ENSG00000133740


Homo sapiens

Features
Gene ID: ENSG00000133740
  
Biological name :E2F5
  
Synonyms : E2F5 / E2F transcription factor 5 / Q15329
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: q21.2
Gene start: 85177225
Gene end: 85217158
  
Corresponding Affymetrix probe sets: 221586_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000428606
Ensembl peptide - ENSP00000430461
Ensembl peptide - ENSP00000429669
Ensembl peptide - ENSP00000429120
Ensembl peptide - ENSP00000256117
Ensembl peptide - ENSP00000398124
Ensembl peptide - ENSP00000414312
NCBI entrez gene - 1875     See in Manteia.
OMIM - 600967
RefSeq - NM_001083588
RefSeq - NM_001083589
RefSeq - NM_001951
RefSeq Peptide - NP_001942
RefSeq Peptide - NP_001077057
RefSeq Peptide - NP_001077058
swissprot - Q15329
swissprot - C9JYE9
swissprot - H0YBK0
swissprot - H0YBW8
swissprot - E5RHD4
Ensembl - ENSG00000133740
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 e2f5ENSDARG00000038812Danio rerio
 E2F5ENSGALG00000038915Gallus gallus
 E2f5ENSMUSG00000027552Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
E2F4 / Q16254 / E2F transcription factor 4ENSG0000020525060
E2F2 / Q14209 / E2F transcription factor 2ENSG0000000796836
E2F3 / O00716 / E2F transcription factor 3ENSG0000011224232
E2F1 / Q01094 / E2F transcription factor 1ENSG0000010141231
E2F6 / O75461 / E2F transcription factor 6ENSG0000016901621


Protein motifs (from Interpro)
Interpro ID Name
 IPR003316  E2F/DP family, winged-helix DNA-binding domain
 IPR015633  E2F Family
 IPR028316  Transcription factor E2F5
 IPR032198  E2F transcription factor, CC-MB domain
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily
 IPR037241  E2F-DP heterodimerization region


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II TAS
 biological_processGO:0051726 regulation of cell cycle IEA
 cellular_componentGO:0001650 fibrillar center IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
G0 and Early G1
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Activation of E2F1 target genes at G1/S
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
Cyclin A:Cdk2-associated events at S phase entry


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000110092 CCND1 / P24385 / cyclin D1  / reaction
 ENSG00000111276 CDKN1B / P46527 / cyclin dependent kinase inhibitor 1B  / reaction
 ENSG00000124762 CDKN1A / P38936 / cyclin dependent kinase inhibitor 1A  / reaction
 ENSG00000175387 SMAD2 / Q15796 / SMAD family member 2  / reaction / complex
 ENSG00000123374 CDK2 / P24941 / cyclin dependent kinase 2  / complex / reaction
 ENSG00000103479 RBL2 / Q08999 / RB transcriptional corepressor like 2  / complex
 ENSG00000135446 CDK4 / P11802 / cyclin dependent kinase 4  / reaction
 ENSG00000166949 SMAD3 / P84022 / SMAD family member 3  / reaction / complex
 ENSG00000141646 SMAD4 / Q13485 / SMAD family member 4  / complex / reaction
 ENSG00000080839 RBL1 / P28749 / RB transcriptional corepressor like 1  / complex
 ENSG00000116478 HDAC1 / Q13547 / histone deacetylase 1  / complex / reaction
 ENSG00000198176 TFDP1 / Q14186 / transcription factor Dp-1  / complex
 ENSG00000114126 TFDP2 / Q14188 / transcription factor Dp-2  / complex






 

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