ENSMUSG00000000037


Mus musculus

Features
Gene ID: ENSMUSG00000000037
  
Biological name :Scml2
  
Synonyms : Scml2 / Scm polycomb group protein like 2
  
Possible biological names infered from orthology : Q9UQR0
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: F4
Gene start: 161117193
Gene end: 161258213
  
Corresponding Affymetrix probe sets: 10602977 (MoGene1.0st)   1421514_a_at (Mouse Genome 430 2.0 Array)   1456984_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000019101
Ensembl peptide - ENSMUSP00000107964
Ensembl peptide - ENSMUSP00000098672
Ensembl peptide - ENSMUSP00000084325
Ensembl peptide - ENSMUSP00000076593
Ensembl peptide - ENSMUSP00000074356
NCBI entrez gene - 107815     See in Manteia.
MGI - MGI:1340042
RefSeq - XM_006528673
RefSeq - NM_001290651
RefSeq - NM_001290652
RefSeq - XM_006528670
RefSeq - XM_006528672
RefSeq Peptide - NP_001277581
RefSeq Peptide - NP_001277580
swissprot - B1AVB4
swissprot - B1AVB3
swissprot - B1AVB2
swissprot - B1AVB5
swissprot - B1AVB1
swissprot - E9Q796
Ensembl - ENSMUSG00000000037
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 scml2ENSDARG00000012949Danio rerio
 SCML2ENSGALG00000016537Gallus gallus
 SCML2ENSG00000102098Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Scmh1 / Q8K214 / Polycomb protein SCMH1 / Q96GD3* / Scm polycomb group protein homolog 1*ENSMUSG0000000008527
Q9JMD1 / Sfmbt1 / Scm-like with four MBT domains protein 1 / Q9UHJ3* / Scm like with four mbt domains 1*ENSMUSG0000000652713
Sfmbt2 / Scm-like with four mbt domains 2 / Q5VUG0*ENSMUSG0000006118613
Q8BLB7 / L3mbtl3 / Mus musculus L3MBTL3 histone methyl-lysine binding protein (L3mbtl3), transcript variant 3, mRNA. / Q96JM7* / L3MBTL3, histone methyl-lysine binding protein*ENSMUSG0000003908911
A2A5N8 / L3mbtl1 / Lethal(3)malignant brain tumor-like protein 1 / Q9Y468* / L3MBTL1, histone methyl-lysine binding protein*ENSMUSG0000003557611
L3mbtl4 / lethal(3)malignant brain tumor-like protein 4 / Q8NA19* / L3MBTL4, histone methyl-lysine binding protein*ENSMUSG0000004156511
Mbtd1 / Q6P5G3 / MBT domain-containing protein 1 / Q05BQ5* / mbt domain containing 1*ENSMUSG000000594749
P59178 / L3mbtl2 / Lethal(3)malignant brain tumor-like protein 2 / Q969R5* / L3MBTL2, polycomb repressive complex 1 subunit*ENSMUSG000000223949
Scml4 / Q80VG1 / Scm polycomb group protein like 4 / Q8N228*ENSMUSG000000447709


Protein motifs (from Interpro)
Interpro ID Name
 IPR004092  Mbt repeat
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR021987  SLED domain
 IPR033763  Polycomb group protein, RNA binding region


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006915 apoptotic process IMP
 biological_processGO:0034613 cellular protein localization IMP
 biological_processGO:0036353 histone H2A-K119 monoubiquitination IMP
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0001741 XY body IDA
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Sumo2tm1Weiy/Sumo2+,Sumo3tm1Weiy/Sumo3+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Scml2em2Shnk/Scml2em2Shnk
Genetic Background: C57BL/6J-Scml2em2Shnk

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Sumo2tm1Weiy/Sumo2+,Sumo3tm1Weiy/Sumo3+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Scml2em2Shnk/Scml2em2Shnk
Genetic Background: C57BL/6J-Scml2em2Shnk

 MP:0001932 abnormal spermiogenesis "failure of sperm cells to form or differentiate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sumo2tm1Weiy/Sumo2+,Sumo3tm1Weiy/Sumo3+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Scml2em2Shnk/Scml2em2Shnk
Genetic Background: C57BL/6J-Scml2em2Shnk

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sumo2tm1Weiy/Sumo2+,Sumo3tm1Weiy/Sumo3+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Scml2em2Shnk/Scml2em2Shnk
Genetic Background: C57BL/6J-Scml2em2Shnk

 MP:0006362 abnormal male germ cell morphology "any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sumo2tm1Weiy/Sumo2+,Sumo3tm1Weiy/Sumo3+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Scml2em2Shnk/Scml2em2Shnk
Genetic Background: C57BL/6J-Scml2em2Shnk

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sumo2tm1Weiy/Sumo2+,Sumo3tm1Weiy/Sumo3+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Scml2em2Shnk/Scml2em2Shnk
Genetic Background: C57BL/6J-Scml2em2Shnk

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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