ENSG00000169016


Homo sapiens

Features
Gene ID: ENSG00000169016
  
Biological name :E2F6
  
Synonyms : E2F6 / E2F transcription factor 6 / O75461
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: p25.1
Gene start: 11444375
Gene end: 11466177
  
Corresponding Affymetrix probe sets: 203957_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000438864
Ensembl peptide - ENSP00000413678
Ensembl peptide - ENSP00000446315
Ensembl peptide - ENSP00000302159
Ensembl peptide - ENSP00000370936
Ensembl peptide - ENSP00000389113
Ensembl peptide - ENSP00000403449
Ensembl peptide - ENSP00000406891
Ensembl peptide - ENSP00000407650
NCBI entrez gene - 1876     See in Manteia.
OMIM - 602944
RefSeq - XM_017003548
RefSeq - NM_001278275
RefSeq - NM_001278276
RefSeq - NM_001278277
RefSeq - NM_001278278
RefSeq - NM_198256
RefSeq - NM_212540
RefSeq - XM_017003547
RefSeq Peptide - NP_001265205
RefSeq Peptide - NP_997705
RefSeq Peptide - NP_001265206
RefSeq Peptide - NP_001265207
RefSeq Peptide - NP_937987
RefSeq Peptide - NP_001265204
swissprot - A0A0S2Z3K8
swissprot - Q53YM3
swissprot - F8WC40
swissprot - F8WEZ5
swissprot - O75461
swissprot - Q2Z196
swissprot - Q2Z197
Ensembl - ENSG00000169016
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-195d17.2ENSDARG00000008119Danio rerio
 E2F6ENSGALG00000016454Gallus gallus
 E2f6ENSMUSG00000057469Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
E2F3 / O00716 / E2F transcription factor 3ENSG0000011224244
E2F2 / Q14209 / E2F transcription factor 2ENSG0000000796841
E2F1 / Q01094 / E2F transcription factor 1ENSG0000010141236
E2F4 / Q16254 / E2F transcription factor 4ENSG0000020525028
E2F5 / Q15329 / E2F transcription factor 5ENSG0000013374026


Protein motifs (from Interpro)
Interpro ID Name
 IPR003316  E2F/DP family, winged-helix DNA-binding domain
 IPR015633  E2F Family
 IPR015635  Transcription factor E2F6
 IPR032198  E2F transcription factor, CC-MB domain
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily
 IPR037241  E2F-DP heterodimerization region


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle IEA
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0070317 negative regulation of G0 to G1 transition TAS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0071339 MLL1 complex IDA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding TAS
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003714 transcription corepressor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
Activation of E2F1 target genes at G1/S
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100395 Q969R5 / L3MBTL2 / L3MBTL2, polycomb repressive complex 1 subunit  / reaction / complex
 ENSG00000174197 MGA / Q8IWI9 / MGA, MAX dimerization protein  / reaction / complex
 ENSG00000125952 MAX / P61244 / MYC associated factor X  / complex / reaction
 ENSG00000074266 EED / O75530 / embryonic ectoderm development  / complex / reaction
 ENSG00000162521 RBBP4 / Q09028 / RB binding protein 4, chromatin remodeling factor  / complex / reaction
 ENSG00000178691 SUZ12 / Q15022 / SUZ12 polycomb repressive complex 2 subunit  / reaction / complex
 ENSG00000120616 EPC1 / Q9H2F5 / enhancer of polycomb homolog 1  / complex / reaction
 ENSG00000122565 CBX3 / Q13185 / chromobox 3  / complex / reaction
 ENSG00000102054 RBBP7 / Q16576 / RB binding protein 7, chromatin remodeling factor  / complex / reaction
 ENSG00000106462 EZH2 / Q15910 / enhancer of zeste 2 polycomb repressive complex 2 subunit  / reaction / complex
 ENSG00000149554 CHEK1 / O14757 / checkpoint kinase 1  / reaction
 ENSG00000156374 PCGF6 / Q9BYE7 / polycomb group ring finger 6  / reaction / complex
 ENSG00000015153 YAF2 / Q8IY57 / YY1 associated factor 2  / reaction / complex
 ENSG00000181090 EHMT1 / Q9H9B1 / euchromatic histone lysine methyltransferase 1  / reaction / complex
 ENSG00000121481 RNF2 / Q99496 / ring finger protein 2  / reaction / complex
 ENSG00000204227 RING1 / Q06587 / ring finger protein 1  / complex / reaction
 ENSG00000204371 EHMT2 / Q96KQ7 / euchromatic histone lysine methyltransferase 2  / reaction / complex
 ENSG00000198176 TFDP1 / Q14186 / transcription factor Dp-1  / reaction / complex
 ENSG00000114126 TFDP2 / Q14188 / transcription factor Dp-2  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr