| MP:0000042 | abnormal organ of Corti | "abnormalities associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Ncam1tm1Cgn/Ncam1tm1Cgn
Genetic Background: involves: C57BL/6J
Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Tg(Pou4f3-cre)1Devet/0
Genetic Background: involves: 129 * 129S/SvEv
Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0000061 | fragile skeleton | "easily damaged or broken bones" [J:14208] |
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas
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| MP:0000149 | abnormal scapula morphology | "malformation of either or both of the large, flat bones of the back part of the shoulder" [J:13049] |
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas
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| MP:0000159 | abnormal xiphoid process | "malformed posterior tip of the sternum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:42932] |
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas
Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Rb1tm1Tyj/Rb1+,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas
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| MP:0000160 | kyphosis | "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0000163 | abnormal cartilage morphology | "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Twist1tm1Bhr/Twist1+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6
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| MP:0000245 | abnormal erythropoiesis | "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator] |
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Allelic Composition: Rb1tm1Mlh/Rb1tm1Mlh
Genetic Background: either: 129P2/OlaHsd-Rb1tm1Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
Allelic Composition: Rb1tm2Mlh/Rb1tm2Mlh
Genetic Background: either: 129P2/OlaHsd-Rb1tm2Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Rb1tm1Dwg/Rb1tm1Tyj
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6
Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0000274 | enlarged heart | "increase over normal size of the heart" [J:29971] |
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Rbl2tm1Tyj/Rbl2tm1Tyj,Tg(Myh6-cre)2182Mds/Tg(Myh6-cre)2182Mds
Genetic Background: involves: 129 * 129S2/SvPas * FVB/N
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| MP:0000350 | abnormal cell proliferation | "anomalous growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Rb1tm1Tyj/Rb1tm2Brn,Rbl1tm1Tyj/Rbl1tm1Tyj,Trp53tm1Brn/Trp53tm1Tyj,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL
|
| MP:0000351 | increased cell proliferation | "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Trim27Gt(XP0484)Wtsi/Trim27Gt(XP0484)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0000512 | intestinal ulcer | "lesions in the mucous lining of the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Rb1tm1.1Jyjw/Rb1tm1.1Jyjw,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: 129S6.129-Trp53tm1Tyj Rb1tm1.1Jyjw
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| MP:0000598 | abnormal liver morphology | "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170] |
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Allelic Composition: Twist1tm1Bhr/Twist1+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6
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| MP:0000600 | liver hypoplasia | "reduced size of liver due to decreased cell number " [J:57631] |
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| MP:0000601 | small liver | "reduced size of the liver" [J:23170] |
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0000602 | enlarged sinusoidal spaces | "larger than normal sized cavities in the liver " [J:23170] |
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Rb1tm1Mlh/Rb1tm1Mlh
Genetic Background: either: 129P2/OlaHsd-Rb1tm1Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
Allelic Composition: Rb1tm2Mlh/Rb1tm2Mlh
Genetic Background: either: 129P2/OlaHsd-Rb1tm2Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
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| MP:0000606 | decreased hepatocyte number | "fewer than normal number of parenchymal liver cells" [J:23170] |
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Rb1tm1Mlh/Rb1tm1Mlh
Genetic Background: either: 129P2/OlaHsd-Rb1tm1Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
Allelic Composition: Rb1tm2Mlh/Rb1tm2Mlh
Genetic Background: either: 129P2/OlaHsd-Rb1tm2Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
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| MP:0000607 | abnormal hepatocyte morphology | "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * FVB/N
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| MP:0000630 | mammary gland hyperplasia | "increased size of mammary gland due to increased cell number" [J:63229] |
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Allelic Composition: Glb1tm1Jmat/Glb1tm1Jmat
Genetic Background: involves: C57BL/6 * CBA * ICR
Allelic Composition: Rb1tm2.1Jyjw/Rb1tm2.1Jyjw
Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Rb1tm1Fad/Rb1tm1Fad,Tg(MMTVTGFB1)46Hlm/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2
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| MP:0000631 | abnormal neuroendocrine gland morphology | "anomalous structure of any of the organized aggregations of cells that function as secretory or excretory organs and that release hormones in response to neural stimuli
" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Psen1tm1Vln/Psen1tm1Vln,Tg(Thy1-APPLon)2Vln/0,Tg(Thy1-cre)1Vln/0
Genetic Background: involves: FVB/N
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| MP:0000681 | abnormal thyroid gland morphology | "anomalous structure of the endocrine gland located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: E2f1tm1Njd/E2f1+,Rb1tm1Tyj/Rb1+
Genetic Background: either: 129S2/SvPas or (involves: 129S2/SvPas * C57BL/6)
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| MP:0000729 | abnormal myogenesis | "anomaly in embryonic formation of muscle cells or fibers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Apctm4Mmt/Apc+
Genetic Background: B6.129X1-Apctm4Mmt
Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas
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| MP:0000745 | tremors | "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Ace2tm1Hira/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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| MP:0000759 | abnormal skeletal muscle morphology | "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0000774 | reduced brain size | "smaller appearance of the brain" [J:35802] |
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0000798 | abnormal frontal lobe morphology | "malformation or absence of the anterior part of the cerebral hemisphere" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Rb1tm1Mlh/Rb1tm1Mlh
Genetic Background: either: 129P2/OlaHsd-Rb1tm1Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
Allelic Composition: Rb1tm2Mlh/Rb1tm2Mlh
Genetic Background: either: 129P2/OlaHsd-Rb1tm2Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
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| MP:0000826 | abnormal third ventricle morphology | "malformation or absence of the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6
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| MP:0000828 | abnormal fourth ventricle morphology | "malformed or absent irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind; it is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6
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| MP:0000829 | dilated fourth ventricle | "enlarged irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind; it is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Rb1tm1Mlh/Rb1tm1Mlh
Genetic Background: either: 129P2/OlaHsd-Rb1tm1Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
Allelic Composition: Rb1tm2Mlh/Rb1tm2Mlh
Genetic Background: either: 129P2/OlaHsd-Rb1tm2Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
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| MP:0000851 | cerebellum hypoplasia | "reduced cell number in the cerebellum" [MGI:CLS, J:45302] |
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Rbl1tm1Htr/Rbl1+,Tg(En2-cre)22Alj/0
Genetic Background: involves: 129P2/OlaHsd * CD-1
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| MP:0000864 | abnormal vermis | "malformation in the narrow middle zone between the two hemispheres of the cerebellum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61509] |
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Rbl1tm1Htr/Rbl1tm1Htr,Tg(En2-cre)22Alj/0
Genetic Background: involves: 129P2/OlaHsd * CD-1
Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Rbl1tm1Htr/Rbl1+,Tg(En2-cre)22Alj/0
Genetic Background: involves: 129P2/OlaHsd * CD-1
Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Tg(Pcp2-cre)756Mro/0
Genetic Background: involves: 129P2/OlaHsd * FVB
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| MP:0000872 | abnormal external granule cell layer | "malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator] |
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Allelic Composition: Phc2tm1Hko/Phc2+,Scmh1tm1Hko/Scmh1tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0000873 | thin external granule cell layer | "reduced thickness of the transient layer of the cerebellar cortex which is composed of dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896] |
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Allelic Composition: Phc2tm1Hko/Phc2+,Scmh1tm1Hko/Scmh1tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0000877 | abnormal Purkinje cell | "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Phc2tm1Hko/Phc2+,Scmh1tm1Hko/Scmh1tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Rbl1tm1Htr/Rbl1tm1Htr,Tg(En2-cre)22Alj/0
Genetic Background: involves: 129P2/OlaHsd * CD-1
Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Rbl1tm1Htr/Rbl1tm1Htr,Tg(Pcp2-cre)756Mro/0
Genetic Background: involves: 129P2/OlaHsd * FVB
Allelic Composition: Rb1tm1Tyj/Rb1tm2Tyj
Genetic Background: chimera involves: 129S2/SvPas * C57BL/6
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| MP:0000885 | ectopic Purkinje cell | "Purkinje cell body resides in places other than the Purkinje cell layer in the cerebellum" [MGI:tc, J:60896] |
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Allelic Composition: Rb1tm1Tyj/Rb1tm2Tyj
Genetic Background: chimera involves: 129S2/SvPas * C57BL/6
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| MP:0000886 | abnormal cerebellar granule layer | "any malformation or absence of the innermost cortical layer of the cerebellum; contains densly packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Phc2tm1Hko/Phc2+,Scmh1tm1Hko/Scmh1tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0000890 | thin cerebellar molecular layer | "reduced width of the outer of the three cortical layers of the cerebellum" [J:46854] |
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Rbl1tm1Htr/Rbl1tm1Htr,Tg(En2-cre)22Alj/0
Genetic Background: involves: 129P2/OlaHsd * CD-1
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| MP:0000961 | abnormal dorsal root ganglia morphology | "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159] |
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Allelic Composition: Rb1tm1Brd/Rb1tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Rb1tm1Mlh/Rb1tm1Mlh
Genetic Background: either: 129P2/OlaHsd-Rb1tm1Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
Allelic Composition: Rb1tm1Mlh/Rb1+
Genetic Background: either: 129P2/OlaHsd-Rb1tm1Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
Allelic Composition: Rb1tm2Mlh/Rb1tm2Mlh
Genetic Background: either: 129P2/OlaHsd-Rb1tm2Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
Allelic Composition: Rb1tm2Mlh/Rb1+
Genetic Background: either: 129P2/OlaHsd-Rb1tm2Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6
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| MP:0000964 | small dorsal root ganglia | "reduced size of the dorsal root ganglia" [J:17123] |
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Allelic Composition: Rb1tm1Brd/Rb1tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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| MP:0001004 | abnormal photoreceptor morphology | "structural or developmental anomaly of the receptors sensitive to light " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Rb1tm1Tyj/Rb1+,Rbl1tm1Tyj/Rbl1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0001092 | abnormal trigeminal ganglion morphology | "malformed group of sensory neuron cell bodies associated with the trigeminal nerve (fifth cranial nerve)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33038] |
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6
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| MP:0001144 | fused vaginal opening | "condition in which the external vaginal opening is closed by the adherence of the epithelium of the vagina" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Rb1tm1Tyj/Rb1+,Rbl1tm1Tyj/Rbl1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0001147 | small testis | "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959] |
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Allelic Composition: Pnpla2tm1Eek/Pnpla2tm1Eek,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129S * C57BL/6
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| MP:0001156 | abnormal spermatogenesis | "incomplete maturation or aberrant formation of the male gametes" [J:58959] |
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Allelic Composition: Pnpla2tm1Eek/Pnpla2tm1Eek,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129S * C57BL/6
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| MP:0001175 | abnormal lung morphology | "malformed organ of respiration" [J:35802] |
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Lejo/Trp53tm1Lejo
Genetic Background: involves: 129
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| MP:0001222 | epidermal hyperplasia | "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146] |
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Allelic Composition: Rb1tm1Fad/Rb1+,Tg(KRT14-HPV16E7)2304Plam/0
Genetic Background: involves: 129 * C57BL/6 * FVB
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(KRT14-cre)8Brn/0,Tg(KRT14-HPV16E7)2304Plam/0
Genetic Background: involves: 129 * C57BL/6 * FVB
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| MP:0001233 | abnormal suprabasal layer morphology | "malformed or atypical condition of the suprabasal layer of the skin" [J:56777] |
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Allelic Composition: Sgk3tm1Efu/Sgk3tm1Efu
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Rb1tm1Fad/Rb1+,Tg(KRT14-HPV16E7)2304Plam/0
Genetic Background: involves: 129 * C57BL/6 * FVB
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129 * C57BL/6 * FVB
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(KRT14-cre)8Brn/0,Tg(KRT14-HPV16E7)2304Plam/0
Genetic Background: involves: 129 * C57BL/6 * FVB
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(KRT14-HPV16E7)2304Plam/0
Genetic Background: involves: 129 * C57BL/6 * FVB
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| MP:0001239 | abnormal granular layer morphology | "structural or developmental anomaly of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Rb1tm1Fad/Rb1+,Tg(KRT14-HPV16E7)2304Plam/0
Genetic Background: involves: 129 * C57BL/6 * FVB
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(KRT14-cre)8Brn/0,Tg(KRT14-HPV16E7)2304Plam/0
Genetic Background: involves: 129 * C57BL/6 * FVB
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(KRT14-HPV16E7)2304Plam/0
Genetic Background: involves: 129 * C57BL/6 * FVB
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| MP:0001261 | obese | "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
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Allelic Composition: Psen1tm1Vln/Psen1tm1Vln,Tg(Thy1-APPLon)2Vln/0,Tg(Thy1-cre)1Vln/0
Genetic Background: involves: FVB/N
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| MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Rb1tm1Tyj/Rb1+,Rbl1tm1Tyj/Rbl1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(Ren-cre)#Kwg/0
Genetic Background: involves: 129 * 129P2/OlaHsd
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| MP:0001263 | weight loss | "progressive reduction of body weight below normal average for age" [J:45400] |
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Allelic Composition: Rb1tm1.1Jyjw/Rb1tm1.1Jyjw,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: 129S6.129-Trp53tm1Tyj Rb1tm1.1Jyjw
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| MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
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Allelic Composition: Cd207tm2Mal/Cd207tm3(DTR/GFP)Mal
Genetic Background: involves: 129S2/SvPas
|
| MP:0001270 | distended abdomen | "abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Cd207tm2Mal/Cd207tm3(DTR/GFP)Mal
Genetic Background: involves: 129S2/SvPas
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| MP:0001272 | increased metastatic potential | |
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Allelic Composition: Psen1tm1Vln/Psen1tm1Vln,Tg(Thy1-APPLon)2Vln/0,Tg(Thy1-cre)1Vln/0
Genetic Background: involves: FVB/N
Allelic Composition: Rb1tm1Tyj/Rb1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J
Allelic Composition: Men1tm1.1Ctre/Men1+,Rb1tm1Tyj/Rb1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J * FVB/N
Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Calcatm1.1(cre/ERT2)Ptch/Calca+,Trp53tm1Brn/Trp53tm1Brn,Rb1tm2Brn/Rb1tm2Brn,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S4/SvJae * BALB/c * FVB/N
Allelic Composition: Rb1tm3Tyj/Rb1+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6J * CD-1 * FVB/N
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Trp53tm1Brn/Trp53+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6J * CD-1 * FVB/N
Allelic Composition: Rb1tm3Tyj/Rb1+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Trp53tm1Brn/Trp53+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6J * CD-1 * FVB/N
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Tg(tetO-RNAi:Trp53)ASlowe/0
Genetic Background: involves: C57BL/6 * CD-1
Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(Ren-cre)#Kwg/0
Genetic Background: involves: 129 * 129P2/OlaHsd
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| MP:0001304 | cataracts | "complete or partial opacity of the lens" [J:65031] |
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * FVB/N
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| MP:0001325 | abnormal retina morphology | "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Rb1tm1Tyj/Rb1+,Rbl1tm1Tyj/Rbl1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Rbl2tm2.1Tyj/Rbl2tm2.1Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Rbl1tm1Tyj/Rbl1tm1Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * FVB/N
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N
Allelic Composition: Rb1tm1Tyj/Rb1tm2Brn,Rbl1tm1Tyj/Rbl1tm1Tyj,Trp53tm1Brn/Trp53tm1Brn,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL
Allelic Composition: Rb1tm1Tyj/Rb1tm2Brn,Rbl1tm1Tyj/Rbl1+,Trp53tm1Brn/Trp53tm1Brn,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL
Allelic Composition: Rb1tm1Tyj/Rb1tm2Brn,Rbl1tm1Tyj/Rbl1+,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: Not Specified
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Rbl1tm1Tyj/Rbl1tm1Tyj,Tg(Nes-cre)1Atp/0
Genetic Background: involves: 129S2/SvPas * FVB/N
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Trp53tm1Tyj/Trp53tm1Tyj,Tg(Nes-cre)1Atp/0
Genetic Background: involves: 129S2/SvPas * FVB/N
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| MP:0001327 | reduced retinal photoreceptor cell number | "fewer than the expected number of rods and/or cones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Rb1tm1Tyj/Rb1tm2Brn,Rbl1tm1Tyj/Rbl1+,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Trp53tm1Tyj/Trp53tm1Tyj,Tg(Nes-cre)1Atp/0
Genetic Background: involves: 129S2/SvPas * FVB/N
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N
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| MP:0001388 | abnormal stationary movement | "altered ability or inability to change body posture or shift a body part" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Sox10m2C3HeB/FeJ/Sox10m2C3HeB/FeJ,Sox10Dom/Sox10Dom
Genetic Background: involves: C3HeB/FeJ * C57BL/6J
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| MP:0001393 | ataxia | "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231] |
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Tg(En2-cre)22Alj/0
Genetic Background: involves: 129P2/OlaHsd * CD-1
Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Rbl1tm1Htr/Rbl1+,Tg(En2-cre)22Alj/0
Genetic Background: involves: 129P2/OlaHsd * CD-1
Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brd/Trp53tm1Brd,Tg(Gfap-cre)2Brn/0
Genetic Background: involves: 129 * 129S7/SvEvBrd * FVB/N
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| MP:0001394 | circling | "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295] |
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brd/Trp53tm1Brd,Tg(Gfap-cre)2Brn/0
Genetic Background: involves: 129 * 129S7/SvEvBrd * FVB/N
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| MP:0001406 | abnormal gait | "unusual or distinctive way of walking" [J:65038] |
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brd/Trp53tm1Brd,Tg(Gfap-cre)2Brn/0
Genetic Background: involves: 129 * 129S7/SvEvBrd * FVB/N
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| MP:0001492 | piloerection | "the involuntary bristling of hairs" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Ttntm1Her/Ttntm1Her
Genetic Background: Not Specified
Allelic Composition: Rb1tm1Jyjw/Rb1tm1Jyjw
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)
Allelic Composition: Rb1tm1Jyjw/Rb1+
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)
Allelic Composition: Rb1tm1.1Jyjw/Rb1+
Genetic Background: either: (involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6) or (involves: 129S4/SvJae * 129S6/SvEvTac)
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| MP:0001504 | abnormal posture | "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984] |
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Allelic Composition: Hgstn/Hgstn
Genetic Background: B6.C3-Hgstn
Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas
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| MP:0001505 | hunched posture | "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404] |
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Rb1tm3Tyj/Rb1tm3.1Tyj,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N
Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas
Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae
Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas
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| MP:0001522 | impaired swimming | "reduced ability or inability to swim" [J:45446, J:39081] |
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * DBA/2J
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| MP:0001525 | impaired balance | "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123] |
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brd/Trp53tm1Brd,Tg(Gfap-cre)2Brn/0
Genetic Background: involves: 129 * 129S7/SvEvBrd * FVB/N
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| MP:0001577 | anemia | "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370] |
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0001601 | abnormal myelopoiesis | "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc] |
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Allelic Composition: Cd8atm1Mak/Cd8atm1Mak,Zbtb7bhd/Zbtb7bhd
Genetic Background: involves: B6.129S2-Cd8atm1Mak * B6.Cg-Thpokhd
Allelic Composition: Rb1tm2Mlh/Rb1tm2Mlh
Genetic Background: either: 129P2/OlaHsd-Rb1tm2Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
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| MP:0001614 | abnormal vasculature | "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0001672 | abnormal embryogenesis/ development | "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0001698 | reduced embryo size | "smaller proportions of embryo compared to littermates" [J:61790] |
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Rbl1tm1Tyj/Rbl1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Rb1tm1Dwg/Rb1tm1Tyj
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6
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| MP:0001716 | abnormal placental labyrinth | "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171] |
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6
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| MP:0001722 | pale yolk sac | "bloodless yolk sac" [J:62571] |
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Allelic Composition: Rb1tm1Mlh/Rb1tm1Mlh
Genetic Background: either: 129P2/OlaHsd-Rb1tm1Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
Allelic Composition: Rb1tm2Mlh/Rb1tm2Mlh
Genetic Background: either: 129P2/OlaHsd-Rb1tm2Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Rbl1tm1Tyj/Rbl1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0001732 | postnatal growth retardation | "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Rb1tm1Tyj/Rb1+,Rbl1tm1Tyj/Rbl1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6J * CD-1 * FVB/N
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| MP:0001785 | edema | "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065] |
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Rbl2tm1Tyj/Rbl2tm1Tyj,Tg(Myh6-cre)2182Mds/Tg(Myh6-cre)2182Mds
Genetic Background: involves: 129 * 129S2/SvPas * FVB/N
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| MP:0001786 | skin edema | "accumulation of an excessive amount of fluid in the skin" [J:65039] |
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0001787 | pericardial edema | "accumulation of watery fluid in the pericardial sac of the heart" [J:52597] |
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0001823 | thymus hypoplasia | "small size due to reduced cell number in the thymus" [J:23255] |
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Allelic Composition: Ccnd3tm1Pisc/Ccnd3tm1Pisc,Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor
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| MP:0001885 | mammary ductal hyperplasia | |
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Allelic Composition: Glb1tm1Jmat/Glb1tm1Jmat
Genetic Background: involves: C57BL/6 * CBA * ICR
Allelic Composition: Rb1tm2.1Jyjw/Rb1tm2.1Jyjw
Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Rb1tm2.1Fad/Rb1tm2.1Fad
Genetic Background: involves: 129 * C57BL/6
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| MP:0001914 | hemorrhage | "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas
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| MP:0001925 | male infertility | "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409] |
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Allelic Composition: Ddx4tm1.1(cre/mOrange)Dcp/Ddx4+,Rb1tm3Tyj/Rb1tm3Tyj
Genetic Background: involves: C57BL/6
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| MP:0001954 | respiratory distress | "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931] |
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Rbl2tm1Tyj/Rbl2tm1Tyj,Tg(Myh6-cre)2182Mds/Tg(Myh6-cre)2182Mds
Genetic Background: involves: 129 * 129S2/SvPas * FVB/N
Allelic Composition: Rb1tm2.1Fad/Rb1tm2.1Fad
Genetic Background: involves: 129 * C57BL/6
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| MP:0001963 | abnormal hearing | "anomaly in the ability to receive auditory stimuli" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Ncam1tm1Cgn/Ncam1tm1Cgn
Genetic Background: involves: C57BL/6J
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| MP:0001967 | deafness | "inability to hear" [J:57651] |
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Tg(Pou4f3-cre)1Devet/0
Genetic Background: involves: 129 * 129S/SvEv
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| MP:0002009 | preneoplasia | "state preceding the pathological process resulting in a neoplasm; does not necessarily imply cancerous development" [J:47225] |
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * FVB/N
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| MP:0002014 | papilloma | "benign epithelial tumor" [J:47225] |
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(Gfap-cre)2Brn/0
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
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| MP:0002020 | increased tumor incidence | "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193] |
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB
Allelic Composition: Rb1tm1Tyj/Rb1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Rb1tm1.2Gfk/Rb1+
Genetic Background: involves: 129T2/SvEms * C57BL/6 * SJL
Allelic Composition: Msh2tm1Whl/Msh2tm1Whl,Rb1tm1Brd/Rb1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
Allelic Composition: E2f1tm1Njd/E2f1+,Rb1tm1Tyj/Rb1+
Genetic Background: either: 129S2/SvPas or (involves: 129S2/SvPas * C57BL/6)
Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Tg(KRT14-cre)8Brn/0,Tg(KRT5-Akt1*)Jmpa/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2 * DBA/2J * FVB/N
Allelic Composition: Rb1tm1Tyj/Rb1+,Trim27Gt(XP0484)Wtsi/Trim27Gt(XP0484)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6J * CD-1 * FVB/N
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| MP:0002027 | lung adenocarcinoma | "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542] |
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Allelic Composition: Krastm4Tyj/Kras+,Rb1tm3Tyj/Rb1tm3Tyj
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53+
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Rb1tm2Brn/Rb1+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd
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| MP:0002031 | adrenal tumor | "tumors of the adrenal gland, including phaeochomocytomas" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542] |
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Allelic Composition: Men1tm1.1Ctre/Men1+,Rb1tm1Tyj/Rb1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J * FVB/N
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| MP:0002032 | sarcoma | "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877] |
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Allelic Composition: Rb1tm1Tyj/Rb1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(Ren-cre)#Kwg/0
Genetic Background: involves: 129 * 129P2/OlaHsd
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| MP:0002035 | leiomyosarcoma | "malignant tumor derived from smooth (nonstriated) muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877] |
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Allelic Composition: Rb1tm1Tyj/Rb1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0002038 | carcinoma | "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877] |
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Tg(Gfap-cre)2Brn/0
Genetic Background: involves: 129 * FVB/N
Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(MMTV-cre)105Ayn/0
Genetic Background: FVB.Cg-Trp53tm1Brn Rb1tm2Brn Tg(MMTV-cre)105Ayn
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bmi1,-EGFP)Nki/Gt(ROSA)26Sor+,Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(Gfap-cre)2Brn/0
Genetic Background: either: (involves: 129 * 129P2/OlaHsd * FVB/N) or (involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N)
Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(Gfap-cre)2Brn/0
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
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| MP:0002039 | neuroblastoma | "malignant neoplasm characterized by immature nerve cells of embryonic type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58877] |
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Allelic Composition: Nf1tm1Tyj/Nf1+,Tg(Th-MYCN)41Waw/0
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6J
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| MP:0002041 | pituitary adenoma | "appearance of benign neoplasms of the pituitary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042] |
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Allelic Composition: Psen1tm1Vln/Psen1tm1Vln,Tg(Thy1-APPLon)2Vln/0,Tg(Thy1-cre)1Vln/0
Genetic Background: involves: FVB/N
Allelic Composition: Rb1tm1Tyj/Rb1tm2Tyj
Genetic Background: chimera involves: 129S2/SvPas * C57BL/6
Allelic Composition: Rb1tm1Brn/Rb1tm1Brn,Tg(Pomc-FLP)1aBrn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Rb1tm1Brn/Rb1+,Tg(Pomc-FLP)1aBrn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Rb1tm1Brn/Rb1tm1Brn,X/Tg(Pomc-FLP)1bBrn
Genetic Background: involves: 129P2/OlaHsd * FVB/N
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| MP:0002044 | colonic adenoma | "benign tumors of the large intestine" [J:38772] |
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Allelic Composition: Rb1tm1.1Jyjw/Rb1tm1.1Jyjw,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: 129S6.129-Trp53tm1Tyj Rb1tm1.1Jyjw
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| MP:0002050 | pheochromocytoma | "a benign neoplasm derived from adrenal medullary cells; usually associated with hypertension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63229] |
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Allelic Composition: Msh2tm1Whl/Msh2tm1Whl,Rb1tm1Brd/Rb1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
Allelic Composition: Rb1tm1Brd/Rb1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
Allelic Composition: Rb1tm1Tyj/Rb1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J
Allelic Composition: Men1tm1.1Ctre/Men1+,Rb1tm1Tyj/Rb1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J * FVB/N
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| MP:0002052 | decreased tumor incidence | "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Morf4l1tm1Kto/Morf4l1tm1Kto,Morf4l2tm1.1Kto/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
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| MP:0002081 | perinatal lethality | "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ncam1tm1Cgn/Ncam1tm1Cgn
Genetic Background: involves: C57BL/6J
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| MP:0002082 | postnatal lethality | "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: Not Specified
Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas
Allelic Composition: Calcatm1.1(cre/ERT2)Ptch/Calca+,Trp53tm1Brn/Trp53tm1Brn,Rb1tm2Brn/Rb1tm2Brn
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
Allelic Composition: Calcatm1.1(cre/ERT2)Ptch/Calca+,Trp53tm1Brn/Trp53tm1Brn,Rb1tm2Brn/Rb1tm2Brn,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S4/SvJae * BALB/c * FVB/N
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| MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Morf4l1tm1Kto/Morf4l1tm1Kto,Morf4l2tm1.1Kto/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
Allelic Composition: E2f4tm1Lees/E2f4+,Rb1tm1Tyj/Rb1+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Rb1tm1Tyj/Rb1+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Rb1tm1Tyj/Rb1+,Rbl1tm1Tyj/Rbl1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Rb1tm1Tyj/Rb1+,Rbl1tm1Tyj/Rbl1+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Rb1tm1Tyj/Rb1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Rb1tm1.2Gfk/Rb1+
Genetic Background: involves: 129T2/SvEms * C57BL/6 * SJL
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Rbl2tm2.1Tyj/Rbl2tm2.1Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N
Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Rbl2tm1Tyj/Rbl2tm1Tyj,Tg(Myh6-cre)2182Mds/Tg(Myh6-cre)2182Mds
Genetic Background: involves: 129 * 129S2/SvPas * FVB/N
Allelic Composition: Rb1tm1.1Jyjw/Rb1tm1.1Jyjw,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: 129S6.129-Trp53tm1Tyj Rb1tm1.1Jyjw
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj,Tg(Nes-cre)1Atp/0
Genetic Background: involves: 129S2/SvPas * FVB/N
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Trp53tm1Tyj/Trp53tm1Tyj,Tg(Nes-cre)1Atp/0
Genetic Background: involves: 129S2/SvPas * FVB/N
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N
Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Tg(Gfap-cre)2Brn/0
Genetic Background: involves: 129 * FVB/N
Allelic Composition: Msh2tm1Whl/Msh2tm1Whl,Rb1tm1Brd/Rb1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
Allelic Composition: Rb1tm1Brd/Rb1+,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
Allelic Composition: Rb1tm1Tyj/Rb1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J
Allelic Composition: Men1tm1.1Ctre/Men1+,Rb1tm1Tyj/Rb1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J * FVB/N
Allelic Composition: E2f1tm1Njd/E2f1+,Rb1tm1Tyj/Rb1+
Genetic Background: either: 129S2/SvPas or (involves: 129S2/SvPas * C57BL/6)
Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,Rb1tm1Tyj/Rb1+
Genetic Background: either: 129S2/SvPas or (involves: 129S2/SvPas * C57BL/6)
Allelic Composition: Krastm4Tyj/Kras+,Rb1tm3Tyj/Rb1tm3Tyj
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Rb1tm1Brn/Rb1tm1Brn,Tg(Pomc-FLP)1aBrn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Rb1tm1Brn/Rb1tm1Brn,X/Tg(Pomc-FLP)1bBrn
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Rbl2tm2Tyj/Rbl2tm2Tyj,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(tetO-MYC)36aBop/0,Tg(Cebpb-tTA)5Bjd/0
Genetic Background: involves: FVB/N * NMRI
Allelic Composition: Kdm5atm1.1Kael/Kdm5atm1.1Kael,Rb1tm1Tyj/Rb1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * FVB/N
Allelic Composition: Rb1tm1Tyj/Rb1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bmi1,-EGFP)Nki/Gt(ROSA)26Sor+,Rb1tm2Brn/Rb1tm2Brn,Tg(Gfap-cre)2Brn/0
Genetic Background: either: (involves: 129 * 129P2/OlaHsd * FVB/N) or (involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N)
Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Lejo/Trp53tm1Lejo
Genetic Background: involves: 129
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6J * CD-1 * FVB/N
Allelic Composition: Rb1tm3Tyj/Rb1+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6J * CD-1 * FVB/N
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Trp53tm1Brn/Trp53+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6J * CD-1 * FVB/N
Allelic Composition: Rb1tm3Tyj/Rb1+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Trp53tm1Brn/Trp53+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6J * CD-1 * FVB/N
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Tg(tetO-RNAi:Trp53)ASlowe/0
Genetic Background: involves: C57BL/6 * CD-1
Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(Ren-cre)#Kwg/0
Genetic Background: involves: 129 * 129P2/OlaHsd
Allelic Composition: Rb1tm1Tyj/Rb1+,Smarca4tm1Mag/Smarca4+
Genetic Background: involves: 129S/Sv * 129S2/SvPas * C57BL/6J * CD-1
Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
Allelic Composition: Rb1tm2Brn/Rb1+,Trp53tm1Brn/Trp53tm1Brn,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
Allelic Composition: Prkar1atm1.2Lsk/Prkar1a+,Rb1tm2Brn/Rb1+,Tg(Col1a1-cre)1Kry/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N
Allelic Composition: Prkar1atm1.2Lsk/Prkar1a+,Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N
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| MP:0002092 | abnormal eye morphology | "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj,Tg(Nes-cre)1Atp/0
Genetic Background: involves: 129S2/SvPas * FVB/N
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| MP:0002106 | abnormal muscle physiology | "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hgstn/Hgstn
Genetic Background: B6.C3-Hgstn
Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae
Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas
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| MP:0002123 | abnormal hematopoiesis | "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Rb1tm1Mlh/Rb1tm1Mlh
Genetic Background: either: 129P2/OlaHsd-Rb1tm1Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
Allelic Composition: Rb1tm2Mlh/Rb1tm2Mlh
Genetic Background: either: 129P2/OlaHsd-Rb1tm2Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
Allelic Composition: Msh2tm1Whl/Msh2tm1Whl,Rb1tm1Brd/Rb1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
Allelic Composition: Msh2tm1Whl/Msh2tm1Whl,Rb1tm1Brd/Rb1tm1Brd
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
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| MP:0002152 | abnormal brain morphology | "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk] |
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0002161 | abnormal fertility/fecundity | "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Pnpla2tm1Eek/Pnpla2tm1Eek,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129S * C57BL/6
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| MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Slc4a4tm1Ges/Slc4a4+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
Allelic Composition: Rb1tm1Brn/Rb1tm1Brn
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Rb1tm2.1Dwg/Rb1tm2.1Dwg
Genetic Background: B6.129S4-Rb1tm2.1Dwg
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| MP:0002176 | high brain weight | "greater than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Rb1tm3Tyj/Rb1tm3.1Tyj,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N
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| MP:0002183 | gliosis | "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: Not Specified
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| MP:0002229 | CNS neurodegeneration | "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Rb1tm1Mlh/Rb1tm1Mlh
Genetic Background: either: 129P2/OlaHsd-Rb1tm1Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
Allelic Composition: Rb1tm2Mlh/Rb1tm2Mlh
Genetic Background: either: 129P2/OlaHsd-Rb1tm2Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
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| MP:0002267 | abnormal bronchiole morphology | "any structural anomaly of the conducting airway of the lungs found terminal to the bronchi. These structures contain neither cartilage nor mucous-secreting glands; the epithelium of the bronchioles becomes thinner with each branching. " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0] |
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Allelic Composition: Krastm4Tyj/Kras+,Rb1tm3Tyj/Rb1tm3Tyj
Genetic Background: involves: 129S4/SvJae
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| MP:0002406 | increased susceptibility to infection | "greater likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Morf4l1tm1Kto/Morf4l1tm1Kto,Morf4l2tm1.1Kto/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
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| MP:0002446 | abnormal macrophage morphology | "anomalous structure, number, or composition of the large mononuclear phagocytic cells found in most tissues of the body" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6
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| MP:0002447 | abnormal erythrocyte morphology | "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Rb1tm1Mlh/Rb1tm1Mlh
Genetic Background: either: 129P2/OlaHsd-Rb1tm1Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
Allelic Composition: Rb1tm2Mlh/Rb1tm2Mlh
Genetic Background: either: 129P2/OlaHsd-Rb1tm2Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0002594 | low mean erythrocyte count | "less than average numbers of red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0002622 | abnormal cochlear hair cell morphology | "malformation of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Tg(Pou4f3-cre)1Devet/0
Genetic Background: involves: 129 * 129S/SvEv
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| MP:0002623 | abnormal vestibular hair cell morphology | "malformation of the sensory epithelial cells of the membraneous labyrinth of the inner ear; these cells are in synaptic contact with the vestibular nerve" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Tg(Pou4f3-cre)1Devet/0
Genetic Background: involves: 129 * 129S/SvEv
Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0002627 | teratoma | "neoplasms composed of multiple tissue types; includes types not found in tissue in which lesion arises" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Rb1tm1.1Jyjw/Rb1tm1.1Jyjw,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: 129S6.129-Trp53tm1Tyj Rb1tm1.1Jyjw
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| MP:0002712 | increased circulating glucagon level | "greater than normal blood concentration of this peptide hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(Ren-cre)#Kwg/0
Genetic Background: involves: 129 * 129P2/OlaHsd
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| MP:0002753 | dilated left ventricle | "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Rbl2tm1Tyj/Rbl2tm1Tyj,Tg(Myh6-cre)2182Mds/Tg(Myh6-cre)2182Mds
Genetic Background: involves: 129 * 129S2/SvPas * FVB/N
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| MP:0002840 | abnormal lens fibers morphology | "structural anomaly of the elongated cells of the crystalline lens of the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Rb1tm1Mlh/Rb1tm1Mlh
Genetic Background: either: 129P2/OlaHsd-Rb1tm1Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
Allelic Composition: Rb1tm2Mlh/Rb1tm2Mlh
Genetic Background: either: 129P2/OlaHsd-Rb1tm2Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0002875 | decreased erythrocyte count | "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Rb1tm1Mlh/Rb1tm1Mlh
Genetic Background: either: 129P2/OlaHsd-Rb1tm1Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
Allelic Composition: Rb1tm2Mlh/Rb1tm2Mlh
Genetic Background: either: 129P2/OlaHsd-Rb1tm2Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
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| MP:0002877 | abnormal melanocyte morphology | "malformation of the cells that produce pigment " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ
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| MP:0002947 | hemangioma | "proliferation of blood vessels leading to a mass that resembles a neoplasm" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87544] |
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Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,Rb1tm1Tyj/Rb1+
Genetic Background: either: 129S2/SvPas or (involves: 129S2/SvPas * C57BL/6)
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| MP:0002957 | intestinal adenocarcinoma | "malignant neoplasm of epithelial cells in the intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Rb1tm1.1Jyjw/Rb1tm1.1Jyjw,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: 129S6.129-Trp53tm1Tyj Rb1tm1.1Jyjw
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| MP:0002968 | increased circulating alkaline phosphatase level | "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Tg(tetO-RNAi:Trp53)ASlowe/0
Genetic Background: involves: C57BL/6 * CD-1
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| MP:0002970 | abnormal white fat morphology | "structural aberration in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Rbl1tm1Mru/Rbl1tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/c
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| MP:0002984 | retina hypoplasia | "less than normal number of cells in the thin layer of neural tissue lining the back of the eyeball which contains visual receptors" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80994] |
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Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Rbl2tm2.1Tyj/Rbl2tm2.1Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N
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| MP:0003077 | abnormal cell cycle | "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266] |
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas
Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae
Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas
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| MP:0003084 | abnormal skeletal muscle fiber morphology | "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas
Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae
Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas
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| MP:0003203 | increased neuron apoptosis | "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission] |
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Allelic Composition: Rb1tm1Brd/Rb1tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Rb1tm3Tyj/Rb1tm3.1Tyj,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N
Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Tg(En2-cre)22Alj/0
Genetic Background: involves: 129P2/OlaHsd * CD-1
Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Rbl1tm1Htr/Rbl1+,Tg(En2-cre)22Alj/0
Genetic Background: involves: 129P2/OlaHsd * CD-1
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| MP:0003229 | abnormal vitelline vasculature | "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257] |
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Rbl1tm1Tyj/Rbl1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0003315 | abnormal perineum morphology | "malformation in the area between the genital organs and the anus that lies beneath the pelvic diaphragm" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Rb1tm1Tyj/Rb1+,Rbl1tm1Tyj/Rbl1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0003331 | hepatocellular carcinoma | "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(tetO-MYC)36aBop/0,Tg(Cebpb-tTA)5Bjd/0
Genetic Background: involves: FVB/N * NMRI
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm2.1Tyj/Rbl2tm2.1Tyj
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
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| MP:0003354 | astrocytosis | "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Tg(En2-cre)22Alj/0
Genetic Background: involves: 129P2/OlaHsd * CD-1
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| MP:0003365 | glucagonoma | "a pancreatic islet alpha cell adenoma that secretes excess glucagon" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(Ren-cre)#Kwg/0
Genetic Background: involves: 129 * 129P2/OlaHsd
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| MP:0003448 | altered tumor morphology | "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brd/Trp53+,Tg(Rbp3-cre)1Brn/0
Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6 * FVB/N
Allelic Composition: Rb1tm1Tyj/Rb1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Msh2tm1Whl/Msh2tm1Whl,Rb1tm1Brd/Rb1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
Allelic Composition: Krastm4Tyj/Kras+,Rb1tm3Tyj/Rb1tm3Tyj
Genetic Background: involves: 129S4/SvJae
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| MP:0003496 | thyroid adenoma | "appearance of benign neoplasms in the thyroid gland" [ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: E2f1tm1Njd/E2f1+,Rb1tm1Tyj/Rb1+
Genetic Background: either: 129S2/SvPas or (involves: 129S2/SvPas * C57BL/6)
Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,Rb1tm1Tyj/Rb1+
Genetic Background: either: 129S2/SvPas or (involves: 129S2/SvPas * C57BL/6)
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| MP:0003579 | ovarian carcinoma | |
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd
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| MP:0003638 | abnormal response/metabolism to endogenous compounds | "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Glb1tm1Jmat/Glb1tm1Jmat
Genetic Background: involves: C57BL/6 * CBA * ICR
Allelic Composition: Rb1tm2.1Jyjw/Rb1tm2.1Jyjw
Genetic Background: involves: 129 * C57BL/6
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| MP:0003702 | abnormal chromosome morphology | "anomalies in the structure of the compact, intertwined molecules of DNA found in the nucleus which carry genetic information " [hdene:Howard Dene , Mouse Genome Informatics Curator] |
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Allelic Composition: Glb1tm1Jmat/Glb1tm1Jmat
Genetic Background: involves: C57BL/6 * CBA * ICR
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| MP:0003717 | pallor | "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Rb1tm1Dwg/Rb1tm1Tyj
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6
|
| MP:0003721 | increased tumor growth/size | "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(MMTV-cre)105Ayn/0
Genetic Background: FVB.Cg-Trp53tm1Brn Rb1tm2Brn Tg(MMTV-cre)105Ayn
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| MP:0003733 | abnormal inner nuclear layer morphology | "malformation/anomalous structure of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: Not Specified
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N
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| MP:0003734 | abnormal inner plexiform layer morphology | "malformation/anomalous structure of the retinal cell layer where bipolar and amacrine cell axons synapse with ganglion cell dendrites
" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: Not Specified
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| MP:0003745 | abnormal mucosal lining of the mouth | "anomalous structure or development of the mucus -secreting tissue that lines the oral cavity" [ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Tg(KRT14-cre)8Brn/0,Tg(KRT5-Akt1*)Jmpa/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2 * DBA/2J * FVB/N
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| MP:0003787 | abnormal imprinting | "defect in the normal inactivation of specific loci during gametogenesis" [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
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Allelic Composition: Rb1tm1Brd/Rb1+,Snrpntm4Alb/Snrpn+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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| MP:0003789 | osteosarcoma | "malignant neoplasm derived from bone" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6J * CD-1 * FVB/N
Allelic Composition: Rb1tm3Tyj/Rb1+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6J * CD-1 * FVB/N
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Trp53tm1Brn/Trp53+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6J * CD-1 * FVB/N
Allelic Composition: Rb1tm3Tyj/Rb1+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Trp53tm1Brn/Trp53+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6J * CD-1 * FVB/N
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Tg(tetO-RNAi:Trp53)ASlowe/0
Genetic Background: involves: C57BL/6 * CD-1
Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
Allelic Composition: Rb1tm2Brn/Rb1+,Trp53tm1Brn/Trp53tm1Brn,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
Allelic Composition: Prkar1atm1.2Lsk/Prkar1a+,Rb1tm2Brn/Rb1+,Tg(Col1a1-cre)1Kry/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N
Allelic Composition: Prkar1atm1.2Lsk/Prkar1a+,Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N
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| MP:0003838 | abnormal milk ejection | "impaired milk ejection reflex in response to suckling during lactation" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:36926] |
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Allelic Composition: Glb1tm1Jmat/Glb1tm1Jmat
Genetic Background: involves: C57BL/6 * CBA * ICR
Allelic Composition: Rb1tm2.1Jyjw/Rb1tm2.1Jyjw
Genetic Background: involves: 129 * C57BL/6
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| MP:0003984 | embryonic growth retardation | "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Rb1tm1Mlh/Rb1tm1Mlh
Genetic Background: either: 129P2/OlaHsd-Rb1tm1Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
Allelic Composition: Rb1tm2Mlh/Rb1tm2Mlh
Genetic Background: either: 129P2/OlaHsd-Rb1tm2Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
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| MP:0004024 | aneuploidy | "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Glb1tm1Jmat/Glb1tm1Jmat
Genetic Background: involves: C57BL/6 * CBA * ICR
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| MP:0004025 | polyploidy | "more than two chromosome sets are present" [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas
Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae
Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(tetO-MYC)36aBop/0,Tg(Cebpb-tTA)5Bjd/0
Genetic Background: involves: FVB/N * NMRI
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj
Genetic Background: Not Specified
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| MP:0004045 | abnormal cell cycle checkpoint function | "anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6
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| MP:0004046 | abnormal mitosis | "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Glb1tm1Jmat/Glb1tm1Jmat
Genetic Background: involves: C57BL/6 * CBA * ICR
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| MP:0004097 | abnormal cerebellar cortex morphology | "any structural anomaly of the thin mantle of gray matter that covers the surface of each cerebral hemisphere, including the six layers of nerve cells and the nerve pathways that connect them; together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Tg(En2-cre)22Alj/0
Genetic Background: involves: 129P2/OlaHsd * CD-1
Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Rbl1tm1Htr/Rbl1tm1Htr,Tg(En2-cre)22Alj/0
Genetic Background: involves: 129P2/OlaHsd * CD-1
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| MP:0004098 | abnormal granule neuron | "any structural anomaly of the small neurons of the granule cell layer that send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Tg(En2-cre)22Alj/0
Genetic Background: involves: 129P2/OlaHsd * CD-1
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| MP:0004101 | abnormal brain interneuron morphology | "malformation or absence of neurons that exclusively interact with other neurons in the brain; this includes most brain neuronal cell types" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Tg(En2-cre)22Alj/0
Genetic Background: involves: 129P2/OlaHsd * CD-1
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| MP:0004174 | abnormal spine curvature | "deviation from the typical S-shape of the spine" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0004179 | transmission ratio distortion | "the occurence of an allele or haplotype in the offspring of an organism at skewed Mendelian ratios" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj,Tg(Nes-cre)1Atp/0
Genetic Background: involves: 129S2/SvPas * FVB/N
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N
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| MP:0004200 | reduced fetal size | "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rb1tm1Brd/Rb1tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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| MP:0004207 | squamous cell carcinoma | "a carcinoma that arises from stratified squamous epithelium that occurs in sites where glandular or columnar epithelium is normally present, such as the skin, esophagus, lungs and cervix" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(MMTV-cre)105Ayn/0
Genetic Background: FVB.Cg-Trp53tm1Brn Rb1tm2Brn Tg(MMTV-cre)105Ayn
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| MP:0004215 | abnormal myocardial fiber physiology | "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Rbl2tm1Tyj/Rbl2tm1Tyj,Tg(Myh6-cre)2182Mds/Tg(Myh6-cre)2182Mds
Genetic Background: involves: 129 * 129S2/SvPas * FVB/N
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| MP:0004265 | abnormal placental transport | "anomaly in the conveyance of metabolic products and nutrients across the placenta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6
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| MP:0004324 | vestibular hair cell degeneration | "degeneration or loss of the sensory epithelial cells of the maculae and cristae of the membranous labyrinth of the inner ear which are normally in synaptic contact with the vestibular nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Tg(Pou4f3-cre)1Devet/0
Genetic Background: involves: 129 * 129S/SvEv
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| MP:0004327 | increased vestibular hair cell number | "increased number of cells in the sensory epithelium of the maculae and cristae of the membranous labyrinth of the internal ear which are normally in synaptic contact with the vestibular nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ncam1tm1Cgn/Ncam1tm1Cgn
Genetic Background: involves: C57BL/6J
Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak,Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
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| MP:0004333 | abnormal utricular macula morphology | "any structural abnormalities in the neuroepithelial sensory receptor in the inferolateral wall of the utricle; hair cells of the neuroepithelium support the statoconial membrane and have terminal arborizations of vestibular nerve fibers around their bodies; normally sensitive to linear acceleration in the longitudinal axis of the body and to gravitational influences" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0004353 | abnormal deltoid tuberosity morphology | "any structural anomaly of a rough elevation at the middle of the lateral side of the shaft of the humerus to which the deltoid muscle attaches" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas
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| MP:0004354 | absent deltoid tuberosity | "missing the rough elevation at the middle of the lateral side of the shaft of the humerus to which the deltoid muscle attaches" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas
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| MP:0004362 | cochlear hair cell degeneration | "degeneration or loss of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Tg(Pou4f3-cre)1Devet/0
Genetic Background: involves: 129 * 129S/SvEv
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| MP:0004395 | increased cochlear inner hair cell number | "increased number (or more than the expected single row) of the flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ncam1tm1Cgn/Ncam1tm1Cgn
Genetic Background: involves: C57BL/6J
Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Tg(Pou4f3-cre)1Devet/0
Genetic Background: involves: 129 * 129S/SvEv
Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0004399 | abnormal cochlear outer hair cell morphology | "any structural abnormality in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there are three rows of columnar outer hair cells largely surrounded by cortilymph and supporting phalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a V-shaped pattern extend from the cell s surface through the cuticular plate into the tectorial membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Tg(Pou4f3-cre)1Devet/0
Genetic Background: involves: 129 * 129S/SvEv
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| MP:0004401 | increased cochlear outer hair cell number | "increased number (or more than the expected 3 rows) of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ncam1tm1Cgn/Ncam1tm1Cgn
Genetic Background: involves: C57BL/6J
Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Tg(Pou4f3-cre)1Devet/0
Genetic Background: involves: 129 * 129S/SvEv
Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0004404 | cochlear outer hair cell degeneration | "degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Tg(Pou4f3-cre)1Devet/0
Genetic Background: involves: 129 * 129S/SvEv
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| MP:0004407 | increased cochlear hair cell number | "increased number of the sensory epithelial cells of the cochlea, which are normally in synaptic contact with the auditory nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ncam1tm1Cgn/Ncam1tm1Cgn
Genetic Background: involves: C57BL/6J
Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak,Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
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| MP:0004478 | testicular teratoma | "neoplasms found in the testis that are composed of multiple tissue types; includes types not normally found in tesis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Rb1tm1.1Jyjw/Rb1tm1.1Jyjw,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: 129S6.129-Trp53tm1Tyj Rb1tm1.1Jyjw
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| MP:0004498 | increased supporting cell number | "increased number of the highly differentiated epithelial cells with distinctive morphological features which surround the hair cells in the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0004515 | abnormal vestibular hair cell stereociliary bundle morphology | "any structural anomaly or disruption of the typical staircase-like arrangement of the mechanosensitive hair bundles which are composed of thick long microvilli (stereocilia) and are located at the apical end of vestibular hair cells of the utricle and saccule" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0004564 | enlarged myocardial fiber | "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Rbl2tm1Tyj/Rbl2tm1Tyj,Tg(Myh6-cre)2182Mds/Tg(Myh6-cre)2182Mds
Genetic Background: involves: 129 * 129S2/SvPas * FVB/N
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| MP:0004686 | decreased length of long bones | "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas
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| MP:0004742 | abnormal vestibular system physiology | "any functional anomaly of the sensory system responsible for the sense of head position and movement of the body through space; such anomalies may include impaired balance, dizziness, poor regulation of postural muscle tone and inability to detect quick movements of the head " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Tg(Pou4f3-cre)1Devet/0
Genetic Background: involves: 129 * 129S/SvEv
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| MP:0004760 | increased mitotic index | "increased number of cells in G2/M phase" [Bertram_Weiss:Bayer_Schering_Pharma_AG] |
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0004819 | decreased skeletal muscle mass | "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0004840 | increased Dieters cell number | "increased number of the supporting cells of the spiral organ which are attached to the basement membrane and receive the hair cells between their free extremities" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ncam1tm1Cgn/Ncam1tm1Cgn
Genetic Background: involves: C57BL/6J
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| MP:0004852 | decreased testis weight | "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ddx4tm1.1(cre/mOrange)Dcp/Ddx4+,Rb1tm3Tyj/Rb1tm3Tyj
Genetic Background: involves: C57BL/6
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| MP:0004898 | uterine hemorrhage | "presence of bleeding in the uterus; often in response to failed pregnancy" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,Rb1tm1Tyj/Rb1+
Genetic Background: either: 129S2/SvPas or (involves: 129S2/SvPas * C57BL/6)
