ENSMUSG00000022394


Mus musculus

Features
Gene ID: ENSMUSG00000022394
  
Biological name :L3mbtl2
  
Synonyms : L3mbtl2 / Lethal(3)malignant brain tumor-like protein 2 / P59178
  
Possible biological names infered from orthology : L3MBTL2, polycomb repressive complex 1 subunit / Q969R5
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: E1
Gene start: 81663889
Gene end: 81688315
  
Corresponding Affymetrix probe sets: 10425559 (MoGene1.0st)   1433777_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000133967
Ensembl peptide - ENSMUSP00000023029
Ensembl peptide - ENSMUSP00000133549
Ensembl peptide - ENSMUSP00000134333
Ensembl peptide - ENSMUSP00000155456
NCBI entrez gene - 214669     See in Manteia.
MGI - MGI:2443584
RefSeq - NM_001289711
RefSeq - NM_001289712
RefSeq - NM_145993
RefSeq Peptide - NP_001276640
RefSeq Peptide - NP_001276641
RefSeq Peptide - NP_666105
swissprot - G3UY70
swissprot - Q80XB0
swissprot - G3UX47
swissprot - Q80XB1
swissprot - P59178
Ensembl - ENSMUSG00000022394
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 l3mbtl2ENSDARG00000056079Danio rerio
 L3MBTL2ENSGALG00000011976Gallus gallus
 Q969R5ENSG00000100395Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mbtd1 / Q6P5G3 / MBT domain-containing protein 1 / Q05BQ5* / mbt domain containing 1*ENSMUSG0000005947449
Q9JMD1 / Sfmbt1 / Scm-like with four MBT domains protein 1 / Q9UHJ3* / Scm like with four mbt domains 1*ENSMUSG0000000652723
Sfmbt2 / Scm-like with four mbt domains 2 / Q5VUG0*ENSMUSG0000006118622
A2A5N8 / L3mbtl1 / Lethal(3)malignant brain tumor-like protein 1 / Q9Y468* / L3MBTL1, histone methyl-lysine binding protein*ENSMUSG0000003557621
Q8BLB7 / L3mbtl3 / Mus musculus L3MBTL3 histone methyl-lysine binding protein (L3mbtl3), transcript variant 3, mRNA. / Q96JM7* / L3MBTL3, histone methyl-lysine binding protein*ENSMUSG0000003908920
L3mbtl4 / lethal(3)malignant brain tumor-like protein 4 / Q8NA19* / L3MBTL4, histone methyl-lysine binding protein*ENSMUSG0000004156519
Scmh1 / Q8K214 / Polycomb protein SCMH1 / Q96GD3* / Scm polycomb group protein homolog 1*ENSMUSG0000000008512
Scml2 / Scm polycomb group protein like 2 / Q9UQR0*ENSMUSG0000000003711
Scml4 / Q80VG1 / Scm polycomb group protein like 4 / Q8N228*ENSMUSG000000447704


Protein motifs (from Interpro)
Interpro ID Name
 IPR004092  Mbt repeat
 IPR012313  Zinc finger, FCS-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007398 ectoderm development IMP
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0031062 positive regulation of histone methylation IMP
 biological_processGO:0035067 negative regulation of histone acetylation IMP
 biological_processGO:0048863 stem cell differentiation IMP
 biological_processGO:0072089 stem cell proliferation IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0035064 methylated histone binding IEA
 molecular_functionGO:0042393 histone binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:1990841 promoter-specific chromatin binding IDA


Pathways (from Reactome)
Pathway description
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgf4tm1Gol/Fgf4tm1Gol
Genetic Background: involves: C57BL/6J

 MP:0003036 vertebral transformation "homeotic transformation of a specific vertebrae to adopt the fate of another" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1+
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

 MP:0003886 abnormal embryonic epiblast morphology "anomaly in the development/organization of the tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgf4tm1Gol/Fgf4tm1Gol
Genetic Background: involves: C57BL/6J

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgf4tm1Gol/Fgf4tm1Gol
Genetic Background: involves: C57BL/6J

 MP:0004647 decreased lumbar vertebrae number "reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1+
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

 MP:0006207 embryonic lethality during organogenesis "death anytime after embryo turning but before the completion of organogenesis (E9 to less than E14)" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgf4tm1Gol/Fgf4tm1Gol
Genetic Background: involves: C57BL/6J

 MP:0010101 increased sacral vertebrae number "increase of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1+
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

 MP:0010123 increased bone mineral content "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1+
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1+
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Jam3tm1.1(KOMP)Vlcg/Jam3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Jam3tm1.1(KOMP)Vlcg/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000059436 Max / Max protein / P61244* / MYC associated factor X*  / reaction / complex
 ENSMUSG00000038482 Tfdp1 / Q08639 / transcription factor Dp 1 / TFDP3* / Q14186* / Q5H9I0* / transcription factor Dp family member 3*  / reaction / complex
 ENSMUSG00000022634 Yaf2 / Q99LW6 / YY1 associated factor 2 / Q8IY57*  / complex
 ENSMUSG00000013787 Ehmt2 / Q9Z148 / Histone-lysine N-methyltransferase EHMT2 / Q96KQ7* / euchromatic histone lysine methyltransferase 2*  / reaction / complex
 ENSMUSG00000057469 E2f6 / O54917 / Transcription factor E2F6 / O75461* / E2F transcription factor 6*  / complex / reaction
 ENSMUSG00000036893 Ehmt1 / Q5DW34 / Histone-lysine N-methyltransferase EHMT1 / Q9H9B1* / euchromatic histone lysine methyltransferase 1*  / reaction / complex
 ENSMUSG00000024325 Ring1 / O35730 / E3 ubiquitin-protein ligase RING1 / Q06587* / ring finger protein 1*  / complex
 ENSMUSG00000033943 Mga / A2AWL7 / MAX-associated protein / Q8IWI9* / MGA, MAX dimerization protein*  / reaction / complex
 ENSMUSG00000025050 Pcgf6 / Q99NA9 / Polycomb group RING finger protein 6 / Q9BYE7* / polycomb group ring finger 6*  / complex
 ENSMUSG00000026484 Rnf2 / Q9CQJ4 / E3 ubiquitin-protein ligase RING2 / Q99496* / ring finger protein 2*  / complex
 ENSMUSG00000029836 Cbx3 / chromobox protein homolog 3 / Q13185* / chromobox 3*  / complex / reaction






 

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