ENSMUSG00000033943


Mus musculus

Features
Gene ID: ENSMUSG00000033943
  
Biological name :Mga
  
Synonyms : A2AWL7 / MAX-associated protein / Mga
  
Possible biological names infered from orthology : MGA, MAX dimerization protein / Q8IWI9
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: E5
Gene start: 119897228
Gene end: 119969581
  
Corresponding Affymetrix probe sets: 10475051 (MoGene1.0st)   1422646_at (Mouse Genome 430 2.0 Array)   1431232_a_at (Mouse Genome 430 2.0 Array)   1433012_at (Mouse Genome 430 2.0 Array)   1434746_at (Mouse Genome 430 2.0 Array)   1442356_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000043795
Ensembl peptide - ENSMUSP00000106400
Ensembl peptide - ENSMUSP00000106401
Ensembl peptide - ENSMUSP00000119044
Ensembl peptide - ENSMUSP00000078853
NCBI entrez gene - 29808     See in Manteia.
MGI - MGI:1352483
RefSeq - XM_017318964
RefSeq - XM_011239590
RefSeq - XM_011239591
RefSeq - XM_011239592
RefSeq - XM_017318962
RefSeq - XM_017318963
RefSeq - NM_001164274
RefSeq - NM_013720
RefSeq - XM_006499687
RefSeq - XM_006499688
RefSeq - XM_006499689
RefSeq - XM_006499690
RefSeq - XM_006499691
RefSeq - XM_011239589
RefSeq Peptide - NP_038748
RefSeq Peptide - NP_001157746
swissprot - H7BX50
swissprot - E9QLG3
swissprot - A2AWL7
Ensembl - ENSMUSG00000033943
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mgaaENSDARG00000078784Danio rerio
 ENSGALG00000031456Gallus gallus
 ENSGALG00000008653Gallus gallus
 MGAENSG00000174197Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
T / P20293 / brachyury, T-box transcription factor T / TBXT* / O15178* / T-box transcription factor T*ENSMUSG000000623275
Eomes / O54839 / Eomesodermin homolog / O95936* / eomesodermin*ENSMUSG000000324465
Tbx19 / Q99ME7 / T-box transcription factor TBX19 / O60806* / T-box 19*ENSMUSG000000265725
Tbr1 / Q64336 / T-box brain protein 1 / Q16650* / T-box, brain 1*ENSMUSG000000350335
Tbx21 / Q9JKD8 / T-box transcription factor TBX21 / Q9UL17* / T-box 21*ENSMUSG000000014445


Protein motifs (from Interpro)
Interpro ID Name
 IPR001699  Transcription factor, T-box
 IPR008967  p53-like transcription factor, DNA-binding
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR018186  Transcription factor, T-box, conserved site
 IPR032060  Domain of unknown function DUF4801
 IPR036638  Helix-loop-helix DNA-binding domain superfamily
 IPR036960  T-box superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0071339 MLL1 complex ISO
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001713 reduced trophoblast cell number "fewer than normal number of cells of the extraembryonic cell layer that contributes to the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:23171]
Show

Allelic Composition: Gata6tm2.2Sad/Gata6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002399 abnormal pluripotent precursor cell morphology/development "anomalous structure or fomation of the cells that give rise to most types of cells necessary for fetal development" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gata6tm2.2Sad/Gata6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003886 abnormal embryonic epiblast morphology "anomaly in the development/organization of the tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gata6tm2.2Sad/Gata6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004964 absent inner cell mass "absence of the cells of the blastocyst that develop into the body of the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gata6tm2.2Sad/Gata6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004965 inner cell mass degeneration 
Show

Allelic Composition: Gata6tm2.2Sad/Gata6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gata6tm2.2Sad/Gata6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009687 empty decidua capsularis "the implanted embryo normally covered opposite the placenta by uterine mucosa and epithelium following implantation is missing, suggesting the embryo died early during implantation but after the decidual response and modification of uterine stromal cells" [ISBN:0198542771 "Rugh, Roberts, The Mouse: Its Reproduction and Development", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gata6tm2.2Sad/Gata6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Gata6tm2.2Sad/Gata6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0012743 increased inner cell mass apoptosis "increased number of cells of the blastocyst that develop into the body of the embryo undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Gata6tm2.2Sad/Gata6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Gata6tm2.2Sad/Gata6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000057469 E2f6 / O54917 / Transcription factor E2F6 / O75461* / E2F transcription factor 6*  / reaction / complex
 ENSMUSG00000013787 Ehmt2 / Q9Z148 / Histone-lysine N-methyltransferase EHMT2 / Q96KQ7* / euchromatic histone lysine methyltransferase 2*  / reaction / complex
 ENSMUSG00000025050 Pcgf6 / Q99NA9 / Polycomb group RING finger protein 6 / Q9BYE7* / polycomb group ring finger 6*  / complex / reaction
 ENSMUSG00000024325 Ring1 / O35730 / E3 ubiquitin-protein ligase RING1 / Q06587* / ring finger protein 1*  / complex / reaction
 ENSMUSG00000022394 P59178 / L3mbtl2 / Lethal(3)malignant brain tumor-like protein 2 / Q969R5* / L3MBTL2, polycomb repressive complex 1 subunit*  / reaction / complex
 ENSMUSG00000029836 Cbx3 / chromobox protein homolog 3 / Q13185* / chromobox 3*  / complex / reaction
 ENSMUSG00000036893 Ehmt1 / Q5DW34 / Histone-lysine N-methyltransferase EHMT1 / Q9H9B1* / euchromatic histone lysine methyltransferase 1*  / complex / reaction
 ENSMUSG00000059436 Max / Max protein / P61244* / MYC associated factor X*  / complex
 ENSMUSG00000026484 Rnf2 / Q9CQJ4 / E3 ubiquitin-protein ligase RING2 / Q99496* / ring finger protein 2*  / reaction / complex
 ENSMUSG00000022634 Yaf2 / Q99LW6 / YY1 associated factor 2 / Q8IY57*  / complex / reaction
 ENSMUSG00000038482 Tfdp1 / Q08639 / transcription factor Dp 1 / TFDP3* / Q14186* / Q5H9I0* / transcription factor Dp family member 3*  / complex / reaction






 

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