ENSMUSG00000027641


Mus musculus

Features
Gene ID: ENSMUSG00000027641
  
Biological name :Rbl1
  
Synonyms : Q64701 / Rbl1 / Retinoblastoma-like protein 1
  
Possible biological names infered from orthology : P28749 / RB transcriptional corepressor like 1
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: H1
Gene start: 157145893
Gene end: 157204534
  
Corresponding Affymetrix probe sets: 10489127 (MoGene1.0st)   1424156_at (Mouse Genome 430 2.0 Array)   1425166_at (Mouse Genome 430 2.0 Array)   1432604_at (Mouse Genome 430 2.0 Array)   1454293_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029170
NCBI entrez gene - 19650     See in Manteia.
MGI - MGI:103300
RefSeq - NM_011249
RefSeq - XM_006499018
RefSeq Peptide - NP_035379
swissprot - Q64701
Ensembl - ENSMUSG00000027641
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rbl1ENSDARG00000008141Danio rerio
 RBL1ENSGALG00000001332Gallus gallus
 RBL1ENSG00000080839Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rbl2 / Q64700 / Retinoblastoma-like protein 2 / Q08999* / RB transcriptional corepressor like 2*ENSMUSG0000003166649
Rb1 / P13405 / Retinoblastoma-associated protein / P06400* / RB transcriptional corepressor 1*ENSMUSG0000002210523


Protein motifs (from Interpro)
Interpro ID Name
 IPR002719  Retinoblastoma-associated protein, B-box
 IPR002720  Retinoblastoma-associated protein, A-box
 IPR013763  Cyclin-like
 IPR015030  Retinoblastoma-associated protein, C-terminal
 IPR024599  Retinoblastoma-associated protein, N-terminal
 IPR028309  Retinoblastoma protein family
 IPR028310  Retinoblastoma-like protein 1
 IPR036915  Cyclin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0043550 regulation of lipid kinase activity IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:2000773 negative regulation of cellular senescence IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:1990841 promoter-specific chromatin binding IEA


Pathways (from Reactome)
Pathway description
G0 and Early G1
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Cyclin D associated events in G1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000078 abnormal supraoccipital bone morphology "malformed upper part of the occipital bone" [J:61509]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000116 abnormal tooth development "anomalous formation of the teeth" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000125 absent incisors "missing long pointed teeth; most anterior and prominent in the jaw" [J:17489]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000166 abnormal chondrocyte morphology "anomalous structure, organization, or differentiation of nondividing cartilage cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rbl1tm1Mru/Rbl1tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ

 MP:0000321 increased bone marrow cell number "increased number of cells that make up the core cavitites of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Rbl1tm1Mru/Rbl1tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ

 MP:0000350 abnormal cell proliferation "anomalous growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rb1tm1Tyj/Rb1tm2Brn,Rbl1tm1Tyj/Rbl1tm1Tyj,Trp53tm1Brn/Trp53tm1Tyj,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rbl1tm1Mru/Rbl1tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ

 MP:0000379 reduced hair follicle number "fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000382 underdeveloped hair follicles "arrest of or retarded differentiation of the epidermal invaginations from which the hair shaft develops" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000383 abnormal hair follicle orientation "misaligned hair follicles; hair follicles that do not orient in a typical pattern" [J:47620]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000397 abnormal guard hair "anomalies of truncal hairs that contain two air cells in the medulla" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000400 abnormal awl hair "anomalies of truncal hairs that contain two or more air cells in the medulla" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000402 abnormal zigzag hairs "anomalies of truncal hairs that contain one air cell in the medulla" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000427 abnormal hair cycle "aberrant growth or asynchronous timing of the hair growth " [J:65302]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000550 abnormal forelimb morphology "malformation of the entire anterior extremities" [MGI:tc]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000652 enlarged sebaceous gland "increased size of the sebum secreting glands of the hair shaft" [J:30249]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000851 cerebellum hypoplasia "reduced cell number in the cerebellum" [MGI:CLS, J:45302]
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Rbl1tm1Htr/Rbl1+,Tg(En2-cre)22Alj/0
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0000864 abnormal vermis "malformation in the narrow middle zone between the two hemispheres of the cerebellum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61509]
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Rbl1tm1Htr/Rbl1tm1Htr,Tg(En2-cre)22Alj/0
Genetic Background: involves: 129P2/OlaHsd * CD-1

Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Rbl1tm1Htr/Rbl1+,Tg(En2-cre)22Alj/0
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Rbl1tm1Htr/Rbl1tm1Htr,Tg(En2-cre)22Alj/0
Genetic Background: involves: 129P2/OlaHsd * CD-1

Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Rbl1tm1Htr/Rbl1tm1Htr,Tg(Pcp2-cre)756Mro/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0000890 thin cerebellar molecular layer "reduced width of the outer of the three cortical layers of the cerebellum" [J:46854]
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Rbl1tm1Htr/Rbl1tm1Htr,Tg(En2-cre)22Alj/0
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0001004 abnormal photoreceptor morphology "structural or developmental anomaly of the receptors sensitive to light " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rb1tm1Tyj/Rb1+,Rbl1tm1Tyj/Rbl1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001144 fused vaginal opening "condition in which the external vaginal opening is closed by the adherence of the epithelium of the vagina" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rb1tm1Tyj/Rb1+,Rbl1tm1Tyj/Rbl1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001209 spontaneous skin ulceration "unpredictable appearance of skin lesions, usually with inflammation" [J:65302]
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Allelic Composition: Rbl1tm1Mru/Rbl1tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001239 abnormal granular layer morphology "structural or developmental anomaly of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Rb1tm1Tyj/Rb1+,Rbl1tm1Tyj/Rbl1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Rbl1tm1Mru/Rbl1tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Cd207tm2Mal/Cd207tm3(DTR/GFP)Mal
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Rbl1tm1Mru/Rbl1tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ

Allelic Composition: Rbl1tm1Mru/Rbl1tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

Allelic Composition: Rbl1tm1.1Fad/Rbl1tm1.1Fad,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0001270 distended abdomen "abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd207tm2Mal/Cd207tm3(DTR/GFP)Mal
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
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Allelic Composition: Wt1tm1Nhsn/Wt1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: E2f1tm1Meg/E2f1+,Rbl1tm1Htr/Rbl1tm1Htr,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI

Allelic Composition: E2f3tm1.1Gle/E2f3tm1.1Gle,Rbl1tm1Htr/Rbl1tm1Htr,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI

Allelic Composition: Rbl1tm1Htr/Rbl1tm1Htr,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rb1tm1Tyj/Rb1+,Rbl1tm1Tyj/Rbl1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Rbl1tm1Tyj/Rbl1tm1Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Rb1tm1Tyj/Rb1tm2Brn,Rbl1tm1Tyj/Rbl1tm1Tyj,Trp53tm1Brn/Trp53tm1Brn,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Rb1tm1Tyj/Rb1tm2Brn,Rbl1tm1Tyj/Rbl1+,Trp53tm1Brn/Trp53tm1Brn,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Rb1tm1Tyj/Rb1tm2Brn,Rbl1tm1Tyj/Rbl1+,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,Rbl1tm1Htr/Rbl1tm1Htr,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI

Allelic Composition: Rbl1tm1Htr/Rbl1tm1Htr,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI

Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Rbl1tm1Tyj/Rbl1tm1Tyj,Tg(Nes-cre)1Atp/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0001327 reduced retinal photoreceptor cell number "fewer than the expected number of rods and/or cones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rb1tm1Tyj/Rb1tm2Brn,Rbl1tm1Tyj/Rbl1+,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

 MP:0001330 abnormal optic nerve morphology "malformation, misprojection or atrophy in the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rbl1tm1Htr/Rbl1tm1Htr,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Tg(En2-cre)22Alj/0
Genetic Background: involves: 129P2/OlaHsd * CD-1

Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Rbl1tm1Htr/Rbl1+,Tg(En2-cre)22Alj/0
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Rbl1tm1Tyj/Rbl1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Rbl1tm1Tyj/Rbl1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rb1tm1Tyj/Rb1+,Rbl1tm1Tyj/Rbl1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Rbl1tm1Tyj/Rbl1+,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Rbl1tm1Mru/Rbl1tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rbl1tm1Mru/Rbl1tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Rbl1tm1Mru/Rbl1tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001951 abnormal breathing "irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001957 apnea "absence of breathing; sometimes episodic" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17384]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: Not Specified

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd207tm2Mal/Cd207tm3(DTR/GFP)Mal
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Rb1tm1Tyj/Rb1+,Rbl1tm1Tyj/Rbl1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Rbl1tm1Mru/Rbl1tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rbl1tm1Mru/Rbl1tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ

 MP:0002115 abnormal skeleton extremities morphology "abnormal development of limb, foot or tail bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002116 abnormal craniofacial bone morphology "abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rbl1tm1Mru/Rbl1tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pik3r1tm1Khn/Pik3r1tm1Khn
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002356 abnormal spleen red pulp morphology "anomalous structure of the area of the spleen that screens and eliminates defective or foreign cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Rbl1tm1Mru/Rbl1tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Rbl1tm1Mru/Rbl1tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0002656 abnormal keratinocyte differentiation "developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002683 delayed fertility "ability to produce live offspring occuring at a later than expected age" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Rbl1tm1.1Fad/Rbl1tm1.1Fad,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0002765 short fibula "reduced length of the lateral and smaller of bone of the lower leg" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:12736]
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Allelic Composition: Rbl1tm1.1Fad/Rbl1tm1.1Fad,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0002823 abnormal rib development "anomalous formation of the bones forming the bony wall of the chest" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84754]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rbl1tm1.1Fad/Rbl1tm1.1Fad,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0002970 abnormal white fat morphology "structural aberration in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rbl1tm1Mru/Rbl1tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rbl1tm1.1Fad/Rbl1tm1.1Fad,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0003120 abnormal tracheal cartilage "any structural anomaly of the cartilaginous structures that support the trachea" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:97123]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Rbl1tm1Htr/Rbl1+,Tg(En2-cre)22Alj/0
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Rbl1tm1Tyj/Rbl1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003315 abnormal perineum morphology "malformation in the area between the genital organs and the anus that lies beneath the pelvic diaphragm" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rb1tm1Tyj/Rb1+,Rbl1tm1Tyj/Rbl1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm2.1Tyj/Rbl2tm2.1Tyj
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0003408 increased width of hypertrophic chondrocyte zone "increased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003419 delayed endochondral bone ossification "late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003427 parakeratosis "abnormal retention of the nuclei of the keratinocytes in the stratum corneum of the epidermis" [smb:Susan M Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003662 abnormal proliferative zone "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Rbl1tm1.1Fad/Rbl1tm1.1Fad,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0003704 abnormal hair follicle development "anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003733 abnormal inner nuclear layer morphology "malformation/anomalous structure of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Rbl1tm1Htr/Rbl1tm1Htr,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI

 MP:0003734 abnormal inner plexiform layer morphology "malformation/anomalous structure of the retinal cell layer where bipolar and amacrine cell axons synapse with ganglion cell dendrites " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,Rbl1tm1Htr/Rbl1tm1Htr,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI

Allelic Composition: Rbl1tm1Htr/Rbl1tm1Htr,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Rbl1tm1Htr/Rbl1tm1Htr,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI

 MP:0004022 abnormal cone electrophysiology "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,Rbl1tm1Htr/Rbl1tm1Htr,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI

Allelic Composition: Rbl1tm1Htr/Rbl1tm1Htr,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI

 MP:0004097 abnormal cerebellar cortex morphology "any structural anomaly of the thin mantle of gray matter that covers the surface of each cerebral hemisphere, including the six layers of nerve cells and the nerve pathways that connect them; together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Rbl1tm1Htr/Rbl1tm1Htr,Tg(En2-cre)22Alj/0
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004275 abnormal postnatal subventricular zone morphology "any structural anomaly of the mitotically active layer of cells surrounding the brain ventricles in the adult that consists of migrating neuroblasts, astrocytes and transitory amplifying progenitor cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Rbl1tm1Mru/Rbl1tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0004347 abnormal scapular spine morphology "any structural anomaly of the trianguar ridge on the dorsal aspect of the scapula which separates the supra- from the infraspinatous fossa and where the trapezius and deltoid muscles are attached " [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Rbl1tm1.1Fad/Rbl1tm1.1Fad,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0004351 short humerus "reduced length of one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004355 short radius "reduced length of the short bone of the lateral forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Rbl1tm1.1Fad/Rbl1tm1.1Fad,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0004359 short ulna "reduced length of the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Rbl1tm1.1Fad/Rbl1tm1.1Fad,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0004385 interparietal bone hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, in the bone of the cranium that lies above and anterior to the occipital bone in some mammals" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Rbl1tm1.1Fad/Rbl1tm1.1Fad,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0004444 small supraoccipital bone "reduced size of the bone on the dorsal side of the great foramen of the skull, usually forming a part of the occipital in the adult, but distinct in the young" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rbl1tm1.1Fad/Rbl1tm1.1Fad,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rbl1tm1.1Fad/Rbl1tm1.1Fad,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Rbl1tm1Htr/Rbl1tm1Htr,Tg(En2-cre)22Alj/0
Genetic Background: involves: 129P2/OlaHsd * CD-1

Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Rbl1tm1Htr/Rbl1+,Tg(En2-cre)22Alj/0
Genetic Background: involves: 129P2/OlaHsd * CD-1

Allelic Composition: Rbl1tm1Mru/Rbl1tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0004980 increased neuronal precursor cell number "increased number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rbl1tm1Mru/Rbl1tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Rbl1tm1Mru/Rbl1tm1Mru
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * BALB/c * C57BL/6

 MP:0005105 abnormal middle ear ossicle morphology "anomalous structure or development of the three small bones of the middle ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rbl1tm1.1Fad/Rbl1tm1.1Fad,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0005161 hematuria "presence of blood in the urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:78193]
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Allelic Composition: Syt2m1Btlr/Syt2m1Btlr
Genetic Background: C57BL/6J-Syt2m1Btlr

 MP:0005205 abnormal eye anterior chamber "anomaly of the space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rb1tm1Tyj/Rb1tm2Brn,Rbl1tm1Tyj/Rbl1tm1Tyj,Trp53tm1Brn/Trp53tm1Brn,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Rb1tm1Tyj/Rb1tm2Brn,Rbl1tm1Tyj/Rbl1tm1Tyj,Trp53tm1Brn/Trp53tm1Tyj,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

 MP:0005240 abnormal amacrine cell morphology "anomalous structure of the interneurons of the retina" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,Rbl1tm1Htr/Rbl1tm1Htr,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI

Allelic Composition: E2f3tm1.1Gle/E2f3tm1.1Gle,Rbl1tm1Htr/Rbl1tm1Htr,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI

Allelic Composition: Rbl1tm1Htr/Rbl1tm1Htr,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI

Allelic Composition: Rbl1tm1Htr/Rbl1tm1Htr,Tg(Chx10-EGFP/cre,-ALPP)2Clc/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI * SJL

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rbl1tm1Mru/Rbl1tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0005296 abnormal humerus morphology "malformation of the bone of the forelimb that articulates with the scapula above and the radius and ulna below" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005299 abnormal eye posterior chamber "anomaly of the ringlike space, filled with aqueous humor, between the iris/pupil anteriorly and the lens and ciliary body posteriorly" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rb1tm1Tyj/Rb1tm2Brn,Rbl1tm1Tyj/Rbl1tm1Tyj,Trp53tm1Brn/Trp53tm1Brn,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Rb1tm1Tyj/Rb1tm2Brn,Rbl1tm1Tyj/Rbl1tm1Tyj,Trp53tm1Brn/Trp53tm1Tyj,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Rb1tm1Tyj/Rb1tm2Brn,Rbl1tm1Tyj/Rbl1+,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rbl1tm1Mru/Rbl1tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Rbl1tm1Tyj/Rbl1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0006072 abnormal retinal apoptosis "increase or decrease in the number of cells in the retina undergoing programmed cell death" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92622:]
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Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Rbl1tm1Tyj/Rbl1tm1Tyj,Tg(Nes-cre)1Atp/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0006073 abnormal retinal bipolar cell morphology "anomalous structure of the cells that transmit signals from the photoreceptors to retinal amacrine and ganglion cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92623:]
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Allelic Composition: Wt1tm1Nhsn/Wt1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,Rbl1tm1Htr/Rbl1tm1Htr,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI

Allelic Composition: E2f3tm1.1Gle/E2f3tm1.1Gle,Rbl1tm1Htr/Rbl1tm1Htr,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI

Allelic Composition: Rbl1tm1Htr/Rbl1tm1Htr,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI

 MP:0006309 decreased retinal ganglion cell number "reduced number of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Wt1tm1Nhsn/Wt1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,Rbl1tm1Htr/Rbl1tm1Htr,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI

Allelic Composition: E2f3tm1.1Gle/E2f3tm1.1Gle,Rbl1tm1Htr/Rbl1tm1Htr,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI

Allelic Composition: Rbl1tm1Htr/Rbl1tm1Htr,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI

 MP:0006310 retinoblastoma "a malignant tumor of the retina composed of cells arising from the retinoblasts" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Rbl1tm1Tyj/Rbl1tm1Tyj,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Rb1tm1Tyj/Rb1tm2Brn,Rbl1tm1Tyj/Rbl1tm1Tyj,Trp53tm1Brn/Trp53tm1Brn,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Rb1tm1Tyj/Rb1tm2Brn,Rbl1tm1Tyj/Rbl1tm1Tyj,Trp53tm1Brn/Trp53tm1Tyj,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Rb1tm1Tyj/Rb1tm2Brn,Rbl1tm1Tyj/Rbl1+,Trp53tm1Brn/Trp53tm1Brn,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Rb1tm1Tyj/Rb1tm2Brn,Rbl1tm1Tyj/Rbl1+,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

 MP:0006396 decreased long bone epiphyseal plate size "reduced size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Rbl1tm1.1Fad/Rbl1tm1.1Fad,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0006399 abnormal long bone epiphyseal ossification zone morphology "any anomaly in the structure of the layer of the epiphyseal plate where new bone matrix is deposited" [CALnet tutorial:http://137.222.110.150/calnet/Introanat/Introanat.htm, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Rbl1tm1.1Fad/Rbl1tm1.1Fad,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Rbl1tm1Mru/Rbl1tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ

 MP:0008151 increased diameter of long bones "increased width of the cross-sectional distance that extends from one lateral edge of a long bone, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd207tm2Mal/Cd207tm3(DTR/GFP)Mal
Genetic Background: involves: 129S2/SvPas

 MP:0008160 increased diameter of humerus "increased width of the cross-sectional distance that extends from one lateral edge of the humerus, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008161 increased diameter of radius "increased width of the cross-sectional distance that extends from one lateral edge of the radius, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008163 increased diameter of ulna "increased width of the cross-sectional distance that extends from one lateral edge of the ulna, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008218 delayed emergence of vibrissae "eruption of the vibrissae from the skin later than embryonic day E17-18" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008453 decreased retinal rod cell number "reduced number of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane" [MESH:A08.663.650.650.670.650]
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Allelic Composition: Wt1tm1Nhsn/Wt1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: E2f3tm1.1Gle/E2f3tm1.1Gle,Rbl1tm1Htr/Rbl1tm1Htr,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI

Allelic Composition: Rbl1tm1Htr/Rbl1tm1Htr,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,Rbl1tm1Htr/Rbl1tm1Htr,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI