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| MP:0004948 | abnormal neuronal precursor proliferation | "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Tg(En2-cre)22Alj/0
Genetic Background: involves: 129P2/OlaHsd * CD-1
Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Rbl1tm1Htr/Rbl1tm1Htr,Tg(En2-cre)22Alj/0
Genetic Background: involves: 129P2/OlaHsd * CD-1
Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Rbl1tm1Htr/Rbl1+,Tg(En2-cre)22Alj/0
Genetic Background: involves: 129P2/OlaHsd * CD-1
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| MP:0004980 | increased neuronal precursor cell number | "increased number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Rbl1tm1Mru/Rbl1tm1Mru
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * BALB/c * C57BL/6
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| MP:0005039 | hypoxia | "reduced concentration of O2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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| MP:0005076 | abnormal cell differentiation | "anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism s life history" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Kdm5atm1.1Kael/Kdm5a+,Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * FVB/N
Allelic Composition: Kdm5atm1.1Kael/Kdm5atm1.1Kael,Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * FVB/N
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| MP:0005092 | decreased double-positive T cell count | "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Ccnd3tm1Pisc/Ccnd3tm1Pisc,Rb1tm2Brn/Rb1tm2Brn,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129 * C57BL/6 * CBA
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| MP:0005095 | decreased T cell proliferation | "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Ccnd3tm1Pisc/Ccnd3tm1Pisc,Rb1tm2Brn/Rb1tm2Brn,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129 * C57BL/6 * CBA
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| MP:0005150 | cachexia | "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Psen1tm1Vln/Psen1tm1Vln,Tg(Thy1-APPLon)2Vln/0,Tg(Thy1-cre)1Vln/0
Genetic Background: involves: FVB/N
Allelic Composition: Rb1tm1Tyj/Rb1+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Rb1tm1Tyj/Rb1tm2Tyj
Genetic Background: chimera involves: 129S2/SvPas * C57BL/6
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| MP:0005161 | hematuria | "presence of blood in the urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:78193] |
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Allelic Composition: Syt2m1Btlr/Syt2m1Btlr
Genetic Background: C57BL/6J-Syt2m1Btlr
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| MP:0005202 | lethargy | "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Ttntm1Her/Ttntm1Her
Genetic Background: Not Specified
Allelic Composition: Rb1tm1Jyjw/Rb1tm1Jyjw
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)
Allelic Composition: Rb1tm1Jyjw/Rb1+
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)
Allelic Composition: Rb1tm1.1Jyjw/Rb1+
Genetic Background: either: (involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6) or (involves: 129S4/SvJae * 129S6/SvEvTac)
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| MP:0005205 | abnormal eye anterior chamber | "anomaly of the space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Rb1tm1Tyj/Rb1tm2Brn,Rbl1tm1Tyj/Rbl1tm1Tyj,Trp53tm1Brn/Trp53tm1Brn,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL
Allelic Composition: Rb1tm1Tyj/Rb1tm2Brn,Rbl1tm1Tyj/Rbl1tm1Tyj,Trp53tm1Brn/Trp53tm1Tyj,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL
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| MP:0005238 | increased brain size | "larger than the normal physical proportions of the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57958] |
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Allelic Composition: Rb1tm3Tyj/Rb1tm3.1Tyj,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N
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| MP:0005240 | abnormal amacrine cell morphology | "anomalous structure of the interneurons of the retina" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Rbl2tm2.1Tyj/Rbl2tm2.1Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N
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| MP:0005241 | abnormal retinal ganglion layer morphology | "anomalous structure of the innermost nuclear layer of the retina, which projects axons through the optic nerve to the brain " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N
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| MP:0005299 | abnormal eye posterior chamber | "anomaly of the ringlike space, filled with aqueous humor, between the iris/pupil anteriorly and the lens and ciliary body posteriorly" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Rb1tm1Tyj/Rb1tm2Brn,Rbl1tm1Tyj/Rbl1tm1Tyj,Trp53tm1Brn/Trp53tm1Brn,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL
Allelic Composition: Rb1tm1Tyj/Rb1tm2Brn,Rbl1tm1Tyj/Rbl1tm1Tyj,Trp53tm1Brn/Trp53tm1Tyj,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL
Allelic Composition: Rb1tm1Tyj/Rb1tm2Brn,Rbl1tm1Tyj/Rbl1+,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL
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| MP:0005333 | decreased heart rate | "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764] |
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Rbl2tm1Tyj/Rbl2tm1Tyj,Tg(Myh6-cre)2182Mds/Tg(Myh6-cre)2182Mds
Genetic Background: involves: 129 * 129S2/SvPas * FVB/N
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| MP:0005488 | bronchial epithelial hyperplasia | "increased numbers of cells lining the inner surfaces of the bronchi" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Rb1tm1Tyj/Rb1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0005498 | hyporesponsive to tactile stimuli | "reduced reflex action normally induced by touch or pain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae
Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas
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| MP:0005545 | abnormal lens development | "aberrant formation of the transparent structure of the eye responsible for focusing light rays" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Rb1tm3Tyj/Rb1tm3.1Tyj,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N
Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0005598 | decreased ventricle muscle contractility | "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission] |
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Rbl2tm1Tyj/Rbl2tm1Tyj,Tg(Myh6-cre)2182Mds/Tg(Myh6-cre)2182Mds
Genetic Background: involves: 129 * 129S2/SvPas * FVB/N
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| MP:0006042 | increased apoptosis | "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Rb1tm1Mlh/Rb1tm1Mlh
Genetic Background: either: 129P2/OlaHsd-Rb1tm1Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
Allelic Composition: Rb1tm2Mlh/Rb1tm2Mlh
Genetic Background: either: 129P2/OlaHsd-Rb1tm2Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Rbl1tm1Tyj/Rbl1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0006043 | decreased apoptosis | "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Ttntm1Her/Ttntm1Her
Genetic Background: Not Specified
Allelic Composition: Rb1tm1Jyjw/Rb1tm1Jyjw
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)
Allelic Composition: Rb1tm1Jyjw/Rb1+
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)
Allelic Composition: Rb1tm1.1Jyjw/Rb1+
Genetic Background: either: (involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6) or (involves: 129S4/SvJae * 129S6/SvEvTac)
Allelic Composition: Rb1tm1.1Jyjw/Rb1tm1.1Jyjw,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: 129S6.129-Trp53tm1Tyj Rb1tm1.1Jyjw
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| MP:0006068 | abnormal horizontal cell morphology | "anomalous structure of the laterally interconnecting neurons in the outer plexiform layer" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Rbl2tm2.1Tyj/Rbl2tm2.1Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N
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| MP:0006069 | abnormal retinal neuronal layer morphology | "malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3] |
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Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Rbl2tm2.1Tyj/Rbl2tm2.1Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N
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| MP:0006072 | abnormal retinal apoptosis | "increase or decrease in the number of cells in the retina undergoing programmed cell death" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92622:] |
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Allelic Composition: Ttntm1Her/Ttntm1Her
Genetic Background: Not Specified
Allelic Composition: Rb1tm1Jyjw/Rb1+
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Rbl1tm1Tyj/Rbl1tm1Tyj,Tg(Nes-cre)1Atp/0
Genetic Background: involves: 129S2/SvPas * FVB/N
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj,Tg(Nes-cre)1Atp/0
Genetic Background: involves: 129S2/SvPas * FVB/N
Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas
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| MP:0006087 | increased body mass index | "greater than normal average of a measure of weight for height" [ncbi:NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Psen1tm1Vln/Psen1tm1Vln,Tg(Thy1-APPLon)2Vln/0,Tg(Thy1-cre)1Vln/0
Genetic Background: involves: FVB/N
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| MP:0006096 | absent retinal bipolar cells | "absence of the cells that transmit signals from the photoreceptors to retinal amacrine and ganglion cells" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator, J:65410] |
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Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Rbl2tm2.1Tyj/Rbl2tm2.1Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: Not Specified
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| MP:0006099 | thin granule layer | "reduced thickness of the innermost cortical layer of the cerebellum that contains granule cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65410] |
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Allelic Composition: Rb1tm1Tyj/Rb1tm2Tyj
Genetic Background: chimera involves: 129S2/SvPas * C57BL/6
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| MP:0006283 | medulloblastoma | "a solid, cancerous tumor originating in the cerebellum of the brain and of primitive neuroectodermal origin " [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brd/Trp53tm1Brd,Tg(Gfap-cre)2Brn/0
Genetic Background: involves: 129 * 129S7/SvEvBrd * FVB/N
Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(Gfap-cre)2Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bmi1,-EGFP)Nki/Gt(ROSA)26Sor+,Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(Gfap-cre)2Brn/0
Genetic Background: either: (involves: 129 * 129P2/OlaHsd * FVB/N) or (involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N)
Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(Gfap-cre)2Brn/0
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
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| MP:0006309 | decreased retinal ganglion cell number | "reduced number of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: Not Specified
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| MP:0006310 | retinoblastoma | "a malignant tumor of the retina composed of cells arising from the retinoblasts" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Rbl2tm2.1Tyj/Rbl2tm2.1Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Rbl1tm1Tyj/Rbl1tm1Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * FVB/N
Allelic Composition: Rb1tm1Tyj/Rb1tm2Brn,Rbl1tm1Tyj/Rbl1tm1Tyj,Trp53tm1Brn/Trp53tm1Brn,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL
Allelic Composition: Rb1tm1Tyj/Rb1tm2Brn,Rbl1tm1Tyj/Rbl1tm1Tyj,Trp53tm1Brn/Trp53tm1Tyj,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL
Allelic Composition: Rb1tm1Tyj/Rb1tm2Brn,Rbl1tm1Tyj/Rbl1+,Trp53tm1Brn/Trp53tm1Brn,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL
Allelic Composition: Rb1tm1Tyj/Rb1tm2Brn,Rbl1tm1Tyj/Rbl1+,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj,Tg(Nes-cre)1Atp/0
Genetic Background: involves: 129S2/SvPas * FVB/N
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| MP:0008000 | ovary tumor | "presence of abnormal rapidly proliferating cells in the ovary, usually in the form of a distinct mass" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd
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| MP:0008014 | lung tumor | "presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rb1tm1Tyj/Rb1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J
Allelic Composition: Krastm4Tyj/Kras+,Rb1tm3Tyj/Rb1tm3Tyj
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53+
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Rbl2tm2Tyj/Rbl2tm2Tyj,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(MMTV-cre)105Ayn/0
Genetic Background: FVB.Cg-Trp53tm1Brn Rb1tm2Brn Tg(MMTV-cre)105Ayn
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| MP:0008019 | liver tumor | "presence of abnormal, rapidly proliferating cells in the liver usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(tetO-MYC)36aBop/0,Tg(Cebpb-tTA)5Bjd/0
Genetic Background: involves: FVB/N * NMRI
