ENSG00000185513


Homo sapiens

Features
Gene ID: ENSG00000185513
  
Biological name :L3MBTL1
  
Synonyms : L3MBTL1 / L3MBTL1, histone methyl-lysine binding protein / Q9Y468
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: 1
Band: q13.12
Gene start: 43507680
Gene end: 43550950
  
Corresponding Affymetrix probe sets: 206822_s_at (Human Genome U133 Plus 2.0 Array)   206823_at (Human Genome U133 Plus 2.0 Array)   210306_at (Human Genome U133 Plus 2.0 Array)   213837_at (Human Genome U133 Plus 2.0 Array)   216076_at (Human Genome U133 Plus 2.0 Array)   216077_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000387971
Ensembl peptide - ENSP00000415971
Ensembl peptide - ENSP00000412938
Ensembl peptide - ENSP00000410139
Ensembl peptide - ENSP00000402107
Ensembl peptide - ENSP00000398516
Ensembl peptide - ENSP00000362226
Ensembl peptide - ENSP00000362227
NCBI entrez gene - 26013     See in Manteia.
OMIM - 608802
RefSeq - NM_015478
RefSeq - NM_032107
RefSeq Peptide - NP_056293
RefSeq Peptide - NP_115479
swissprot - B0QYN5
swissprot - Q9Y468
swissprot - B0QYN4
swissprot - A0A0C4DG70
swissprot - A0A0A0MRR4
swissprot - H0Y7I2
Ensembl - ENSG00000185513
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 l3mbtl1aENSDARG00000014828Danio rerio
 L3MBTL1ENSGALG00000030710Gallus gallus
 A2A5N8ENSMUSG00000035576Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q96JM7 / L3MBTL3 / L3MBTL3, histone methyl-lysine binding proteinENSG0000019894537
Q8NA19 / L3MBTL4 / L3MBTL4, histone methyl-lysine binding proteinENSG0000015465535
Q9UHJ3 / SFMBT1 / Scm like with four mbt domains 1ENSG0000016393519
Q5VUG0 / SFMBT2 / Scm like with four mbt domains 2ENSG0000019887919
Q969R5 / L3MBTL2 / L3MBTL2, polycomb repressive complex 1 subunitENSG0000010039519
MBTD1 / Q05BQ5 / mbt domain containing 1ENSG0000001125816
SCMH1 / Q96GD3 / Scm polycomb group protein homolog 1ENSG0000001080315
SCML2 / Q9UQR0 / Scm polycomb group protein like 2ENSG0000010209815
SCML4 / Q8N228 / Scm polycomb group protein like 4ENSG000001462855


Protein motifs (from Interpro)
Interpro ID Name
 IPR001660  Sterile alpha motif domain
 IPR002515  Zinc finger, C2HC-type
 IPR004092  Mbt repeat
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR036060  Zinc finger, C2HC-type superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007088 regulation of mitotic nuclear division IMP
 biological_processGO:0030097 hemopoiesis IEP
 biological_processGO:0045652 regulation of megakaryocyte differentiation IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0051726 regulation of cell cycle NAS
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 cellular_componentGO:0000785 chromatin IDA
 cellular_componentGO:0000793 condensed chromosome IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005886 plasma membrane IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0031491 nucleosome binding IDA
 molecular_functionGO:0031493 nucleosomal histone binding IDA
 molecular_functionGO:0032093 SAM domain binding IPI
 molecular_functionGO:0035064 methylated histone binding IPI
 molecular_functionGO:0042393 histone binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation of TP53 Activity through Methylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000141510 TP53 / P04637 / tumor protein p53  / reaction / complex






 

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