Allelic Composition: Rbl1tm1Htr/Rbl1tm1Htr,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI

 MP:0008907 decreased total fat pad weight "less than average weight of the fat pads" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rbl1tm1Mru/Rbl1tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0009133 decreased white fat cell size "reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rbl1tm1Mru/Rbl1tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0009283 decreased gonadal fat pad weight "less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Rbl1tm1Mru/Rbl1tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0009293 decreased inguinal fat pad weight 
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Allelic Composition: Rbl1tm1Mru/Rbl1tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0009295 decreased interscapular fat pad weight 
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Allelic Composition: Rbl1tm1Mru/Rbl1tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0009550 urinary bladder carcinoma "a malignant neoplasm of the urinary bladder, arising from epithelial cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Syt2m1Btlr/Syt2m1Btlr
Genetic Background: C57BL/6J-Syt2m1Btlr

 MP:0010103 small thoracic cage "reduced size of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010320 increased pituitary gland tumor incidence "greater than the expected number of neoplams in the pituitary gland occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rb1tm1Tyj/Rb1+,Rbl1tm1Tyj/Rbl1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Rb1tm1Tyj/Rb1+,Rbl1tm1Tyj/Rbl1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Rbl1tm1.1Fad/Rbl1tm1.1Fad,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Rb1tm1Tyj/Rb1+,Rbl1tm1Tyj/Rbl1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Rbl1tm1Mru/Rbl1tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Rbl1tm1.1Fad/Rbl1tm1.1Fad,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Rbl1tm1Tyj/Rbl1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011703 increased fibroblast proliferation "greater the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Rbl1tm1Mru/Rbl1tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ

Allelic Composition: Rbl1tm3.1Jsag/Rbl1tm3.1Jsag
Genetic Background: involves: C57BL/6

 MP:0030079 small incisors "reduced size of the set of long teeth that are the most anterior and prominent in the jaw" [MGI:anna]
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Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003031 Cdkn1b / P46414 / Cyclin-dependent kinase inhibitor 1B / P46527*  / reaction
 ENSMUSG00000006728 Cdk4 / P30285 / Cyclin-dependent kinase 4 / P11802*  / reaction
 ENSMUSG00000014859 E2f4 / Q8R0K9 / Transcription factor E2F4 / Q16254* / E2F transcription factor 4*  / complex
 ENSMUSG00000025358 Cdk2 / P97377 / Cyclin-dependent kinase 2 / P24941*  / complex / reaction
 ENSMUSG00000023067 Cdkn1a / P39689 / Cyclin-dependent kinase inhibitor 1 / P38936* / cyclin dependent kinase inhibitor 1A*  / reaction
 ENSMUSG00000027552 E2f5 / Q61502 / Transcription factor E2F5 / Q15329* / E2F transcription factor 5*  / complex
 ENSMUSG00000038482 Tfdp1 / Q08639 / transcription factor Dp 1 / TFDP3* / Q14186* / Q5H9I0* / transcription factor Dp family member 3*  / complex
 ENSMUSG00000024563 Smad2 / Q62432 / Mothers against decapentaplegic homolog 2 / Q15796* / SMAD family member 2*  / reaction / complex
 ENSMUSG00000032402 Smad3 / Q8BUN5 / Mothers against decapentaplegic homolog 3 / P84022* / SMAD family member 3*  / reaction / complex
 ENSMUSG00000028800 Hdac1 / O09106 / Histone deacetylase 1 / Q13547*  / complex / reaction
 ENSMUSG00000024515 Smad4 / P97471 / Mothers against decapentaplegic homolog 4 / Q13485* / SMAD family member 4*  / reaction / complex
 ENSMUSG00000061062 Gm10093 / HDAC1* / Q13547* / histone deacetylase 1*  / reaction / complex
 ENSMUSG00000070348 Ccnd1 / P25322 / G1/S-specific cyclin-D1 / P24385* / cyclin D1*  / reaction






 

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