ENSMUSG00000000085


Mus musculus

Features
Gene ID: ENSMUSG00000000085
  
Biological name :Scmh1
  
Synonyms : Polycomb protein SCMH1 / Q8K214 / Scmh1
  
Possible biological names infered from orthology : Q96GD3 / Scm polycomb group protein homolog 1
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D2.1
Gene start: 120405281
Gene end: 120530186
  
Corresponding Affymetrix probe sets: 10507699 (MoGene1.0st)   1426241_a_at (Mouse Genome 430 2.0 Array)   1439554_at (Mouse Genome 430 2.0 Array)   1441573_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120950
Ensembl peptide - ENSMUSP00000101908
Ensembl peptide - ENSMUSP00000115343
Ensembl peptide - ENSMUSP00000000087
Ensembl peptide - ENSMUSP00000069813
Ensembl peptide - ENSMUSP00000101905
NCBI entrez gene - 29871     See in Manteia.
MGI - MGI:1352762
RefSeq - XM_017320254
RefSeq - XM_006503150
RefSeq - XM_011240550
RefSeq - XM_011240551
RefSeq - XM_011240552
RefSeq - XM_017320252
RefSeq - XM_017320253
RefSeq - NM_001159630
RefSeq - NM_013883
RefSeq - XM_006503149
RefSeq Peptide - NP_001153102
RefSeq Peptide - NP_001342352
RefSeq Peptide - NP_038911
swissprot - F6UK33
swissprot - Q8K214
swissprot - B1AS49
Ensembl - ENSMUSG00000000085
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 scmh1ENSDARG00000104311Danio rerio
 SCMH1ENSGALG00000000672Gallus gallus
 SCMH1ENSG00000010803Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Scml2 / Scm polycomb group protein like 2 / Q9UQR0*ENSMUSG0000000003735
Scml4 / Q80VG1 / Scm polycomb group protein like 4 / Q8N228*ENSMUSG0000004477025
Q9JMD1 / Sfmbt1 / Scm-like with four MBT domains protein 1 / Q9UHJ3* / Scm like with four mbt domains 1*ENSMUSG0000000652723
L3mbtl4 / lethal(3)malignant brain tumor-like protein 4 / Q8NA19* / L3MBTL4, histone methyl-lysine binding protein*ENSMUSG0000004156520
A2A5N8 / L3mbtl1 / Lethal(3)malignant brain tumor-like protein 1 / Q9Y468* / L3MBTL1, histone methyl-lysine binding protein*ENSMUSG0000003557620
Sfmbt2 / Scm-like with four mbt domains 2 / Q5VUG0*ENSMUSG0000006118620
Q8BLB7 / L3mbtl3 / Mus musculus L3MBTL3 histone methyl-lysine binding protein (L3mbtl3), transcript variant 3, mRNA. / Q96JM7* / L3MBTL3, histone methyl-lysine binding protein*ENSMUSG0000003908919
P59178 / L3mbtl2 / Lethal(3)malignant brain tumor-like protein 2 / Q969R5* / L3MBTL2, polycomb repressive complex 1 subunit*ENSMUSG0000002239412
Mbtd1 / Q6P5G3 / MBT domain-containing protein 1 / Q05BQ5* / mbt domain containing 1*ENSMUSG0000005947412


Protein motifs (from Interpro)
Interpro ID Name
 IPR001660  Sterile alpha motif domain
 IPR004092  Mbt repeat
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR021987  SLED domain
 IPR033763  Polycomb group protein, RNA binding region


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006338 chromatin remodeling IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0016458 gene silencing ISS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated NAS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0010369 chromocenter IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription cofactors
SUMOylation of chromatin organization proteins
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of PTEN gene transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000480 increased number of ribs "greater than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Phc2tm1Hko/Phc2+,Scmh1tm1Hko/Scmh1tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0003036 vertebral transformation "homeotic transformation of a specific vertebrae to adopt the fate of another" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0004615 cervical vertebral transformation "homeotic transformation of any cervical vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0004620 cervical vertebral fusion "the union of one or more cervical vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0004808 abnormal hematopoietic stem cell morphology "any structural anomaly of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cers1tm1.1Kwi/Cers1tm1.1Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004809 increased hematopoietic stem cell number "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cers1tm1.1Kwi/Cers1tm1.1Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cers1tm1.1Kwi/Cers1tm1.1Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cers1tm1.1Kwi/Cers1tm1.1Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0008148 abnormal rib-sternum attachment "any anomaly in the in the normal joining of the ribs to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0010373 myeloid hyperplasia "greater than normal number of nucleated cells of the myeloid lineage (a monocyte, granulocyte, or mast cell), found in blood or other tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cers1tm1.1Kwi/Cers1tm1.1Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011246 abnormal fetal liver hematopoietic progenitor cell morphology "any structural anomaly of a hematopoietic stem cell that resides in the fetal liver; in mice, this cell type is first observed at E10.5" [CL:0002353]
Show

Allelic Composition: Cers1tm1.1Kwi/Cers1tm1.1Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0020550 multinucleated giant male germ cells "presence of large cells containing multiple nuclei formed abnormal opening of the cytoplasmic bridges that are part of normal germ cell division" [PMID:16272280, url:https://ntp.niehs.nih.gov/nnl/male_reproductive/testis/setubmgcel/index.htm]
Show

Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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