ENSG00000112242


Homo sapiens

Features
Gene ID: ENSG00000112242
  
Biological name :E2F3
  
Synonyms : E2F3 / E2F transcription factor 3 / O00716
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p22.3
Gene start: 20401906
Gene end: 20493715
  
Corresponding Affymetrix probe sets: 203692_s_at (Human Genome U133 Plus 2.0 Array)   203693_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000483249
Ensembl peptide - ENSP00000262904
Ensembl peptide - ENSP00000443418
NCBI entrez gene - 1871     See in Manteia.
OMIM - 600427
RefSeq - XM_017010330
RefSeq - NM_001243076
RefSeq - NM_001949
RefSeq - XM_005248865
RefSeq - XM_005248866
RefSeq - XM_011514324
RefSeq - XM_011514328
RefSeq Peptide - NP_001230005
RefSeq Peptide - NP_001940
swissprot - O00716
swissprot - A0A087X0B6
Ensembl - ENSG00000112242
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 e2f3ENSDARG00000070463Danio rerio
 E2F3ENSGALG00000012680Gallus gallus
 E2f3ENSMUSG00000016477Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
E2F2 / Q14209 / E2F transcription factor 2ENSG0000000796846
E2F1 / Q01094 / E2F transcription factor 1ENSG0000010141238
E2F6 / O75461 / E2F transcription factor 6ENSG0000016901626
E2F4 / Q16254 / E2F transcription factor 4ENSG0000020525025
E2F5 / Q15329 / E2F transcription factor 5ENSG0000013374024


Protein motifs (from Interpro)
Interpro ID Name
 IPR003316  E2F/DP family, winged-helix DNA-binding domain
 IPR015633  E2F Family
 IPR032198  E2F transcription factor, CC-MB domain
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily
 IPR037241  E2F-DP heterodimerization region


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0070345 negative regulation of fat cell proliferation ISS
 biological_processGO:1905461 positive regulation of vascular associated smooth muscle cell apoptotic process IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001047 core promoter binding IDA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
Pre-NOTCH Transcription and Translation
Oxidative Stress Induced Senescence
Oncogene Induced Senescence
CDC6 association with the ORC:origin complex
G2 Phase
Cyclin D associated events in G1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000123374 CDK2 / P24941 / cyclin dependent kinase 2  / complex / reaction
 ENSG00000139687 RB1 / P06400 / RB transcriptional corepressor 1  / complex / reaction
 ENSG00000185591 SP1 / P08047 / Sp1 transcription factor  / complex / reaction
 ENSG00000198176 TFDP1 / Q14186 / transcription factor Dp-1  / complex
 ENSG00000114126 TFDP2 / Q14188 / transcription factor Dp-2  / complex






 

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