells of the hematopoietic lineage" [MGI:csmith]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn,E2f6^tm1Lees/E2f6^tm1Lees Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0012180	abnormal somatic mesoderm morphology	"any structural abnormality of the outer layer of lateral plate mesoderm, located under (ventrally) the ectoderm, which forms the future body wall" [MGI:anna]	Show Allelic Composition: Pcgf2^tm1Hko/Pcgf2^tm1Hko,Bmi1^tm1Brn/Bmi1^tm1Brn Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0012264	hindbrain hypoplasia	"underdevelopment or reduced size, usually due to a reduced number of cells, of the part of the brain developed from the posterior of the three primary brain vesicles of the embryonic neural tube from which the metencephalon and myelencephalon are derived" [MGI:anna]	Show Allelic Composition: Pcgf2^tm1Hko/Pcgf2^tm1Hko,Bmi1^tm1Brn/Bmi1^tm1Brn Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0012424	decreased alimentary system tumor incidence	"less than the expected number of tumors originating in the alimentary system in a given population in a given time period" [MGI:csmith]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn,Apc^tm2Cip/Apc⁺,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 Allelic Composition: Bmi1^tm1.1Lees/Bmi1^tm1.1Lees,Apc^tm2Cip/Apc⁺,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2
MP:0012434	decreased intestinal adenoma incidence	"less than the expected number of a benign epithelial neoplasm with a glandular organization arising in the small and/or large intestine, occurring in a specific population in a given time period" [MGI:csmith]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn,Apc^tm2Cip/Apc⁺,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 Allelic Composition: Bmi1^tm1.1Lees/Bmi1^tm1.1Lees,Apc^tm2Cip/Apc⁺,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2
MP:0012435	decreased colon tumor incidence	"less than the expected number of neoplasms in the colon, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn,Apc^tm2Cip/Apc⁺,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 Allelic Composition: Bmi1^tm1.1Lees/Bmi1^tm1.1Lees,Apc^tm2Cip/Apc⁺,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2
MP:0012505	increased neural tube apoptosis	"increase in the number of cells of the neural tube undergoing programmed cell death" [MGI:anna]	Show Allelic Composition: Pcgf2^tm1Hko/Pcgf2^tm1Hko,Bmi1^tm1Brn/Bmi1^tm1Brn Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0013482	abnormal duodenum crypts of Lieberkuhn morphology	"any structural anomaly of the intestinal crypts located in the mucosa of the duodenum, the first division of the small intestine that extends from the pyloris to the junction with the jejunum" [MGI:Anna]	Show Allelic Composition: Bmi1^{tm1(cre/ERT)Mrc}/Bmi1⁺,Gt(ROSA)26Sor^tm1(DTA)Mrc/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0013483	abnormal jejunum crypts of Lieberkuhn morphology	"any structural anomaly of the intestinal crypts located in the mucosa of the jejunum, the portion of the small intestine that extends from the duodenum to the ileum" [MGI:Anna]	Show Allelic Composition: Bmi1^{tm1(cre/ERT)Mrc}/Bmi1⁺,Gt(ROSA)26Sor^tm1(DTA)Mrc/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0013662	decreased myeloid cell number	"reduction in the expected number of cells of the myeloid lineage" [CL:0000763]	Show Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon,Commd10^{Tg(Vav1-icre)A2Kio}/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca
MP:0013693	abnormal hemopoiesis	"any anomaly in the process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure; the site of hemopoiesis is variable during development, but occurs primarily in bone marrow in mammals" [GO:0030097]	Show Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon,Commd10^{Tg(Vav1-icre)A2Kio}/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca
MP:0013892	increased common lymphocyte progenitor cell number	"increased number of a progenitor cell committed to the lymphoid lineage" [CL:0000051, PMID:10407577]	Show Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon,Commd10^{Tg(Vav1-icre)A2Kio}/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000024325	Ring1 / O35730 / E3 ubiquitin-protein ligase RING1 / Q06587* / ring finger protein 1*	/ complex
ENSMUSG00000026021	Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*	/ complex
ENSMUSG00000072872	Rybp / Q8CCI5 / RING1 and YY1-binding protein / Q8N488*	/ complex
ENSMUSG00000037652	Phc3 / Q8CHP6 / Polyhomeotic-like protein 3 / Q8NDX5* / polyhomeotic homolog 3*	/ complex

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr