ENSMUSG00000035576


Mus musculus

Features
Gene ID: ENSMUSG00000035576
  
Biological name :L3mbtl1
  
Synonyms : A2A5N8 / L3mbtl1 / Lethal(3)malignant brain tumor-like protein 1
  
Possible biological names infered from orthology : L3MBTL1, histone methyl-lysine binding protein / Q9Y468
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: H2
Gene start: 162943472
Gene end: 162974522
  
Corresponding Affymetrix probe sets: 10478299 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000123217
Ensembl peptide - ENSMUSP00000044038
Ensembl peptide - ENSMUSP00000116118
NCBI entrez gene - 241764     See in Manteia.
MGI - MGI:2676663
RefSeq - XM_017318271
RefSeq - XM_011239548
RefSeq - XM_011239549
RefSeq - XM_011239550
RefSeq - XM_017318263
RefSeq - NM_001081338
RefSeq - XM_011239540
RefSeq - XM_011239541
RefSeq - XM_011239542
RefSeq - XM_011239543
RefSeq - XM_011239544
RefSeq - XM_011239545
RefSeq - XM_011239546
RefSeq - XM_011239547
RefSeq Peptide - NP_001074807
swissprot - A2A6Y5
swissprot - A2A5N8
swissprot - Q3V558
Ensembl - ENSMUSG00000035576
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 l3mbtl1aENSDARG00000014828Danio rerio
 L3MBTL1ENSGALG00000030710Gallus gallus
 Q9Y468ENSG00000185513Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8BLB7 / L3mbtl3 / Mus musculus L3MBTL3 histone methyl-lysine binding protein (L3mbtl3), transcript variant 3, mRNA. / Q96JM7* / L3MBTL3, histone methyl-lysine binding protein*ENSMUSG0000003908939
L3mbtl4 / lethal(3)malignant brain tumor-like protein 4 / Q8NA19* / L3MBTL4, histone methyl-lysine binding protein*ENSMUSG0000004156536
Q9JMD1 / Sfmbt1 / Scm-like with four MBT domains protein 1 / Q9UHJ3* / Scm like with four mbt domains 1*ENSMUSG0000000652720
P59178 / L3mbtl2 / Lethal(3)malignant brain tumor-like protein 2 / Q969R5* / L3MBTL2, polycomb repressive complex 1 subunit*ENSMUSG0000002239419
Sfmbt2 / Scm-like with four mbt domains 2 / Q5VUG0*ENSMUSG0000006118618
Scmh1 / Q8K214 / Polycomb protein SCMH1 / Q96GD3* / Scm polycomb group protein homolog 1*ENSMUSG0000000008517
Mbtd1 / Q6P5G3 / MBT domain-containing protein 1 / Q05BQ5* / mbt domain containing 1*ENSMUSG0000005947416
Scml2 / Scm polycomb group protein like 2 / Q9UQR0*ENSMUSG0000000003712
Scml4 / Q80VG1 / Scm polycomb group protein like 4 / Q8N228*ENSMUSG000000447707


Protein motifs (from Interpro)
Interpro ID Name
 IPR001660  Sterile alpha motif domain
 IPR002515  Zinc finger, C2HC-type
 IPR004092  Mbt repeat
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR036060  Zinc finger, C2HC-type superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization ISO
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007088 regulation of mitotic nuclear division IEA
 biological_processGO:0030097 hemopoiesis IEA
 biological_processGO:0040029 regulation of gene expression, epigenetic NAS
 biological_processGO:0045652 regulation of megakaryocyte differentiation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0000793 condensed chromosome IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0031491 nucleosome binding IEA
 molecular_functionGO:0031493 nucleosomal histone binding IEA
 molecular_functionGO:0032093 SAM domain binding IEA
 molecular_functionGO:0035064 methylated histone binding IEA
 molecular_functionGO:0042393 histone binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation of TP53 Activity through Methylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000059552 Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*  / complex / reaction






 

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