ENSMUSG00000025050


Mus musculus

Features
Gene ID: ENSMUSG00000025050
  
Biological name :Pcgf6
  
Synonyms : Pcgf6 / Polycomb group RING finger protein 6 / Q99NA9
  
Possible biological names infered from orthology : polycomb group ring finger 6 / Q9BYE7
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: C3
Gene start: 47033619
Gene end: 47050845
  
Corresponding Affymetrix probe sets: 10468275 (MoGene1.0st)   1424081_at (Mouse Genome 430 2.0 Array)   1432108_at (Mouse Genome 430 2.0 Array)   1454120_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026032
NCBI entrez gene - 71041     See in Manteia.
MGI - MGI:1918291
RefSeq - XM_006527338
RefSeq - NM_027654
RefSeq - XM_006527337
RefSeq Peptide - NP_081930
swissprot - Q99NA9
Ensembl - ENSMUSG00000025050
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pcgf6ENSDARG00000069681Danio rerio
 PCGF6ENSGALG00000008230Gallus gallus
 PCGF6ENSG00000156374Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pcgf1 / Q8R023 / Polycomb group RING finger protein 1 / Q9BSM1* / polycomb group ring finger 1*ENSMUSG0000006967825
Pcgf5 / Q3UK78 / Polycomb group RING finger protein 5 / Q86SE9* / polycomb group ring finger 5*ENSMUSG0000002480523
Pcgf2 / P23798 / Polycomb group RING finger protein 2 / P35227* / polycomb group ring finger 2*ENSMUSG0000001853723
Pcgf3 / Q8BTQ0 / Polycomb group RING finger protein 3 / Q3KNV8* / polycomb group ring finger 3*ENSMUSG0000003362323
Bmi1 / P25916 / Polycomb complex protein BMI-1 / P35226* / COMMD3-BMI1* / COMMD3-BMI1 readthrough* / BMI1 proto-oncogene, polycomb ring finger*ENSMUSG0000002673922


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0036353 histone H2A-K119 monoubiquitination IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0031519 PcG protein complex ISS
 cellular_componentGO:0035102 PRC1 complex ISS
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019904 protein domain specific binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000059436 Max / Max protein / P61244* / MYC associated factor X*  / complex / reaction
 ENSMUSG00000038482 Tfdp1 / Q08639 / transcription factor Dp 1 / TFDP3* / Q14186* / Q5H9I0* / transcription factor Dp family member 3*  / complex / reaction
 ENSMUSG00000013787 Ehmt2 / Q9Z148 / Histone-lysine N-methyltransferase EHMT2 / Q96KQ7* / euchromatic histone lysine methyltransferase 2*  / complex / reaction
 ENSMUSG00000024325 Ring1 / O35730 / E3 ubiquitin-protein ligase RING1 / Q06587* / ring finger protein 1*  / complex
 ENSMUSG00000036893 Ehmt1 / Q5DW34 / Histone-lysine N-methyltransferase EHMT1 / Q9H9B1* / euchromatic histone lysine methyltransferase 1*  / complex / reaction
 ENSMUSG00000057469 E2f6 / O54917 / Transcription factor E2F6 / O75461* / E2F transcription factor 6*  / reaction / complex
 ENSMUSG00000022634 Yaf2 / Q99LW6 / YY1 associated factor 2 / Q8IY57*  / complex
 ENSMUSG00000026484 Rnf2 / Q9CQJ4 / E3 ubiquitin-protein ligase RING2 / Q99496* / ring finger protein 2*  / complex
 ENSMUSG00000033943 Mga / A2AWL7 / MAX-associated protein / Q8IWI9* / MGA, MAX dimerization protein*  / complex / reaction
 ENSMUSG00000022394 P59178 / L3mbtl2 / Lethal(3)malignant brain tumor-like protein 2 / Q969R5* / L3MBTL2, polycomb repressive complex 1 subunit*  / complex
 ENSMUSG00000029836 Cbx3 / chromobox protein homolog 3 / Q13185* / chromobox 3*  / complex / reaction






 

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