ENSMUSG00000031666


Mus musculus

Features
Gene ID: ENSMUSG00000031666
  
Biological name :Rbl2
  
Synonyms : Q64700 / Rbl2 / Retinoblastoma-like protein 2
  
Possible biological names infered from orthology : Q08999 / RB transcriptional corepressor like 2
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: C4
Gene start: 91070057
Gene end: 91123844
  
Corresponding Affymetrix probe sets: 10573867 (MoGene1.0st)   1418146_a_at (Mouse Genome 430 2.0 Array)   1425981_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000147579
Ensembl peptide - ENSMUSP00000034091
Ensembl peptide - ENSMUSP00000147327
NCBI entrez gene - 19651     See in Manteia.
MGI - MGI:105085
RefSeq - NM_001282000
RefSeq - NM_001282001
RefSeq - NM_011250
RefSeq Peptide - NP_035380
RefSeq Peptide - NP_001268929
RefSeq Peptide - NP_001268930
swissprot - Q64700
swissprot - A0A1B0GRM0
swissprot - A0A1B0GR06
Ensembl - ENSMUSG00000031666
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rbl2ENSDARG00000045636Danio rerio
 RBL2ENSGALG00000003663Gallus gallus
 RBL2ENSG00000103479Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rbl1 / Q64701 / Retinoblastoma-like protein 1 / P28749* / RB transcriptional corepressor like 1*ENSMUSG0000002764146
Rb1 / P13405 / Retinoblastoma-associated protein / P06400* / RB transcriptional corepressor 1*ENSMUSG0000002210521


Protein motifs (from Interpro)
Interpro ID Name
 IPR002719  Retinoblastoma-associated protein, B-box
 IPR002720  Retinoblastoma-associated protein, A-box
 IPR013763  Cyclin-like
 IPR015030  Retinoblastoma-associated protein, C-terminal
 IPR024599  Retinoblastoma-associated protein, N-terminal
 IPR028308  Retinoblastoma-like protein 2
 IPR028309  Retinoblastoma protein family
 IPR036915  Cyclin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0043550 regulation of lipid kinase activity IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:1990841 promoter-specific chromatin binding IEA


Pathways (from Reactome)
Pathway description
G0 and Early G1
Cyclin D associated events in G1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000078 abnormal supraoccipital bone morphology "malformed upper part of the occipital bone" [J:61509]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000116 abnormal tooth development "anomalous formation of the teeth" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000125 absent incisors "missing long pointed teeth; most anterior and prominent in the jaw" [J:17489]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000166 abnormal chondrocyte morphology "anomalous structure, organization, or differentiation of nondividing cartilage cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mafatm1Staka/Mafa+
Genetic Background: involves: ICR

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Mafatm1Staka/Mafa+
Genetic Background: involves: ICR

Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Rbl2tm1Tyj/Rbl2tm1Tyj,Tg(Myh6-cre)2182Mds/Tg(Myh6-cre)2182Mds
Genetic Background: involves: 129 * 129S2/SvPas * FVB/N

 MP:0000350 abnormal cell proliferation "anomalous growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mafatm1Staka/Mafa+
Genetic Background: involves: ICR

 MP:0000379 reduced hair follicle number "fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000382 underdeveloped hair follicles "arrest of or retarded differentiation of the epidermal invaginations from which the hair shaft develops" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000383 abnormal hair follicle orientation "misaligned hair follicles; hair follicles that do not orient in a typical pattern" [J:47620]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000397 abnormal guard hair "anomalies of truncal hairs that contain two air cells in the medulla" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000400 abnormal awl hair "anomalies of truncal hairs that contain two or more air cells in the medulla" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000402 abnormal zigzag hairs "anomalies of truncal hairs that contain one air cell in the medulla" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000427 abnormal hair cycle "aberrant growth or asynchronous timing of the hair growth " [J:65302]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000550 abnormal forelimb morphology "malformation of the entire anterior extremities" [MGI:tc]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000652 enlarged sebaceous gland "increased size of the sebum secreting glands of the hair shaft" [J:30249]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000737 abnormal myotome development "malformation of or absence of the part of the somite that develops into the musculature" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29279]
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Allelic Composition: Mafatm1Staka/Mafa+
Genetic Background: involves: ICR

 MP:0000925 abnormal floor plate morphology "malformation or absence of a transient group of neuroepithelial cells located at the ventral midline of the neural tube that profoundly influences the development of the vertebrate central nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mafatm1Staka/Mafa+
Genetic Background: involves: ICR

 MP:0000926 absent floor plate "missing ventral midline thinning of the developing neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35802]
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Allelic Composition: Mafatm1Staka/Mafa+
Genetic Background: involves: ICR

 MP:0000932 absent notochord "missing axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
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Allelic Composition: Mafatm1Staka/Mafa+
Genetic Background: involves: ICR

 MP:0001179 thicker alveolar septa 
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Allelic Composition: Krastm4Tyj/Kras+,Rbl2tm2Tyj/Rbl2tm2Tyj
Genetic Background: involves: 129S4/SvJae

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001239 abnormal granular layer morphology "structural or developmental anomaly of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Rbl1tm1.1Fad/Rbl1tm1.1Fad,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0001270 distended abdomen "abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rbl2tm1Tyj/Rbl2+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Rbl2tm2.1Tyj/Rbl2tm2.1Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0001689 incomplete somite formation "arrest of differentiation or patterning of the somites" [J:62882]
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Allelic Composition: Mafatm1Staka/Mafa+
Genetic Background: involves: ICR

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Mafatm1Staka/Mafa+
Genetic Background: involves: ICR

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Mafatm1Staka/Mafa+
Genetic Background: involves: ICR

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: CrygeElo/CrygeElo
Genetic Background: C3N.Cg-CrygeElo

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Rbl2tm1Tyj/Rbl2tm1Tyj,Tg(Myh6-cre)2182Mds/Tg(Myh6-cre)2182Mds
Genetic Background: involves: 129 * 129S2/SvPas * FVB/N

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001951 abnormal breathing "irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Rbl2tm1Tyj/Rbl2tm1Tyj,Tg(Myh6-cre)2182Mds/Tg(Myh6-cre)2182Mds
Genetic Background: involves: 129 * 129S2/SvPas * FVB/N

 MP:0001957 apnea "absence of breathing; sometimes episodic" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17384]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Krastm4Tyj/Kras+,Rbl2tm2Tyj/Rbl2tm2Tyj
Genetic Background: involves: 129S4/SvJae

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Chattm1Jrs/Chattm1Jrs,Tg(CAG-cre/Esr1*)1Lbe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Rbl2tm1Tyj/Rbl2tm1Tyj,Tg(Myh6-cre)2182Mds/Tg(Myh6-cre)2182Mds
Genetic Background: involves: 129 * 129S2/SvPas * FVB/N

Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj,Tg(Nes-cre)1Atp/0
Genetic Background: involves: 129S2/SvPas * FVB/N

Allelic Composition: Krastm4Tyj/Kras+,Rbl2tm2Tyj/Rbl2tm2Tyj
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Rbl2tm2Tyj/Rbl2tm2Tyj,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mafatm1Staka/Mafa+
Genetic Background: involves: ICR

 MP:0002115 abnormal skeleton extremities morphology "abnormal development of limb, foot or tail bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002116 abnormal craniofacial bone morphology "abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rb1tm1Tyj/Rb1+,Rbl1tm1Tyj/Rbl1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Rbl2tm1Tyj/Rbl2+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0002267 abnormal bronchiole morphology "any structural anomaly of the conducting airway of the lungs found terminal to the bronchi. These structures contain neither cartilage nor mucous-secreting glands; the epithelium of the bronchioles becomes thinner with each branching. " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Krastm4Tyj/Kras+,Rbl2tm2Tyj/Rbl2tm2Tyj
Genetic Background: involves: 129S4/SvJae

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mafatm1Staka/Mafa+
Genetic Background: involves: ICR

 MP:0002656 abnormal keratinocyte differentiation "developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002683 delayed fertility "ability to produce live offspring occuring at a later than expected age" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Rbl2tm1Tyj/Rbl2tm1Tyj,Tg(Myh6-cre)2182Mds/Tg(Myh6-cre)2182Mds
Genetic Background: involves: 129 * 129S2/SvPas * FVB/N

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Rbl1tm1.1Fad/Rbl1tm1.1Fad,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0002765 short fibula "reduced length of the lateral and smaller of bone of the lower leg" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:12736]
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Allelic Composition: Rbl1tm1.1Fad/Rbl1tm1.1Fad,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0002823 abnormal rib development "anomalous formation of the bones forming the bony wall of the chest" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84754]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rbl1tm1.1Fad/Rbl1tm1.1Fad,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0002984 retina hypoplasia "less than normal number of cells in the thin layer of neural tissue lining the back of the eyeball which contains visual receptors" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80994]
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Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Rbl2tm2.1Tyj/Rbl2tm2.1Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rbl1tm1.1Fad/Rbl1tm1.1Fad,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0003120 abnormal tracheal cartilage "any structural anomaly of the cartilaginous structures that support the trachea" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:97123]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Mafatm1Staka/Mafa+
Genetic Background: involves: ICR

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm2.1Tyj/Rbl2tm2.1Tyj
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0003408 increased width of hypertrophic chondrocyte zone "increased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003419 delayed endochondral bone ossification "late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003427 parakeratosis "abnormal retention of the nuclei of the keratinocytes in the stratum corneum of the epidermis" [smb:Susan M Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003448 altered tumor morphology "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Krastm4Tyj/Kras+,Rbl2tm2Tyj/Rbl2tm2Tyj
Genetic Background: involves: 129S4/SvJae

 MP:0003662 abnormal proliferative zone "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]
Show

Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Rbl1tm1.1Fad/Rbl1tm1.1Fad,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0003704 abnormal hair follicle development "anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Krastm4Tyj/Kras+,Rbl2tm2Tyj/Rbl2tm2Tyj
Genetic Background: involves: 129S4/SvJae

 MP:0004179 transmission ratio distortion "the occurence of an allele or haplotype in the offspring of an organism at skewed Mendelian ratios" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj,Tg(Nes-cre)1Atp/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0004180 failure of initiation of embryo turning "failure to begin the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mafatm1Staka/Mafa+
Genetic Background: involves: ICR

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Rbl2tm1Tyj/Rbl2tm1Tyj,Tg(Myh6-cre)2182Mds/Tg(Myh6-cre)2182Mds
Genetic Background: involves: 129 * 129S2/SvPas * FVB/N

 MP:0004251 failure of looping morphogenesis "failure of the primitive heart tube to initiate or complete looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mafatm1Staka/Mafa+
Genetic Background: involves: ICR

 MP:0004347 abnormal scapular spine morphology "any structural anomaly of the trianguar ridge on the dorsal aspect of the scapula which separates the supra- from the infraspinatous fossa and where the trapezius and deltoid muscles are attached " [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Rbl1tm1.1Fad/Rbl1tm1.1Fad,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0004351 short humerus "reduced length of one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004355 short radius "reduced length of the short bone of the lateral forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Rbl1tm1.1Fad/Rbl1tm1.1Fad,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0004359 short ulna "reduced length of the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Rbl1tm1.1Fad/Rbl1tm1.1Fad,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0004385 interparietal bone hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, in the bone of the cranium that lies above and anterior to the occipital bone in some mammals" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Rbl1tm1.1Fad/Rbl1tm1.1Fad,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0004444 small supraoccipital bone "reduced size of the bone on the dorsal side of the great foramen of the skull, usually forming a part of the occipital in the adult, but distinct in the young" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rbl1tm1.1Fad/Rbl1tm1.1Fad,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0004564 enlarged myocardial fiber "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Rbl2tm1Tyj/Rbl2tm1Tyj,Tg(Myh6-cre)2182Mds/Tg(Myh6-cre)2182Mds
Genetic Background: involves: 129 * 129S2/SvPas * FVB/N

