ENSMUSG00000029836


Mus musculus

Features
Gene ID: ENSMUSG00000029836
  
Biological name :Cbx3
  
Synonyms : Cbx3 / chromobox protein homolog 3
  
Possible biological names infered from orthology : chromobox 3 / Q13185
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: B3
Gene start: 51470360
Gene end: 51483704
  
Corresponding Affymetrix probe sets: 10346549 (MoGene1.0st)   10421573 (MoGene1.0st)   10538282 (MoGene1.0st)   1416884_at (Mouse Genome 430 2.0 Array)   1432628_at (Mouse Genome 430 2.0 Array)   1439421_x_at (Mouse Genome 430 2.0 Array)   1441616_at (Mouse Genome 430 2.0 Array)   1448504_a_at (Mouse Genome 430 2.0 Array)   1454305_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000110089
Ensembl peptide - ENSMUSP00000121370
Ensembl peptide - ENSMUSP00000110091
Ensembl peptide - ENSMUSP00000031862
Ensembl peptide - ENSMUSP00000110088
NCBI entrez gene - 12417     See in Manteia.
MGI - MGI:108515
RefSeq - XM_017321373
RefSeq - XM_017321374
RefSeq - NM_007624
RefSeq Peptide - NP_001341931
RefSeq Peptide - NP_031650
swissprot - Q9DCC5
swissprot - D3Z313
swissprot - D3Z1A9
Ensembl - ENSMUSG00000029836
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cbx3aENSDARG00000003860Danio rerio
 cbx3bENSDARG00000092158Danio rerio
 CBX3ENSGALG00000011038Gallus gallus
 CBX3ENSG00000122565Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cbx1 / P83917 / Chromobox protein homolog 1 / P83916* / chromobox 1*ENSMUSG0000001866672
Cbx5 / Q61686 / Mus musculus chromobox 5 (Cbx5), transcript variant 4, mRNA. / P45973* / chromobox 5*ENSMUSG0000000957563


Protein motifs (from Interpro)
Interpro ID Name
 IPR000953  Chromo/chromo shadow domain
 IPR008251  Chromo shadow domain
 IPR016197  Chromo-like domain superfamily
 IPR017984  Chromo domain subgroup
 IPR023779  Chromo domain, conserved site
 IPR023780  Chromo domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005719 nuclear euchromatin IEA
 cellular_componentGO:0005720 nuclear heterochromatin IEA
 cellular_componentGO:0005819 spindle IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:1990226 histone methyltransferase binding IEA


Pathways (from Reactome)
Pathway description
RNA Polymerase I Chain Elongation
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Pklrslc/Pklrslc
Genetic Background: CBA/NSlc-Pklrslc

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Pklrslc/Pklrslc
Genetic Background: CBA/NSlc-Pklrslc

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
Show

Allelic Composition: Zbtb16lu-Sfd/Zbtb16+
Genetic Background: involves: C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Pklrslc/Pklrslc
Genetic Background: CBA/NSlc-Pklrslc

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pklrslc/Pklrslc
Genetic Background: CBA/NSlc-Pklrslc

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Pklrslc/Pklrslc
Genetic Background: CBA/NSlc-Pklrslc

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Pklrslc/Pklrslc
Genetic Background: CBA/NSlc-Pklrslc

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025050 Pcgf6 / Q99NA9 / Polycomb group RING finger protein 6 / Q9BYE7* / polycomb group ring finger 6*  / complex / reaction
 ENSMUSG00000057469 E2f6 / O54917 / Transcription factor E2F6 / O75461* / E2F transcription factor 6*  / reaction / complex
 ENSMUSG00000036893 Ehmt1 / Q5DW34 / Histone-lysine N-methyltransferase EHMT1 / Q9H9B1* / euchromatic histone lysine methyltransferase 1*  / reaction / complex
 ENSMUSG00000024325 Ring1 / O35730 / E3 ubiquitin-protein ligase RING1 / Q06587* / ring finger protein 1*  / reaction / complex
 ENSMUSG00000022394 P59178 / L3mbtl2 / Lethal(3)malignant brain tumor-like protein 2 / Q969R5* / L3MBTL2, polycomb repressive complex 1 subunit*  / complex / reaction
 ENSMUSG00000026484 Rnf2 / Q9CQJ4 / E3 ubiquitin-protein ligase RING2 / Q99496* / ring finger protein 2*  / complex / reaction
 ENSMUSG00000033943 Mga / A2AWL7 / MAX-associated protein / Q8IWI9* / MGA, MAX dimerization protein*  / complex / reaction
 ENSMUSG00000059436 Max / Max protein / P61244* / MYC associated factor X*  / reaction / complex
 ENSMUSG00000038482 Tfdp1 / Q08639 / transcription factor Dp 1 / TFDP3* / Q14186* / Q5H9I0* / transcription factor Dp family member 3*  / reaction / complex
 ENSMUSG00000013787 Ehmt2 / Q9Z148 / Histone-lysine N-methyltransferase EHMT2 / Q96KQ7* / euchromatic histone lysine methyltransferase 2*  / complex / reaction
 ENSMUSG00000022634 Yaf2 / Q99LW6 / YY1 associated factor 2 / Q8IY57*  / reaction / complex
 ENSMUSG00000100210 P84228 / Hist1h3f / Histone H3.2   / complex
 ENSMUSG00000099517 P68433 / Hist1h3g / Histone H3.1   / complex
 ENSMUSG00000060743 H3f3a / P84244 / Histone H3.3 / P84243* / H3 histone family member 3A*  / complex
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / complex






 

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