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| MP:0008068 | absent retinal ganglion cell | "absence of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Rbl2tm2.1Tyj/Rbl2tm2.1Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N
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| MP:0008113 | abnormal macrophage differentiation | "atypical production of or inability to produce the large mononuclear phagocytes which differentiate from monocytes, are typically resident in a particular tissue, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells" [CL:0000235, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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| MP:0008130 | abnormal pituitary intermediate lobe | "any structural anomaly of the thin boundary between the adenohypophysis and neurohypophysis of the pituitary that produces melanocyte stimulating hormone (MSH); this area is small or absent in mammalian adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rb1tm1Brn/Rb1+,Tg(Pomc-FLP)1aBrn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N
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| MP:0008148 | abnormal rib-sternum attachment | "any anomaly in the in the normal joining of the ribs to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas
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| MP:0008254 | increased megakaryocyte cell number | "greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464] |
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Allelic Composition: Rb1tm1Mlh/Rb1tm1Mlh
Genetic Background: either: 129P2/OlaHsd-Rb1tm1Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
Allelic Composition: Rb1tm2Mlh/Rb1tm2Mlh
Genetic Background: either: 129P2/OlaHsd-Rb1tm2Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
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| MP:0008277 | abnormal sternum ossification | "anomaly in the process of the formation of the sternum bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958, MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas
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| MP:0008301 | adrenal medulla hyperplasia | "overdevelopment or increased size of the inner portion of the adrenal gland that consists mainly of chromaffin cells, usually due to an increase in the number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,Rb1tm1Tyj/Rb1+
Genetic Background: either: 129S2/SvPas or (involves: 129S2/SvPas * C57BL/6)
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| MP:0008306 | abnormal supporting cell proliferation | "aberrant timing or any anomaly in the ability of supporting cells in the organ of Corti to undergo expansion by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ncam1tm1Cgn/Ncam1tm1Cgn
Genetic Background: involves: C57BL/6J
Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Tg(Pou4f3-cre)1Devet/0
Genetic Background: involves: 129 * 129S/SvEv
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| MP:0008371 | pituitary intermediate lobe hyperplasia | "overdevelopment or increased size, usually due to increased cell number, of the thin boundary between the adenohypophysis and neurohypophysis of the pituitary that produces melanocyte stimulating hormone (MSH); this area is small or absent in mammalian adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rb1tm1Brn/Rb1tm1Brn,X/Tg(Pomc-FLP)1bBrn
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Rb1tm1Brn/Rb1+,X/Tg(Pomc-FLP)1bBrn
Genetic Background: involves: 129P2/OlaHsd * FVB/N
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| MP:0008446 | decreased retinal cone cell number | "reduced number of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment" [MESH:A08.663.650.650.670.100, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Rbl2tm2.1Tyj/Rbl2tm2.1Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N
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| MP:0008453 | decreased retinal rod cell number | "reduced number of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane" [MESH:A08.663.650.650.670.650] |
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)
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| MP:0008511 | thin retinal inner nuclear layer | "reduced thickness of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: Not Specified
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| MP:0008512 | disorganized retinal inner nuclear layer | "derangement of the normal pattern of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N
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| MP:0008513 | thin retinal inner plexiform layer | "reduced thickness of the retinal cell layer where bipolar and amacrine cell axons synapse with ganglion cell dendrites" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: Not Specified
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| MP:0008515 | thin retinal outer nuclear layer | "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: Not Specified
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Trp53tm1Tyj/Trp53tm1Tyj,Tg(Nes-cre)1Atp/0
Genetic Background: involves: 129S2/SvPas * FVB/N
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N
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| MP:0008534 | enlarged fourth ventricle | "increased size of the irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind; it is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space" [MESH:A08.186.211.276.500, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rb1tm1Brd/Rb1tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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| MP:0008714 | lung carcinoma | "a malignant neoplasm of the ling, arising from epithelial cells, usually glandular or squamous" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd
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| MP:0008715 | lung small cell carcinoma | "an anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm" [MESH:C04.557.465.625.650.240.390] |
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53+
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Rbl2tm2Tyj/Rbl2tm2Tyj,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Lejo/Trp53tm1Lejo
Genetic Background: involves: 129
Allelic Composition: Calcatm1.1(cre/ERT2)Ptch/Calca+,Trp53tm1Brn/Trp53tm1Brn,Rb1tm2Brn/Rb1tm2Brn
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
Allelic Composition: Calcatm1.1(cre/ERT2)Ptch/Calca+,Trp53tm1Brn/Trp53tm1Brn,Rb1tm2Brn/Rb1tm2Brn,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S4/SvJae * BALB/c * FVB/N
Allelic Composition: Rb1tm2Brn/Rb1+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd
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| MP:0008796 | increased lens fiber apoptosis | "increase in the number of lens fibers cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6
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| MP:0008866 | chromosomal instability | "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840] |
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(MMTV-cre)105Ayn/0
Genetic Background: FVB.Cg-Trp53tm1Brn Rb1tm2Brn Tg(MMTV-cre)105Ayn
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| MP:0008877 | abnormal DNA methylation | "any anomaly in the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine of DNA" [GO:0006306] |
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Allelic Composition: Rb1tm1Brd/Rb1+,Snrpntm4Alb/Snrpn+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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| MP:0008883 | abnormal enterocyte proliferation | "anomaly in the ability of the enterocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm3(CAG-Chrm3*,-mCitrine)Ute/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
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| MP:0009153 | pancreas tumor | "tumors or cancer of the pancreas" [MESH:C04.588.274.761] |
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Allelic Composition: Men1tm1.1Ctre/Men1+,Rb1tm1Tyj/Rb1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J * FVB/N
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| MP:0009277 | brain tumor | "presence of abnormal rapidly proliferating cells in the brain, usually in the form of a distinct mass" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"] |
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Allelic Composition: Psen1tm1Vln/Psen1tm1Vln,Tg(Thy1-APPLon)2Vln/0,Tg(Thy1-cre)1Vln/0
Genetic Background: involves: FVB/N
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| MP:0009320 | lymphoblastic lymphoma | "diffuse lymphoma with supradiaphragmatic distribution and T lymphocytes having convoluted nuclei" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Msh2tm1Whl/Msh2tm1Whl,Rb1tm1Brd/Rb1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
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| MP:0009395 | persistence of primitive erythrocytes | "presence of increased numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rb1tm1Brd/Rb1tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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| MP:0009408 | decreased skeletal muscle fiber density | "decrease in the number of skeletal muscle fibers in a given cross-sectional area of a skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0009417 | skeletal muscle atrophy | "a wasting of skeletal muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Rb1tm2.1Fad/Rb1tm2.1Fad
Genetic Background: involves: 129 * C57BL/6
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| MP:0009550 | urinary bladder carcinoma | "a malignant neoplasm of the urinary bladder, arising from epithelial cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Syt2m1Btlr/Syt2m1Btlr
Genetic Background: C57BL/6J-Syt2m1Btlr
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| MP:0009763 | increased sensitivity to induced morbidity/mortality | "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ttntm1Her/Ttntm1Her
Genetic Background: Not Specified
Allelic Composition: Rb1tm1Jyjw/Rb1tm1Jyjw
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)
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| MP:0009764 | decreased sensitivity to induced morbidity/mortality | "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ttntm1Her/Ttntm1Her
Genetic Background: Not Specified
Allelic Composition: Rb1tm1Jyjw/Rb1tm1Jyjw
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)
Allelic Composition: Rb1tm1Jyjw/Rb1+
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)
Allelic Composition: Rb1tm1.1Jyjw/Rb1+
Genetic Background: either: (involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6) or (involves: 129S4/SvJae * 129S6/SvEvTac)
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| MP:0009937 | abnormal neuron differentiation | "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rb1tm3Tyj/Rb1tm3.1Tyj,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N
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| MP:0010278 | increased glioma incidence | "greater than the expected number of tumors that arise from glial cells, non-neuronal cells of the nervous tissue, occurring in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cdkn2atm1Rdp/Cdkn2a+,Tg(S100b-v-erbB)4496Waw/0
Genetic Background: involves: 129/Sv * C57BL/6J * DBA/2J * FVB/N * SJL
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| MP:0010279 | increased gastrointestinal tumor incidence | "greater than the expected number of tumors originating in the gastrointestinal system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Msh2tm1Whl/Msh2tm1Whl,Rb1tm1Brd/Rb1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
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| MP:0010281 | increased nervous system tumor incidence | "greater than the expected number of tumors originating in the nervous system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Ptentm1Mro/Ptentm1Mro,Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB/N
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| MP:0010299 | increased mammary gland tumor incidence | "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(MMTV-cre)105Ayn/0
Genetic Background: FVB.Cg-Trp53tm1Brn Rb1tm2Brn Tg(MMTV-cre)105Ayn
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| MP:0010300 | increased skin tumor incidence | "greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Msh2tm1Whl/Msh2tm1Whl,Rb1tm1Brd/Rb1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
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| MP:0010316 | increased thyroid tumor incidence | "greater than the expected number of neoplams in the thyroid occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: E2f4tm1Lees/E2f4+,Rb1tm1Tyj/Rb1+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Rb1tm1Tyj/Rb1+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Rb1tm1Tyj/Rb1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Kdm5atm1.1Kael/Kdm5a+,Rb1tm1Tyj/Rb1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * FVB/N
Allelic Composition: Kdm5atm1.1Kael/Kdm5atm1.1Kael,Rb1tm1Tyj/Rb1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * FVB/N
Allelic Composition: Rb1tm1Tyj/Rb1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * FVB/N
Allelic Composition: Rb1tm1Tyj/Rb1+,Trim27Gt(XP0484)Wtsi/Trim27Gt(XP0484)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Calcatm1.1(cre/ERT2)Ptch/Calca+,Trp53tm1Brn/Trp53tm1Brn,Rb1tm2Brn/Rb1tm2Brn
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
Allelic Composition: Calcatm1.1(cre/ERT2)Ptch/Calca+,Trp53tm1Brn/Trp53tm1Brn,Rb1tm2Brn/Rb1tm2Brn,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S4/SvJae * BALB/c * FVB/N