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rbl1tm1.1Fad/Rbl1tm1.1Fad,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0005105 abnormal middle ear ossicle morphology "anomalous structure or development of the three small bones of the middle ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rbl1tm1.1Fad/Rbl1tm1.1Fad,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0005161 hematuria "presence of blood in the urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:78193]
Show

Allelic Composition: Syt2m1Btlr/Syt2m1Btlr
Genetic Background: C57BL/6J-Syt2m1Btlr

 MP:0005240 abnormal amacrine cell morphology "anomalous structure of the interneurons of the retina" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Rbl2tm2.1Tyj/Rbl2tm2.1Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0005296 abnormal humerus morphology "malformation of the bone of the forelimb that articulates with the scapula above and the radius and ulna below" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Rbl2tm1Tyj/Rbl2tm1Tyj,Tg(Myh6-cre)2182Mds/Tg(Myh6-cre)2182Mds
Genetic Background: involves: 129 * 129S2/SvPas * FVB/N

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Rbl2tm1Tyj/Rbl2tm1Tyj,Tg(Myh6-cre)2182Mds/Tg(Myh6-cre)2182Mds
Genetic Background: involves: 129 * 129S2/SvPas * FVB/N

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mafatm1Staka/Mafa+
Genetic Background: involves: ICR

 MP:0006068 abnormal horizontal cell morphology "anomalous structure of the laterally interconnecting neurons in the outer plexiform layer" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Rbl2tm2.1Tyj/Rbl2tm2.1Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0006069 abnormal retinal neuronal layer morphology "malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]
Show

Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Rbl2tm2.1Tyj/Rbl2tm2.1Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0006072 abnormal retinal apoptosis "increase or decrease in the number of cells in the retina undergoing programmed cell death" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92622:]
Show

Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj,Tg(Nes-cre)1Atp/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0006096 absent retinal bipolar cells "absence of the cells that transmit signals from the photoreceptors to retinal amacrine and ganglion cells" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator, J:65410]
Show

Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Rbl2tm2.1Tyj/Rbl2tm2.1Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0006310 retinoblastoma "a malignant tumor of the retina composed of cells arising from the retinoblasts" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Rbl2tm2.1Tyj/Rbl2tm2.1Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj,Tg(Nes-cre)1Atp/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0006396 decreased long bone epiphyseal plate size "reduced size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rbl1tm1.1Fad/Rbl1tm1.1Fad,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0006399 abnormal long bone epiphyseal ossification zone morphology "any anomaly in the structure of the layer of the epiphyseal plate where new bone matrix is deposited" [CALnet tutorial:http://137.222.110.150/calnet/Introanat/Introanat.htm, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rbl1tm1.1Fad/Rbl1tm1.1Fad,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0008014 lung tumor "presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krastm4Tyj/Kras+,Rbl2tm2Tyj/Rbl2tm2Tyj
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Rbl2tm2Tyj/Rbl2tm2Tyj,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0008068 absent retinal ganglion cell "absence of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Rbl2tm2.1Tyj/Rbl2tm2.1Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0008160 increased diameter of humerus "increased width of the cross-sectional distance that extends from one lateral edge of the humerus, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008161 increased diameter of radius "increased width of the cross-sectional distance that extends from one lateral edge of the radius, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008163 increased diameter of ulna "increased width of the cross-sectional distance that extends from one lateral edge of the ulna, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008218 delayed emergence of vibrissae "eruption of the vibrissae from the skin later than embryonic day E17-18" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008446 decreased retinal cone cell number "reduced number of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment" [MESH:A08.663.650.650.670.100, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Rbl2tm2.1Tyj/Rbl2tm2.1Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0008715 lung small cell carcinoma "an anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm" [MESH:C04.557.465.625.650.240.390]
Show

Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Rbl2tm2Tyj/Rbl2tm2Tyj,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0009550 urinary bladder carcinoma "a malignant neoplasm of the urinary bladder, arising from epithelial cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Syt2m1Btlr/Syt2m1Btlr
Genetic Background: C57BL/6J-Syt2m1Btlr

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mafatm1Staka/Mafa+
Genetic Background: involves: ICR

 MP:0010103 small thoracic cage "reduced size of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Rbl1tm1.1Fad/Rbl1tm1.1Fad,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Rbl1tm1.1Fad/Rbl1tm1.1Fad,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Mafatm1Staka/Mafa+
Genetic Background: involves: ICR

 MP:0013168 absent hindlimb buds "absence or loss of the limb bud that normally develops into a hindlimb (usually the leg or back limb in mammalian species)" [MGI:anna]
Show

Allelic Composition: Mafatm1Staka/Mafa+
Genetic Background: involves: ICR

 MP:0030005 increased retinal apoptosis "increase in the number of cells in the retina undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Rbl2tm2.1Tyj/Rbl2tm2.1Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0030079 small incisors "reduced size of the set of long teeth that are the most anterior and prominent in the jaw" [MGI:anna]
Show

Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003031 Cdkn1b / P46414 / Cyclin-dependent kinase inhibitor 1B / P46527*  / reaction
 ENSMUSG00000006728 Cdk4 / P30285 / Cyclin-dependent kinase 4 / P11802*  / reaction
 ENSMUSG00000014859 E2f4 / Q8R0K9 / Transcription factor E2F4 / Q16254* / E2F transcription factor 4*  / complex
 ENSMUSG00000023067 Cdkn1a / P39689 / Cyclin-dependent kinase inhibitor 1 / P38936* / cyclin dependent kinase inhibitor 1A*  / reaction
 ENSMUSG00000029686 Cul1 / Q9WTX6 / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA. / Q13616* / cullin 1*  / complex / reaction
 ENSMUSG00000027552 E2f5 / Q61502 / Transcription factor E2F5 / Q15329* / E2F transcription factor 5*  / complex
 ENSMUSG00000036309 Skp1a / Q9WTX5 / S-phase kinase-associated protein 1A / SKP1* / P63208* / AC104109.3* / S-phase kinase associated protein 1*  / complex / reaction
 ENSMUSG00000025358 Cdk2 / P97377 / Cyclin-dependent kinase 2 / P24941*  / reaction / complex
 ENSMUSG00000038482 Tfdp1 / Q08639 / transcription factor Dp 1 / TFDP3* / Q14186* / Q5H9I0* / transcription factor Dp family member 3*  / complex
 ENSMUSG00000062687 Cks1brt / CDC28 protein kinase 1b, retrogene / CKS1B* / P61024* / CDC28 protein kinase regulatory subunit 1B*  / reaction / complex
 ENSMUSG00000061062 Gm10093 / HDAC1* / Q13547* / histone deacetylase 1*  / complex / reaction
 ENSMUSG00000054115 Skp2 / Q9Z0Z3 / S-phase kinase-associated protein 2 (p45) / Q13309* / S-phase kinase associated protein 2*  / complex / reaction
 ENSMUSG00000070348 Ccnd1 / P25322 / G1/S-specific cyclin-D1 / P24385* / cyclin D1*  / reaction
 ENSMUSG00000028800 Hdac1 / O09106 / Histone deacetylase 1 / Q13547*  / complex / reaction






 

1 s.

 
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