ENSMUSG00000059474


Mus musculus

Features
Gene ID: ENSMUSG00000059474
  
Biological name :Mbtd1
  
Synonyms : Mbtd1 / MBT domain-containing protein 1 / Q6P5G3
  
Possible biological names infered from orthology : mbt domain containing 1 / Q05BQ5
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: D
Gene start: 93885852
Gene end: 93946985
  
Corresponding Affymetrix probe sets: 10380321 (MoGene1.0st)   1417261_at (Mouse Genome 430 2.0 Array)   1441100_at (Mouse Genome 430 2.0 Array)   1441287_at (Mouse Genome 430 2.0 Array)   1448641_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000103486
Ensembl peptide - ENSMUSP00000103484
Ensembl peptide - ENSMUSP00000103485
Ensembl peptide - ENSMUSP00000065442
Ensembl peptide - ENSMUSP00000070248
Ensembl peptide - ENSMUSP00000103482
NCBI entrez gene - 103537     See in Manteia.
MGI - MGI:2143977
RefSeq - XM_017314206
RefSeq - NM_134012
RefSeq - XM_017314200
RefSeq - XM_017314201
RefSeq - XM_017314202
RefSeq - XM_017314203
RefSeq - XM_017314204
RefSeq - XM_017314205
RefSeq - XM_006531884
RefSeq - XM_006531885
RefSeq - XM_006531887
RefSeq - XM_006531889
RefSeq - XM_006531891
RefSeq - XM_006531893
RefSeq - XM_006531894
RefSeq - XM_006531895
RefSeq - XM_006531897
RefSeq - XM_006531898
RefSeq - XM_006531899
RefSeq - XM_006531900
RefSeq - XM_006531901
RefSeq - XM_006531902
RefSeq - XM_006531903
RefSeq - XM_006531904
RefSeq - XM_006531905
RefSeq - XM_006531906
RefSeq - XM_006531907
RefSeq - XM_006531908
RefSeq - XM_006531909
RefSeq - XM_006531910
RefSeq - XM_006531911
RefSeq - XM_006531912
RefSeq Peptide - NP_001333454
RefSeq Peptide - NP_598773
swissprot - Q5NC75
swissprot - Q5NC76
swissprot - Q6P5G3
swissprot - A2ABG6
Ensembl - ENSMUSG00000059474
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mbtd1ENSDARG00000060868Danio rerio
 MBTD1ENSGALG00000002954Gallus gallus
 MBTD1ENSG00000011258Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P59178 / L3mbtl2 / Lethal(3)malignant brain tumor-like protein 2 / Q969R5* / L3MBTL2, polycomb repressive complex 1 subunit*ENSMUSG0000002239457
Q9JMD1 / Sfmbt1 / Scm-like with four MBT domains protein 1 / Q9UHJ3* / Scm like with four mbt domains 1*ENSMUSG0000000652724
Sfmbt2 / Scm-like with four mbt domains 2 / Q5VUG0*ENSMUSG0000006118624
Q8BLB7 / L3mbtl3 / Mus musculus L3MBTL3 histone methyl-lysine binding protein (L3mbtl3), transcript variant 3, mRNA. / Q96JM7* / L3MBTL3, histone methyl-lysine binding protein*ENSMUSG0000003908922
A2A5N8 / L3mbtl1 / Lethal(3)malignant brain tumor-like protein 1 / Q9Y468* / L3MBTL1, histone methyl-lysine binding protein*ENSMUSG0000003557621
L3mbtl4 / lethal(3)malignant brain tumor-like protein 4 / Q8NA19* / L3MBTL4, histone methyl-lysine binding protein*ENSMUSG0000004156520
Scmh1 / Q8K214 / Polycomb protein SCMH1 / Q96GD3* / Scm polycomb group protein homolog 1*ENSMUSG0000000008513
Scml2 / Scm polycomb group protein like 2 / Q9UQR0*ENSMUSG0000000003713
Scml4 / Q80VG1 / Scm polycomb group protein like 4 / Q8N228*ENSMUSG000000447703


Protein motifs (from Interpro)
Interpro ID Name
 IPR004092  Mbt repeat
 IPR012313  Zinc finger, FCS-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0048706 embryonic skeletal system development IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0035064 methylated histone binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000077 abnormal interparietal bone morphology "malformed bone of the cranium; lies above and anterior to the occipital bone " [J:61509]
Show

Allelic Composition: Adgra2tm1.1Vlcg/Adgra2tm1.1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0000153 rib bifurcation "forking or division of ribs, may be a result of partial rib fusions" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Adgra2tm1.1Vlcg/Adgra2tm1.1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
Show

Allelic Composition: Adgra2tm1.1Vlcg/Adgra2tm1.1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0000596 abnormal liver development "anomalous differentiation of the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Adgra2tm1.1Vlcg/Adgra2tm1.1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0000600 liver hypoplasia "reduced size of liver due to decreased cell number " [J:57631]
Show

Allelic Composition: Adgra2tm1.1Vlcg/Adgra2tm1.1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Hprttm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg

 MP:0003048 abnormal cervical vertebrae morphology "malformation of any or all of the seven bony segments of the spine located anterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Adgra2tm1.1Vlcg/Adgra2tm1.1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0003841 abnormal lambdoidal suture morphology "malformation of the articulation of the parietal bones and the occipital bone" [Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Adgra2tm1.1Vlcg/Adgra2tm1.1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0004174 abnormal spine curvature "deviation from the typical S-shape of the spine" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Adgra2tm1.1Vlcg/Adgra2tm1.1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0004607 abnormal cervical atlas morphology "any structural anomaly of the first (topmost, C1) cervical vertebra which supports the globe of the head" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adgra2tm1.1Vlcg/Adgra2tm1.1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0004608 abnormal cervical axis morphology "any structural anomaly of the second cervical vertebra (C2) which forms the pivot upon which the first cervical (atlas, C1) vertebra rotates" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adgra2tm1.1Vlcg/Adgra2tm1.1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0004620 cervical vertebral fusion "the union of one or more cervical vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adgra2tm1.1Vlcg/Adgra2tm1.1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0004624 abnormal thoracic cage "any structural anomaly of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adgra2tm1.1Vlcg/Adgra2tm1.1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0004703 abnormal vertebral column "any structural anomaly of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adgra2tm1.1Vlcg/Adgra2tm1.1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adgra2tm1.1Vlcg/Adgra2tm1.1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Adgra2tm1.1Vlcg/Adgra2tm1.1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0008149 abnormal rib-vertebral column attachment "any anomaly in the in the normal joining of the ribs to the vertebral column" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adgra2tm1.1Vlcg/Adgra2tm1.1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Adgra2tm1.1Vlcg/Adgra2tm1.1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0030286 occipital bone hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the bone at the lower, posterior part of the skull" [MGI:anna]
Show

Allelic Composition: Adgra2tm1.1Vlcg/Adgra2tm1.1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0030289 flat occipital bone "abnormal flatness of the bone at the lower, posterior part of the skull" [MGI:anna]
Show

Allelic Composition: Adgra2tm1.1Vlcg/Adgra2tm1.1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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