ENSG00000100395


Homo sapiens

Features
Gene ID: ENSG00000100395
  
Biological name :L3MBTL2
  
Synonyms : L3MBTL2 / L3MBTL2, polycomb repressive complex 1 subunit / Q969R5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: 1
Band: q13.2
Gene start: 41205205
Gene end: 41231271
  
Corresponding Affymetrix probe sets: 1555815_a_at (Human Genome U133 Plus 2.0 Array)   223205_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000216237
Ensembl peptide - ENSP00000403767
Ensembl peptide - ENSP00000405849
Ensembl peptide - ENSP00000414423
Ensembl peptide - ENSP00000399405
NCBI entrez gene - 83746     See in Manteia.
OMIM - 611865
RefSeq - XM_017028980
RefSeq - XM_011530420
RefSeq - XM_011530421
RefSeq - XM_017028976
RefSeq - XM_017028977
RefSeq - XM_017028978
RefSeq - XM_017028979
RefSeq - NM_031488
RefSeq Peptide - NP_113676
swissprot - F8WBL1
swissprot - H0Y5M2
swissprot - H7C228
swissprot - A0A0S2Z5X6
swissprot - Q969R5
Ensembl - ENSG00000100395
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 l3mbtl2ENSDARG00000056079Danio rerio
 L3MBTL2ENSGALG00000011976Gallus gallus
 P59178ENSMUSG00000022394Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MBTD1 / Q05BQ5 / mbt domain containing 1ENSG0000001125851
Q5VUG0 / SFMBT2 / Scm like with four mbt domains 2ENSG0000019887926
Q9UHJ3 / SFMBT1 / Scm like with four mbt domains 1ENSG0000016393525
Q9Y468 / L3MBTL1 / L3MBTL1, histone methyl-lysine binding proteinENSG0000018551322
Q96JM7 / L3MBTL3 / L3MBTL3, histone methyl-lysine binding proteinENSG0000019894521
Q8NA19 / L3MBTL4 / L3MBTL4, histone methyl-lysine binding proteinENSG0000015465519
SCML2 / Q9UQR0 / Scm polycomb group protein like 2ENSG0000010209814
SCMH1 / Q96GD3 / Scm polycomb group protein homolog 1ENSG0000001080312
SCML4 / Q8N228 / Scm polycomb group protein like 4ENSG000001462854


Protein motifs (from Interpro)
Interpro ID Name
 IPR004092  Mbt repeat
 IPR012313  Zinc finger, FCS-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0016925 protein sumoylation TAS
 biological_processGO:0070317 negative regulation of G0 to G1 transition TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0035064 methylated histone binding IEA
 molecular_functionGO:0042393 histone binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
SUMOylation of chromatin organization proteins
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000122565 CBX3 / Q13185 / chromobox 3  / reaction / complex
 ENSG00000174197 MGA / Q8IWI9 / MGA, MAX dimerization protein  / reaction / complex
 ENSG00000156374 PCGF6 / Q9BYE7 / polycomb group ring finger 6  / complex
 ENSG00000125952 MAX / P61244 / MYC associated factor X  / reaction / complex
 ENSG00000204371 EHMT2 / Q96KQ7 / euchromatic histone lysine methyltransferase 2  / complex / reaction
 ENSG00000181090 EHMT1 / Q9H9B1 / euchromatic histone lysine methyltransferase 1  / reaction / complex
 ENSG00000204227 RING1 / Q06587 / ring finger protein 1  / complex
 ENSG00000121481 RNF2 / Q99496 / ring finger protein 2  / complex
 ENSG00000198176 TFDP1 / Q14186 / transcription factor Dp-1  / reaction / complex
 ENSG00000169016 E2F6 / O75461 / E2F transcription factor 6  / reaction / complex
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction
 ENSG00000015153 YAF2 / Q8IY57 / YY1 associated factor 2  / complex
 ENSG00000188612 SUMO2 / P61956 / small ubiquitin-like modifier 2  / reaction






 

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