ENSMUSG00000016477


Mus musculus

Features
Gene ID: ENSMUSG00000016477
  
Biological name :E2f3
  
Synonyms : E2f3 / O35261 / Transcription factor E2F3
  
Possible biological names infered from orthology : E2F transcription factor 3 / O00716
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: A3.2
Gene start: 29906575
Gene end: 29986063
  
Corresponding Affymetrix probe sets: 10408475 (MoGene1.0st)   10408477 (MoGene1.0st)   1427462_at (Mouse Genome 430 2.0 Array)   1434564_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000100012
Ensembl peptide - ENSMUSP00000152368
Ensembl peptide - ENSMUSP00000152782
NCBI entrez gene - 13557     See in Manteia.
MGI - MGI:1096340
RefSeq - XM_011244277
RefSeq - NM_001289920
RefSeq - NM_010093
RefSeq - XM_011244275
RefSeq - XM_011244276
RefSeq Peptide - NP_001276849
RefSeq Peptide - NP_034223
swissprot - O35261
swissprot - Q3TMJ9
swissprot - Q3UZJ0
swissprot - A0A1Y7VML1
Ensembl - ENSMUSG00000016477
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 e2f3ENSDARG00000070463Danio rerio
 E2F3ENSGALG00000012680Gallus gallus
 E2F3ENSG00000112242Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
E2f2 / P56931 / Transcription factor E2F2 / Q14209* / E2F transcription factor 2*ENSMUSG0000001898345
E2f1 / Q61501 / Transcription factor E2F1 / Q01094* / E2F transcription factor 1*ENSMUSG0000002749037
E2f6 / O54917 / Transcription factor E2F6 / O75461* / E2F transcription factor 6*ENSMUSG0000005746927
E2f4 / Q8R0K9 / Transcription factor E2F4 / Q16254* / E2F transcription factor 4*ENSMUSG0000001485926
E2f5 / Q61502 / Transcription factor E2F5 / Q15329* / E2F transcription factor 5*ENSMUSG0000002755224


Protein motifs (from Interpro)
Interpro ID Name
 IPR003316  E2F/DP family, winged-helix DNA-binding domain
 IPR015633  E2F Family
 IPR032198  E2F transcription factor, CC-MB domain
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily
 IPR037241  E2F-DP heterodimerization region


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0070345 negative regulation of fat cell proliferation IMP
 biological_processGO:1905461 positive regulation of vascular associated smooth muscle cell apoptotic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0001047 core promoter binding IEA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
CDC6 association with the ORC:origin complex
G2 Phase
Cyclin D associated events in G1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000163 abnormal cartilage morphology "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: E2f3tm3Lees/E2f3tm3Lees
Genetic Background: either: 129S/Sv-E2f3tm3Lees or (involves: 129S4/SvJae * C57BL/6)

 MP:0000166 abnormal chondrocyte morphology "anomalous structure, organization, or differentiation of nondividing cartilage cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,E2f3tm2Lees/E2f3tm2Lees
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rbl1tm1Htr/Rbl1tm1Htr,Tg(Chx10-EGFP/cre,-ALPP)2Clc/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI * SJL

Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f2tm1Zubi/E2f2tm1Zubi,E2f3tm2.1Gle/E2f3tm2.1Gle
Genetic Background: involves: 129 * FVB/N * NIH Black Swiss

Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f2tm1Zubi/E2f2tm1Zubi,E2f3tm3.1Gle/E2f3tm3.1Gle
Genetic Background: involves: 129 * FVB/N * NIH Black Swiss

Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f3tm2.1Gle/E2f3tm2.1Gle
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,E2f3tm2Lees/E2f3tm2Lees
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0000420 ruffled hair "fuzzy, irregular appearance of the hair" [J:50844]
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Allelic Composition: Rbl1tm1Htr/Rbl1tm1Htr,Tg(Chx10-EGFP/cre,-ALPP)2Clc/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI * SJL

 MP:0000771 abnormal brain size "deviation from the average range of brain size for a given strain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f3tm2.1Gle/E2f3tm2.1Gle
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f2tm1Zubi/E2f2tm1Zubi,E2f3tm3.1Gle/E2f3tm3.1Gle
Genetic Background: involves: 129 * FVB/N * NIH Black Swiss

Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f3tm2.1Gle/E2f3tm2.1Gle
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss

Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f3tm3.1Gle/E2f3tm3.1Gle
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,E2f3tm2Lees/E2f3tm2Lees
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f2tm1Zubi/E2f2tm1Zubi,E2f3tm3.1Gle/E2f3tm3.1Gle
Genetic Background: involves: 129 * FVB/N * NIH Black Swiss

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f2tm1Zubi/E2f2tm1Zubi,E2f3tm3.1Gle/E2f3tm3.1Gle
Genetic Background: involves: 129 * FVB/N * NIH Black Swiss

Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f3tm2.1Gle/E2f3tm2.1Gle
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss

 MP:0001855 atrial thrombosis "formation or presence of a thrombus in the atria of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rbl1tm1Htr/Rbl1tm1Htr,Tg(Chx10-EGFP/cre,-ALPP)2Clc/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI * SJL

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Rbl1tm1Htr/Rbl1tm1Htr,Tg(Chx10-EGFP/cre,-ALPP)2Clc/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI * SJL

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f3tm2.1Gle/E2f3tm2.1Gle
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f3tm2.1Gle/E2f3tm2.1Gle
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss

 MP:0001940 testicular hypoplasia "decreased cell number in the testicles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f3tm2.1Gle/E2f3tm2.1Gle
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Rbl1tm1Htr/Rbl1tm1Htr,Tg(Chx10-EGFP/cre,-ALPP)2Clc/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI * SJL

 MP:0002081 perinatal lethality "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: E2f3tm1.1Gle/E2f3tm1.1Gle
Genetic Background: 129-E2f3tm1.1Gle

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rbl1tm1Htr/Rbl1tm1Htr,Tg(Chx10-EGFP/cre,-ALPP)2Clc/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI * SJL

Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f3tm2.1Gle/E2f3tm2.1Gle
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f2tm1Zubi/E2f2tm1Zubi,E2f3tm3.1Gle/E2f3tm3.1Gle
Genetic Background: involves: 129 * FVB/N * NIH Black Swiss

Allelic Composition: E2f2tm1Zubi/E2f2tm1Zubi,E2f3tm3.1Gle/E2f3tm3.1Gle
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/N * NIH Black Swiss

Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f3tm5(E2f1)Gle/E2f3tm5(E2f1)Gle
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss

Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f3tm4Gle/E2f3tm4Gle
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss

Allelic Composition: E2f3tm3Lees/E2f3tm3Lees
Genetic Background: either: 129S/Sv-E2f3tm3Lees or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,E2f3tm3Lees/E2f3tm3Lees
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f3tm2.1Gle/E2f3tm2.1Gle
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss

 MP:0002679 abnormal corpora lutea "malformed or absent yellow endocrine body formed in the ovary after follicle rupture" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f3tm2.1Gle/E2f3tm2.1Gle
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,E2f3tm2Lees/E2f3tm2Lees
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: E2f3tm1Lees/E2f3tm1Lees
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: E2f3tm2Lees/E2f3tm2Lees
Genetic Background: either: 129S/Sv-E2f3tm2Lees or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,E2f3tm2Lees/E2f3tm2Lees
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0003205 testicular atrophy "wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission]
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Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,E2f3tm1Lees/E2f3+
Genetic Background: involves: 129S2/SvPas

 MP:0003828 pulmonary edema "an accumulation of an excessive amount of watery fluid in the lung " [J:44108, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: E2f3tm1Lees/E2f3tm1Lees
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004701 decreased circulating insulin-like growth factor I level "reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f3tm2.1Gle/E2f3tm2.1Gle
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss

 MP:0005120 decreased circulating growth hormone level "less than the expected blood concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f3tm2.1Gle/E2f3tm2.1Gle
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss

 MP:0005158 ovary hypoplasia "underdeveloped ovaries, usually due to reduced cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:78931]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f3tm2.1Gle/E2f3tm2.1Gle
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss

 MP:0005240 abnormal amacrine cell morphology "anomalous structure of the interneurons of the retina" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: E2f3tm1.1Gle/E2f3tm1.1Gle,Rbl1tm1Htr/Rbl1tm1Htr,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Rbl1tm1Htr/Rbl1tm1Htr,Tg(Chx10-EGFP/cre,-ALPP)2Clc/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI * SJL