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| MP:0010320 | increased pituitary gland tumor incidence | "greater than the expected number of neoplams in the pituitary gland occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: E2f4tm1Lees/E2f4+,Rb1tm1Tyj/Rb1+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Rb1tm1Tyj/Rb1+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Rb1tm1Tyj/Rb1+,Rbl1tm1Tyj/Rbl1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Rb1tm1Tyj/Rb1+,Rbl1tm1Tyj/Rbl1+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Trp53tm1Tyj/Trp53tm1Tyj,Tg(Nes-cre)1Atp/0
Genetic Background: involves: 129S2/SvPas * FVB/N
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N
Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Tg(Gfap-cre)2Brn/0
Genetic Background: involves: 129 * FVB/N
Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,Rb1tm1Tyj/Rb1+
Genetic Background: either: 129S2/SvPas or (involves: 129S2/SvPas * C57BL/6)
Allelic Composition: Kdm5atm1.1Kael/Kdm5a+,Rb1tm1Tyj/Rb1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * FVB/N
Allelic Composition: Kdm5atm1.1Kael/Kdm5atm1.1Kael,Rb1tm1Tyj/Rb1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * FVB/N
Allelic Composition: Rb1tm1Tyj/Rb1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bmi1,-EGFP)Nki/Gt(ROSA)26Sor+,Rb1tm2Brn/Rb1tm2Brn,Tg(Gfap-cre)2Brn/0
Genetic Background: either: (involves: 129 * 129P2/OlaHsd * FVB/N) or (involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N)
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bmi1,-EGFP)Nki/Gt(ROSA)26Sor+,Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(Gfap-cre)2Brn/0
Genetic Background: either: (involves: 129 * 129P2/OlaHsd * FVB/N) or (involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N)
Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(Gfap-cre)2Brn/0
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
Allelic Composition: Rb1tm1Tyj/Rb1+,Trim27Gt(XP0484)Wtsi/Trim27Gt(XP0484)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Rb1tm1Tyj/Rb1+,Smarca4tm1Mag/Smarca4+
Genetic Background: involves: 129S/Sv * 129S2/SvPas * C57BL/6J * CD-1
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| MP:0010321 | increased parathyroid gland tumor incidence | "greater than the expected number of neoplams in the parathyroid gland occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Men1tm1.1Ctre/Men1+,Rb1tm1Tyj/Rb1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J * FVB/N
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| MP:0010344 | increased hibernoma incidence | "greater than the expected number of a benign neoplasm derived from brown fat occurring in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
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| MP:0010345 | increased thyroid C-cell carcinoma incidence | "greater than the expected number of a malignant neoplasm derived from the calcitonin producing C-cells of the thyroid gland, occurring in a specific population in a given time period" [MPATH:308] |
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Allelic Composition: Msh2tm1Whl/Msh2tm1Whl,Rb1tm1Brd/Rb1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
Allelic Composition: Rb1tm1Brd/Rb1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
Allelic Composition: Rb1tm1Tyj/Rb1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J
Allelic Composition: Men1tm1.1Ctre/Men1+,Rb1tm1Tyj/Rb1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J * FVB/N
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| MP:0010346 | increased thyroid carcinioma incidence | "greater than the expected number of a malignant epithelial neoplasms of the thyroid gland, occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0010348 | increased pancreatic islet cell carcinoma incidence | "greater than the expected number of malignant neoplasms arising in the pancreatic islet cells, occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rb1tm1Tyj/Rb1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(Ren-cre)#Kwg/0
Genetic Background: involves: 129 * 129P2/OlaHsd
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| MP:0010350 | increased pituitary adenohypophysis tumor incidence | "greater than the expected number of neoplasms in the anterior part of the pituitary that secretes a variety of hormones, occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB
Allelic Composition: Msh2tm1Whl/Msh2tm1Whl,Rb1tm1Brd/Rb1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
Allelic Composition: Rb1tm1Brd/Rb1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
Allelic Composition: Rb1tm1Tyj/Rb1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J
Allelic Composition: Men1tm1.1Ctre/Men1+,Rb1tm1Tyj/Rb1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J * FVB/N
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| MP:0010351 | increased pituitary melanotroph tumor incidence | "greater than the expected number of neoplasms derived from the cells of intermediate pituitary that produce melanocyte stimulating hormone and other peptides from the post-translational processing of pro-opiomelanocortin (POMC)" [CL:0000440, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB
Allelic Composition: Rb1tm1Mlh/Rb1+
Genetic Background: either: 129P2/OlaHsd-Rb1tm1Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
Allelic Composition: Rb1tm2Mlh/Rb1+
Genetic Background: either: 129P2/OlaHsd-Rb1tm2Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
Allelic Composition: Rb1tm1Tyj/Rb1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Msh2tm1Whl/Msh2tm1Whl,Rb1tm1Brd/Rb1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
Allelic Composition: Rb1tm1Brd/Rb1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
Allelic Composition: Rb1tm1Tyj/Rb1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J
Allelic Composition: Men1tm1.1Ctre/Men1+,Rb1tm1Tyj/Rb1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J * FVB/N
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| MP:0010639 | altered tumor pathology | "any changes associated with the chemistry, immunohistology, cellular alterations or environmental interactions of tumors compared to the expected state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Rb1tm2Brn/Rb1+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd
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| MP:0010918 | abnormal pulmonary neuroendocrine bodies | "any structural anomaly of the corpuscular, organoid structures composed of PNECs, found as distinctive innervated clusters only within intrapulmonary airways, where they appear concentrated at airway branch points; NEBs reach from the basement membrane to the airway lumen and are thought to function as oxygen sensors" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Calcatm1.1(cre/ERT2)Ptch/Calca+,Trp53tm1Brn/Trp53tm1Brn,Rb1tm2Brn/Rb1tm2Brn
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
Allelic Composition: Calcatm1.1(cre/ERT2)Ptch/Calca+,Trp53tm1Brn/Trp53tm1Brn,Rb1tm2Brn/Rb1tm2Brn,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S4/SvJae * BALB/c * FVB/N
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| MP:0011085 | complete postnatal lethality | "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ
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| MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Rb1tm1Tyj/Rb1+,Rbl1tm1Tyj/Rbl1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,Rb1tm2.1Fad/Rb1tm2.1Fad
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Rb1tm1Tyj/Rb1+
Genetic Background: involves: 129S2/SvPas
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| MP:0011087 | complete neonatal lethality | "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith] |
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Allelic Composition: Rb1tm3Tyj/Rb1tm3.1Tyj,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N
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| MP:0011088 | partial neonatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith] |
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Allelic Composition: Rb1tm2.1Fad/Rb1tm2.1Fad
Genetic Background: involves: 129 * C57BL/6
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| MP:0011089 | complete perinatal lethality | "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith] |
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0011091 | complete prenatal lethality | "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Muttm1Cpv/Muttm1Cpv
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N
Allelic Composition: E2f1tm1Njd/E2f1+,Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: either: 129S2/SvPas or (involves: 129S2/SvPas * C57BL/6)
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| MP:0011092 | complete embryonic lethality | "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith] |
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Allelic Composition: Rb1tm1Mlh/Rb1tm1Mlh
Genetic Background: either: 129P2/OlaHsd-Rb1tm1Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
Allelic Composition: Rb1tm2Mlh/Rb1tm2Mlh
Genetic Background: either: 129P2/OlaHsd-Rb1tm2Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
Allelic Composition: Kdm5atm1.1Kael/Kdm5a+,Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * FVB/N
Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * FVB/N
Allelic Composition: Kdm5atm1.1Kael/Kdm5atm1.1Kael,Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * FVB/N
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| MP:0011098 | complete embryonic lethality during organogenesis | "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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| MP:0011099 | complete lethality throughout fetal growth and development | "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Rb1tm1Brd/Rb1tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Rb1tm1Dwg/Rb1tm1Tyj
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6
Allelic Composition: Rb1tm2.1Brn/Rb1tm2.1Brn
Genetic Background: Not Specified
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| MP:0011101 | partial prenatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Ttntm1Her/Ttntm1Her
Genetic Background: Not Specified
Allelic Composition: Rb1tm1Jyjw/Rb1tm1Jyjw
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)
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| MP:0011108 | partial embryonic lethality during organogenesis | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Rbl1tm1Tyj/Rbl1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0011110 | partial preweaning lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith] |
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Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ
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| MP:0011703 | increased fibroblast proliferation | "greater the expansion rate of a fibroblast cell population by cell division" [MGI:csmith] |
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Kdm5atm1.1Kael/Kdm5a+,Rb1tm1Tyj/Rb1tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * FVB/N
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| MP:0011804 | increased cell migration | "increased or faster movement of cells from one site to another, often occuring during developmental or chemotactic processes" [GO:0016477, MGI:csmith] |
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Allelic Composition: Prkar1atm1.2Lsk/Prkar1a+,Rb1tm2Brn/Rb1+,Tg(Col1a1-cre)1Kry/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N
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| MP:0012431 | increased lymphoma incidence | "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith] |
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Allelic Composition: Rb1tm1.1Jyjw/Rb1tm1.1Jyjw,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: 129S6.129-Trp53tm1Tyj Rb1tm1.1Jyjw
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| MP:0030005 | increased retinal apoptosis | "increase in the number of cells in the retina undergoing programmed cell death" [MGI:anna] |
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Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Rbl2tm2.1Tyj/Rbl2tm2.1Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: Not Specified
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Trp53tm1Tyj/Trp53tm1Tyj,Tg(Nes-cre)1Atp/0
Genetic Background: involves: 129S2/SvPas * FVB/N
Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N
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| MP:0030006 | decreased retinal apoptosis | "decrease in the number of cells in the retina undergoing programmed cell death" [MGI:anna] |
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Allelic Composition: Rb1tm1Jyjw/Rb1tm1Jyjw
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)
Allelic Composition: Rb1tm1.1Jyjw/Rb1+
Genetic Background: either: (involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6) or (involves: 129S4/SvJae * 129S6/SvEvTac)
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| MP:0030047 | flat forehead | "abnormal flatness of the forehead" [MGI:anna] |
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Allelic Composition: Rb1tm1Mlh/Rb1tm1Mlh
Genetic Background: either: 129P2/OlaHsd-Rb1tm1Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
Allelic Composition: Rb1tm2Mlh/Rb1tm2Mlh
Genetic Background: either: 129P2/OlaHsd-Rb1tm2Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
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