ENSMUSG00000024325


Mus musculus

Features
Gene ID: ENSMUSG00000024325
  
Biological name :Ring1
  
Synonyms : E3 ubiquitin-protein ligase RING1 / O35730 / Ring1
  
Possible biological names infered from orthology : Q06587 / ring finger protein 1
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: B1
Gene start: 34020792
Gene end: 34024680
  
Corresponding Affymetrix probe sets: 10450089 (MoGene1.0st)   1422647_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025183
NCBI entrez gene - 19763     See in Manteia.
MGI - MGI:1101770
RefSeq - NM_009066
RefSeq Peptide - NP_033092
swissprot - O35730
Ensembl - ENSMUSG00000024325
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RING1ENSG00000204227Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rnf2 / Q9CQJ4 / E3 ubiquitin-protein ligase RING2 / Q99496* / ring finger protein 2*ENSMUSG0000002648453


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR032443  RAWUL domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0016574 histone ubiquitination IGI
 biological_processGO:0035518 histone H2A monoubiquitination IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0048593 camera-type eye morphogenesis IGI
 biological_processGO:0050790 regulation of catalytic activity IEA
 cellular_componentGO:0000151 ubiquitin ligase complex IEA
 cellular_componentGO:0001739 sex chromatin IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0031519 PcG protein complex ISO
 cellular_componentGO:0035102 PRC1 complex ISO
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0097027 ubiquitin-protein transferase activator activity IDA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription cofactors
SUMOylation of chromatin organization proteins
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of PTEN gene transcription
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tbpl1tm1Saco/Tbpl1tm1Saco
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0000480 increased number of ribs "greater than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Tbpl1tm1Saco/Tbpl1tm1Saco
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003036 vertebral transformation "homeotic transformation of a specific vertebrae to adopt the fate of another" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbpl1tm1Saco/Tbpl1tm1Saco
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0004607 abnormal cervical atlas morphology "any structural anomaly of the first (topmost, C1) cervical vertebra which supports the globe of the head" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbpl1tm1Saco/Tbpl1tm1Saco
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0004608 abnormal cervical axis morphology "any structural anomaly of the second cervical vertebra (C2) which forms the pivot upon which the first cervical (atlas, C1) vertebra rotates" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbpl1tm1Saco/Tbpl1tm1Saco
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025050 Pcgf6 / Q99NA9 / Polycomb group RING finger protein 6 / Q9BYE7* / polycomb group ring finger 6*  / complex
 ENSMUSG00000033943 Mga / A2AWL7 / MAX-associated protein / Q8IWI9* / MGA, MAX dimerization protein*  / complex / reaction
 ENSMUSG00000059436 Max / Max protein / P61244* / MYC associated factor X*  / complex / reaction
 ENSMUSG00000072872 Rybp / Q8CCI5 / RING1 and YY1-binding protein / Q8N488*  / complex
 ENSMUSG00000036893 Ehmt1 / Q5DW34 / Histone-lysine N-methyltransferase EHMT1 / Q9H9B1* / euchromatic histone lysine methyltransferase 1*  / complex / reaction
 ENSMUSG00000057469 E2f6 / O54917 / Transcription factor E2F6 / O75461* / E2F transcription factor 6*  / reaction / complex
 ENSMUSG00000013787 Ehmt2 / Q9Z148 / Histone-lysine N-methyltransferase EHMT2 / Q96KQ7* / euchromatic histone lysine methyltransferase 2*  / complex / reaction
 ENSMUSG00000026739 Bmi1 / P25916 / Polycomb complex protein BMI-1 / P35226* / COMMD3-BMI1* / COMMD3-BMI1 readthrough* / BMI1 proto-oncogene, polycomb ring finger*  / complex
 ENSMUSG00000038482 Tfdp1 / Q08639 / transcription factor Dp 1 / TFDP3* / Q14186* / Q5H9I0* / transcription factor Dp family member 3*  / complex / reaction
 ENSMUSG00000018537 Pcgf2 / P23798 / Polycomb group RING finger protein 2 / P35227* / polycomb group ring finger 2*  / complex
 ENSMUSG00000022394 P59178 / L3mbtl2 / Lethal(3)malignant brain tumor-like protein 2 / Q969R5* / L3MBTL2, polycomb repressive complex 1 subunit*  / complex
 ENSMUSG00000029836 Cbx3 / chromobox protein homolog 3 / Q13185* / chromobox 3*  / reaction / complex
 ENSMUSG00000037652 Phc3 / Q8CHP6 / Polyhomeotic-like protein 3 / Q8NDX5* / polyhomeotic homolog 3*  / complex
 ENSMUSG00000022634 Yaf2 / Q99LW6 / YY1 associated factor 2 / Q8IY57*  / complex






 

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