Allelic Composition: E2f3tm1Lees/E2f3tm1Lees
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: E2f3tm1Lees/E2f3+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: E2f3tm2Lees/E2f3tm2Lees
Genetic Background: either: 129S/Sv-E2f3tm2Lees or (involves: 129S4/SvJae * C57BL/6)

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f3tm2.1Gle/E2f3tm2.1Gle
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss

 MP:0006073 abnormal retinal bipolar cell morphology "anomalous structure of the cells that transmit signals from the photoreceptors to retinal amacrine and ganglion cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92623:]
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Allelic Composition: E2f3tm1.1Gle/E2f3tm1.1Gle,Rbl1tm1Htr/Rbl1tm1Htr,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: E2f3tm1Lees/E2f3tm1Lees
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0006309 decreased retinal ganglion cell number "reduced number of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: E2f3tm1.1Gle/E2f3tm1.1Gle,Rbl1tm1Htr/Rbl1tm1Htr,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI

 MP:0006382 abnormal lung epithelium morphology "any structural anomaly of the epithelial layer of the lung" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f3tm2.1Gle/E2f3tm2.1Gle
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss

 MP:0006395 abnormal epiphyseal plate morphology "any structural anomaly of the cartilaginous center of ossification on the bones permitting growth of the bone in both directions during development" [MESH:A02.835.232.251.352]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f3tm2.1Gle/E2f3tm2.1Gle
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss

 MP:0008288 abnormal adrenal cortex morphology "any structural anomaly of the thick outer layer of the adrenal gland that produces and secretes steroid hormones such as corticosterone, estrone and aldosterone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f3tm2.1Gle/E2f3tm2.1Gle
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss

 MP:0008453 decreased retinal rod cell number "reduced number of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane" [MESH:A08.663.650.650.670.650]
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Allelic Composition: E2f3tm1.1Gle/E2f3tm1.1Gle,Rbl1tm1Htr/Rbl1tm1Htr,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: E2f3tm1Lees/E2f3tm1Lees
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,E2f3tm1Lees/E2f3+
Genetic Background: involves: 129S2/SvPas

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,E2f3tm2.1Gle/E2f3tm2.1Gle
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss

 MP:0009431 decreased fetal weight "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: E2f3tm1Lees/E2f3tm1Lees
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010334 pleural effusion "accumulation of excess fluid in the pleural cavity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: E2f3tm1Lees/E2f3tm1Lees
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: E2f3tm1Lees/E2f3tm1Lees
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,E2f3tm2Lees/E2f3tm2Lees
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Rtn4rtm1Gogo/Rtn4r+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: E2f3tm1.1Gle/E2f3tm1.1Gle
Genetic Background: B6.129P2-E2f3tm1.1Gle

Allelic Composition: E2f3tm1.1Gle/E2f3tm1.1Gle
Genetic Background: 129-E2f3tm1.1Gle

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: E2f1tm1Njd/E2f1+,E2f3tm1Lees/E2f3tm1Lees
Genetic Background: involves: 129S2/SvPas

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Rac2tm1Mddw/Rac2tm1Mddw
Genetic Background: involves: 129S/SvEv

Allelic Composition: E2f1tm1Njd/E2f1+,E2f3tm1Lees/E2f3tm1Lees
Genetic Background: involves: 129S2/SvPas

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Rbl1tm1Htr/Rbl1tm1Htr,Tg(Chx10-EGFP/cre,-ALPP)2Clc/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI * SJL

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: E2f3tm1Lees/E2f3tm1Lees
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0020409 abnormal cardiac thrombosis "any anomaly in the formation or presence of thrombi in the heart" [PMID:15870284]
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Allelic Composition: E2f3tm1Lees/E2f3tm1Lees
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025358 Cdk2 / P97377 / Cyclin-dependent kinase 2 / P24941*  / complex / reaction
 ENSMUSG00000038482 Tfdp1 / Q08639 / transcription factor Dp 1 / TFDP3* / Q14186* / Q5H9I0* / transcription factor Dp family member 3*  / complex
 ENSMUSG00000022105 Rb1 / P13405 / Retinoblastoma-associated protein / P06400* / RB transcriptional corepressor 1*  / reaction / complex






 

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